6 research outputs found
Trouble-Free Multicomponent Method for Combinatorial Synthesis of 2‑Amino-4-phenyl-5‑<i>H</i>‑indeno[1,2‑<i>d</i>]pyrimidine-5-one and Their Screening against Cancer Cell Lines
No full textThe present study describes an alkaline
water–ethanol mediated
series of combinatorial synthesis of 2-amino-4-phenyl-5-<i>H</i>-indenoÂ[1,2<i>d</i>]Âpyrimidine-5-one derivatives through
sequential multicomponent reaction of 1,3indandione, aromatic aldehydes,
and guanidine hydrochloride along with their anticancer evaluation.
The effect of sequential addition of the components in the configuration
of the desired product has been studied by UV–visible absorption
spectroscopy. The synthetic method obeys most of the green chemistry
principles in regard to high atom economy and greener, nontoxic, and
noncarcinogenic solvent system (water–ethanol). The selected
synthesized compounds have been screened against the human breast
cancer cell line MCF7, human colon cancer cell line HT29, and normal
viro monkey cell line, out of which 2-amino-4-(4-methÂoxyÂphenyl)-5<i>H</i>-indenoÂ[1,2-<i>d</i>]Âpyrimidin-5-one showed
significant potency toward human breast cancer cell line (MCF7)
(±)-Camphor-10-sulfonic acid as recyclable and efficient catalyst for the synthesis of some novel coumarin derivatives
No full textAn Expedient Four Component Synthesis of Substituted Pyrido-Pyrimidine Heterocycles in Glycerol:Proline Based Low Transition Temperature Mixture and Their Antioxidant Activity with Molecular Docking Studies
No full textSynthesis, biological evaluation and molecular docking studies of some novel indenospiro derivatives as anticancer agents
No full text
