A combined administration of Aragvādādi kaṣāyam and Syrup Talekt induced skin rashes

It is a common notion among people in India that herbal or Ayurvedic products are safe and do not produce any adverse effect. This is not true since Ayurveda has evaded many adverse effects which occur by combination of herbs. This axiom is potentiated by our report that occurs in the form of skin rashes. A 20-year-old South Indian female of Pittakapha prakṛti (constitution) after beginning therapy with Aragvādādi kaṣāyam (ARK) (poly-herbal formulation) and Syrup Talekt (poly-herbal patent formulation) for the treatment of recurrent incidence of abscess. Rash disappeared after stopping the suspected drug and treatment with Vibhîtakî kaṣāyam (decoction of Terminilia bellarica) and Śatadhauta ghṛtam . Possible and probable (score 6) were the causality according to WHO-Uppsala Monitoring Centre and Naranjo′s Adverse Drug Reaction Probability Scale and grouped under type-B reaction. To the best of our knowledge, this is the first case of skin rashes which seen after administration of ARK and Syrup Talekt. This report highlights the need of implementation of pharmacovigilance center in the hospital level and additional research in the field of skin toxicity of ARK and Syrup Talekt

Detection and confirmation of various varieties of Haritaki (Terminalia chebula Retz.) in North-Western Ghats of North Karnataka

Background: The fruit of Myrobalan (Terminalia chebula Retz.) is considered as Amruta (Nectar) and ‘King of Medicines’ in Ayurveda as it has wide range of therapeutic benefits. Ayurveda has explained 7-varieties of it with botanical and pharmacological characters. Actual identification of these variety and it’s botanical correlation was not done. Thus, present study was done to identify these varieties with available species of Terminalia in North-Western Ghats of North Karnataka. Methods: A prospective survey study was conducted in 10 localities of north-western Ghats of north Karnataka along with GPS system. Each identified plant and fruit was further analyzed with botanist for confirmation and collected after its maturity. The fruit was analyzed on shape, size, dimension, weight per fruit, color, mesocarp contents, seed character and size in relation with Ayurvedic classification. Further each classified fruit was analyzed on its microscopic and Powder characters etc. Results: The study identified the collected samples as Vijaya (Terminalia chebula Ver. 2 (typica)), Rohini (Terminalia chebula Ver. 3 (citrina)), Pootana (Terminalia chebula Ver. tomentella), Amirtha (Terminalia chebula Ver. gangitica) and Abhaya (Terminalia chebula Ver. parviflora, Thewaites Enum). Further, each variety has shown difference on its botanical, organoleptic, physicochemical analysis. Conclusion: The study potentially demonstrated the availability of varieties of Myrobalan in North-Western Ghats of North Karnataka and there is prominent disparity on physical and phytochemicals. Thus, it would certainly open the new pathway of research on its clinical efficacy

Detection and confirmation of various varieties of Haritaki (Terminalia chebula Retz.) in North-Western Ghats of North Karnataka

Background: The fruit of Myrobalan (Terminalia chebula Retz.) is considered as Amruta (Nectar) and ‘King of Medicines’ in Ayurveda as it has wide range of therapeutic benefits. Ayurveda has explained 7-varieties of it with botanical and pharmacological characters. Actual identification of these variety and it's botanical correlation was not done. Thus, present study was done to identify these varieties with available species of Terminalia in North-Western Ghats of North Karnataka. Methods: A prospective survey study was conducted in 10 localities of north-western Ghats of north Karnataka along with GPS system. Each identified plant and fruit was further analyzed with botanist for confirmation and collected after its maturity. The fruit was analyzed on shape, size, dimension, weight per fruit, color, mesocarp contents, seed character and size in relation with Ayurvedic classification. Further each classified fruit was analyzed on its microscopic and Powder characters etc. Results: The study identified the collected samples as Vijaya (Terminalia chebula Ver. 2 (typica)), Rohini (Terminalia chebula Ver. 3 (citrina)), Pootana (Terminalia chebula Ver. tomentella), Amirtha (Terminalia chebula Ver. gangitica) and Abhaya (Terminalia chebula Ver. parviflora, Thewaites Enum). Further, each variety has shown difference on its botanical, organoleptic, physicochemical analysis. Conclusion: The study potentially demonstrated the availability of varieties of Myrobalan in North-Western Ghats of North Karnataka and there is prominent disparity on physical and phytochemicals. Thus, it would certainly open the new pathway of research on its clinical efficacy