Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Manifestaciones cutáneas en el sida: estudio en 147 pacientes

Tesis doctoral inédita leída el 16-10-1990 en la Universidad Autónoma de Madrid, Facultad de Medicina. Departamento de Medicina

Management of eosinophilassociated inflammatory diseases: the importance of a multidisciplinary approach

Elevated eosinophil counts in blood and tissue are a feature of many pathological processes. Eosinophils can migrate and accumulate in a wide variety of tissues and, by infiltrating a target organ, can mediate the development of several inflammatory diseases. The normalization of eosinophilia is a common biomarker of a treatable trait and can also be used as a prognostic and predictive biomarker since it implies a reduction in type 2 inflammation that contributes to disease pathogenesis. Biological therapies targeting this cell type and its proinflammatory mediators have been shown to be effective in the management of a number of eosinophilic diseases, and for this reason they constitute a potential common strategy in the treatment of patients with various multimorbidities that present with type 2 inflammation. Various biological options are available that could be used to simultaneously treat multiple target organs with a single drug, bearing in mind the need to offer personalized treatments under the umbrella of precision medicine in all patients with eosinophil-associated diseases (EADs). In addition to reviewing these issues, we also discuss a series of perspectives addressing the management of EAD patients from a multidisciplinary approach, with the collaboration of health professionals from different specialties who manage the different multimorbidities that frequently occur in these patients. We examine the basic principles of care that this multidisciplinary approach must cover and present a multidisciplinary expert opinion regarding the ideal management of patients with EADs, from diagnosis to therapeutic approach and follow-u

Otro título: Obras de clásicos españoles e hispanoamericanos

Intérpretes: Miguel RubioMadrid, Instituto de Cultura Hispánica. Sábado, 18 de febrero a las siete y cuarto de la tardeCinta 1: Canarios / Gaspar Sanz – Min. 02.04: Aplausos – Min. 02.44: Biancafiore / Vicente Galileo – Min. 05.10: Aplausos – Min. 05.25: Saltarello / Vicente Galileo – Min. 08.49: Aplausos – Min. 09.18: Fantasía / Alonso de Mudarra -- 12.16: Aplausos – Min. 12.53: Sonata / Scarlatti – Min. 15.02: Aplausos – Min. 15.41: Vals, op. 39 / Johannes Brahms – Min. 19.28: Aplausos – Min. 19.55: Variaciones en un tema de Mozart op.9 / Fernando Sor – Min. 26.06: Aplausos – Min. 26.18: Preludio nº2 / Francisco Tárrega – Min. 27.51: Francisco Tárrega – Min. 30.36: Aplausos -- Cinta 2: Carnavalito – Min. 01.47: Aplausos – Min. 01.55: Vals criollo / Antonio Lauro – Min. 04.13: Aplausos – Min. 04.26: Aire del Caribe / Raúl Borges – Min. 07.45: Aplausos – Min. 07.59: Norteña / J. Gómez Crespo – Min. 10.40: Aplausos – Min. 10.53: Choros nº1 / Heitor Villa-Lobos—Min. 14.25: Aplausos – Min. 15.10: Valse / M. Ponce – Min. 18.05: Aplausos – Min. 18.19: Colibirí / Sagreras – Min. 19.37: Aplausos – Min. 19.52: Danza paraguaya / Agustín Barrios – Min. 22.40: Aplausos – Min. 23.01: Fandanguillo / Moreno Torroba – Min. 24.57: Aplausos – Min. 25.05: Danza X / E. Granados – Min. 29.13: Aplausos – Min. 29.23: Asturias / Isaac Albéniz – Min. 30.37: Falta contenido