Cell death machinery makes life more robust

CED-3, a protein that is essential for programmed cell death, also has an unexpected role in the regulation of non-apoptotic genes during normal development

The missing metals problem. III How many metals are expelled from galaxies?

[Abridged] We revisit the metal budget at z~2. In the first two papers of this series, we already showed that ~30% (to <60% if extrapolating the LF) of the metals are observed in all z~2.5 galaxies detected in current surveys. Here, we extend our analysis to the metals outside galaxies, i.e. in intergalactic medium (IGM), using observational data and analytical calculations. Our results for the two are strikingly similar: (1) Observationally, we find that, besides the small (5%) contribution of DLAs, the forest and sub-DLAs contribute subtantially to make <30--45% of the metal budget, but neither of these appear to be sufficient to close the metal budget. The forest accounts for 15--30% depending on the UV background, and sub-DLAs for >2% to <17% depending on the ionization fraction. Together, the `missing metals' problem is substantially eased. (2) We perform analytical calculations based on the effective yield--mass relation. At z=2, we find that the method predicts that 2$--50% of the metals have been ejected from galaxies into the IGM, consistent with the observations. The metal ejection is predominantly by L<1/3L_B^*(z=2) galaxies, which are responsible for 90% the metal enrichment, while the 50 percentile is at L~1/10L^*_B(z=2). As a consequence, if indeed 50% of the metals have been ejected from galaxies, 3--5 bursts of star formation are required per galaxy prior to z=2. The ratio between the mass of metals outside galaxies to those in stars has changed from z=2 to z=0: it was 2:1 or 1:1 and is now 1:8 or 1:9. This evolution implies that a significant fraction of the IGM metals will cool and fall back into galaxies.Comment: 18pages, MNRAS, in press; small changes to match proofs; extended version with summary tabl

Electron degeneracy and intrinsic magnetic properties of epitaxial Nb:SrTiO3_3 thin-films controlled by defects

We report thermoelectric power experiments in e-doped thin films of SrTiO$_3$ (STO) which demonstrate that the electronic band degeneracy can be lifted through defect management during growth. We show that even small amounts of cationic vacancies, combined with epitaxial stress, produce a homogeneous tetragonal distortion of the films, resulting in a Kondo-like resistance upturn at low temperature, large anisotropic magnetoresistance, and non-linear Hall effect. Ab-initio calculations confirm a different occupation of each band depending on the degree of tetragonal distortion. The phenomenology reported in this paper for tetragonally distorted e-doped STO thin films, is similarto that observed in LaAlO$_3$/STO interfaces and magnetic STO quantum wells.Comment: 5 pages, 5 figure

Testing Asteroseismic Radii of Dwarfs and Subgiants with Kepler and Gaia

We test asteroseismic radii of Kepler main-sequence and subgiant stars by deriving their parallaxes which are compared with those of the first Gaia data release. We compute radii based on the asteroseismic scaling relations as well as by fitting observed oscillation frequencies to stellar models for a subset of the sample, and test the impact of using effective temperatures from either spectroscopy or the infrared flux method. An offset of 3%, showing no dependency on any stellar parameters, is found between seismic parallaxes derived from frequency modelling and those from Gaia. For parallaxes based on radii from the scaling relations, a smaller offset is found on average; however, the offset becomes temperature dependent which we interpret as problems with the scaling relations at high stellar temperatures. Using the hotter infrared flux method temperature scale, there is no indication that radii from the scaling relations are inaccurate by more than about 5%. Taking the radii and masses from the modelling of individual frequencies as reference values, we seek to correct the scaling relations for the observed temperature trend. This analysis indicates that the scaling relations systematically overestimate radii and masses at high temperatures, and that they are accurate to within 5% in radius and 13% in mass for main-sequence stars with temperatures below 6400 K. However, further analysis is required to test the validity of the corrections on a star-by-star basis and for more evolved stars.Comment: 12 pages, 9 figures. Accepted for publication in MNRA

Development of Aluminum LEKIDs for Balloon-Borne Far-IR Spectroscopy

We are developing lumped-element kinetic inductance detectors (LEKIDs) designed to achieve background-limited sensitivity for far-infrared (FIR) spectroscopy on a stratospheric balloon. The Spectroscopic Terahertz Airborne Receiver for Far-InfraRed Exploration (STARFIRE) will study the evolution of dusty galaxies with observations of the [CII] 158 $\mu$m and other atomic fine-structure transitions at $z=0.5-1.5$, both through direct observations of individual luminous infrared galaxies, and in blind surveys using the technique of line intensity mapping. The spectrometer will require large format ($\sim$1800 detectors) arrays of dual-polarization sensitive detectors with NEPs of $1 \times 10^{-17}$ W Hz$^{-1/2}$. The low-volume LEKIDs are fabricated with a single layer of aluminum (20 nm thick) deposited on a crystalline silicon wafer, with resonance frequencies of $100-250$ MHz. The inductor is a single meander with a linewidth of 0.4 $\mu$m, patterned in a grid to absorb optical power in both polarizations. The meander is coupled to a circular waveguide, fed by a conical feedhorn. Initial testing of a small array prototype has demonstrated good yield, and a median NEP of $4 \times 10^{-18}$ W Hz$^{-1/2}$.Comment: accepted for publication in Journal of Low Temperature Physic

LIN-42, the Caenorhabditis elegans PERIOD homolog, Negatively Regulates MicroRNA Transcription

During C. elegans development, microRNAs (miRNAs) function as molecular switches that define temporal gene expression and cell lineage patterns in a dosage-dependent manner. It is critical, therefore, that the expression of miRNAs be tightly regulated so that target mRNA expression is properly controlled. The molecular mechanisms that function to optimize or control miRNA levels during development are unknown. Here we find that mutations in lin-42, the C. elegans homolog of the circadian-related period gene, suppress multiple dosage-dependent miRNA phenotypes including those involved in developmental timing and neuronal cell fate determination. Analysis of mature miRNA levels in lin-42 mutants indicates that lin-42 functions to attenuate miRNA expression. Through the analysis of transcriptional reporters, we show that the upstream cis-acting regulatory regions of several miRNA genes are sufficient to promote highly dynamic transcription that is coupled to the molting cycles of post-embryonic development. Immunoprecipitation of LIN-42 complexes indicates that LIN-42 binds the putative cis-regulatory regions of both non-coding and protein-coding genes and likely plays a role in regulating their transcription. Consistent with this hypothesis, analysis of miRNA transcriptional reporters in lin-42 mutants indicates that lin-42 regulates miRNA transcription. Surprisingly, strong loss-of-function mutations in lin-42 do not abolish the oscillatory expression patterns of lin-4 and let-7 transcription but lead to increased expression of these genes. We propose that lin-42 functions to negatively regulate the transcriptional output of multiple miRNAs and mRNAs and therefore coordinates the expression levels of genes that dictate temporal cell fate with other regulatory programs that promote rhythmic gene expression

First Observational Tests of Eternal Inflation: Analysis Methods and WMAP 7-Year Results

In the picture of eternal inflation, our observable universe resides inside a single bubble nucleated from an inflating false vacuum. Many of the theories giving rise to eternal inflation predict that we have causal access to collisions with other bubble universes, providing an opportunity to confront these theories with observation. We present the results from the first observational search for the effects of bubble collisions, using cosmic microwave background data from the WMAP satellite. Our search targets a generic set of properties associated with a bubble collision spacetime, which we describe in detail. We use a modular algorithm that is designed to avoid a posteriori selection effects, automatically picking out the most promising signals, performing a search for causal boundaries, and conducting a full Bayesian parameter estimation and model selection analysis. We outline each component of this algorithm, describing its response to simulated CMB skies with and without bubble collisions. Comparing the results for simulated bubble collisions to the results from an analysis of the WMAP 7-year data, we rule out bubble collisions over a range of parameter space. Our model selection results based on WMAP 7-year data do not warrant augmenting LCDM with bubble collisions. Data from the Planck satellite can be used to more definitively test the bubble collision hypothesis.Comment: Companion to arXiv:1012.1995. 41 pages, 23 figures. v2: replaced with version accepted by PRD. Significant extensions to the Bayesian pipeline to do the full-sky non-Gaussian source detection problem (previously restricted to patches). Note that this has changed the normalization of evidence values reported previously, as full-sky priors are now employed, but the conclusions remain unchange

The shape of jamming arches in two-dimensional deposits of granular materials

We present experimental results on the shape of arches that block the outlet of a two dimensional silo. For a range of outlet sizes, we measure some properties of the arches such as the number of particles involved, the span, the aspect ratio, and the angles between mutually stabilizing particles. These measurements shed light on the role of frictional tangential forces in arching. In addition, we find that arches tend to adopt an aspect ratio (the quotient between height and half the span) close to one, suggesting an isotropic load. The comparison of the experimental results with data from numerical models of the arches formed in the bulk of a granular column reveals the similarities of both, as well as some limitations in the few existing models.Comment: 8 pages; submitted to Physical Review