CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Velocity dispersion and dynamical masses for 388 galaxy clusters and groups

The second catalogue of Planck Sunyaev-Zeldovich (SZ) sources, hereafter PSZ2, represents the largest galaxy cluster sample selected by means of their SZ signature in a full-sky survey. Using telescopes at the Canary Island observatories, we conducted the long-term observational program 128- MULTIPLE-16/15B (hereafter LP15), a large and complete optical follow-up campaign of all the unidentified PSZ2 sources in the northern sky, with declinations above −15° and no correspondence in the first Planck catalogue PSZ1. This paper is the third and last in the series of LP15 results, after Streblyanska et al. (2019, A&A, 628, A13) and Aguado-Barahona et al. (2019, A&A, 631, A148), and presents all the spectroscopic observations of the full program. We complement these LP15 spectroscopic results with Sloan Digital Sky Survey archival data and other observations from a previous program (ITP13-08), and present a catalogue of 388 clusters and groups of galaxies including estimates of their velocity dispersion. The majority of them (356) are optical counterparts of PSZ2 sources. A subset of 297 of those clusters are used to construct the MSZ − Mdyn scaling relation based on the estimated SZ mass from Planck measurements and our dynamical mass estimates. We discuss and correct for different statistical and physical biases in the estimation of the masses, such as the Eddington bias when estimating MSZ and the aperture and the number of galaxies used to calculate Mdyn. The SZ-to-dynamical mass ratio for those 297 PSZ2 clusters is (1 − B) = 0.80 ± 0.04 (stat) ± 0.05 (sys), with only marginal evidence for a possible mass dependence for this factor. Our value is consistent with previous results in the literature, but is associated with a significantly smaller uncertainty due to the use of the largest sample size for this type of study

Optical validation and characterization of

Aims. The second catalogue of Planck Sunyaev–Zeldovich (SZ) sources, hereafter PSZ2, is the largest sample of galaxy clusters selected through their SZ signature in the full sky. At the time of publication, 21% of these objects had no known counterpart at other wavelengths. Using telescopes at the Canary Island observatories, we conducted the long-term observational programme 128-MULTIPLE-16/15B (hereafter LP15), a large and complete optical follow-up campaign of all the unidentified PSZ2 sources in the northern sky, with declinations above −15° and no correspondence in the first Planck catalogue PSZ1. The main aim of LP15 is to validate all those SZ cluster candidates, and to contribute to the characterization of the actual purity and completeness of full Planck SZ sample. In this paper, we describe the full programme and present the results of the first year of observations. Methods. The LP15 programme was awarded 44 observing nights, spread over two years in three telescopes at the Roque de los Muchachos Observatory. The full LP15 sample comprises 190 previously unidentified PSZ2 sources. For each target, we performed deep optical imaging and spectroscopy. Our validation procedure combined this optical information with SZ emission as traced by the publicly available Planck Compton y-maps. The final classification of the new galaxy clusters as optical counterparts of the SZ signal is established according to several quantitative criteria based on the redshift, velocity dispersion, and richness of the clusters. Results. This paper presents the detailed study of 106 objects out of the LP15 sample, corresponding to all the observations carried out during the first year of the programme. We confirmed the optical counterpart for 41 new PSZ2 sources, 31 of them being validated using also velocity dispersion based on our spectroscopic information. This is the largest dataset of newly confirmed PSZ2 sources without any previous optical information. All the confirmed counterparts are rich structures (i.e. they show high velocity dispersion), and are well aligned with the nominal Planck coordinates (i.e. ∼70% of them are located at less than 3′ distance). In total, 65 SZ sources are classified as unconfirmed, 57 of them being due to the absence of an optical over-density, and eight of them due to a weak association with the observed SZ decrement. Most of the sources with no optical counterpart are located at low galactic latitudes and present strong galactic cirrus in the optical images, the dust contamination being the most probable explanation for their inclusion in the PSZ2 catalogue

Optical validation and characterization of

Context. The second legacy catalog of Planck Sunyaev–Zeldovich (SZ) sources, hereafter PSZ2, provides the largest galaxy cluster sample selected by means of the SZ signature of the clusters in a full sky survey. In order to fully characterize this PSZ2 sample for cosmological studies, all the members should be validated and the physical properties of the clusters, including mass and redshift, should be derived. However, at the time of its publication, roughly 21% of the 1653 PSZ2 members had no known counterpart at other wavelengths. Aims. Here, we present the second and last year of observations of our optical follow-up program 128-MULTIPLE-16/15B (hereafter LP15), which has been developed with the aim of validating all the unidentified PSZ2 sources in the northern sky with declinations higher than −15° that have no correspondence in the first Planck catalog PSZ1. The description of the program and the first year of observations have been presented previously. Methods. The LP15 program was awarded 44 observing nights that were spread over two years with the Isaac Newton Telescope (INT), the Telescopio Nazionale Galileo (TNG), and the Gran Telescopio Canarias (GTC), all at Roque de los Muchachos Observatory (La Palma). Following the same method as described previously, we performed deep optical imaging for more than 200 sources with the INT and spectroscopy for almost 100 sources with the TNG and GTC at the end of the LP15 program. We adopted robust confirmation criteria based on velocity dispersion and richness estimates for the final classification of the new galaxy clusters as the optical counterparts of the PSZ2 detections. Results. Here, we present the observations of the second year of LP15, as well as the final results of the program. The full LP15 sample comprises 190 previously unidentified PSZ2 sources. Of these, 106 objects were studied before, while the remaining sample (except for 6 candidates) has been completed in the second year and is discussed here. In addition to the LP15 sample, we here study 42 additional PSZ2 objects that were originally validated as real clusters because they matched a WISE or PSZ1 counterpart, but they had no measured spectroscopic redshift. In total, we confirm the optical counterparts for 81 PSZ2 sources after the full LP15 program, 55 of them with new spectroscopic information. Forty of these 81 clusters are presented in this paper. After the LP15 observational program the purity of the PSZ2 catalog has increased from 76.7% originally to 86.2%. In addition, we study the possible reasons for false detection, and we report a clear correlation between the number of unconfirmed sources and galactic thermal dust emission

Velocity dispersion and dynamical mass for 270 galaxy clusters in the Planck PSZ1 catalogue

We present the velocity dispersion and dynamical mass estimates for 270 galaxy clusters included in the first Planck Sunyaev-Zeldovich (SZ) source catalogue, the PSZ1. Part of the results presented here were achieved during a two-year observational program, the ITP, developed at the Roque de los Muchachos Observatory (La Palma, Spain). In the ITP we carried out a systematic optical follow-up campaign of all the 212 unidentified PSZ1 sources in the northern sky that have a declination above -15° and are without known counterparts at the time of the publication of the catalogue. We present for the first time the velocity dispersion and dynamical mass of 58 of these ITP PSZ1 clusters, plus 35 newly discovered clusters that are not associated with the PSZ1 catalogue. Using Sloan Digital Sky Survey archival data, we extend this sample, including 212 already confirmed PSZ1 clusters in the northern sky. Using a subset of 207 of these galaxy clusters, we constrained the MSZ-Mdyn scaling relation, finding a mass bias of (1 - B) = 0.83 ± 0.07(stat) ± 0.02(sys). We show that this value is consistent with other results in the literature that were obtained with different methods (X-ray, dynamical masses, or weak-lensing mass proxies). This result cannot dissolve the tension between primordial cosmic microwave background anisotropies and cluster number counts in the ωM-σ8 plane

Velocity dispersion and dynamical mass for 270 galaxy clusters in the

We present the velocity dispersion and dynamical mass estimates for 270 galaxy clusters included in the first Planck Sunyaev-Zeldovich (SZ) source catalogue, the PSZ1. Part of the results presented here were achieved during a two-year observational program, the ITP, developed at the Roque de los Muchachos Observatory (La Palma, Spain). In the ITP we carried out a systematic optical follow-up campaign of all the 212 unidentified PSZ1 sources in the northern sky that have a declination above −15° and are without known counterparts at the time of the publication of the catalogue. We present for the first time the velocity dispersion and dynamical mass of 58 of these ITP PSZ1 clusters, plus 35 newly discovered clusters that are not associated with the PSZ1 catalogue. Using Sloan Digital Sky Survey archival data, we extend this sample, including 212 already confirmed PSZ1 clusters in the northern sky. Using a subset of 207 of these galaxy clusters, we constrained the MSZ–Mdyn scaling relation, finding a mass bias of (1 − B) = 0.83 ± 0.07(stat) ± 0.02(sys). We show that this value is consistent with other results in the literature that were obtained with different methods (X-ray, dynamical masses, or weak-lensing mass proxies). This result cannot dissolve the tension between primordial cosmic microwave background anisotropies and cluster number counts in the ΩM–σ8 plane

Characterization of a subsample of the

Aims. The Planck catalogues of Sunyaev –Zeldovich (SZ) sources, PSZ1 and PSZ2, are the largest catalogues of galaxy clusters selected through their SZ signature in the full sky. In 2013, we started a long-term observational programme at Canary Island observatories with the aim of validating ∼500 unconfirmed SZ sources. In this work we present results of the initial pre-screening of possible cluster counterparts using photometric and spectroscopic data of the Sloan Digital Sky Survey DR12. Our main aim is to identify previously unconfirmed PSZ2 cluster candidates and to contribute in the determination of the actual purity and completeness of Planck SZ source sample. Methods. Using the latest version of the PSZ2 catalogue, we selected all sources overlapping with the SDSS DR12 footprint and without redshift information. We validated these cluster fields following optical criteria (mainly distance with respect to the Planck pointing, magnitude of the brightest cluster galaxy, and cluster richness), and combined these criteria with the profiles of the Planck Compton y-maps. This combined procedure allows for a more robust identification of optical counterparts compared to simply cross-matching with existing SDSS cluster catalogues that have been constructed from earlier SDSS data releases. Results. The sample contains new redshifts for 37 Planck galaxy clusters that were not included in the original release of PSZ2 Planck catalogue. We detect three cases as possible multiple counterparts. We show that a combination of all available information (optical images and profile of SZ signal) can provide correct associations between the observed Planck SZ source and the optically identified cluster. We also show that Planck SZ detection is very sensitive even to high-z (z > 0.5) clusters. In addition, we also present updated spectroscopic information for 34 Planck PSZ1 sources (33 previously photometrically confirmed and 1 new identification)

Optical validation and characterisation of Planck PSZ1 sources at the Canary Islands observatories: II. Second year of ITP13 observations

We report new galaxy clusters previously unknown included in the first Planck Sunyaev–Zeldovich (SZ) sources catalogue, the PSZ1. The results presented here were achieved during the second year of a two-year observational programme, the ITP13, developed at the Roque de los Muchachos Observatory (La Palma, Spain). Using the 2.5 m Isaac Newton telescope, the 3.5 m Telescopio Nazionale Galileo, the 4.2 m William Herschel telescope and the 10.4 m Gran Telescopio Canarias we characterised 75 SZ sources with low SZ significance, SZ S <  5.32. We performed deep optical imaging and spectroscopy in order to associate actual galaxy clusters with the SZ Planck source. We adopted robust criteria, based on the 2D spatial distribution, richness, and velocity dispersions to confirm actual optical counterparts up to z <  0.85. The selected systems are confirmed only if they are well aligned with respect to the PSZ1 coordinate and show high richness and high velocity dispersion. In addition, we also inspected the Compton y-maps and SZ significance in order to identify unrealistic detections. Following this procedure, we identify 26 cluster counterparts associated with the SZ emission, which means that only about 35% of the clusters considered in this low S/N PSZ1 subsample are validated. Forty-nine SZ sources (∼65% of this PSZ1 subset) remain unconfirmed. At the end of the ITP13 observational programme, we have studied 256 SZ sources with Dec ≥ −15° (212 of them completely unknown), finding optical counterparts for 152 SZ sources. The ITP13 validation programme has allowed us to update the PSZ1 purity, which is now more refined, increasing from 72% to 83% in the low SZ S/N regime. Our results are consistent with the predicted purity curve for the full PSZ1 catalogue and with the expected fraction of false detections caused by the non-Gaussian noise of foreground signals. We find a strong correlation between the number of unconfirmed sources and the thermal emission of diffuse galactic dust at 857 GHz, thus increasing the fraction of false Planck SZ detections at low galactic latitudes

Optical validation and characterization of Planck PSZ1 sources at the Canary Islands observatories

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