Não factores psicológicos desempenham um papel crucial no desempenho esportivo? - Investigação sobre personalidade e psicológicos variáveis de atletas na Hungria

ABSTRACT: Contemporary research aims to investigate background factors that contribute to successful sport performance. Of these factors the psychological well-being and mental health status should be underlined that have gained a significant role, particularly in the frames of sport psychological counseling. The aim of the present study is to seek for interrelations of psychological variables and sport performance of young athletes, and to reveal what advantages might be utilized in younger ages to strengthen sport performance. No gender differences were found in sport performance; while age showed significant difference. The findings indicated differences of the investigated psychological variables by age and gender. Regression analyses were employed to test how psychological factors predict successful sport performance. The analyses strengthened the role of age and gender specific factors that should be considered during sport psychological counseling. The benefits should be highlighted in young age in order to ensure more successful performance in adulthood.RESUMEN: La investigación contemporánea tiene como objetivo investigar los vairables explicativas que contribuyen al rendimiento deportivo exitoso. De estos factores vale la pena destacar el bienestar mental y el estado de salud psicológica que han ganado un papel importante, sobre todo en los marcos de asesoramiento psicológico de deporte. El objetivo del presente estudio es la búsqueda de interrelaciones de variables psicológicas y el rendimiento deportivo de los atletas jóvenes, y revelar qué ventajas podrían ser utilizadas con los más jóvenes para fortalecer el rendimiento deportivo. No se encontraron diferencias de género en el rendimiento deportivo; mientras que la edad mostró diferencias significativas. Los resultados indicaron diferencias en las variables psicológicas estudiadas por edad y género. Se utilizó análisis de regresión para probar cómo los factores psicológicos predicen el rendimiento exitoso. El análisis demostró el papel de los factores específicos de edad y género que deben ser considerados durante el asesoramiento psicológico de deporte. El trabajo psicológico debe comenzar a edades tempranas para garantizar el rendimiento mas exitoso a la edad adultaRESUMO: A investigação contemporânea tem procurado identificar os factores basilares que contribuem para um desempenho desportivo de sucesso. Deste factores, o bem-estar psicológico e o estado de saúde mental devem ser enfatizados tendo ganho um papel significativo, particularmente nas abordagens relativas ao aconselhamento psicológico no âmbito desportivo. O objectivo do presente estudo é identificar interrelações entre as variáveis psicológicas e o desempenho desportivo em jovens atletas e revelar quais as vantagens que podem ser utilizadas por estes jovens para potenciar a sua performance desportiva. Não se verificaram diferenças de género na performance desportiva; enquanto o contrário se verificou relativamente à idade. Estes resultados indicam diferenças nas variáveis psicológicas investigadas tendo em conta o género e a idade. Foram efectuadas análises de regressão para testar como os factores psicológicos predizem uma performance de sucesso. Os resultados enfatizam o papel da idade e do género como factores específicos que devem ser considerados durante o aconselhamento psicoló- gico desportivo. Os benefícios devem ser reforçados nos jovens de forma a garantir uma performance de sucesso na prática desportiva adulta

Pancreatic Autoantibodies Are Associated with Reactivity to Microbial Antibodies, Penetrating Disease Behavior, Perianal Disease, and Extraintestinal Manifestations, But Not with NOD2/CARD15 or TLR4 Genotype in a Hungarian IBD Cohort

Background: Pancreatic autoantibodies (PAB) and goblet cell autoantibodies (GAB) are specific for Crohn's disease (CD) and ulcerative colitis (UC). but the sensitivity alone is low. Conventional antibodies and carbohydrates (glycans) are associated with disease phenotype and may be of diagnostic importance in inflammatory bowel disease (IBD). Our aim was to determine the accuracy of PAB and GAB autoantibodies as well LIS to Study relevant phenotype-serotype associations. Methods: A Hungarian study cohort of 1092 subjects, including 689 well-characterized, unrelated IBD patients (CD: 579, m/f ratio: 274/305. duration: 7.9 +/- 11.2 years UC: 110 m/f ratio: 53/57, duration: 8.9 +/- 9.8 years), 139 celiac patients, 100 healthy, and 64 non-IBD gastrointestinal controls were investigated. Sera were assayed for PAB-GAB IgA/IgG. anti-Omp. cerevisiae antibodies (ASCA), and anti-glycans. TLR4 and NOD2/CARD15 was tested by polymerase chain reaction / restriction fragment length polymorphism (PCR-RFLP). Detailed clinical phenotypes were determined. Results: The prevalence of PAB was significantly more frequent in CD (41.1%) versus UC (22.7%). celiac (22.3%), and controls (8% and 4.6%, P < 0.01 for each). while GAB detection was poor in all groups except UC (15.4%). In CD the combination of PAB and/or anti-glycans/ASCA increased the sensitivity to 72% and 59%, respectively, for isolated colonic disease. PAB was associated to gylcans (odds ratio [OR] 1.74, P = 0.002), ASCA IgG/IgA (OR 1.75. P = 0.002), Omp (OR 1.86 P = 0.001) Lis well as perforating, perianal disease, arthritis, ocular, and cutaneous manifestations (P = 0.002-0.032). In contrast, PAB and GAB antibodies were not associated with NOD2/CARD15 or TLR4. response to medical therapy, or need for surgery. No associations were found in UC. Conclusions: PAB autoantibodies in combination with ASCA or anti-glycan antibodies increase the sensitivity for detecting CD, especially isolated colonic CD. Antibody response to PAB was associated with complicated disease phenotype and extraintestinal manifestations in this Eastern European IBD cohort

Seroreactivity to microbial components in Crohn's disease is associated with ileal involvement, noninflammatory disease behavior andNOD2/CARD15 genotype, but not with risk for surgery in a Hungarian cohort of IBD patients

BACKGROUND: Antibodies directed against Saccharomyces cerevisiae (ASCA), perinuclear components of neutrophils (pANCA), and porin protein C of Escherichia coli (anti-OmpC) are reported to be associated with disease phenotype and may be of diagnostic importance in inflammatory bowel disease (IBD). Since limited data are available from Eastern Europe, we assessed the above antibodies in Hungarian IBD patients. METHODS: In all, 653 well-characterized, unrelated consecutive IBD patients (Crohn's disease [CD]: 558, m/f: 263/295, duration: 8.1 +/- 10.7 years; ulcerative colitis [UC]: 95, m/f: 44/51, duration: 8.9 +/- 9.8 years) and 100 healthy subjects were investigated. Sera were assayed for anti-Omp and ASCA by enzyme-linked immunosorbent assay (ELISA) and ANCA by indirect immunofluorescence assay (IIF). TLR4 and NOD2/CARD15 variants were tested by polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP). Detailed clinical phenotypes were determined by reviewing the medical charts. RESULTS: Anti-Omp, ASCA, and atypical pANCA antibodies were present in 31.2%, 59.3%, and 13.8% of CD, 24.2%, 13.7%, and 48.5% of UC patients, and in 20%, 16%, and 5.6% of controls, respectively. ASCA and anti-Omp positivity were associated with increased risk for CD (odds ratio [OR](ASCA) = 7.65, 95% confidence interval [CI]: 4.37-13.4; OR(Omp) = 1.81, 95% CI: 1.08-3.05). In a logistic regression analysis, anti-Omp and ASCA were independently associated with ileal and noninflammatory disease, but not with a risk for surgery or response to steroids or infliximab. A serology dosage effect was also observed. ASCA and anti-Omp antibodies were associated with NOD2/CARD15, in addition to a gene dosage effect. No associations were found in UC. CONCLUSIONS: Serological markers were useful in the differentiation between CD and UC in an Eastern European IBD cohort. Reactivity to microbial components was associated with disease phenotype and NOD2/CARD15 genotype, further supporting the role of altered microbial sensing in the pathogenesis of CD