Human papillomavirus genotype distribution in tonsil cancers.

International audienceBACKGROUND: The incidence of tonsil cancers has increased in several countries. French data on HPV prevalence in tonsil cancers are scarce. The objective of this study was thus to assess the overall and type specific HPV prevalence in tonsil histological samples. METHODS: This French retrospective multicenter study involved 12 centres located throughout the country. Were included 185 histological samples collected from year 2000 to 2009 with a validated diagnosis of tonsil invasive carcinomas. HPV prevalence was studied according to gender, age and histological type of cancer. RESULTS: Overall HPV prevalence was 57% in tonsil cancers. Mean age of diagnosis was comparable in HPV positive tonsils cases (60 ± 11.2) and HPV negative tonsil cases (59 ± 9.6). HPV prevalence was significantly higher in female than in male cases (28/35 versus 78/150 in tonsil cases, respectively, P = 0.003). About 53% of tonsil cases were infected by a single HPV type. Only eight (4%) samples were infected by more than one HPV type. Among HPV positive samples, HPV 16 was found in 89% of tonsil cases. All other HPV types had prevalence below 5%. CONCLUSIONS: Our results indicate that HPV is common in tonsil carcinomas and emphasize the predominant role of HPV 16

Extra low interstitial titanium based fully porous morphological bone scaffolds manufactured using selective laser melting

This is an accepted manuscript of an article published by Elsevier in Journal of the Mechanical Behavior of Biomedical Materials on 29/03/2019, available online: https://doi.org/10.1016/j.jmbbm.2019.03.025 The accepted version of the publication may differ from the final published version.Lattice structure based morphologically matched scaffolds is rapidly growing facilitated by developments in Additive Manufacturing. These porous structures are particularly promising due to their potential in reducing stress shielding and maladapted stress concentration. Accordingly, this study presents Extra Low Interstitial (ELI) Titanium alloy based morphological scaffolds featuring three different porous architecture. All scaffolds were additively manufactured using Selective Laser Melting from Ti6Al4V ELI with porosities of 73.85, 60.53 and 55.26% with the global geometry dictated through X-Ray Computed Tomography. The elastic and plastic performance of both the scaffold prototypes and the bone section being replaced were evaluated through uniaxial compression testing. Comparing the data, the suitability of the Maxwell criterion in evaluating the stiffness behaviour of fully porous morphological scaffolds are carried out. The outcomes show that the best performing scaffolds presented in this study have high strength (169 MPa) and low stiffness (5.09 GPa) suitable to minimise stress shielding. The matching morphology in addition to high porosity allow adequate space for flow circulation and has the potential to reduce maladapted stress concentration. Finally, the Electron Diffraction X-ray analysis revealed a small difference in the composition of aluminium between the particle and the bonding material at the scaffold surface

Vaccination contre l'hyépatite B et affections démyélinisantes

POITIERS-BU Médecine pharmacie (861942103) / SudocSudocFranceF

Epidémie de rougeole (cas admis au CHU de Poitiers de septembre 2008 à juin 2011)

POITIERS-BU Médecine pharmacie (861942103) / SudocSudocFranceF

Etude comparative de deux techniques de dépistage de l'infection à virus de l'immunodéficience humaine

POITIERS-BU Médecine pharmacie (861942103) / SudocSudocFranceF

Etiologies virales des infections respiratoires de l'enfant observées dans le service de pédiatrie du CHU [centre hospitalier universitaire] de Poitiers d'octobre 2003 à mai 2004

POITIERS-BU Médecine pharmacie (861942103) / SudocSudocFranceF

Bioterrorisme et guerre biologique

POITIERS-BU Médecine pharmacie (861942103) / SudocSudocFranceF

Aspects cliniques, épidémiologiques et virologiques de l'infection à HPV [papillomavirus] du col utérin chez des femmes co-infectées par le HIV[virus de l'immunodéficience humaine]

POITIERS-BU Médecine pharmacie (861942103) / SudocSudocFranceF

Place de la recherche des papillomavirus dans la pathologie cervicale utérine (expérience au CHU [centre hospitalier universitaire] de Poitiers)

POITIERS-BU Médecine pharmacie (861942103) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Pathogenèse du syndrome sec associé à l'infection par le virus HTVL-I (recherche de variants, modèle d'étude in vitro)

POITIERS-BU Sciences (861942102) / SudocSudocFranceF