Parallelization of Support Vector Machines

Tugivektormasin (Support Vector Machine) on masinõppe meetod, mida kasutakse andmete klassifitseerimiseks. Binaarse klassifikatsiooni probleem seisneb sellise funktsiooni või mudeli leidmisel, mis oskaks ennustada, mis klassi etteantud punkt x kuulub. Mudeli treenimiseks kasutatakse treeningandmeid. Oma töös võrdlesime iteratiivsed ja paralleelseid tugivektormasina algoritmide implementatsioone. Uurimise käigus avastasime et paralleelsed algoritmid, nagu oligi oodatud, töötavad palju kiiremini kui iteratiivsed, seejuures valesti klassifitseeritud punktide arv ei suurene.One of the techniques used for data classification is support vector machine (SVM). SVM takes binary classification as the fundamental problem and follows the geometrically intuitive approach to find a hyperplane that divides objects into two separate classes. The training part of the SVM aims to both maximize the width of the margin that surrounds the separating hyperplane and minimize the occurrence of classification errors. The goal of given thesis is to research efficiency in performance gained by using parallel approach to solve SVM and compare proposed techniques for parallelization in accuracy and computation speed

The Static Future of the International Financial System

The international financial system is all the participating economies of the world acting independently, yet bound together by the need for trade and currency exchange. The international floating exchange rate system has been the international financial system since its inception in 1973. Since the inception of the floating exchange rate system there has been constant criticism and questioning over whether it is the best international financial model for the present and future. The purpose of this thesis is to critically examine the history of the international financial system and determine what kind of international system best meets the need of the globally interdependent world moving forward. The history of international finance has been characterized by three major international monetary systems. The gold standard, Bretton Woods, and international floating system all have strengths, weaknesses and unique differences that this thesis seeks to analyze. An object of this thesis is to identify how a desirable international monetary system might look and function in the future. This thesis will examine a number of problems that have plagued the international monetary system and how those difficulties might be remedied in the future

Claudius Greer Clemmer, Doctor of Humane Letters January 4, 1911-November 20, 2005.

While there are facts that are known about Claudius Greer Clemmer, there is much that is not known. By most accounts, he was a generous man who grew up during some of the hardest years of the Great Depression, worked to get an education, and had a successful teaching career. Clemmer worked diligently to do what he could to support himself and his family, working at two jobs. When his career track changed from teaching to business, in 1946, he experienced success in business and investments, sharing that wealth with East Tennessee State University and others. The intent of this qualitative study was to learn about the life of Claudius Greer Clemmer, and determine the events of his lifetime that made him who he was. The examination of his life was grounded by a series of six research questions that framed the study and expanded to include his family and work: What influenced him to pursue high educational standards?What influenced his view of education?What contributed to his philanthropy?What are people\u27s perceptions about his life and work?Who influenced him, and in what way?Who was influenced by him, and in what way? Maslow\u27s Hierarchy of Needs Theory outlines five levels of basic need, beginning with physiological needs, safety and security, love and belonging, esteem, and finishing with the highest level at self-actualization, which is described as accomplishing all that one can accomplish. Maslow\u27s theory describes Clemmer, as he had either achieved or was as close to self-actualization as possible. While the author was considering that he had accomplished self-actualization, it was expressed first by his son and acknowledged later during interviews with friends and associates. The study is significant in that there are no other studies about the life of Claudius Greer Clemmer. Research findings will be of interest to many, including the Clemmer family, the East Tennessee State University family, friends, and alumni of the Claudius G. Clemmer College of Education, along with individuals interested in biography, oral history, and philanthropy

REDUCED CARDIOTOXICITY AND INCREASED CYTOTOXICITY IN A NOVEL ANTHRACYCLINE ANALOG, 4'-AMINO-3'-HYDROXY-DOXORUBICIN

The acute and chronic cardiotoxicity and cytotoxicity of the novel doxorubicin (DXR) derivative 4'-amino-3'-hydroxy-DXR were compared with those of 4'-deoxy-DXR and DXR. In the acute cardiotoxicity study, the ECG and hemodynamic changes recorded in anesthetized rats that had been treated i.v. with 10 mg/kg 4'-amino-3'-hydroxy-DXR or 8.6 mg/kg 4'-deoxy-DXR were significantly less severe than those caused by 13 mg/kg DXR. In the chronic cardiotoxicity study, rats received 3 weekly i.v. injections of 3 mg/kg DXR, 3 mg/kg 4'-amino-3'-hydroxy-DXR, or 2 mg/kg 4'-deoxy-DXR during the first 14 days of the study and were observed for an additional 35-day period. DXR induced severe cardiomyopathy that was characterized by ECG changes in vivo (S-alpha-T-segment widening and T-wave flattening) and by impairment of the contractile responses (F(max), +/- dF/dt(max)) to adrenaline of hearts isolated from treated animals. 4'-Deoxy-DXR caused a progressive enlargement of the S-alpha-T segment in vivo and a significant impairment of the - dF/dt(max) value in vitro, which were less severe than those produced by DXR. The least cardiotoxic drug was 4'-amino-3'-hydroxy-DXR, which induced minor ECG changes without causing significant alterations in the contractile responses of isolated hearts to adrenaline. On the basis of the drug concentration required to inhibit 50% of the colony formation (IC50) of cell lines in vitro, 4'-amino-3'-hydroxy-DXR was less active than 4'-deoxy-DXR but at least twice as active as DXR against human cancer and murine transformed cell lines. These data indicate that 4'-amino-3'-hydroxy-DXR is significantly less cardiotoxic and more cytotoxic than DXR

Factores asociados a la brecha de recursos humanos y estrategias de cierre de brechas en el Complejo Hospitalario PNP Luis N. S?enz

La nueva infraestructura del Complejo Hospitalario PNP Luis N. S?enz generar? un incremento de brecha de Recursos Humanos en Salud (RHUS), que ha llevado a plantear diferentes estrategias de cierre de brechas y an?lisis de requerimientos de profesionales en salud. Esta tesis tiene como objetivos identificar la brecha de RHUS, identificar y analizar los factores asociados a la brecha y plantear estrategias con miras a cerrar la brecha; mediante la recopilaci?n de experiencias regionales y globales, recolecci?n de datos de las diferentes ?reas y un instrumento que consisti? en una entrevista a 14 jefes de diferentes ?reas. Esta investigaci?n determin? que, con la apertura de los nuevos ambientes, la brecha de m?dicos ascender? a 382. La Divisi?n de Cirug?a es la m?s comprometida, con una brecha de 113 m?dicos. Los factores econ?micos (80%), repercuten tanto en la baja captaci?n, como en la deserci?n del personal. Asimismo, la principal fuente de dotaci?n de RHUS es el residentado m?dico (66.7%) y el principal atractivo es la estabilidad laboral (73.3%). Finalmente, recomienda implementar estrategias para lograr atraer y retener al personal, principalmente con un aumento del salario e incentivos econ?micos, as? como, aumentar las vacantes para la asimilaci?n de profesionales y t?cnicos

A novel method for engineering autologous non-thrombogenic in situ tissue-engineered blood vessels for arteriovenous grafting

The durability of prosthetic arteriovenous (AV) grafts for hemodialysis access is low, predominantly due to stenotic lesions in the venous outflow tract and infectious complications. Tissue engineered blood vessels (TEBVs) might offer a tailor-made autologous alternative for prosthetic grafts. We have designed a method in which TEBVs are grown in vivo, by utilizing the foreign body response to subcutaneously implanted polymeric rods in goats, resulting in the formation of an autologous fibrocellular tissue capsule (TC). One month after implantation, the polymeric rod is extracted, whereupon TCs (length 6 cm, diameter 6.8 mm) were grafted as arteriovenous conduit between the carotid artery and jugular vein of the same goats. At time of grafting, the TCs were shown to have sufficient mechanical strength in terms of bursting pressure (2382 +/- 129 mmHg), and suture retention strength (SRS: 1.97 +/- 0.49 N). The AV grafts were harvested at 1 or 2 months after grafting. In an ex vivo whole blood perfusion system, the lumen of the vascular grafts was shown to be less thrombogenic compared to the initial TCs and ePTFE grafts. At 8 weeks after grafting, the entire graft was covered with an endothelial layer and abundant elastin expression was present throughout the graft. Patency at 1 and 2 months was comparable with ePTFE AV-grafts. In conclusion, we demonstrate the remodeling capacity of cellularized in vivo engineered TEBVs, and their potential as autologous alternative for prosthetic vascular grafts.Vascular Surger