31 research outputs found

    Penggunaan Tepung Daging Dan Tulang Sebagai Alternatif Sumber Protein Hewani Pada Pakan Ikan Nila Merah (Oreochromis Niloticus)

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    Penelitian dilakukan untuk mengetahui persentase subsitusi tepung daging dan tulang (TDT) terhadap tepung ikan (TI) untuk pertumbuhan nila merah (Oreochromis niloticus). Penelitian dilakukan dengan menggunakan rancangan acak lengkap dengan 5 perlakuan. Pakan A (kontrol/TI), pakan B (TDT 20%), pakan C (TDT 25%), pakan D (TDT 30%) dan pakan E (TDT 35%). Ikan uji yang digunakan adalah nila merah sebanyak 225 ekor, dengan berat total 4 ± 0,4 gram. Akuarium berukuran 60 x 40 x 40 cm yang berisi nila merah sebanyak 15 ekor digunakan untuk percobaan. Pemberian pakan sebanyak tiga kali sehari dengan feeding rate 5% selama 60 hari pemeliharaan. Hasil penelitian menunjukkan bahwa pakan E (TDT 35%) memberikan hasil yang terbaik untuk pertumbuhan nila merah. Pertumbuhan mutlak sebesar 10,34 ± 0,43 gram, laju pertumbuhan harian sebesar 0,17±0,01gram/hari, dan efisiensi pakan 44,37 ± 3,32%. Tingkat kelangsungan hidup nila merah rata - rata mencapai 97,3% dan kualitas air pada semua perlakuan masih dalam keadaan optimum untuk budidaya

    A reporting and analysis framework for structured evaluation of COVID-19 clinical and imaging data

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    The COVID-19 pandemic has worldwide individual and socioeconomic consequences. Chest computed tomography has been found to support diagnostics and disease monitoring. A standardized approach to generate, collect, analyze, and share clinical and imaging information in the highest quality possible is urgently needed. We developed systematic, computer-assisted and context-guided electronic data capture on the FDA-approved mint LesionTM software platform to enable cloud-based data collection and real-time analysis. The acquisition and annotation include radiological findings and radiomics performed directly on primary imaging data together with information from the patient history and clinical data. As proof of concept, anonymized data of 283 patients with either suspected or confirmed SARS-CoV-2 infection from eight European medical centers were aggregated in data analysis dashboards. Aggregated data were compared to key findings of landmark research literature. This concept has been chosen for use in the national COVID-19 response of the radiological departments of all university hospitals in Germany

    Protocol for the development of a CONSORT extension for RCTs using cohorts and routinely collected health data.

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    Background: Randomized controlled trials (RCTs) are often complex and expensive to perform. Less than one third achieve planned recruitment targets, follow-up can be labor-intensive, and many have limited real-world generalizability. Designs for RCTs conducted using cohorts and routinely collected health data, including registries, electronic health records, and administrative databases, have been proposed to address these challenges and are being rapidly adopted. These designs, however, are relatively recent innovations, and published RCT reports often do not describe important aspects of their methodology in a standardized way. Our objective is to extend the Consolidated Standards of Reporting Trials (CONSORT) statement with a consensus-driven reporting guideline for RCTs using cohorts and routinely collected health data. Methods: The development of this CONSORT extension will consist of five phases. Phase 1 (completed) consisted of the project launch, including fundraising, the establishment of a research team, and development of a conceptual framework. In phase 2, a systematic review will be performed to identify publications (1) that describe methods or reporting considerations for RCTs conducted using cohorts and routinely collected health data or (2) that are protocols or report results from such RCTs. An initial "long list" of possible modifications to CONSORT checklist items and possible new items for the reporting guideline will be generated based on the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) and The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statements. Additional possible modifications and new items will be identified based on the results of the systematic review. Phase 3 will consist of a three-round Delphi exercise with methods and content experts to evaluate the "long list" and generate a "short list" of key items. In phase 4, these items will serve as the basis for an in-person consensus meeting to finalize a core set of items to be included in the reporting guideline and checklist. Phase 5 will involve drafting the checklist and elaboration-explanation documents, and dissemination and implementation of the guideline. Discussion: Development of this CONSORT extension will contribute to more transparent reporting of RCTs conducted using cohorts and routinely collected health data

    Soft liver phantom with a hollow biliary system

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    Hepatobiliary interventions are regarded as difficult minimally-invasive procedures that require experience and skills of physicians. To facilitate the surgical training, we develop a soft, high-fidelity and durable liver phantom with detailed morphology. The phantom is anatomically accurate and feasible for the multi-modality medical imaging, including computer tomography (CT), ultrasound, and endoscopy. The CT results show that the phantom resembles the detailed anatomy of real livers including the biliary ducts, with a spatial root mean square error (RMSE) of 1.7 ± 0.7 mm and 0.9 ± 0.2 mm for the biliary duct and the liver outer shape, respectively. The sonographic signals and the endoscopic appearance highly mimic those of the real organ. An electric sensing system was developed for the real-time quantitative tracking of the transhepatic puncturing needle. The fabrication method herein is accurate and reproducible, and the needle tracking system offers a robust and general approach to evaluate the centesis outcome
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