Overview study on challenges of additive manufacturing for a healthcare application

Additive manufacturing is a rapidly evolving manufacturing technology bringing numerous and wide opportunities for the design team involved in the process by creating intricate and customized products with saving labor, time, and other expenses. Innovative AM methods and numerous practical applications in aerospace, automotive, medical, energy, and other industries have been developed and commercialized through extensive research over the last two decades. One embraced industry among others that benefited from the advances of AM is the healthcare industry. This paper focuses on addressing the challenges and opportunities in Additive manufacturing for healthcare. Although there are advanced possibilities in AM, there are also numerous issues needed to be overcome. The paper is based upon the current state-of-the-art review and study visits. The purpose of this work has been to identify the opportunities and limitations associated with additive manufacturing in healthcare applications and to highlight the identified research needs

Overview study on challenges of additive manufacturing for a healthcare application

Additive manufacturing is a rapidly evolving manufacturing technology bringing numerous and wide opportunities for the design team involved in the process by creating intricate and customized products with saving labor, time, and other expenses. Innovative AM methods and numerous practical applications in aerospace, automotive, medical, energy, and other industries have been developed and commercialized through extensive research over the last two decades. One embraced industry among others that benefited from the advances of AM is the healthcare industry. This paper focuses on addressing the challenges and opportunities in Additive manufacturing for healthcare. Although there are advanced possibilities in AM, there are also numerous issues needed to be overcome. The paper is based upon the current state-of-the-art review and study visits. The purpose of this work has been to identify the opportunities and limitations associated with additive manufacturing in healthcare applications and to highlight the identified research needs.publishedVersio

Occurrence of fungal diseases of Coffea arabica L. in montane rainforests of Ethiopia

Coffee Berry Disease (CBD), Colletotrichum kahawae, Coffee Wilt Disease (CWD), Gibberella xylarioides and Coffee Leaf Rust (CLR), Hemileia vastatrix are the three major diseases reducing production and consumption of coffee in Ethiopia. A survey was conducted from July to September 2005 for CBD and CWD and from 2003 until 2007 for CLR in montane rainforest coffee areas of Ethiopia to estimate the occurrence and distribution of these diseases. Diseases were prevalent in all the surveyed forest coffee areas of Ethiopia: Harenna, Bonga, Berhane-Kontir and Yayu. Depending on the forest coffee area the mean percent incidence of CBD ranged from 2 to 40 % in general and from 2 to 17.9 % at Berhane-Kontir and Bonga, respectively. The mean incidence of CWD varied from 2.4 % at Berhane-Kontir to 16.9 % at Yayu forest coffee areas. The mean incidence of CLR also varied for instance in 2005 from 32.2 % at Berhane-Kontir to 96 % at Harenna forest coffee areas. The detection of the diseases during our surveys requires an integrated management of major coffee diseases for a sustainable conservation and wise use of coffee in montane rainforests of Ethiopia

deSpeckNet: Generalizing Deep Learning Based SAR Image Despeckling

Deep learning (DL) has proven to be a suitable approach for despeckling synthetic aperture radar (SAR) images. So far, most DL models are trained to reduce speckle that follows a particular distribution, either using simulated noise or a specific set of real SAR images, limiting the applicability of these methods for real SAR images with unknown noise statistics. In this paper, we present a DL method, deSpeckNet1, that estimates the speckle noise distribution and the despeckled image simultaneously. Since it does not depend on a specific noise model, deSpeckNet generalizes well across SAR acquisitions in a variety of landcover conditions. We evaluated the performance of deSpeckNet on single polarized Sentinel-1 images acquired in Indonesia, The Democratic Republic of Congo and The Netherlands, a single polarized ALOS-2/PALSAR-2 image acquired in Japan and an Iceye X2 image acquired in Germany. In all cases, deSpeckNet was able to effectively reduce speckle and restor

Outbreak of Aeromonas hydrophila associated with the parasitic infection Ichthyophthirius multifiliis in pond of African catfish (Clarias gariepinus) fingerlings at Sebeta, Ethiopia

Outbreak of a disease was observed on African catfish (Clarias gariepinus) fingerlings manifested by white nodules all over the body and hemorrhage in the skin that occurred on June 20, 2011 in an earthen pond at Sebeta, Ethiopia. The outbreak was investigated by using a combination of methods that included clinical observations, gross and histopathology examination and bacterial isolation. On histopathological  examination co-infection of Aeromonas hydrophila with Ichthyophthirius multifiliis a holotrichous ciliate, was found to be the cause of the outbreak. In order to control the outbreak, the fish density was reduced and the fish were removed and treated with sodium chloride (3%) and moved to another properly disinfected pond that contains fresh and good quality water. The former pond was drained and left empty for two  weeks to dry and then lime was added over it before filling it with water. The sick fish got cured after three weeks and no new case was observed; which may be due to development of immunity or the intervention measures taken to control the problem. This intervention protocols need to be further investigated in a properly designed experiment as a possible control of co-infection of these two pathogens in catfish  fingerlings.Keywords: Aeromonas hydrophila, Co-infection, Ethiopia, Ichthyophthirius multifilii

Maternal dietary diversity and micronutrient adequacy during pregnancy and related factors in East Gojjam Zone, Northwest Ethiopia, 2016.

BackgroundMonotonous and less diversified diets are associated with micronutrient deficiency. Evidence on maternal dietary intakes during pregnancy is essential to achieve the 2025 global nutrition target and reduce maternal and child mortalities. This study assessed pregnant women's dietary diversity and identified factors associated with inadequate dietary diversity in East Gojjam Zone.MethodsWe conducted a community-based cross-sectional study between April and June 2016. Eight hundred thirty-four pregnant women were randomly sampled. The Women Dietary Diversity Score tool developed by the Food and Agricultural Organization (FAO) and Food and Nutrition Technical Assistance (FANTA) was used. Data were entered into EpiData with double entry verification, and analysis was done using IBM SPSS version 20. Level of significance was set to P ResultsThe mean (±SD) dietary diversity score was 3.68 (±2.10). Inadequate dietary diversity was prevalent in 55% [95% CI (52.3-59.3%)] of pregnant women, or indirectly micronutrient was inadequate in more than half of the pregnant women. Commonly consumed dietary groups were legumes, nuts, and seeds (85.5%) followed by starchy staples (64.7%). Inadequate dietary diversity was higher among non-educated [Adjusted Odds Ratio (AOR) = 7.30, 95% CI (2.35-22.68)] compared to college and above completed women. Wealth index had significant association with dietary diversity, in which women in the poorest [AOR = 8.83, 95% CI, (1.60-48.61)], poorer [AOR = 6.34, 95% CI (1.16-34.65)], poor [AOR = 8.46, 95% CI (1.56-45.70)], and richer [AOR = 6.57, 95% CI (2.16-20.01)] had higher odds of inadequate dietary diversity. Those who had not received dietary counseling had three folds [AOR = 3.31, 95% CI (1.49-7.35)] of inadequate dietary diversity compared to their counterparts. Less likelihood of inadequate dietary diversity was among women with an increased meal frequency [AOR = 0.53, 95% CI (0.38-0.74)].ConclusionConsumption of less diversified food during pregnancy is common in the study area. Adequacy of micronutrients is insufficient for more than half of the studied pregnant women. We conclude that being non-educated affects pregnant women to depend on less diversified diet. Providing dietary counseling during pregnancy can improve nutritional practice for pregnant women

Antimicrobial resistance surveillance in Ethiopia: Implementation experiences and lessons learned

Introduction: Antimicrobial resistance (AMR) poses a global threat. High levels of AMR to commonly used antibiotics have been reported in East Africa. A situation analysis of AMR in Ethiopia also indicated high resistance levels. To prevent and contain AMR, Ethiopia established a national surveillance network. Objectives: This article describes the steps taken to prioritise AMR and establish the National Antimicrobial Resistance Surveillance System in Ethiopia, as well as present the challenges and lessons learned through implementation. Methods: In April 2017, Ethiopia had developed and approved the National AMR Surveillance Plan for laboratory-based AMR surveillance. The World Health Organization recommendations and Ethiopias’s current microbiology capacity were used to prioritise organisms for reporting. The surveillance system is comprised of a network linking the national reference laboratory with surveillance sentinel sites. Roll-out of the AMR surveillance network occurred in three phases in order to ensure successful implementation. Results: Electronic capture and transmission of data, supply chain for the microbiology laboratory and communication problems were challenges observed after implementation started. Support from Ethiopian Public Health Institute focal persons for data entry, regular scheduled communication establishment and procurement of supplies by the American Society for Microbiology were some of the measures taken to address the challenges. Conclusion: Ethiopia has demonstrated that setting up AMR surveillance in lower resource settings is possible with strong leadership and stakeholder engagement

Bacillus thuringiensis Cry5B Protein Is Highly Efficacious as a Single-Dose Therapy against an Intestinal Roundworm Infection in Mice

Intestinal parasitic nematode diseases infect over one billion people and cause significant disease burden in children (growth and cognitive stunting, malnutrition), in pregnant women, and via their dampening of the immune system in infected individuals. In over thirty years, no new classes of anti-roundworm drugs (anthelmintics) for treating humans have been developed. Because of limitations of the current drugs and the threat of parasite resistance, new anthelmintics are needed. The soil bacterium Bacillus thuringiensis (Bt) produces crystal (Cry) proteins that specifically target and kill insects and nematodes and is used around the world as a safe insecticide. Here we test the effects of the Bt Cry protein Cry5B on a chronic, natural intestinal roundworm infection in mice, namely the helminth parasite Heligmosomoides bakeri. We find that a single dose of Cry5B can eliminate 70% of the parasites and can almost completely block the ability of the parasites to produce progeny. Comparisons of Cry5B's efficacy with known anthelmintics suggest its activity is as good as or perhaps even better than those currently used. Furthermore, this protein is rapidly digested by simulated stomach juices, suggesting that protecting it from these juices would reveal a superior anthelmintic

Barriers and facilitators of maternal health care services use among pastoralist women in Ethiopia: Systems thinking perspective

We explored the barriers and facilitators of maternal health care service use among women in the pastoralist region of Ethiopia. We used a mixed methods design—focus group discussions, key informant interviews, review of the literature and Participatory Ethnographic Evaluation Research (PEER) methods followed by a household survey among randomly chosen pastoralist women of reproductive age (n = 1,499). We used multi-variable regression analyses, and a p value ≤ 0.05 was set to determine statistical significance. In addition, we analysed qualitative data thematically and developed a causal loop diagram using dynamic synthesis methodology to analyse non-linearity, intricate relationships of the variable of interests. In this study, 20.6% of women used modern contraceptive methods, 44.6% had four or more antenatal visits and 38.4% of sampled women received skilled delivery services. We observed multiple individual and community related factors such as education, income and women’s and their partner’s knowledge, perceptions, husband approval, social norms and value-expectations and providers’ gender preferences and health systems factors such as access to health facilities, place of living, provider's cultural competency skills, supplies, delivery positions, economic and political stability, and provider's attitude were linked to maternal health care services utilization among women in pastoralist regions. Approaches towards pastoralists’ health care delivery systems should be responsive to their cultural and political ecology and human agency