Crack! Harm reduction has stopped, or was the death drive?

O que a psicanálise tem a dizer sobre tantas questões que envolvem as drogas, que de longe ultrapassam a questão de seu uso? Questões, diríamos, históricas, clínicas e políticas. O objetivo desse texto é discutir vicissitudes que as perpassam. Não apenas nos acercarmos do “problema drogas”, mas pensar como a presença da psicanálise pode fazer frente a determinados discursos que se presentificam nesse campo de atuação e que estão longe de pôr o sujeito em questão. Trabalhar com a psicanálise é levar em conta a pulsão de morte. É lançar mão de um saber que nos permite uma orientação de tratamento que leve em conta o que há de mortífero no uso de drogas nas toxicomanias, pondo em relevo a posição de gozo do sujeito. É, além disso, pôr em questão o que há de mortífero em determinados direcionamentos políticos que transformam o sujeito em objeto.What does psychoanalysis have to say about so many issues involving drugs, which far outpass the question of their use? Historical, clinical and political issues, as we could say. The purpose of this text is to discuss vicissitudes that pervade them. We do not only approach the “drug problem,” but also think about how the presence of psychoanalysis can deal with certain discourses that can be found in this field and which are far from questioning the subject. Working with psychoanalysis is to take the death drive into account. It is to use a knowledge that allows us a treatment orientation that considers what is deadly in the use of drugs in drug addiction, highlighting the position of jouissance of the subject. It is, moreover, to question what is deadly in certain political directions that transform the subject into an object

Singular kernels, multiscale decomposition of microstructure, and dislocation models

We consider a model for dislocations in crystals introduced by Koslowski, Cuiti\~no and Ortiz, which includes elastic interactions via a singular kernel behaving as the $H^{1/2}$ norm of the slip. We obtain a sharp-interface limit of the model within the framework of $\Gamma$-convergence. From an analytical point of view, our functional is a vector-valued generalization of the one studied by Alberti, Bouchitt\'e and Seppecher to which their rearrangement argument no longer applies. Instead we show that the microstructure must be approximately one-dimensional on most length scales and exploit this property to derive a sharp lower bound

A Numerical Study on the Impact of Grouting Material on Borehole Heat Exchangers Performance in Aquifers

U-pipesforgroundsourceheatpump(GSHP)installationsaregenerallyinsertedinvertical boreholes back-filled with pumpable grouts. Grout thermal conductivity is a crucial parameter, dominating the borehole thermal resistance and impacting the heat exchanger efficiency. In order to seal the borehole and prevent leakages of the heat carrier fluid, grouting materials are also hydraulicallyimpermeable,sothatgroundwaterflowinsidetheboreholeisinhibited. Theinfluenceof groundwater flow on the borehole heat exchangers (BHE) performance has recently been highlighted by several authors. However groundwater impact and grouting materials influence are usually evaluated separately, disregarding any combined effect. Therefore simulation is used to investigate the role of the thermal and hydraulic conductivities of the grout when the BHE operates in an aquiferwitharelevantgroundwaterflow. Here3maincasesforasingleU-pipeinasandyaquiferare compared. InCase1theboreholeisback-filledwiththesurroundingsoilformation,whileathermally enhancedgroutandalowthermalconductivitygroutareconsideredinCase2andCase3respectively. Simulations are carried out maintaining the inlet temperature constant in order to reproduce the yearly operation of the GSHP system. For each of the 3 cases three different groundwater flow velocities are considered. The results show that a high thermal conductivity grout further enhances the effects of a significant groundwater flow. The conditions when neglecting the grout material in the numerical model does not lead to relevant errors are also identified

Combinación de fibras de acero de última generación para el refuerzo de hormigón autocompactante

[ES] Dado que la mayor desventaja mecánica del hormigón son sus propiedades en tracción, las fibras normalmente se utilizan para mejorar la respuesta frente a solicitaciones de tracción y flexión, siendo las fibras de acero las más comúnmente utilizadas. Este tipo de fibras se ha utilizado con éxito en aplicaciones estructurales en los últimos 50 años y, como consecuencia, se han desarrollado nuevas fibras de acero de última generación de las que existe una bibliografía muy limitada. En este estudio se realizó una caracterización de un hormigón autocompactante reforzado con fibras de acero de última generación a través de ensayos de caracterización mecánica y de resistencia a la tracción por flexión. Se realizaron tres amasadas diferentes con la misma dosificación de 70 kg/m³ de fibras (0,89% en fracción volumétrica). Las dos primeras con un solo tipo de fibra por amasada (5D y OL) y la tercera con la combinación de estas dos fibras en iguales proporciones, observando que combinadas presentan un comportamiento optimizado como refuerzo del hormigón. Los resultados obtenidos mostraron importantes mejoras combinando ambas tipologías de fibras.Los autores agradecen al Ministerio de Economía, Industria y Competitividad la financiación del trabajo mediante el proyecto del Plan Estatal BIA 2016-78742-C2-2-RAlberti, M.; Enfedaque, A.; Galvez, J.; Cortez, A. (2018). Combinación de fibras de acero de última generación para el refuerzo de hormigón autocompactante. En HAC 2018. V Congreso Iberoamericano de hormigón autocompactable y hormigones especiales. Editorial Universitat Politècnica de València. 97-106. https://doi.org/10.4995/HAC2018.2018.5152OCS9710

Borehole Heat Exchangers: heat transfer simulation in the presence of a groundwater flow

The correct design of the Borehole Heat Exchanger is crucial for the operation and the energy performance of a Ground Source Heat Pump. Most design methods and tools are based on the assumption that the ground is a solid medium where conduction is the only heat transfer mechanism. In turn in regions rich in groundwater the groundwater flow influence has to be assessed, by including the convection effects. In this paper a numerical model of a 100 m U-pipe in a saturated porous medium is presented. The model is created adopting MT3DMS coupled to MODFLOW. A Darcy flow is imposed across the medium. The typical operation of a Borehole Heat Exchanger operating both in winter and in summer is simulated for two years, under different groundwater velocities. The energy injected to and extracted from the ground is derived as a function of the Darcy velocity and compared with the purely conductive case. Temperature fields in the ground at key moments are shown and discussed. From both the energy and the aquifer temperature field points of view, the velocity ranges for respectively negligible and relevant influence of the groundwater flow are identified

Lecturas en tensión: articulaciones discursivas en la exhibición de la exhibición Daros Latinamerica

En el siguiente trabajo se realizará un recorrido comparativo entre una selección de textos de sala de Daros Latinamerica en Fundación Proa con el texto curatorial de Rodrigo Alonso incluido en el catálogo de la exhibición. Llamaremos textos poéticos a los fragmentos que se presentan en las salas con la intención de vincular obras y artistas. Esta diferenciación será clave en nuestro análisis ya que el otro texto, el de catálogo tiene cualidades científicas y académicas. Por lo tanto será necesario un análisis desde la disciplina de la Museología, haciendo énfasis en la pedagogía museológica para comprender de qué modo se relacionan los textos curatoriales y aquellos de sala.Mesa BFacultad de Bellas Arte

Lecturas en tensión: articulaciones discursivas en la exhibición de la exhibición Daros Latinamerica

En el siguiente trabajo se realizará un recorrido comparativo entre una selección de textos de sala de Daros Latinamerica en Fundación Proa con el texto curatorial de Rodrigo Alonso incluido en el catálogo de la exhibición. Llamaremos textos poéticos a los fragmentos que se presentan en las salas con la intención de vincular obras y artistas. Esta diferenciación será clave en nuestro análisis ya que el otro texto, el de catálogo tiene cualidades científicas y académicas. Por lo tanto será necesario un análisis desde la disciplina de la Museología, haciendo énfasis en la pedagogía museológica para comprender de qué modo se relacionan los textos curatoriales y aquellos de sala.Mesa BFacultad de Bellas Arte

Lecturas en tensión: articulaciones discursivas en la exhibición de la exhibición Daros Latinamerica

En el siguiente trabajo se realizará un recorrido comparativo entre una selección de textos de sala de Daros Latinamerica en Fundación Proa con el texto curatorial de Rodrigo Alonso incluido en el catálogo de la exhibición. Llamaremos textos poéticos a los fragmentos que se presentan en las salas con la intención de vincular obras y artistas. Esta diferenciación será clave en nuestro análisis ya que el otro texto, el de catálogo tiene cualidades científicas y académicas. Por lo tanto será necesario un análisis desde la disciplina de la Museología, haciendo énfasis en la pedagogía museológica para comprender de qué modo se relacionan los textos curatoriales y aquellos de sala.Mesa BFacultad de Bellas Arte

Qualidade de vida no trabalho: uma análise sobre a percepção dos colaboradores da cooperativa Camnpal

This study aimed to identify with collaborators of Camnpal Cooperative, how they evaluate their Quality of Life at Work. It is an applied research, with quantitative approach, as the objectives is exploratory, descriptive and a field research. Data collection occurred through a questionnaire with 30 questions considering the eight categories of Walton's model (1973). The results showed that employees are satisfied with the social relevance of working life, constitutionalism, growth opportunities and security. Only the use and development of skills and working conditions need improvement. Este estudo teve o objetivo de identificar junto aos colaboradores da Cooperativa Camnpal, como avaliam sua Qualidade de Vida no Trabalho. É uma pesquisa aplicada, com abordagem quantitativa, quanto aos objetivos é exploratória, descritiva e uma pesquisa de campo. A coleta de dados ocorreu através de um questionário com 30 questões tendo em vista as oito categorias do modelo de Walton (1973). Os resultados mostraram que os funcionários estão satisfeitos em relação à relevância social da vida no trabalho, constitucionalismo, oportunidades de crescimento e segurança, Somente o uso e desenvolvimento das capacidades e as condições de trabalho, necessitam de melhorias

Whole Genome Profiling provides a robust framework for physical mapping and sequencing in the highly complex and repetitive wheat genome

<p>Abstract</p> <p>Background</p> <p>Sequencing projects using a clone-by-clone approach require the availability of a robust physical map. The SNaPshot technology, based on pair-wise comparisons of restriction fragments sizes, has been used recently to build the first physical map of a wheat chromosome and to complete the maize physical map. However, restriction fragments sizes shared randomly between two non-overlapping BACs often lead to chimerical contigs and mis-assembled BACs in such large and repetitive genomes. Whole Genome Profiling (WGP™) was developed recently as a new sequence-based physical mapping technology and has the potential to limit this problem.</p> <p>Results</p> <p>A subset of the wheat 3B chromosome BAC library covering 230 Mb was used to establish a WGP physical map and to compare it to a map obtained with the SNaPshot technology. We first adapted the WGP-based assembly methodology to cope with the complexity of the wheat genome. Then, the results showed that the WGP map covers the same length than the SNaPshot map but with 30% less contigs and, more importantly with 3.5 times less mis-assembled BACs. Finally, we evaluated the benefit of integrating WGP tags in different sequence assemblies obtained after Roche/454 sequencing of BAC pools. We showed that while WGP tag integration improves assemblies performed with unpaired reads and with paired-end reads at low coverage, it does not significantly improve sequence assemblies performed at high coverage (25x) with paired-end reads.</p> <p>Conclusions</p> <p>Our results demonstrate that, with a suitable assembly methodology, WGP builds more robust physical maps than the SNaPshot technology in wheat and that WGP can be adapted to any genome. Moreover, WGP tag integration in sequence assemblies improves low quality assembly. However, to achieve a high quality draft sequence assembly, a sequencing depth of 25x paired-end reads is required, at which point WGP tag integration does not provide additional scaffolding value. Finally, we suggest that WGP tags can support the efficient sequencing of BAC pools by enabling reliable assignment of sequence scaffolds to their BAC of origin, a feature that is of great interest when using BAC pooling strategies to reduce the cost of sequencing large genomes.</p