Hydroclimatic changes in the British Isles through the Last-Glacial-Interglacial Transition:Multiproxy reconstructions from the Vale of Pickering, NE England

European paleoenvironmental records through the Last Glacial-Interglacial Transition (LGIT; ca 16-8 cal ka BP) record a series of climatic events occurring over decadal to multi-centennial timescales. Changes in components of the climatic system other than temperature (e.g. hydrology) through the LGIT are relatively poorly understood however, and further records of hydroclimatic changes are required in order to develop a more complete understanding on the phasing of environmental and anthropogenic responses in Europe to abrupt climate change. Here, we present a multiproxy palaeoenvironmental record (macroscale and microscale sedimentology, macrofossils, and carbonate stable isotopes) from a palaeolake sequence in the Vale of Pickering (VoP), NE England, which enables the reconstruction of hydroclimatic changes constrained by a radiocarbon-based chronology. Relative lake-level changes in the VoP occurred in close association (although not necessarily in phase) to threshold shifts across abrupt climate change transitions, most notably lowering during cooling intervals of the LGIT (∼GI-1d, ∼GI-1b, and ∼GS-1). This reflects more arid hydroclimates associated with these cooling episodes in the British Isles. Comparisons to hydrological records elsewhere in Europe show a latitudinal bifurcation, with Northern Europe (50–60°N) becoming more arid (humid), and Southern Europe (40–50°N) becoming more humid (arid) in response to these cooling (warming) intervals. We attribute these bifurcating signals to the relative positions of the Atlantic storm tracks, sea-ice margin, and North Atlantic Polar Front (NAPF) during the climatic events of the LGIT

The glacial geomorphology of the Lago Buenos Aires and Lago Pueyrredón ice lobes of central Patagonia

<p>This paper presents a glacial geomorphological map of landforms produced by the Lago General Carrera–Buenos Aires and Lago Cochrane–Pueyrredón ice lobes of the former Patagonian Ice Sheet. Over 35,000 landforms were digitized into a Geographical Information System from high-resolution (<15 m) satellite imagery, supported by field mapping. The map illustrates a rich suite of ice-marginal glacigenic, subglacial, glaciofluvial and glaciolacustrine landforms, many of which have not been mapped previously (e.g. hummocky terrain, till eskers, eskers). The map reveals two principal landform assemblages in the central Patagonian landscape: (i) an assemblage of nested latero-frontal moraine arcs, outwash plains or corridors, and inset hummocky terrain, till eskers and eskers, which formed when major ice lobes occupied positions on the Argentine steppe; and (ii) a lake-terminating system, dominated by the formation of glaciolacustrine landforms (deltas, shorelines) and localized ice-contact glaciofluvial features (e.g. outwash fans), which prevailed during deglaciation.</p

Reply to comments by Bourgois et al. (2019) on: “Glacial lake evolution and Atlantic-Pacific drainage reversals during deglaciation of the Patagonia Ice Sheet”

We welcome the comments of Bourgois et al. (2019) and the opportunity to debate geomorphology, geochronology and palaeoclimate during the Late Glacial Interglacial Transition (LGIT, ~18.0-8.0 ka) in the region of the Río Baker, central Patagonia. Bourgois et al. (2019) conclude that we have propagated inconsistencies in our proposed reconstruction of palaeolake evolution due to geomorphic analytical bias. However, in our view the empirical geomorphological data we have compiled over many field seasons has resulted in a data-rich (though still incomplete) relative chronology that enables us to evaluate inconsistencies in landscape interpretations from previously published geochronological datasets. We would argue that a geochronological bias, over any geomorphological bias, has represented the main reason for multiple landscape interpretations in this region. Indeed, the conflicting palaeolake evolution models published for the Río Baker basin (Turner et al. 2005; Bell, 2008; Hein et al., 2010; Bourgois et al., 2016; Glasser et al., 2016; Martinod et al., 2016) was a major impetus for our paper. These contrasting models were in part a result of the coincident publication of two separate geochronological datasets in 2016, one focused on optically stimulated luminescence (OSL) dating of palaeolake landforms (Glasser et al., 2016), the other cosmogenic nuclide exposure ages (Bourgois et al., 2016). Both datasets provided updates on what we termed the Turner/Hein model in Thorndycraft et al. (2019), but as they did not have access to each other’s datasets they ended up with different landscape interpretations

Reply to comments by Bourgois et al. (2019) on: “Glacial lake evolution and Atlantic-Pacific drainage reversals during deglaciation of the Patagonia Ice Sheet”

No abstract available

Visualizing tephra deposits and sedimentary processes in the marine environment: The potential of X‐ray microtomography

Localized tephra deposition in marine sequences is the product of many complex primary and secondary depositional processes. These can significantly influence the potential applicability of tephra deposits as isochronous marker horizons and current techniques, used in isolation, may be insufficient to fully unravel these processes. Here we demonstrate the innovative application of X-ray microtomography (µCT) to successfully identify tephra deposits preserved within marine sediments and use these parameters to reconstruct their internal three-dimensional structure. Three-dimensional visualizations and animations of tephra dispersal in the sediment permit a more thorough assessment of postdepositional processes revealing a number of complex microsedimentological features that are not revealed by conventional methods. These features include bioturbation burrows and horizontally discontinuous tephra packages, which have important ramifications for the stratigraphic placement of the isochron in a sedimentary sequence. Our results demonstrate the potential for utilizing rigorous two and three-dimensional microsedimentological analysis of the ichnofabric to enhance and support the use of tephra deposits as isochronous marker horizons and to identify the stratigraphic position that best reflects the primary fallout of ash. The application also provides an exceptional insight into the style and rate of sedimentation processes and permits an assessment of the stratigraphic integrity of a tephra deposit. We discuss the possibility of applying these µCT methods to the identification of cryptotephras within various paleoclimatic sequences and to enhance our understanding of marine sedimentation processes

Bone-specific alkaline phosphatase concentrations are less variable than those of parathyroid hormone in stable hemodialysis patients

Abnormalities of bone mineral metabolism and vascular calcification are prevalent in patients with kidney failure. Clinical management is based on biochemical targets, in particular parathyroid hormone (PTH) concentrations, but this has many limitations including high biological variation. A possible alternative is bone-specific alkaline phosphatase (ALP); therefore, we evaluated the biological variation of this marker in patients undergoing hemodialysis. Bone ALP was measured in non-fasting serum samples taken twice a week over a 6-week period in 22 stable hemodialysis patients and 12 healthy volunteers. The within-individual coefficients of variance were calculated and used to derive the critical difference required to be certain that an observed change was significant. The coefficient of variance for bone ALP was significantly higher in hemodialysis patients compared to healthy individuals. Seven samples were required to estimate the homeostatic set point of bone ALP, within 10%, in a hemodialysis patient. The concentration of serial bone ALP measurements would need to change by 36% between any two measurements before it can be considered a significant change. Since the biological variation of bone ALP is less than half that reported for PTH, our study provides further support for the use of bone ALP as an alternative marker of bone mineral metabolism in the setting of chronic kidney disease–mineral and bone disorder

The Prognostic and Predictive Value of Melanoma-related MicroRNAs Using Tissue and Serum: A MicroRNA Expression Analysis

The overall 5-year survival for melanoma is 91%. However, if distant metastasis occurs (stage IV), cure rates are = 82%) when = 4 miRNAs were expressed. Moreover, the 'MELmiR-7' panel characterised overall survival of melanoma patients better than both serum LDH and S100B (delta log likelihood=11, p < 0.001). This panel was found to be superior to currently used serological markers for melanoma progression, recurrence, and survival; and would be ideally suited to monitor tumour progression in patients diagnosed with early metastatic disease (stages IIIa-c/IV M1a-b) to detect relapse following surgical or adjuvant treatment. (C) 2015 The Authors. Published by Elsevier B. V

Potential for rapid antibody detection to identify tuberculous cattle with non-reactive tuberculin skin test results

Abstract Background Bovine tuberculosis (TB) control programs generally rely on the tuberculin skin test (TST) for ante-mortem detection of Mycobacterium bovis-infected cattle. Results Present findings demonstrate that a rapid antibody test based on Dual-Path Platform (DPP®) technology, when applied 1-3 weeks after TST, detected 9 of 11 and 34 of 52 TST non-reactive yet M. bovis-infected cattle from the US and GB, respectively. The specificity of the assay ranged from 98.9% (n = 92, US) to 96.0% (n = 50, GB) with samples from TB-free herds. Multi-antigen print immunoassay (MAPIA) revealed the presence of antibodies to multiple antigens of M. bovis in sera from TST non-reactors diagnosed with TB. Conclusions Thus, use of serologic assays in series with TST can identify a significant number of TST non-reactive tuberculous cattle for more efficient removal from TB-affected herds

Introductory programming: a systematic literature review

As computing becomes a mainstream discipline embedded in the school curriculum and acts as an enabler for an increasing range of academic disciplines in higher education, the literature on introductory programming is growing. Although there have been several reviews that focus on specific aspects of introductory programming, there has been no broad overview of the literature exploring recent trends across the breadth of introductory programming. This paper is the report of an ITiCSE working group that conducted a systematic review in order to gain an overview of the introductory programming literature. Partitioning the literature into papers addressing the student, teaching, the curriculum, and assessment, we explore trends, highlight advances in knowledge over the past 15 years, and indicate possible directions for future research