In-vitro evaluation of botanicals and fungicides against Bipolaris sorokiniana, causing spot blotch of wheat

Spot blotch disease of wheat caused by Bipolaris sorokiniana; is one of the most concerning disease in warm and humid regions of Nepal due to its widespread prevalence and increasing severity. An in-vitro experiment was conducted to evaluate the efficacy of different botanicals and fungicides against Bipolaris sorokiniana, in National Plant Pathology Research Centre’s laboratory at Khumaltar, Lalitpur in 2019. The experiment was done in completely randomized design with three replications by poison food technique. Five botanicals viz. neem, garlic, eucalyptus, bojho and asuro at three different concentrations (5%, 10% and 15%) and eight fungicides viz. sectin, curex, bavistin, vacomil plus, saaf, sajha, criptan and tilt at three concentration levels (25 ppm, 50 ppm and 100 ppm) except curex (50 ppm, 100 ppm and 200 ppm) were used to evaluate the effect on the radial mycelial growth and mycelial growth inhibition percentage of the pathogen. The different botanical extracts and fungicides in different concentrations inhibited the mycelial growth of fungus significantly (p<0.01). The highest mycelial growth inhibition percentage was found by the application of garlic clove extract (52.85%) at 15% which was followed by bojho (52.48%) at 15% concentration. While tilt was found effective fungicide which completely inhibits the mycelial growth at all concentrations. Also, fungicides viz. sajha (79.78%), saaf (73.59%) and sectin (70%), at 100 ppm were found effective in controlling the pathogen as compare to others. Mycelial growth inhibition of the fungus was found to be increased with the increase in concentrations of botanicals and fungicides

Intussusception due to non Hodgkin’s lymphoma; different experiences in two children: two case reports

In children, non-Hodgkin’s lymphoma has been found to be the lead point in intussusception involving the terminal ileum. We present here two cases of ileal primary non-Hodgkin’s lymphoma which presented as intussusception, highlighting the differing presentations of these children and their outcome, with a brief review of the literature

Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021

Background: Future trends in disease burden and drivers of health are of great interest to policy makers and the public at large. This information can be used for policy and long-term health investment, planning, and prioritisation. We have expanded and improved upon previous forecasts produced as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) and provide a reference forecast (the most likely future), and alternative scenarios assessing disease burden trajectories if selected sets of risk factors were eliminated from current levels by 2050. Methods: Using forecasts of major drivers of health such as the Socio-demographic Index (SDI; a composite measure of lag-distributed income per capita, mean years of education, and total fertility under 25 years of age) and the full set of risk factor exposures captured by GBD, we provide cause-specific forecasts of mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) by age and sex from 2022 to 2050 for 204 countries and territories, 21 GBD regions, seven super-regions, and the world. All analyses were done at the cause-specific level so that only risk factors deemed causal by the GBD comparative risk assessment influenced future trajectories of mortality for each disease. Cause-specific mortality was modelled using mixed-effects models with SDI and time as the main covariates, and the combined impact of causal risk factors as an offset in the model. At the all-cause mortality level, we captured unexplained variation by modelling residuals with an autoregressive integrated moving average model with drift attenuation. These all-cause forecasts constrained the cause-specific forecasts at successively deeper levels of the GBD cause hierarchy using cascading mortality models, thus ensuring a robust estimate of cause-specific mortality. For non-fatal measures (eg, low back pain), incidence and prevalence were forecasted from mixed-effects models with SDI as the main covariate, and YLDs were computed from the resulting prevalence forecasts and average disability weights from GBD. Alternative future scenarios were constructed by replacing appropriate reference trajectories for risk factors with hypothetical trajectories of gradual elimination of risk factor exposure from current levels to 2050. The scenarios were constructed from various sets of risk factors: environmental risks (Safer Environment scenario), risks associated with communicable, maternal, neonatal, and nutritional diseases (CMNNs; Improved Childhood Nutrition and Vaccination scenario), risks associated with major non-communicable diseases (NCDs; Improved Behavioural and Metabolic Risks scenario), and the combined effects of these three scenarios. Using the Shared Socioeconomic Pathways climate scenarios SSP2-4.5 as reference and SSP1-1.9 as an optimistic alternative in the Safer Environment scenario, we accounted for climate change impact on health by using the most recent Intergovernmental Panel on Climate Change temperature forecasts and published trajectories of ambient air pollution for the same two scenarios. Life expectancy and healthy life expectancy were computed using standard methods. The forecasting framework includes computing the age-sex-specific future population for each location and separately for each scenario. 95% uncertainty intervals (UIs) for each individual future estimate were derived from the 2·5th and 97·5th percentiles of distributions generated from propagating 500 draws through the multistage computational pipeline. Findings: In the reference scenario forecast, global and super-regional life expectancy increased from 2022 to 2050, but improvement was at a slower pace than in the three decades preceding the COVID-19 pandemic (beginning in 2020). Gains in future life expectancy were forecasted to be greatest in super-regions with comparatively low life expectancies (such as sub-Saharan Africa) compared with super-regions with higher life expectancies (such as the high-income super-region), leading to a trend towards convergence in life expectancy across locations between now and 2050. At the super-region level, forecasted healthy life expectancy patterns were similar to those of life expectancies. Forecasts for the reference scenario found that health will improve in the coming decades, with all-cause age-standardised DALY rates decreasing in every GBD super-region. The total DALY burden measured in counts, however, will increase in every super-region, largely a function of population ageing and growth. We also forecasted that both DALY counts and age-standardised DALY rates will continue to shift from CMNNs to NCDs, with the most pronounced shifts occurring in sub-Saharan Africa (60·1% [95% UI 56·8–63·1] of DALYs were from CMNNs in 2022 compared with 35·8% [31·0–45·0] in 2050) and south Asia (31·7% [29·2–34·1] to 15·5% [13·7–17·5]). This shift is reflected in the leading global causes of DALYs, with the top four causes in 2050 being ischaemic heart disease, stroke, diabetes, and chronic obstructive pulmonary disease, compared with 2022, with ischaemic heart disease, neonatal disorders, stroke, and lower respiratory infections at the top. The global proportion of DALYs due to YLDs likewise increased from 33·8% (27·4–40·3) to 41·1% (33·9–48·1) from 2022 to 2050, demonstrating an important shift in overall disease burden towards morbidity and away from premature death. The largest shift of this kind was forecasted for sub-Saharan Africa, from 20·1% (15·6–25·3) of DALYs due to YLDs in 2022 to 35·6% (26·5–43·0) in 2050. In the assessment of alternative future scenarios, the combined effects of the scenarios (Safer Environment, Improved Childhood Nutrition and Vaccination, and Improved Behavioural and Metabolic Risks scenarios) demonstrated an important decrease in the global burden of DALYs in 2050 of 15·4% (13·5–17·5) compared with the reference scenario, with decreases across super-regions ranging from 10·4% (9·7–11·3) in the high-income super-region to 23·9% (20·7–27·3) in north Africa and the Middle East. The Safer Environment scenario had its largest decrease in sub-Saharan Africa (5·2% [3·5–6·8]), the Improved Behavioural and Metabolic Risks scenario in north Africa and the Middle East (23·2% [20·2–26·5]), and the Improved Nutrition and Vaccination scenario in sub-Saharan Africa (2·0% [–0·6 to 3·6]). Interpretation: Globally, life expectancy and age-standardised disease burden were forecasted to improve between 2022 and 2050, with the majority of the burden continuing to shift from CMNNs to NCDs. That said, continued progress on reducing the CMNN disease burden will be dependent on maintaining investment in and policy emphasis on CMNN disease prevention and treatment. Mostly due to growth and ageing of populations, the number of deaths and DALYs due to all causes combined will generally increase. By constructing alternative future scenarios wherein certain risk exposures are eliminated by 2050, we have shown that opportunities exist to substantially improve health outcomes in the future through concerted efforts to prevent exposure to well established risk factors and to expand access to key health interventions

Raising Climate-Resilient Embolden Rice (Oryza sativa L.) Seedlings during the Cool Season through Various Types of Nursery Bed Management

Facing cold stress is amajor constraint in seedling production during the winter season as, most particularly in recent times due to uncertain climatic conditions, no sustainable technology has been reported that could be easily adopted by farmers withlimited resources. Therefore, field experiments were carried out during winter 2017–2018 and 2018–2019 at the Central Research Farm of Bidhan Chandra KrishiViswavidyalaya, West Bengal, India to study the growth, survival potential, yield and nutritional and biochemical properties of boro rice seedlings as influenced by two seedbed management practices viz. conventional seedbed (farmers’ practice) and improved seedbed (polythene protected with micronutrient supplementation). The major objective was to lower the nurserybed duration without compromising seedlings’ health and to studythe economic viability during the winter season. The experiment was laid out in ten experimental units and deployed anindependent-sample t-test to compare the performance of the seedlings. The microclimatic changes were also itemized from both seedbeds. The seeds sownunder improved nursery conditions resulted in better seedling emergence (~90%) and survival percentage (~85%) as compared to the conventional seedbed (~70% and 65%). Growth attributes in terms of plant height, biomass accumulation, root characteristics, tiller count, and growth rate were observed to be better from the polythene-protected nursery bed. Theimproved nursery bed accounted for 20% higher seedling count at the time of transplantation over the conventional bed. The microclimatic situation under a polythene covering was also favorable for germination and seedling growth. Maximum nutrient (N, P, and K) concentrations, as well as chlorophyll content, wererecorded from improved seedlings. Results suggested that the improved seedbed management was apotential alternative toearly embolden seedling production during the winter to avoid climatic abnormalities. Most importantly, improved seedbeds ensured a comprehensive route from germination to healthy seedling production without any failure in thesmalltime window, which involvedless input as well as cost involvement. This technique could diffusethe problem oflate sowing conditions in the rice–rice cropping system

Raising Climate-Resilient Embolden Rice (<i>Oryza sativa</i> L.) Seedlings during the Cool Season through Various Types of Nursery Bed Management

Facing cold stress is amajor constraint in seedling production during the winter season as, most particularly in recent times due to uncertain climatic conditions, no sustainable technology has been reported that could be easily adopted by farmers withlimited resources. Therefore, field experiments were carried out during winter 2017–2018 and 2018–2019 at the Central Research Farm of Bidhan Chandra KrishiViswavidyalaya, West Bengal, India to study the growth, survival potential, yield and nutritional and biochemical properties of boro rice seedlings as influenced by two seedbed management practices viz. conventional seedbed (farmers’ practice) and improved seedbed (polythene protected with micronutrient supplementation). The major objective was to lower the nurserybed duration without compromising seedlings’ health and to studythe economic viability during the winter season. The experiment was laid out in ten experimental units and deployed anindependent-sample t-test to compare the performance of the seedlings. The microclimatic changes were also itemized from both seedbeds. The seeds sownunder improved nursery conditions resulted in better seedling emergence (~90%) and survival percentage (~85%) as compared to the conventional seedbed (~70% and 65%). Growth attributes in terms of plant height, biomass accumulation, root characteristics, tiller count, and growth rate were observed to be better from the polythene-protected nursery bed. Theimproved nursery bed accounted for 20% higher seedling count at the time of transplantation over the conventional bed. The microclimatic situation under a polythene covering was also favorable for germination and seedling growth. Maximum nutrient (N, P, and K) concentrations, as well as chlorophyll content, wererecorded from improved seedlings. Results suggested that the improved seedbed management was apotential alternative toearly embolden seedling production during the winter to avoid climatic abnormalities. Most importantly, improved seedbeds ensured a comprehensive route from germination to healthy seedling production without any failure in thesmalltime window, which involvedless input as well as cost involvement. This technique could diffusethe problem oflate sowing conditions in the rice–rice cropping system