Baryogenesis in a supersymmetric model without R-parity

We propose a simple scenario for baryogenesis in supersymmetric models where baryon number is broken alongwith R-parity. The lightest supersymmetric particle (neutralino) decays to three quarks and $CP-$ violation comes from interference of tree and one loop box diagrams. The bounds on the $R-$parity breaking couplings from the out-of-equilibrium condition are considerably relaxed in this scenario.Comment: 12 pages latex (including 2 eps files

Green corrosion inhibitor from leaves of Purple Knight Hedge plant for mild steel in 1 M HCl medium: Electrochemical, gravimetric, adsorption and SEM studies

Lyophilized hot water extract of Purple Knight leaves (PKLE) has investigated as an environment friendly and cost effective corrosion inhibitor against corrosion of mild steel in 1 M HCl solution. Corrosion inhibition efficiency of PKLE has studied using Gravimetric, potentiodynamic polarization and electrochemical impedance spectroscopic methods. PKLE acts as mixed inhibitor and its adsorption on mild steel surface in 1 M HCl solution follows the Langmuir adsorption isotherm. Thermodynamic parameters of the adsorption process and apparent activation energy for the corrosion process have been determined. Both physical and chemical adsorption contributes to the overall adsorption process. Scanning Electron Microscopy reveals a significant protection of metal surface by PKLE molecules. The chemical characterization of PKLE is carried out by gas chromatography and FT-IR spectroscopy

Effect of physical training on gender difference in trained personal

Many controlled studies and neurological studies demonstrate that men and women are physically and mentally different. The purpose of this study is to find out whether there is any gender difference in respiratory capacity between trained athletes of both gender. This study was conducted at Kolkata (Serampore area), West Bengal, India. The subject was trained table tennis players of age group was 14 – 17 years. Significant differences have been found in height (cm), W/H ratio and PIF (l/s)  between male and female lawn tennis players and all these values are significantly higher (P<0.05) in male than female players. Greater mean height in trained male than female tennis player of same age range is advantageous for male. This might be due to their own growth pattern under the influences of different specific hormones which is not considered in this study. Higher centrally located fats in trained male than female tennis player in this age range might be due to less affectivity of physical training in male. Higher central fat distribution may hinder different lung capacities by influencing abdominal cavity. Higher peak inspiratory flow in trained male than female tennis player indicates inspiratory muscles are more powerful in male player of this age range.  So, it can be concluded from this study that gender differences in lung capacities can be minimized by proper training load in female trained player at least in 14-17 years age range. This study also claimed that stature is not only the decisive factor for differences in lung capacities in male and female trained tennis player of 14-17 years age range. Body composition, central fat distribution, active inspiratory muscles and proper physical training have definite role in improving lung capacities of trained male and female tennis player

Green corrosion inhibitor from leaves of Purple Knight Hedge plant for mild steel in 1 M HCl medium: Electrochemical, gravimetric, adsorption and SEM studies

395-403  Lyophilized hot water extract of Purple Knight leaves (PKLE) has investigated as an environment friendly and cost effective corrosion inhibitor against corrosion of mild steel in 1 M HCl solution. Corrosion inhibition efficiency of PKLE has studied using Gravimetric, potentiodynamic polarization and electrochemical impedance spectroscopic methods.   PKLE acts as mixed inhibitor and its adsorption on mild steel surface in 1 M HCl solution follows the Langmuir adsorption isotherm. Thermodynamic parameters of the adsorption process and apparent activation energy for the corrosion process have been determined. Both physical and chemical adsorption contributes to the overall adsorption process. Scanning Electron Microscopy reveals a significant protection of metal surface by PKLE molecules.   The chemical characterization of PKLE is carried out by gas chromatography and FT-IR spectroscopy

Design and implementation of an improved datacenter broker policy to improve the QoS of a cloud

Cloud Computing offers various remotely accessible services to users either free or on payment. A major issue with Cloud Service Providers (CSP) is to maintain Quality of Service (QoS). The QoS encompasses different parame-ters, like, smart job allocation strategy, efficient load balancing, response time optimization, reduction in wastage of bandwidth, accountability of the overall system, best Virtual Machine (VM) (which reduce the overall execu-tion time of the requested Cloudlets) selection etc. The Datacenter Broker (DCB) policy helps binding a Cloudlet with a VM. An efficient DCB policy reduces the overall execution time of a Cloudlet. Allocating cloudlets properly to the appropriate VMs in a Datacenter makes a system active, alive and balanced. In present study, we proposed a conductance algorithm for effective allocation of Cloudlets to the VMs in a Datacenter by taking into consideration of power and capacity of VMs, and length of Cloudlets. Experimental results obtained using CloudSim toolkit under heavy loads, establishes performance supremacy of our proposed algorithm over existing DCB algorithm

A multi-omics analysis of bone morphogenetic protein 5 (BMP5) mRNA expression and clinical prognostic outcomes in different cancers using bioinformatics approaches

Cumulative studies have provided controversial evidence for the prognostic values of bone morphogenetic protein 5 (BMP5) in different types of cancers such as colon, breast, lung, bladder, and ovarian cancer. To address the inconsistent correlation of BMP5 expression with patient survival and molecular function of BMP5 in relation to cancer progression, we performed a systematic study to determine whether BMP5 could be used as a prognostic marker in human cancers. BMP5 expression and prognostic values were assessed using different bioinformatics tools such as ONCOMINE, GENT, TCGA, GEPIA, UALCAN, PrognoScan, PROGgene V2 server, and Kaplan–Meier Plotter. In addition, we used cBioPortal database for the identification and analysis of BMP5 mutations, copy number alterations, altered expression, and protein–protein interaction (PPI). We found that BMP5 is frequently down-regulated in our queried cancer types. Use of prognostic analysis showed negative association of BMP5 down-regulation with four types of cancer except for ovarian cancer. The highest mutation was found in the R321*/Q amino acid of BMP5 corresponding to colorectal and breast cancer whereas the alteration frequency was higher in lung squamous carcinoma datasets (>4%). In PPI analysis, we found 31 protein partners of BMP5, among which 11 showed significant co-expression (p-value 1). Pathway analysis of differentially co-expressed genes with BMP5 in breast, lung, colon, bladder and ovarian cancers revealed the BMP5-correlated pathways. Collectively, this data-driven study demonstrates the correlation of BMP5 expression with patient survival and identifies the involvement of BMP5 pathways that may serve as targets of a novel biomarker for various types of cancers in human

Detection of retinal and blood Aβ oligomers with nanobodies

Introduction: Abnormal retinal changes are increasingly recognized as an early pathological change in Alzheimer’s disease (AD). Although amyloid beta oligomers (Aβo) have been shown to accumulate in the blood and retina of AD patients and animals, it is not known whether the early Aβo deposition precedes their accumulation in brain. Methods and results: Using nanobodies targeting Aβ1-40 and Aβ1-42 oligomers we were able to detect Aβ oligomers in the retina and blood but not in the brain of 3-month-old APP/PS1 mice. Furthermore, Aβ plaques were detected in the brain but not the retina of 3-month-old APP/PS1 mice. Conclusion: These results suggest that retinal accumulation of Aβo originates from peripheral blood and precedes cognitive decline and Aβo deposition in the brain. This provides a very strong basis to develop and implement an “eye test” for early detection of AD using nanobodies targeting retinal Aβ

Leptogenesis from Neutralino Decay with Nonholomorphic R-Parity Violation

In supersymmetric models with lepton-number violation, hence also R-parity violation, it is easy to have realistic neutrino masses, but then leptogenesis becomes difficult to achieve. After explaining the general problems involved, we study the details of a model which escapes these constraints and generates a lepton asymmetry, which gets converted into the present observed baryon asymmetry of the Universe through the electroweak sphalerons. This model requires the presence of certain nonholomorphic R-parity violating terms. For completeness we also present the most general R-parity violating Lagrangian with soft nonholomorphic terms and study their consequences for the charged-scalar mass matrix. New contributions to neutrino masses in this scenario are discussed.Comment: 30 pages, 6 figure

Cross-linking cellular prion protein induces neuronal type 2-like hypersensitivity

Background: Previous reports identified proteins associated with ‘apoptosis’ following cross-linking PrPC with motif-specific anti-PrP antibodies in vivo and in vitro. The molecular mechanisms underlying this IgG-mediated neurotoxicity and the role of the activated proteins in the apoptotic pathways leading to neuronal death has not been properly defined. Previous reports implicated a number of proteins, including apolipoprotein E, cytoplasmic phospholipase A2, prostaglandin and calpain with antiPrP antibody-mediated ‘apoptosis’, however, these proteins are also known to play an important role in allergy. In this study, we investigated whether cross-linking PrPC with anti-PrP antibodies stimulates a neuronal allergenic response. Methods: Initially, we predicted the allergenicity of the epitope sequences associated with ‘neurotoxic’ anti-PrP antibodies using allergenicity prediction servers. We then investigated whether anti-PrP antibody treatment of mouse primary neurons (MPN), neuroblastoma cells (N2a) and microglia (N11) cell lines lead to a neuronal allergenic response. Results: In-Silico studies showed that both tail- and globular-epitopes were allergenic. Specifically, binding regions that contain epitopes for previously reported ‘neurotoxic’ antibodies such as ICSM18 (146-159), ICSM35 (91-110), POM 1 (138-147) and POM 3 (95-100) lead to activation of allergenic related proteins. Following direct application of antiPrPC antibodies on N2a cells, we identified 4 neuronal allergenic-related proteins when compared with untreated cells. Furthermore, we identified 8 neuronal allergenic-related proteins following treatment of N11 cells with anti-PrPC antibodies prior to co-culture with N2a cells when compared with untreated cells. Antibody treatment of MPN or MPN co-cultured with antibody-treated N11 led to identifying 10 and 7 allergenic-related proteins when compared with untreated cells. However, comparison with 3F4 antibody treatment revealed 5 and 4 allergenic-related proteins respectively. Of importance, we showed that the allergenic effects triggered by the anti-PrP antibodies were more potent when antibody-treated microglia were co-cultured with the neuroblastoma cell line. Finally, co-culture of N2a or MPN with N11-treated with anti-PrP antibodies resulted in significant accumulation of NO and IL6 but not TNF-a in the cell culture media supernatant. Conclusions: This study showed for the first time that anti-PrP antibody binding to PrPC triggers a neuronal hypersensitivity response and highlights the important role of microglia in triggering an IgG-mediated neuronal hypersensitivity response. Moreover, this study provides an important impetus for including allergenic assessment of therapeutic antibodies for neurodegenerative disorders to derive safe and targeted biotherapeutics

Leptogenesis from R parity nonconservation

It is known that realistic neutrino masses for neutrino oscillations may be obtained from R parity nonconserving supersymmetry. It is also known that such interactions would erase any preexisting lepton or baryon asymmetry of the Universe because of the inevitable intervention of the electroweak sphalerons. We now show how a crucial subset of these R parity nonconserving terms may in fact create its own successful leptogenesis.Comment: 4 pages latex file with one postscript figur