Leader, follower or free rider? The economic impacts of different Australian emission targets

This economic analysis by policy experts from CSIRO, The Climate Institute, Monash University and McLennan Magasanik Associates examined a range of scenarios to explore the relative costs of Australia free riding and following other industrialised countries in the global efforts to avoid dangerous climate change versus Australia taking a leadership position. It concludes that making very substantial reductions in Australia\u27s net greenhouse emissions is affordable, and compatible with continuing growth in incomes, employment and living standards.&nbsp

Entropy Crisis, Ideal Glass Transition and Polymer Melting: Exact Solution on a Husimi Cactus

We introduce an extension of the lattice model of melting of semiflexible polymers originally proposed by Flory. Along with a bending penalty, present in the original model and involving three sites of the lattice, we introduce an interaction energy that corresponds to the presence of a pair of parallel bonds and a second interaction energy associated with the presence of a hairpin turn. Both these new terms represent four-site interactions. The model is solved exactly on a Husimi cactus, which approximates a square lattice. We study the phase diagram of the system as a function of the energies. For a proper choice of the interaction energies, the model exhibits a first-order melting transition between a liquid and a crystalline phase. The continuation of the liquid phase below this temperature gives rise to a supercooled liquid, which turns continuously into a new low-temperature phase, called metastable liquid. This liquid-liquid transition seems to have some features that are characteristic of the critical transition predicted by the mode-coupling theory.Comment: To be published in Physical Review E, 68 (2) (2003

Framing and visual type: Effect on future Zika vaccine uptake intent

Introduction: The Zika virus is associated with the birth defect microcephaly, and while a vaccine was not available in early- 2017, several were under development. This study’s purpose was to identify effective communication strategies to promote uptake of a new vaccine, particularly among women of reproductive age.Design and methods: In order to study the effects of Zika message framing (gain vs. loss) and visual type (photo vs. infographic) on future Zika vaccine uptake intent, a 2×2 between-subjects experiment was performed via an online survey in 2017 among 339 U.S. women of reproductive age (18-49 years). Participants were exposed to one of four messages, all resembling Instagram posts: gain-framed vs. loss-framed infographic, and gain-framed vs. loss-framed photo. These messages were followed by questions about Zika vaccine uptake intent as well as intermediate psychosocial variables that could lead to intent. Results: There was no interaction between framing and visual type (P=0.116), and there was no effect for framing (P=0.185) or visual type (P=0.724) on future Zika vaccine uptake intent, which is likely indicative of insufficient dosage of the intervention. However, when focusing on intermediate psychosocial constructs that are known to influence behavior and intent, gain-framed messages were more effective in increasing subjective norms (P=0.005) as related to a future Zika vaccine, as well as perceived benefits (P=0.016) and self-efficacy (P=0.032). Conclusions: Gain-framed messages seem to be more effective than loss-framed messages to increase several constructs that could, in turn, affect future Zika vaccine uptake intent. This is a novel finding since, traditionally, loss-framed messages are considered more beneficial in promoting vaccine-related health behaviors

Acute inhibition of MEK suppresses congenital melanocytic nevus syndrome in a murine model driven by activated NRAS and Wnt signaling

Congenital melanocytic nevus (CMN) syndrome is the association of pigmented melanocytic nevi with extra-cutaneous features, classically melanotic cells within the central nervous system, most frequently caused by a mutation of NRAS codon 61. This condition is currently untreatable and carries a significant risk of melanoma within the skin, brain, or leptomeninges. We have previously proposed a key role for Wnt signaling in the formation of melanocytic nevi, suggesting that activated Wnt signaling may be synergistic with activated NRAS in the pathogenesis of CMN syndrome. Some familial pre-disposition suggests a germ-line contribution to CMN syndrome, as does variability of neurological phenotypes in individuals with similar cutaneous phenotypes. Accordingly, we performed exome sequencing of germ-line DNA from patients with CMN to reveal rare or undescribed Wnt-signaling alterations. A murine model harboring activated NRASQ61K and Wnt signaling in melanocytes exhibited striking features of CMN syndrome, in particular neurological involvement. In the first model of treatment for this condition, these congenital, and previously assumed permanent, features were profoundly suppressed by acute post-natal treatment with a MEK inhibitor. These data suggest that activated NRAS and aberrant Wnt signaling conspire to drive CMN syndrome. Post-natal MEK inhibition is a potential candidate therapy for patients with this debilitating condition

Constructing a CGE database using GEMPACK for an African country

This paper describes how we transformed the 2002 Ugandan Supply Use Table (SUT) into the required structure of a database for the static UgandanCGEmodel Dixon et al. (ORANI: A multisectoral model of the Australian economy, 1982). We describe the unique features captured in the Ugandan SUT as well as that of the CGE database. We highlight the structural differences of the published data and that of the CGE database. In describing the SUT we identify data issues, such as negative capital rentals and omitted data entries that had to be addressed before the database could be constructed. The ideas put forward in this paper describe, in a pragmatic manner, not only how to transform published data into a CGE database, but also how to create an additional sector in the CGE database. For the Ugandan CGE database, we created an additional Oil sector.http://link.springer.com/journal/106142016-12-31hb2016Economic

Superfluid toroidal currents in atomic condensates

The dynamics of toroidal condensates in the presence of condensate flow and dipole perturbation have been investigated. The Bogoliubov spectrum of condensate is calculated for an oblate torus using a discrete-variable representation and a spectral method to high accuracy. The transition from spheroidal to toroidal geometry of the trap displaces the energy levels into narrow bands. The lowest-order acoustic modes are quantized with the dispersion relation $\omega \sim |m| \omega_s$ with $m=0,\pm 1,\pm 2, ...$. A condensate with toroidal current $\kappa$ splits the $|m|$ co-rotating and counter-rotating pair by the amount: $\Delta E \approx 2 |m|\hbar^2 \kappa < r^{-2}>$. Radial dipole excitations are the lowest energy dissipation modes. For highly occupied condensates the nonlinearity creates an asymmetric mix of dipole circulation and nonlinear shifts in the spectrum of excitations so that the center of mass circulates around the axis of symmetry of the trap. We outline an experimental method to study these excitations.Comment: 8 pages, 8 figure

As time flies by: Investigating cardiac aging in the short-lived Drosophila model.

Aging is associated with a decline in heart function across the tissue, cellular, and molecular levels. The risk of cardiovascular disease grows significantly over time, and as developed countries continue to see an increase in lifespan, the cost of cardiovascular healthcare for the elderly will undoubtedly rise. The molecular basis for cardiac function deterioration with age is multifaceted and not entirely clear, and there is a limit to what investigations can be performed on human subjects or mammalian models. Drosophila melanogaster has emerged as a useful model organism for studying aging in a short timeframe, benefitting from a suite of molecular and genetic tools and displaying highly conserved traits of cardiac senescence. Here, we discuss recent advances in our understanding of cardiac aging and how the fruit fly has aided in these developments

The Experiment Data Depot: A Web-Based Software Tool for Biological Experimental Data Storage, Sharing, and Visualization

Although recent advances in synthetic biology allow us to produce biological designs more efficiently than ever, our ability to predict the end result of these designs is still nascent. Predictive models require large amounts of high-quality data to be parametrized and tested, which are not generally available. Here, we present the Experiment Data Depot (EDD), an online tool designed as a repository of experimental data and metadata. EDD provides a convenient way to upload a variety of data types, visualize these data, and export them in a standardized fashion for use with predictive algorithms. In this paper, we describe EDD and showcase its utility for three different use cases: storage of characterized synthetic biology parts, leveraging proteomics data to improve biofuel yield, and the use of extracellular metabolite concentrations to predict intracellular metabolic fluxes

Parton energy loss at strong coupling and the universal bound

The apparent universality of jet quenching observed in heavy ion collisions at RHIC for light and heavy quarks, as well as for quarks and gluons, is very puzzling and calls for a theoretical explanation. Recently it has been proposed that the synchrotron--like radiation at strong coupling gives rise to a universal bound on the energy of a parton escaping from the medium. Since this bound appears quite low, almost all of the observed particles at high transverse momentum have to originate from the surface of the hot fireball. Here I make a first attempt of checking this scenario against the RHIC data and formulate a "Universal Bound Model" of jet quenching that can be further tested at RHIC and LHC.Comment: 8 pages, 2 figures, invited plenary talk given at "Hard Probes 2008" Conference, 8-14 June 2008, Illa da Toxa, Galicia, Spai

On the Quasi-Linear Elliptic PDE −∇⋅(∇u/1−∣∇u∣2)=4π∑kakδsk-\nabla\cdot(\nabla{u}/\sqrt{1-|\nabla{u}|^2}) = 4\pi\sum_k a_k \delta_{s_k} in Physics and Geometry

It is shown that for each finite number of Dirac measures supported at points $s_n$ in three-dimensional Euclidean space, with given amplitudes $a_n$, there exists a unique real-valued Lipschitz function $u$, vanishing at infinity, which distributionally solves the quasi-linear elliptic partial differential equation of divergence form $-\nabla\cdot(\nabla{u}/\sqrt{1-|\nabla{u}|^2})=4\pi\sum_{n=1}^N a_n \delta_{s_n}$. Moreover, $u$ is real analytic away from the $s_n$. The result can be interpreted in at least two ways: (a) for any number of point charges of arbitrary magnitude and sign at prescribed locations $s_n$ in three-dimensional Euclidean space there exists a unique electrostatic field which satisfies the Maxwell-Born-Infeld field equations smoothly away from the point charges and vanishes as $|s|\to\infty$; (b) for any number of integral mean curvatures assigned to locations $s_n$ there exists a unique asymptotically flat, almost everywhere space-like maximal slice with point defects of Minkowski spacetime, having lightcone singularities over the $s_n$ but being smooth otherwise, and whose height function vanishes as $|s|\to\infty$. No struts between the point singularities ever occur.Comment: This is the preprint of the version published in 2012 in Commun. Math. Phys. PLUS an errata which has been accepted 08/13/2018 for publication in Commun. Math. Phy