Pre-service teachers as designers in the context of advertising literacy education

The present study describes how teacher design teams (TDTs) in pre-service education were set up to create in-school programs about advertising. A multiple case-study design was employed to reveal what kinds of input-, process-, and output-related factors facilitate or hinder the collaboration of three voluntarily participating teams of pre-service teachers. By combining pre-TDT questionnaire data with an analysis of audiorecorded team design discussions and reflective data collected after the design process, we found that the participating student teachers (1) were unfamiliar with design assignments at the start of the project, but were all intrinsically motivated to take part; (2) especially express practical concerns when designing learning materials, and (3) argue that TDTs positively contribute to their professional development. As this study revealed both facilitating and hindering factors, recommendations for future organization of and research on TDTs in pre-service education are offered

Variation in the inter-service intervals of UK dairy cows

An understanding of the normal estrous cycle length of the cow is important when managing and monitoring dairy herd fertility. Whilst the normal inter-ovulatory interval is widely considered to be 21 days, some studies have found alternative intervals to be more prevalent; previously most of the variation in interval length was expected to be between cows. The aim of this study was to assess the time between inseminations (inter-service interval, ISI), in a large number of dairy cows and to explore possible associations between cow factors and estrous cycle length. The study used ISI data from 42,252 cows in 159 herds across England and Wales. Univariate analysis of the subset of 114,572 intervals between 15 and 30 days (a range covering the increased frequency of ISIs occurring at the expected time of the first return to estrus) following an insemination revealed a modal ISI of 22 days. Primiparous heifers had a modal ISI of 21 days. There were significant differences between the distribution of ISIs for different yield groups, parity numbers and the number of inseminations. Multilevel regression modelling was used to evaluate the associations between cow factors and ISI, whilst accounting for clustering at the herd and cow level. This revealed significant associations between predicted ISI and insemination number, days in milk, lactation 305 day milk yield, and month and year of insemination. Variance partition coefficients indicated that only 1% of variation in ISIs was at the herd level, 12% at the animal level and 87% at the insemination level, indicating that cycle length varies substantially more between cycles within a cow than between cows or herds. These findings suggest the “normal” range of ISI for modern UK dairy cows is longer than expected and that there is a large amount of unexplained variation in cycle length within individual animals over time

Quality of life utility values for hereditary haemochromatosis in Australia

Background: Hereditary hemochromatosis (HH) is a common autosomal recessive disorder amongst persons of northern European heritage. If untreated, iron accumulates in parenchymal tissues causing morbidity and mortality. As diagnosis often follows irreversible organ damage, screening programs have been suggested to increase early diagnosis. A lack of economic evidence has been cited as a barrier to establishing such a program. Previous analyses used poorly estimated utility values. This study sought to measure utilities directly from people with HH in Australia. Methods: Volunteers with HH were recruited to complete a web-based survey. Utility was assessed using the Assessment of Quality of Life 4D (AQOL-4D) instrument. Severity of HH was graded into four categories. Multivariable regression analysis was performed to identify parameters associated with HSUV. Results: Between November 2013 and November 2014, 221 people completed the survey. Increasing severity of HH was negatively associated with utility. Mean (standard deviation) utilities were 0.76 (0.21), 0.81 (0.18), 0.60 (0.27), and 0.50 (0.27) for categories 1-4 HH respectively. Lower mean utility was found for symptomatic participants (categories 3 and 4) compared with asymptomatic participants (0.583 v. 0.796). Self-reported HH-related symptoms were negatively associated with HSUV (r = -0.685). Conclusions: Symptomatic stages of HH and presence of multiple self-reported symptoms were associated with decreasing utility. Previous economic analyses have used higher utilities which likely resulted in underestimates of the cost effectiveness of HH interventions. The utilities reported in this paper are the most robust available, and will contribute to improving the validity of future economic models for HH

Requirement for Abasic Endonuclease Gene Homologues in Arabidopsis Seed Development

Arabidopsis thaliana has three genes, Ape1L, Ape2, and Arp, that show homology to abasic (apurinic/apyrimidinic) endonuclease genes of bacterial, yeast, or animal cells. In bacteria, yeast, and animals, abasic endonucleases function in base excision repair of oxidized and other modified DNA bases. Here we report that plants with knock-out mutations in any one of Ape1L, Ape2, or Arp show no apparent differences from wild type in growth rate, growth habit, and fertility. However, coincident knock-out mutations in Ape1L and Ape2 are lethal and lead to abortion of developing embryos. Mutations of Arp are not deleterious, even in combination with one of the other two mutations. The results are consistent with the interpretation that the process of base excision repair, involving at least one intact copy of Ape1L or Ape2, is required in the process of embryogenesis