Psychosocial support to foster social cohesion between refugee and host communities in Jordan

The internal conflict in Syria has displaced large numbers of the population into neighbouring countries since the uprising in 2011. The large influx of displaced people into Jordan poses great challenges to the international community as well as local authorities, with increasing competition for already scarce resources and services creating rising tensions between refugee and host communities. In this context, the non-governmental organisation, Action Contre la Faim, implemented a programme aimed at improving psychosocial well-being, fostering resilience and promoting positive interactions between the members of both communities. Through the participation of support groups within community-based organisations, dialogue was facilitated, and interactions took place in a safe and therapeutic environment. Participants reported improved perception of well-being and self confidence, as well as improved mutual understanding and communication, reduced isolation and the extension of social support, enhanced empathy and reduce prejudice

Benefit-risk assessment of sonidegib and vismodegib in the treatment of locally advanced basal cell carcinoma

Sonidegib and vismodegib are Hedgehog pathway inhibitors (HhIs) that play a relevant role in the management of locally advanced basal cell carcinoma (laBCC). This study compared the efficacy and safety of both HhIs based on their available data using effect size measures such as number needed to treat (NNT), number needed to harm (NNH), and likelihood to be helped or harmed (LHH)

Sistema y método de transmisión de datos entre una unidad móvil y una unidad receptora

Número de publicación: ES2253080 A1 (16.05.2006) También publicado como: ES2253080 B1 (16.07.2007) Número de Solicitud: Consulta de Expedientes OEPM (C.E.O.) P200401499 (18.06.2004)La invención se refiere a un método y sistema para transmitir datos entre una unidad móvil (1) y una unidad receptora (2), a través de una red (3) asociada a nodos de repetición (31) que reciben los datos, en forma de paquetes, desde la unidad móvil y los transmiten hasta la unidad receptora (2), que está configurada para descartar paquetes que se reciben de forma repetida, mediante el control de un identificador único asociado a cada paquete. Para mayor seguridad en cuanto a cobertura, se puede completar la posibilidad de transmisión vía los nodos de repetición con una forma alternativa de transmitir los datos, por ejemplo, vía GPRS.Universidad de Almerí

Effects of a concurrent exercise training program on low back and sciatic pain and pain disability in late pregnancy

Objective: The aim of the present study was to explore the influence of a concurrent exercise (aerobic + resistance) training program, from the 17th gestational week (g.w.) until birth on low back and sciatic pain, and pain disability. A total of 93 pregnant women divided into exercise (n = 49) and control (n = 44) groups followed a 60-min, 3 days/week, concurrent exercise training. Methods: Low back and sciatic pain were measured with a Visual Analogic Scale (VAS). The disability resulting from pain was assessed with the Oswestry Disability Index (ODI). Measures were performed at the 16th and 34th g.w. Results: The exercise group increased 21.9 mm less the VAS low back (between-group differences (B): 95% CI: −33.6 to −10.2; p < 0.001) and 12.9 mm less the VAS sciatica score (between-group differences: 95% CI (B): −21.8 to −4.0; p = 0.005) than the control group. Regarding the ODI questionnaire, the exercise group increased 0.7, 0.5, and 0.7 less than the control group in pain while sleeping (between-group differences (B): 95% CI: −1.4 to −0.01; p = 0.025), pain while lifting weight (between-group differences (B): 95% CI: −0.9 to −0.01; p = 0.016), and limitations of the social life due to pain (between-group differences(B): 95% CI: −1.3 to −0.06; p = 0.032). Furthermore, the exercise group suffered 6.9% less pain than the control group in the ODI total score (between-group differences (B): 95% CI: −13.9 to 0.053; p = 0.052). Conclusion: This concurrent exercise training program adapted to pregnant women improved pain compared to controls.Funding information Regional Ministry of Health of the Junta de Andalucía, Grant/Award Number: PI-0395-2016; Spanish Ministry of Education, Culture, and Sports, Grant/Award Number: FPU17/03715; University of Granada, Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES), and by the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades and European Regional Development Fund (ERDF), Grant/ Award Number: REF. SOMM17/6107/UGR10 página

Myc Inhibits p27-Induced Erythroid Differentiation of Leukemia Cells by Repressing Erythroid Master Genes without Reversing p27-Mediated Cell Cycle Arrest

Inhibition of differentiation has been proposed as an important mechanism for Myc-induced tumorigenesis, but the mechanisms involved are unclear. We have established a genetically defined differentiation model in human leukemia K562 cells by conditional expression of the cyclin-dependent kinase (Cdk) inhibitor p27 (inducible by Zn2+) and Myc (activatable by 4-hydroxy-tamoxifen). Induction of p27 resulted in erythroid differentiation, accompanied by Cdk inhibition and G1 arrest. Interestingly, activation of Myc inhibited p27-mediated erythroid differentiation without affecting p27-mediated proliferation arrest. Microarray-based gene expression indicated that, in the presence of p27, Myc blocked the upregulation of several erythroid-cell-specific genes, including NFE2, JUNB, and GATA1 (transcription factors with a pivotal role in erythropoiesis). Moreover, Myc also blocked the upregulation of Mad1, a transcriptional antagonist of Myc that is able to induce erythroid differentiation. Cotransfection experiments demonstrated that Myc-mediated inhibition of differentiation is partly dependent on the repression of Mad1 and GATA1. In conclusion, this model demonstrates that Myc-mediated inhibition of differentiation depends on the regulation of a specific gene program, whereas it is independent of p27-mediated cell cycle arrest. Our results support the hypothesis that differentiation inhibition is an important Myc tumorigenic mechanism that is independent of cell proliferation. Copyright © 2008, American Society for Microbiology. All Rights Reserved.This study was supported by grants CICYT SAF05-00461 from the Spanish Ministerio de Educación y Ciencia (MEC), ISCIII-RETIC RD06/0020 from the Spanish Ministerio de Sanidad y Consumo, API-17-05 from the Fundación Marques de Valdecilla (to J.L), and FIS04/1083 (to M.D.D). J.C.A., G.B., and N.F. were supported by fellowships from the MEC, and V.T. was supported by a Lady Tata Memorial Trust award.Peer Reviewe

Behavior of hospitalized severe influenza cases according to the outcome variable in Catalonia, Spain, during the 2017-2018 season

Infuenza is an important cause of severe illness and death among patients with underlying medical conditions and in the elderly. The aim of this study was to investigate factors associated with ICU admission and death in patients hospitalized with severe laboratory-confrmed infuenza during the 2017-2018 season in Catalonia. An observational epidemiological case-to-case study was carried out. Reported cases of severe laboratory-confrmed infuenza requiring hospitalization in 2017-2018 infuenza season were included. Mixed-efects regression analysis was used to estimate the factors associated with ICU admission and death. A total of 1306 cases of hospitalized severe infuenza cases were included, of whom 175 (13.4%) died and 217 (16.6%) were ICU admitted. Age 65-74 years and≥ 75 years and having≥ 2 comorbidities were positively associated with death (aOR 3.19; 95%CI 1.19-8.50, aOR 6.95, 95%CI 2.76-1.80 and aOR 1.99; 95%CI 1.12-3.52, respectively). Neuraminidase inhibitor treatment and pneumonia were negatively associated with death. The 65-74 years and≥ 75 years age groups were negatively associated with ICU admission (aOR 0.41; 95%CI 0.23-0.74 and aOR 0.30; 95%CI 0.17-0.53, respectively). A factor positively associated with ICU admission was neuraminidase inhibitor treatment. Our results support the need to investigate the worst outcomes of hospitalized severe cases, distinguishing between death and ICU admission

Use of inclusive language in Administrative Law teaching

El presente artículo expone el desarrollo y los principales resultados de un proyecto de innovación docente sobre el uso de lenguaje jurídico inclusivo en el ámbito del Derecho Administrativo. Los estudiantes matriculados en una asignatura de Derecho Administrativo fueron invitados a participar voluntariamente en el proyecto. Aquellos que aceptaron recibieron formación específica sobre cómo reconocer y corregir el sexismo lingüístico en textos legales. Posteriormente, se les pidió que revisaran el manual recomendado de la asignatura y que señalaran los casos de lenguaje no inclusivo que pudieran encontrar. Sus informes finales incluyeron propuestas de modificaciones que fueron transmitidos a los autores y autoras del libro de texto.This paper exposes the development and the main outcomes of an educational innovative project on the use of legal inclusive language in the field of Administrative Law. Students enrolled in an Administrative Law course were invited to join on the project, on a voluntary basis. Those who accepted to take part in it were given specific training in the recognition and correction of linguistic sexism in legal texts. Then, they were asked to review the textbook recommended for the study of the course and to point out all the cases of non-inclusive language that they could find. Their final reports included amendment proposals that were submitted to the authors of the textbook

Comprehensive analysis of three TYK2 gene variants in the susceptibility to Chagas disease infection and cardiomyopathy

Tyrosine kinase 2 (TYK2) is a member of the Janus kinases family implicated in the signal transduction of type I interferons and several interleukins. It has been described that genetic mutations within TYK2 lead to multiple deleterious effects in the immune response. In this work, we have analyzed three functional independent variants from the frequency spectrum on the TYK2 gene (common and low-frequency variants) suggested to reduce the function of the gene in mediating cytokine signaling and the susceptibility to infections by Trypanosoma cruzi and/or the development of Chagas cardiomyopathy in the Colombian population. A total of 1,323 individuals from a Colombian endemic region for Chagas disease were enrolled in the study. They were classified as seronegative (n = 445), seropositive asymptomatic (n = 336), and chronic Chagas Cardiomyopathy subjects (n = 542). DNA samples were genotyped using TaqMan probes. Our results showed no statistically significant differences between the allelic frequencies of the three analyzed variants when seropositive and seronegative individuals were compared, therefore these variants were not associated with susceptibility to Chagas disease. Moreover, when Chagas cardiomyopathy patients were compared to asymptomatic patients, no significant associations were found. Previous reports highlighted the association of this gene in immune-related disorders under an autoimmunity context, but not predisposing patients to infectious diseases, which is consistent with our findings. Therefore, according to our results, TYK2 gene variants do not seem to play an important role in Chagas disease susceptibility and/or chronic Chagas cardiomyopathy.This work has received support from the grant nº 1102-519-29071 from the Departamento Administrativo de Ciencia, Tecnología e Innovación, Colciencias (http://www.colciencias.gov.co), and the Universidad Industrial de Santander, Bucaramanga, Colombia, CIG. This study is part of the “Red Iberoamericana de Medicina Genómica en Enfermedad de Chagas” (RIMGECH-217RT0524). MAH is recipient of a Juan de la Cierva fellowship (FJCI-2015-24028) and FDC is recipient of a grant from the Ramon y Cajal programme (RYC-2014-16458), both from the Spanish Ministry of Economy, Industry and Competitiveness