The Effect of Thermal Coefficients on Temperature Condition of the Blank in FE Analysis of Warm Hydro mechanical Deep Drawing Process

A challenge to conduct the most accurate FE simulations in Warm Hydromechanical Deep Drawing (WHDD) process is to predict temperature condition of the blank which was held between the heated dies and cooled punch. This is possible by knowing effects of thermal coefficients in the FE analysis of WHDD process and modeling of the heat transfer between the blank and tools accurately. In this study effects of thermal coefficients on the temperature condition of the blank in the FE analysis of WHDD to conduct accurate FE simulations of the process. So, it can be possible to predict deformation behavior of the materials accurately and determining the proper forming conditions in less time and shorting development time.&nbsp

Patients with primary restless legs syndrome have higher prevalence of autonomic dysfunction and irritable bowel syndrome

CONCLUSION The presence of autonomic nervous system impairment in patients with pRLS and the strong link between IBS and pRLS merit further, more extensive investigation

Nuclear anomalies in the buccal cells of calcite factory workers

The micronucleus (MN) assay on exfoliated buccal cells is a useful and minimally invasive method for monitoring genetic damage in humans. To determine the genotoxic effects of calcite dust that forms during processing, MN assay was carried out in exfoliated buccal cells of 50 (25 smokers and 25 non-smokers) calcite factory workers and 50 (25 smokers and 25 non-smokers) age- and sex-matched control subjects. Frequencies of nuclear abnormalities (NA) other than micronuclei, such as binucleates, karyorrhexis, karyolysis and ‘broken eggs', were also evaluated. Micronuclei and the other aforementioned anomalies were analysed by two way analysis of covariance. The linear correlations between the types of micronucleus and nuclear abnormalities were determined by Spearman's Rho. There was a positive correlation between micronuclei and other types of nuclear abnormalities in accordance with the Spearman's Rho test. Results showed statistically significant difference between calcite fabric workers and control groups. MN and NA frequencies in calcite fabric workers were significantly higher than those in control groups (p < 0.05). The results of this study indicate that calcite fabric workers are under risk of significant cytogenetic damage

Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension

OBJECTIVE: To evaluate whether eculizumab helps patients with anti-acetylcholine receptor-positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab in AChR+ Refractory Generalized Myasthenia Gravis) and its open-label extension. METHODS: Patients who completed the REGAIN randomized controlled trial and continued into the open-label extension were included in this tertiary endpoint analysis. Patients were assessed for the MGFA post-intervention status of improved, unchanged, worse, MM, and pharmacologic remission at defined time points during REGAIN and through week 130 of the open-label study. RESULTS: A total of 117 patients completed REGAIN and continued into the open-label study (eculizumab/eculizumab: 56; placebo/eculizumab: 61). At week 26 of REGAIN, more eculizumab-treated patients than placebo-treated patients achieved a status of improved (60.7% vs 41.7%) or MM (25.0% vs 13.3%; common OR: 2.3; 95% CI: 1.1-4.5). After 130 weeks of eculizumab treatment, 88.0% of patients achieved improved status and 57.3% of patients achieved MM status. The safety profile of eculizumab was consistent with its known profile and no new safety signals were detected. CONCLUSION: Eculizumab led to rapid and sustained achievement of MM in patients with AChR+ refractory gMG. These findings support the use of eculizumab in this previously difficult-to-treat patient population. CLINICALTRIALSGOV IDENTIFIER: REGAIN, NCT01997229; REGAIN open-label extension, NCT02301624. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that, after 26 weeks of eculizumab treatment, 25.0% of adults with AChR+ refractory gMG achieved MM, compared with 13.3% who received placebo

Minimal Symptom Expression' in Patients With Acetylcholine Receptor Antibody-Positive Refractory Generalized Myasthenia Gravis Treated With Eculizumab

The efficacy and tolerability of eculizumab were assessed in REGAIN, a 26-week, phase 3, randomized, double-blind, placebo-controlled study in anti-acetylcholine receptor antibody-positive (AChR+) refractory generalized myasthenia gravis (gMG), and its open-label extension

On channel estimation for spatial modulated systems over time-varying channels

Spatial Modulation (SM) has been proposed recently for multiple-input multiple-output (MIMO) systems to cope with the interchannel interference and to reduce the detection complexity as compared to the conventional MIMO systems. In SM system, the data symbols are transmitted by a randomly selected active antenna of a MIMO transmitter to the receiver through a wireless channel. The information is carried both by the data symbol from any signal constellation such as M-ary phase shift keying (M-PSK) or M-ary quadrature amplitude modulation (M-QAM), by the index of the selected antenna. The channel estimation is a critical process at the receiver during the coherent detection of the transmitted symbol and the antenna index, randomly selected. Recently, the channel estimation of channel for SM systems has been investigated by the recursive least square (RLS) algorithm for only quasi-static fading channels. In this paper, a novel channel estimation is proposed for SM systems in the presence of rapidly time-varying channels. The Bayesian mean square error (MSE) bound has been derived as a benchmark and the performance of the proposed approaches is studied in terms of MSE and bit-error rate (BER). Computer simulation results have confirmed that the proposed iterative channel estimation technique has significant BER/MSE performance advantages compared with existing channel estimation algorithm proposed earlier in the literature. (C) 2014 Elsevier Inc. All rights reserved