Dynamics of the F1-antibody in great gerbils challenged by different doses of <i>Y. pestis.</i>

a<p>:The antibody titer was recorded as the dilution time, by setting 1∶8 as “1”, 1∶16 as “2”, 1∶32 as “3”, and 1∶4096 as “10”. The antibody was determined by IHA and each sample was repeated three times.</p>b<p>:Only one of the 4 animals produced F1-Ab and there was no measurable F1-Ab for the other three animals.</p>c<p>:Only one animal was available for F1-Ab determination because of the unexpected death of the other three animals.</p

Gross anatomic changes in the liver and spleen of great gerbils (A) and guinea pigs (B).

<p>Approximately 7.4×10¹⁰ CFU of <i>Y. </i><i>pestis</i> strain 2505 was injected subcutaneously into the groin of great gerbils, whereas around 5.0×10⁴ CFU was injected subcutaneously into the groin of guinea pigs. The animals were dissected immediately after death on day 3 p.i. The abscesses are clearly seen on the surface of both the liver and spleen of guinea pigs, but no abscesses were observed on the corresponding organs of great gerbils.</p

Dynamics of bacterial load (BL) in both the liver and spleen of great gerbils challenged with 2.0×10¹⁰ CFU of <i>Y. pestis</i>.

*<p>: At day 14 p.i., <i>Y. pestis</i> was isolated from the liver of a live animal with a bacterial load of 4.31 CFU/g.</p>**<p>: At day 15 p.i., <i>Y. pestis</i> was isolated from the spleen of a live animal with a bacterial load of 176 CFU/g.</p><p>ζ: Six great gerbils died of non-specific causes.</p

Post infection changes in the average body weight (A) and average anal temperature (B).

<p>Approximately 2.0×10⁹ CFU of <i>Y. pestis</i> strain 2505 was injected subcutaneously into the groin of 18 great gerbils on day 0, and then observed for changes in body weight and anal temperature. The average body weight and anal temperature of the 18 animals were employed to represent the changing trends at different time points (days) post infection.</p

Taxonomy of the order Bunyavirales: update 2019

In February 2019, following the annual taxon ratification vote, the order Bunyavirales was amended by creation of two new families, four new subfamilies, 11 new genera and 77 new species, merging of two species, and deletion of one species. This article presents the updated taxonomy of the order Bunyavirales now accepted by the International Committee on Taxonomy of Viruses (ICTV)

Taxonomy of the order Bunyavirales: update 2019

In February 2019, following the annual taxon ratification vote, the order Bunyavirales was amended by creation of two new families, four new subfamilies, 11 new genera and 77 new species, merging of two species, and deletion of one species. This article presents the updated taxonomy of the order Bunyavirales now accepted by the International Committee on Taxonomy of Viruses (ICTV)

Taxonomy of the order Bunyavirales : update 2019

In February 2019, following the annual taxon ratification vote, the order Bunyavirales was amended by creation of two new families, four new subfamilies, 11 new genera and 77 new species, merging of two species, and deletion of one species. This article presents the updated taxonomy of the order Bunyavirales now accepted by the International Committee on Taxonomy of Viruses (ICTV).Peer reviewe

Taxonomy of the order Bunyavirales : update 2019

In February 2019, following the annual taxon ratification vote, the order Bunyavirales was amended by creation of two new families, four new subfamilies, 11 new genera and 77 new species, merging of two species, and deletion of one species. This article presents the updated taxonomy of the order Bunyavirales now accepted by the International Committee on Taxonomy of Viruses (ICTV).This work was supported in part through Battelle Memorial Institute’s prime contract with the US National Institute of Allergy and Infectious Diseases (NIAID) under Contract no. HHSN272200700016I (J. H. K.). This work was also funded in part by Grant 109520 by the UK Department of Health, Public Health England (R. H.). W. M. S. is supported by Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil (17/13981-0). This work was supported by the Intergovernmental Special Program of State Key Research and Development Plan from the Ministry of Science and Technology of China (2016YFE0113500) and European Union’s Horizon 2020 EVAg project (no. 653316).http://link.springer.com/journal/7052020-07-01hj2019Medical Virolog