Individual Accountability for Human Rights Abuses: Historical and Legal Underpinnings

The international legal community is beset today with talk of accountability. Governments, international organizations, non-governmental organizations, and scholars speak of the need to hold individuals responsible for official acts that violate the most cherished of international human rights. Some study the nature of various infractions with an eye toward codification; others seek to create or engage mechanisms for trying or otherwise punishing individuals. Their common mission is based on a shared understanding that international law has a role to play not only in setting standards for governments, non-state actors, and their agents, but in prescribing the consequences of a failure to meet those standards. To understand the promises and limitations of individual accountability as a means to protect human dignity requires treating it as a discrete subject of international law. As such, it demands appraisal of a complex amalgam of law and a wide spectrum of sanctioning processes that transcend orthodox divisions of subjects within international law. Its theory, doctrine, and practice spring from legal sources and events both ancient and modern; and ultimately an appreciation of the topic turns considerably on insights beyond international law, whether political or philosophical in origin. Before any examination of the substantive law and mechanisms can proceed, we begin with the evolution of this concept and the legal threads involved

The functional response of a generalist predator

Peer reviewedPublisher PD

Water Supply Planning: Middle Illinois Assessment of Water Resources for Water Supply-Final Report

Illinois Department of Natural Resourcespublished or submitted for publicationis peer reviewedOpe

The Demise of Islet Allotransplantation in the US: A Call for an Urgent Regulatory Update The ISLETS FOR US Collaborative

Islet allotransplantation in the United States (US) is facing an imminent demise. Despite nearly three decades of progress in the field, an archaic regulatory framework has stymied US clinical practice. Current regulations do not reflect the state-of-the-art in clinical or technical practices. In the US, islets are considered biologic drugs and more than minimally manipulated human cell and tissue products (HCT/Ps). Across the world, human islets are appropriately defined as minimally manipulated tissue which has led to islet transplantation becoming a standard-of-care procedure for patients with type 1 diabetes mellitus and problematic hypoglycemia. As a result of the outdated US regulations, only eleven patients underwent allo-ITx in the US between 2011-2016 and all in the setting of a clinical trial. Herein, we describe the current regulations pertaining to islet transplantation in the United States. We explore the progress which has been made in the field and demonstrate why the regulatory framework must be updated to both, better reflect our current clinical practice and to deal with upcoming challenges. We propose specific updates to current regulations which are required for the renaissance of ethical, safe, effective, and affordable allo-ITx in the United States

Water supply planning: Kankakee watershed assessment of water resources for water supply

This report examines the impacts of current and future demands on water supplies for the Kankakee Watershed Water Supply Planning Subregion (WSPR) in northeastern Illinois, an area comprising most of Kankakee and Iroquois Counties and portions of Ford, Will, Vermilion, and Grundy Counties that intersects the Kankakee River watershed boundary. Initial water demand scenarios were developed for a three-county region (Ford, Iroquois, and Kankakee) out to 2060 for five major water sectors, including thermoelectric power generation, public supply, self-supplied domestic, self-supplied industrial and commercial (IC), and self-supplied irrigation, livestock, and environmental (ILE), and are described in a companion report (Meyer et al., 2019). Total water usage in 2010 was estimated to be 39 million gallons per day (mgd), with two sectors, public supply and ILE, accounting for more than 80 percent of the demand in the region. Most of the ILE demand was for crop irrigation. Self-supplied IC accounted for 13 percent and the domestic sector 6 percent of the usage. Significant water resources are available to meet demands in the Kankakee WSPR, including both groundwater and surface water. Two major aquifer systems occur in the region: (1) productive sand and gravel aquifers, primarily in the south where the Mahomet Aquifer is encountered; and (2) weathered Silurian-Devonian dolomite, which is the most productive aquifer system in the region. Both the dolomite and Mahomet Aquifers are overlain by clay over most of the watershed, limiting leakage from shallower sources. The deeper Cambrian-Ordovician sandstones are generally too saline in this area to use as a water supply, although they are heavily used just outside of the watershed boundary in Will, Kendall, and Grundy Counties. Although the aquifers are generally thought to be adequate to meet most expected future demands, there are some sensitive areas that should be monitored closely. The most important area appears to be southeastern Kankakee and northeastern Iroquois Counties, where demands for irrigation water are highest on account of sandy soils. These demands are met from the dolomite aquifers and have been shown to result in dewatering of the dolomite during the irrigation season.Water quality in the Silurian-Devonian dolomite aquifer system is generally good. At a few locations, nitrate and chloride concentrations are elevated, but at concentrations below their respective drinking water standards. Water moves relatively rapidly from land surface into the Silurian-Devonian dolomite aquifer where it is near land surface, especially in the northern half of the region; aquifer protection activities should be a priority in these areas. The primary surface water sources in the Kankakee WSPR are the Kankakee and Iroquois Rivers. Currently there are four entities withdrawing water from the Kankakee River in the planning region: Aqua Illinois-Kankakee Division, which supplies the city of Kankakee, the city of Wilmington, Exelon Dresden Station, and Exelon Braidwood Generation Station.Although the Kankakee River has reliable water for meeting current power generation and public water supply needs, the cooling water withdrawals from the river could be limited on account of protected minimum flows and water temperature criteria. Therefore, both Dresden and Braidwood plants have a considerable storage capacity in their cooling ponds to buffer the impact of the minimum flow restriction. With increasing water demand and potential climate change, the frequency and duration of the minimum flow restriction may be increased in the 2 future. Both power plants using the Kankakee River for cooling water may rely on storage water more frequently.Water demand from within the watershed is not expected to increase dramatically in the future. However, large portions of Will County are at risk to dewatering of the Cambrian-Ordovician sandstone aquifers. As a result, communities within these at-risk areas are seeking alternate water supplies in anticipation of these impacts. One possible option is the Kankakee River. As part of the process of exploring alternative supplies, both Joliet and Godley have requested withdrawing a large amount of water from the lower reach of the Kankakee River. The communities served by this water lie primarily outside of the watershed, so both withdrawal and consumptive use of Kankakee River water could increase substantially. Unlike within the watershed, water demand for these communities outside of the watershed is expected to increase. Another unknown is how water demand will be met in the future by industries along the Des Plaines River. Many of these industries also rely on the at-risk sandstone aquifers, so the long-term viability of their sandstone wells is contingent on decisions by communities.The major concern with increasing water demand on the Kankakee River is the minimum flow restriction and how to supplement the river water when it is not available during drought conditions, especially when the water is diverted out of the watershed, as the wastewater may not be returned to the river. Other backup supplies are of limited availability in areas of sandstone risk, as currently the sandstone aquifers are likely to be the only viable backup option; however, there are questions about its viability under increasing demand. Off-channel storages and/or abandoned storage pits could also be explored to provide additional backup supply.As a result, conjunctive water management that accounts for impacts on both river and groundwater supplies will be essential moving forward. Water users within the Kankakee River watershed should be cognizant of this potential future demand on the river. Available flow on the Kankakee River during low-flow periods may be contingent on whether the communities in Will County also tap into it as a water supply, so water planners currently using or anticipating growth in use of the Kankakee River water should stay informed on planning decisions outside of the region. Sandstone users considering using the Kankakee River as a backup supply are also currently working with the ISWS to evaluate the viability of the Kankakee River as a backup supply under low-flow scenarios on the Kankakee River. This is critically important because of the rapid response of the sandstone aquifer when demands change.Illinois Department of Natural Resourcespublished or submitted for publicationis peer reviewedOpe

Estimating Fixed Effects: Perfect Prediction and Bias in Binary Response Panel Models, with an Application to the Hospital Readmissions Reduction Program

The maximum likelihood estimator for the regression coefficients, β, in a panel binary response model with fixed effects can be severely biased if N is large and T is small, a consequence of the incidental parameters problem. This has led to the development of conditional maximum likelihood estimators and, more recently, to estimators that remove the O(T–1) bias in β^. We add to this literature in two important ways. First, we focus on estimation of the fixed effects proper, as these have become increasingly important in applied work. Second, we build on a bias-reduction approach originally developed by Kosmidis and Firth (2009) for cross-section data, and show that in contrast to other proposals, the new estimator ensures finiteness of the fixed effects even in the absence of within-unit variation in the outcome. Results from a simulation study document favourable small sample properties. In an application to hospital data on patient readmission rates under the 2010 Affo

The Flexibility of Nonconsciously Deployed Cognitive Processes: Evidence from Masked Congruence Priming

Background: It is well accepted in the subliminal priming literature that task-level properties modulate nonconscious processes. For example, in tasks with a limited number of targets, subliminal priming effects are limited to primes that are physically similar to the targets. In contrast, when a large number of targets are used, subliminal priming effects are observed for primes that share a semantic (but not necessarily physical) relationship with the target. Findings such as these have led researchers to conclude that task-level properties can direct nonconscious processes to be deployed exclusively over central (semantic) or peripheral (physically specified) representations. Principal Findings: We find distinct patterns of masked priming for "novel" and "repeated" primes within a single task context. Novel primes never appear as targets and thus are not seen consciously in the experiment. Repeated primes do appear as targets, thereby lending themselves to the establishment of peripheral stimulus-response mappings. If the source of the masked priming effect were exclusively central or peripheral, then both novel and repeated primes should yield similar patterns of priming. In contrast, we find that both novel and repeated primes produce robust, yet distinct, patterns of priming. Conclusions: Our findings indicate that nonconsciously elicited cognitive processes can be flexibly deployed over both central and peripheral representations within a single task context. While we agree that task-level properties can influence nonconscious processes, our findings sharply constrain the extent of this influence. Specifically, our findings are inconsistent with extant accounts which hold that the influence of task-level properties is strong enough to restrict the deployment of nonconsciously elicited cognitive processes to a single type of representation (i.e. central or peripheral).13 page(s

A qualitative evidence synthesis of employees' views of workplace smoking reduction or cessation interventions

Background The need to reduce smoking rates is a recognised public health policy issue in many countries. The workplace offers a potential context for offering smokers’ programmes and interventions to assist smoking cessation or reduction. A qualitative evidence synthesis of employees’ views about such programmes might explain why some interventions appear effective and others not, and can be used to develop evidence-based interventions for this population and setting. Methods A qualitative evidence synthesis of primary research exploring employees’ views about workplace interventions to encourage smoking cessation, including both voluntary programmes and passive interventions, such as restrictions or bans. The method used was theory-based “best fit” framework synthesis. Results Five relevant theories on workplace smoking cessation were identified and used as the basis for an a priori framework. A comprehensive literature search, including interrogation of eight databases, retrieved 747 unique citations for the review. Fifteen primary research studies of qualitative evidence were found to satisfy the inclusion criteria. The synthesis produced an evidence-based conceptual model explaining employees’ experiences of, and preferences regarding, workplace smoking interventions. Conclusion The synthesis suggests that workplace interventions should employ a range of different elements if they are to prove effective in reducing smoking among employees. This is because an employee who feels ready and able to change their behaviour has different needs and preferences from an employee who is not at that stage. Only a multi-faceted intervention can satisfy the requirements of all employees

IL-2 Immunotherapy to Recently HIV-1 Infected Adults Maintains the Numbers of IL-17 Expressing CD4+ T (TH17) Cells in the Periphery

Little is known about the manipulation of IL-17 producing CD4+ T cells (TH17) on a per-cell basis in humans in vivo. Previous studies on the effects of IL-2 on IL-17 secretion in non-HIV models have shown divergent results. We hypothesized that IL-2 would mediate changes in IL-17 levels among recently HIV-1-infected adults receiving anti-retroviral therapy. We measured cytokine T cell responses to CD3/CD28, HIV-1 Gag, and CMV pp65 stimulation, and changes in multiple CD4+ T cell subsets. Those who received IL-2 showed a robust expansion of naive and total CD4+ T cell counts and T-reg counts. However, after IL-2 treatment, the frequency of TH17 cells declined, while counts of TH17 cells did not change due to an expansion of the CD4+ naïve T cell population (CD27+CD45RA+). Counts of HIV-1 Gag-specific T cells declined modestly, but CMV pp65 and CD3/CD28 stimulated populations did not change. Hence, in contrast with recent studies, our results suggest IL-2 is not a potent in vivo regulator of TH17 cell populations in HIV-1 disease. However, IL-2-mediated T-reg expansions may selectively reduce responses to certain antigen-specific populations, such as HIV-1 Gag