Eye Bank Records on Pediatric Keratoplasty

Purpose: To report eye bank records for pediatric keratoplasty in Iran between 2006 and 2019. Methods: In a retrospective study, all electronic records of the Central Eye Bank of Iran for pediatric keratoplasty between April 2006 and March 2019 were analyzed in terms of indications for keratoplasty, surgical techniques, their corresponding trends, and post-transplantation graft clarity. Results: Our database included 2178 eyes from 2050 pediatric cases. The leading indications for keratoplasty included acquired nontraumatic diseases (75.8%), congenital abnormalities (12.7%), corneal regraft (8.3%), and acquired traumatic diseases (3.2%). Keratoconus was the most common acquired nontraumatic cause (58%) and more common in the age group >12 years than those ≤12 years (P < 0.001). Congenital corneal abnormalities and regrafts were more common in the age group ≤12 years (both Ps < 0.001). The most common surgical technique was penetrating keratoplasty (PKP, 90.9%) followed by deep anterior lamellar keratoplasty (DALK, 7.3%), Descemet stripping automated endothelial keratoplasty (DSAEK, 1.1%), anterior lamellar keratoplasty (0.5%), and keratolimbal allograft transplantation (0.2%). DSAEK was more common in the age group ≤12 years (P = 0.002), which, unlike PKP and DALK, showed a significant ascending trend over the 14-year period (P = 0.018). Posttransplantation graft clarity was 96.8%. Conclusion: Keratoconus was the leading indication for pediatric keratoplasty in Iran. Although PKP was the predominant keratoplasty procedure for the treatment of pediatric corneal disorders, it showed a significant descending trend over the 14 years

Energy security and competition over energy resources in Iran and Caucasus region

Energy security as a dominant factor in international stability is of great importance for major economies. The global energy market with its current level of supply and demand relies on energy sources in the Middle East, Caucasus, Central Asia and Russia. After the Fukushima disaster nuclear powers in Europe view renewable energy sources as a serious alternative. Europe’s energy vulnerability has deteriorated due to the Russia-Ukraine conflict. However, renewable energy sources are not large enough to replace nuclear power completely. This trend will continue with climbing demand especially in the natural gas sector as clean energy. In this research, Caucasus and Iran are considered the main sources and routes for energy transmission to the global market, including Europe. Caucasus plays a key role in bridging Europe and Asia. Also, Iran is an alternative for energy transmission to Europe after lifted sanctions. As part of the European active supply diversification policy Iran has capacity to reduce Europe’s energy dependency on Russia. However, changes in US new administration America First Policy is harmful for the EUs energy security. Caucasus aims to catch a large share of the European energy market since the Baku-Tbilisi-Ceyhan pipeline has started operations and Iran is also trying to expand its market to become a sustainable source of energy for major consumers. Therefore, Iran and Caucasus are considered reliable energy suppliers for Europe. In this regard, we analyze the best motivation for changing the direction new suppliers’ energy policies towards Europe and suggest alternative solutions to compete with rival countries in order to enhance energy security

Prevalence of hypertension and related risk factors in central iran: Results from yazd health study

BACKGROUND: The prevalence of hypertension (HTN) varies across countries due to differences in its related risk factors. This study aimed to investigate the prevalence of HTN and related risk factors among adults. METHODS: This study was conducted on the data from the recruitment phase of Yazd Health Study. Using multi-stage random cluster sampling, 10000 adults of 20-69 years were selected. Self-reported HTN (diagnosed by a physician) was recorded in a home visit. Blood pressure (BP) was measured using a standard protocol and categorized based on the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and �Treatment of High Blood Pressure �(JNC-7) classification. T-test was used to examine the gender differences. Qualitative variables were presented as number (frequency). Chi-square test and bivariate logistic regression were carried out to determine the association between risk factors. RESULTS: The response rate was 95 (n = 9975). The prevalence of positive history of HTN was 18.5. The mean systolic and diastolic BP was 126.5 ± 18.4 and 80.2 ± 12.5 mmHg, respectively. The prevalence of HTN was 36.0 (95CI: 35.1�36.9). Its prevalence reduced by high-education, physical activity, lower BMI, and lack of history of diabetes mellitus �(DM) (P < 0.0001). HTN is less common in smokers (P < 0.0001). Logistic regression analysis showed that HTN was higher among men (OR: 1.83; 95CI: 1.64-2.03), the elderly (OR: 5.15; 95CI: 4.20-6.31), low-educated (OR: 1.40; 95CI: 1.17-1.67), and diabetics (OR: 1.20; 95CI: 1.05-1.38). The prevalence of HTN was 2 times higher in obeses. HTN did not have a significant relationship with inactivity, smoking, and hypercholesterolemia. CONCLUSION: The prevalence of HTN was high. By identifying modifiable risk factors, health policymakers can prioritize intervention programs. It is necessary to inform younger adult groups how these factors can be managed through a healthy lifestyle and nutritional habits. © 2021, Isfahan University of Medical Sciences(IUMS). All rights reserved

Flow rate effect on both efficiency and maximum stored power density of the amplifier in a dye laser

Abstract not availableN. Miri, S. Abolhosseini and M. Mollabashi, S. Jelvan

Risk of Induction of Corneal Neovascularization with Topical Erythropoietin: An Animal Safety Study

Abstract Purpose: To evaluate the pro-angiogenic effect of topical erythropoietin on cornea in chemical burn-injured rabbit eyes. Methods: The corneal alkali-burn injury was induced in 10 eyes of 10 rabbits using filter paper saturated with 1.0 mol sodium hydroxide. The eyes were categorized into the treatment group (n = 5) that received topical erythropoietin (3000 IU/mL) every 8 hr for one month versus the control group (n = 5) that received normal saline every 8 hr for one month. All eyes were treated with topical ciprofloxacin every 8 hr until corneal re-epithelialization was complete. Corneal epithelial defects, stromal opacity, and neovascularization were evaluated after the injury. At the conclusion of the study, the rabbits were euthanized and their corneas were submitted to histopathological examination. Results: Baseline characteristics including the rabbits' weight and the severity of corneal injury were comparable in two groups. Time to complete corneal re-epithelialization was 37 days in the treatment group and 45 days in the control group (P = 0.83). There was no significant difference between the groups in the rate of epithelial healing or corneal opacification. Clinical and microscopic corneal neovascularization was observed in one eye (20%) in the treatment group and two eyes (40%) in the control group (P = 0.49). Conclusion: Recombinant human erythropoietin administered topically did not induce vessel formation in rabbit corneas after chemical burn

Diagnostic accuracy of confocal scan in detecting acanthamoeba keratitis and fungal keratitis: a systematic review and meta-analysis

Purpose: Acanthamoeba keratitis (AK) and fungal keratitis (FK) are two microbial keratitis that cause serious damage and, without early accurate diagnosis and treatment, may lead to blindness. In vivo corneal confocal scan, as an emerging ocular diagnostic method in comparison with microbiological smears and cultures as the gold standard, may assist in accelerating appropriate diagnosis. Objective: To determine the diagnostic accuracy of confocal scan for the diagnosis of AK and FK. Methods: Data were collected via a comprehensive literature search of PubMed, Web of Science, Cochrane Library, Embase and Scopus using keywords related to diagnostic accuracy of confocal scan in AK and FK up to October 2022. Pooled data underwent meta-analysis in terms of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and overall diagnostic odds ratio (DOR) of confocal scan for the diagnosis of AK and FK. Results: The final 14 relevant studies were identified, including 1950 eyes. Meta-analysis in AK group revealed 94% sensitivity, 87% specificity, 89% PPV, 92% NPV, and DOR of 143.32, and in FK group disclosed 88% sensitivity, 85% specificity, 85% PPV, 88% NPV, and DOR of 75.98. Conclusion: The accuracy of confocal scan for the diagnosis of AK was significantly more than that for detecting FK; despite the limitations such as limited numbers of available retrospective studies for the detection of FK, confocal scan had an acceptable performance in detecting FK eyes. The overall performance of NCS was similar with that of HRT-RCM for the detection of both types of keratitis