An Artificial Intelligence Application in Health Developed on Covid-19 Documents

With the developments in computer science, the concept of artificial intelligence has appeared more frequently in recent years. The concept of artificial intelligence, which is basically defined as computers (machines) thinking like people and making decisions, has become very popular today. Artificial intelligence is used in many fields, especially computer science, education, law, trade, tourism and economy. The health sector is one of these areas. The importance of the applications developed in health sciences has emerged once again, especially during the pandemic process. The development of systems that help reduce the workload of healthcare professionals and make decisions by processing medical data is also an important and real problem that can be solved with artificial intelligence. In this study, natural language processing which is one of the main study subjects of artificial intelligence, has been developed a system that automatically determines the concepts such as disease, medication and treatment on medical data with artificial intelligence by the system. During the experimental studies, it was observed that 91% accurate estimation was made with the model developed. For this study, a Turkish dataset was created by scanning medical articles and studies related to Covid-19 disease.Keywords: Artificial Intelligence, Turkish natural language processing, Name entity recognition, Covid-19DOI: 10.7176/JHMN/75-0

Non-linear regression models for time to flowering in wild chickpea combine genetic and climatic factors

Background: Accurate prediction of crop flowering time is required for reaching maximal farm efficiency. Several models developed to accomplish this goal are based on deep knowledge of plant phenology, requiring large investment for every individual crop or new variety. Mathematical modeling can be used to make better use of more shallow data and to extract information from it with higher efficiency. Cultivars of chickpea, Cicer arietanum, are currently being improved by introgressing wild C. reticulatum biodiversity with very different flowering time requirements. More understanding is required for how flowering time will depend on environmental conditions in these cultivars developed by introgression of wild alleles. Results: We built a novel model for flowering time of wild chickpeas collected at 21 different sites in Turkey and grown in 4 distinct environmental conditions over several different years and seasons. We propose a general approach, in which the analytic forms of dependence of flowering time on climatic parameters, their regression coefficients, and a set of predictors are inferred automatically by stochastic minimization of the deviation of the model output from data. By using a combination of Grammatical Evolution and Differential Evolution Entirely Parallel method, we have identified a model that reflects the influence of effects of day length, temperature, humidity and precipitation and has a coefficient of determination of R 2=0.97. Conclusions: We used our model to test two important hypotheses. We propose that chickpea phenology may be strongly predicted by accession geographic origin, as well as local environmental conditions at the site of growth. Indeed, the site of origin-by-growth environment interaction accounts for about 14.7% of variation in time period from sowing to flowering. Secondly, as the adaptation to specific environments is blueprinted in genomes, the effects of genes on flowering time may be conditioned on environmental factors. Genotype-by-environment interaction accounts for about 17.2% of overall variation in flowering time. We also identified several genomic markers associated with different reactions to climatic factor changes. Our methodology is general and can be further applied to extend existing crop models, especially when phenological information is limited

Wpływ testosteronowej terapii zastępczej na stężenia witaminy D i FGF-23 w hipogonadyzmie wrodzonym

Introduction: Patients with hypogonadism are at increased risk of cardiac and metabolic diseases and osteoporosis. Vitamin D and Fibroblast growth factor-23 (FGF-23) play role in the regulation of bone mineral metabolism and endothelial functions. Low vitamin D levels are reported in hypogonadism, while there is no data about the effect of testosterone replacement therapy (TRT). We investigated the effect of TRT on vitamin D and FGF-23 levels along with endothelial functions and insulin resistance in hypogonadal patients. Material and methods: Patients with congenital hypogonadotrophic hypogonadism (CHH) (n=32, age 20.6 ±1.58 years) were enrolled. TRT was implemented in transdermal form. The demographic parameters, FGF-23, 25(OH)D3, Asymmetric dimethylarginine (ADMA) and homeostatic model assessment of insulin resistance (HOMA-IR) levels were measured both before and after TRT. Results: After a follow-up period of 3.63±1.33 months, ADMA and FGF-23 levels were significantly increased (p=0.03 and p=0.005 respectively), while the 25(OH)D3 and HOMA-IR index were not significantly changed. The body mass index and waist circumference levels of the patients were also increased (p<0.001 and p=0.02) along with a significant decrease in the HDL cholesterol levels (p=0.006). Conclusions: The results show that a short term TRT increases plasma FGF-23 and ADMA levels, in young, treatment naive patients with CHH. Whether this is an early implication of TRT related adverse effects in this very young and treatment naïve population of CHH is not clear. Future prospective studies are required to find out the long-term effects of TRT on cardio-metabolic morbidity and mortality in this specific population.  Wstęp: U chorych z hipogonadyzmem występuje zwiększone ryzyko chorób sercowych I metabolicznych oraz osteoporozy. Witamina D i czynnik wzrostu fibroblastów-23 (FGF-23) uczestniczą w regulacji metabolizmu kostnego i czynności śródbłonka. Istnieją doniesienia na temat niskiego stężenia witaminy D w hipogonadyzmie, natomiast brakuje danych dotyczących wpływu testosteronowej terapii zastępczej (TRT) na to stężenie. Autorzy zbadali wpływ TRT na stężenia witaminy D i FGF-23 oraz na czynność śródbłonka i poziom insulinooporności u chorych z hipogonadyzmem. Materiał i metody: Do badania włączono chorych z wrodzonym hipogonadyzmem hipogonadotropowym (CHH) (n = 32, wiek 20,6 ± 1,58 roku). Chorzy otrzymywali TRT w postaci przezskórnej. Przez rozpoczęciem leczenia i po jego zakończeniu u chorych zebrano dane demograficzne, zmierzono stężenia FGF-23, 25(OH)D3 i asymetryczej dimetyloargininy (ADMA) oraz określono wskaźnik insulinooporności HOMA-IR. Wyniki: Po okresie obserwacji trwającym 3,63 ± 1,33 miesiąca stwierdzono istotne zwiększenie stężeń ADMA i FGF-23 (odpowiednio p = 0,03 i p = 0,005), natomiast stężenie 25(OH)D3 i wskaźnik HOMA-IR nie zmieniły się istotnie. Ponadto zaobserwowano u chorych zwiększenie wskaźnika masy ciała i obwodu pasa (p < 0,001 I p = 0,02) oraz istotne zmniejszenie stężenia cholesterol frakcji HDL (p = 0,006). Wnioski: Wyniki badania pokazują, że krótkotrwałe stosowanie TRT u młodych chorych z CHH, uprzednio nieleczonych, powoduje zwiększenie osoczowego stężenia FGF-23 i ADMA, lecz nie wpływa na stężenie witaminy D. Nie jest jasne, czy jest to wczesny efekt działań niepożądanych TRT w tej grupie bardzo młodych pacjentów z CHH. Konieczne są dalsze prospektywne badania w celu ustalenia długookresowego wpływu TRT na chorobowość i śmiertelność w związku z chorobami sercowymi i metabolicznymi w tej szczególnej populacji

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

Institutional Foundations of Military Coups: Constitutional Design and Military Centrality

This dissertation examines how the likelihood of military coups varies depending on a country’s adopted institutions. I focus on two types of institutions—parliamentary versus presidential structures, and the military’s political, financial, and judicial privileges. In regard to the former, I propose a novel theoretical argument explaining why parliamentary systems experience fewer military coups. My argument relies on the inherent features of parliamentary systems, which potentially benefit the military elites such that they do not need to conduct a coup to get the policy outcomes and influence they seek. These features are (1) the presence of a government (coalition) formation process to select the chief executive after legislative elections and (2) the vote of no-confidence procedure to terminate a government early. Both of these features allow the military elites to influence the overall ideology of the government without resorting to a direct government takeover. In regard to the second determinant, military privileges, I argue that the existing ways to capture military centrality, based on the number of military personnel and the military budget, fail to correctly measure the military’s political power. In a highly democratic country such as the US or in a highly authoritarian country such as China, these scores might be quite high, although the likelihood of a coup is definitely not. In this dissertation, I propose an alternative measurement method for the centrality of the military in politics that is based on certain military privileges: the existence of military-owned businesses, the extent of the jurisdiction of military courts, whether or not the chief executive or defense minister is a military officer, and how much military elites are respected during the state’s ceremonial meetings. Using this original measure, I also examine the relationship between the military centrality and the likelihood of coups.Political Science, Department o

Synthesis and characterisation of a calix[4]pyrrole functional polystyrene via ‘click chemistry’ and its use in the extraction of halide anion salts

<p>A polystyrene with pendant calix[4]pyrroles was prepared via ‘click reaction’ strategy. First, a poly(styrene-<i>co</i>-chloromethylstyrene) with approximately 12% of chloro groups was prepared by conventional free radical polymerisation. The chloro groups were then converted to azido groups using NaN₃ in <i>N</i>,<i>N</i>-dimethylformamide. An alkyne-functionalised calix[4]pyrrole was then coupled to the azido-functionalised polystyrene by click chemistry with high efficiency. The resulting polystyrene with pendant calix[4]pyrroles was used to extract fluoride and chloride anions (as their tetrabutylammonium salts) from their aqueous solutions to organic media.</p

5,10,10,15,20,20-Hexamethylcalix[4]pyrrole 5,15-diethyl diester

In the title compound, C32H40N4O4, the pyrrole rings and ester groups adopt a 1,3-alternate conformation in which the alternating pyrrole and ester units are in opposite directions. The structure displays N&amp;#8212;H...O hydrogen bonding and exhibits disorder [site occupancies of 0.81(2) and 0.71(2)] in the peripheral ethyl groups