エジプト産のカリステモン種からの強力な栄養飢餓耐性解除抗がん物質の探索とそれらのヒト膵臓がん細胞株PANC-1に対する作用機序

富山大学・富医薬博甲第345号・Ahmed Mohammed Abdel Latif Mohammed Tawila・2020/09/28・★論文非公開★富山大

Achieving Information Security by multi-Modal Iris-Retina Biometric Approach Using Improved Mask R-CNN

The need for reliable user recognition (identification/authentication) techniques has grown in response to heightened security concerns and accelerated advances in networking, communication, and mobility. Biometrics, defined as the science of recognizing an individual based on his or her physical or behavioral characteristics, is gaining recognition as a method for determining an individual\u27s identity. Various commercial, civilian, and forensic applications now use biometric systems to establish identity. The purpose of this paper is to design an efficient multimodal biometric system based on iris and retinal features to assure accurate human recognition and improve the accuracy of recognition using deep learning techniques. Deep learning models were tested using retinographies and iris images acquired from the MESSIDOR and CASIA-IrisV1 databases for the same person. The Iris region was segmented from the image using the custom Mask R-CNN method, and the unique blood vessels were segmented from retinal images of the same person using principal curvature. Then, in order to aid precise recognition, they optimally extract significant information from the segmented images of the iris and retina. The suggested model attained 98% accuracy, 98.1% recall, and 98.1% precision. It has been discovered that using a custom Mask R-CNN approach on Iris-Retina images improves efficiency and accuracy in person recognition

Correction of anterior hypospadias without urethroplasty: glanular rotation procedure (the Hay technique)

Objectives: The aim was to present a simple technique for the correction of anterior hypospadiases without meatal advancement or urethroplasty.Background: Most of the techniques described for the correction of anterior hypospadias had the risk of complications: recession, flaying of the glans, fistula, and meatal stenosis that is not accepted when dealing with a trivial anomaly that is done only for cosmetic correction. A simple technique for correcting granular and some forms of coronal hypospadias without meatal advancement or urethroplasty is presented.Patients and methods: From June 2013 to June 2016, 183 patients presented for surgical repair of glanular or coronal hypospadias. The technique of glanular rotation procedure (GRP) was applied only for those cases that matched the criteria settled after degloving of the penis with an incision made 2mm proximal to the meatus touching the glans on both sides for 3–4 mm. Once the uppermost part of the meatus is at the same line with the upper end of the glans on both sides, the technique is applicable. The patients were followed in the OPD for 1 year after the repair for the evaluation of the results of the technique: the urinary stream, meatal size and position, presence of fistula, and the final cosmetic appearance.Results: Ninety-eight out of 183 (53.6%) boys had matched the criteria for application of the GRP technique. Their age ranged from 6 months to 3 years. All but three had an apical, slit-like meatus with good stream without stenosis and 2–3mm glans tissue encircling the ventral side of the meatus. Four cases had complications in the form of meatal stenosis in two cases, disruption of the glans in one case, and coronal fistula in one case. The overall complication rate was 4.1%.Conclusion: In properly selected cases, GRP is a simple efficient technique that has the advantage of reconstructing the glans over the urethra without the need of meatal advancement or urethroplasty.Keywords: coronal hypospadias, glanular hypospadias, without urethroplast

Digenetic trematodes from siganid fish Amphacanthus sigan at Macady Bay, Southern Hurghada, Red Sea, Egypt

AbstractForty fish samples of Amphacanthus sigan were collected from Sharm El-Naga southern Hurghada to study the parasitic infection included and present a new individual to Helicometra species using light microscope and re-describe another digenean trematode species using scanning electron microscope (SEM). Two trematode species were identified and described; Helicometra siganus n. sp. Nov belonging to Helicometra Odhner, 1902 (family Opecoelidae Ozaki, 1925) which is different from all the listed species in many features as having an elongated body, tapering anteriorly and larger sucker ratio; the vitellaria extended from the intestinal bifurcation to the posterior extremity of the hind-body and finally the cirrus sac and cirrus longer than the other species and extended to the midpoint of esophagus level. So, these criteria are specific and sufficient to consider it as a new species. The other species, Gyliauchen volubilis Nagaty, 1956 (Gyliauchenidae Fuki, 1929 and Ozaki, 1933) which was described before but some other constituent are not evident and appeared using the electron microscope. However, the present sample illustrated transverse striations on the body surface, the acetabulum evaginates outward, ovoid shaped and surrounded by lip-like structures and finally, the excretory pore is situated at some distance from the acetabulum at the posterior end extremity

Network intrusion detection using genetic algorithm to find best DNA signature

Bioinformatics is part of computer science that joins between computer programming and molecular biology. DNA consists of long sequence of nucleotides which formulates the genome. Our method is to generate normal signature sequence and alignment threshold value from processing the system training data and encode observed network connection into corresponding DNA nucleotides sequence, then to align the signature sequence with observed sequence to find similarity degree value and decide whether the connection is attack or normal. Number of DNA sequences makes up each population, and then new generations are produced to select the Signature with best alignment value with normal network connection sequences. This paper ends up with accuracy value and threshold score for detecting the network anomalies that no known conditions exist for them to be discovered in addition for percentage of generating false positive and true negative alarms

Electrical properties of organic light emitting diodes with post fabrication heat and electric field treatments

The current work presents post-fabrication heat treatment and a combined external electric field-heat post-fabrication treatments for organic light emitting diodes (OLEDs). The devices were fabricated in the same run with a standard device without annealing for comparison, with an identical structure of ITO/PVK/Rhodamine B/Pb. After depositing the Rhodamine B layer on the PVK film, the samples were thermally annealed at different temperatures before depositing Pb. Some of the samples were thermally annealed without any external electric field while others were treated by an external electric field during heating. It is found that the annealing temperature of PVK/Rhodamine B layers increases the turn-on voltage of the device. On the other hand, in the electric field-heat treatment, the turn-on voltage is observed to decrease and the maximum current density of the device is dramatically enhanced

Cardiovascular Complications of Systemic Lupus Erythematosus: Impact of Risk Factors and Therapeutic efficacy--a Tertiary Centre Experience in an Appalachian State

OBJECTIVES: Cardiovascular complications became a notable cause of morbidity and mortality in patients with lupus as therapeutic advancements became more efficient at managing other complications. The Appalachian community in Kentucky has a higher prevalence of traditional cardiovascular risk factors, predisposing them to cardiovascular events. Namely, the mean body mass index of the members of the Kentucky Appalachian community was reported at 33 kg/m2 and 94.3% of male members of this community use tobacco. We sought to identify risk factors that predispose patients with lupus to cardiovascular morbidities and examine the effect of immunomodulatory drugs. METHODS: We identified 20 UKHS patients having both a lupus diagnosis and experienced at least one cardiovascular event. We chose three controls matched for birth-year ±5 years to each case. In a case-control design, we analysed lupus manifestations, cardiovascular risk factors and immunosuppressive therapies. We collected Systemic Lupus Erythematosus Disease Activity Index 2000 disease activity index during the cardiovascular event. RESULTS: We identified 308 patients with lupus from among all University of Kentucky Health System patients. 20 (6.5%) of such patients with lupus were confirmed to cardiovascular complication. Of those 20, 7 (35%) had experienced myocardial infarction, 10 (50%) had experienced stroke and 4 (20%) had peripheral ischaemia. Tobacco use and male gender were the only traditional cardiovascular risk factors higher in the cases group. Hydroxychloroquine and steroids were less utilised in the cases than in the controls (70% vs 100% in hydroxychloroquine, 30% vs 82% in steroids). Venous thrombosis was found to be significantly higher in the cases. On multivariate analysis, venous thrombosis remained significant. CONCLUSION: Despite tobacco use partially explaining the increased risk of cardiovascular disease among the cases group, the higher prevalence of venous thrombosis in the cases group suggests lupus as a potential additional risk factor of cardiovascular morbidity among patients with lupus in this Appalachian community

Dietary Supplementation of Nile Tilapia (Oreochromis niloticus) With Panax ginseng Essential Oil: Positive Impact on Animal Health and Productive Performance, and Mitigating Effects on Atrazine-Induced Toxicity

The present study assessed the impact of Panax ginseng essential oil (GEO) supplementation on physiological parameters related to productive performance and health status in Nile tilapia reared under standard conditions and exposed to a sub-lethal atrazine (ATZ) concentration. Fish were allocated into 6 groups: the control group was reared in clean water and fed with a commercial basal diet (CNT), two groups were fed with the basal diet supplemented with two different levels of GEO (GEO1 and GEO2, respectively), one group was intoxicated with 1/5 of ATZ 96-h lethal concentration 50 (1.39 mg/L) (ATZ group), and the remaining two groups were fed with the GEO-supplemented diets and concurrently exposed to 1.39 mg ATZ/L (GEO1+ATZ and GEO2+ATZ, respectively). The experiment lasted for 60 days. GEO supplementation exerted a significantly positive influence on fish growth, feed utilization, and hepatic antioxidant defense systems at both levels of supplementation. ATZ exposure significantly reduced fish survival rates and impaired fish growth and feed utilization, with the lowest final weights, weight gain, total feed intake, and the highest feed conversion ratio being recorded in the ATZ-intoxicated group. ATZ exposure caused significant changes in intestinal digestive enzyme activity (decreased lipase activity), hematological indices (decreased hemoglobin, packed cell volume, erythrocytes, and leukocytes), blood biochemical variables (decreased total proteins, albumin, globulins, and immunoglobulin M; increased total cholesterol, triglycerides, and cortisol), and hepatic oxidative/antioxidant indices (decreased glutathione level, superoxide dismutase and catalase enzyme activity and mRNA expression levels, and increased malondialdehyde content). Moreover, in the hepatic tissue of ATZ-intoxicated Nile tilapia, histopathological alterations and upregulated mRNA expression levels of stress- and apoptosis-related genes (Hsp70, caspase 3, and p53) were observed. GEO supplementation in ATZ-treated groups significantly attenuated the aforementioned negative effects, though some parameters did not reach the CNT values. These findings provide further and partly new evidence that sub-lethal ATZ toxicity induces reduced survivability, growth retardation, impaired digestive function, anemia, immunosuppression, hepatic oxidative stress damage, and overall increased stress level in Nile tilapia, and suggest that GEO supplementation may be useful for mitigating this toxicity and provide more general support to the productive performance and health status of this fish species

Breast Cancer Diagnosis and Survival Prediction Using JNN

Abstract: Breast cancer is reported to be the most common cancer type among women worldwide and it is the second highest women fatality rate amongst all cancer types. Notwithstanding all the progresses made in prevention and early intervention, early prognosis and survival prediction rates are still not sufficient. In this paper, we propose an ANN model which outperforms all the previous supervised learning methods by reaching 99.57 in terms of accuracy in Wisconsin Breast Cancer dataset. Experimental results on Haberman’s Breast Cancer Survival dataset show the superiority of proposed method by reaching 88.24 % in terms of accuracy. The results are the best reported ones obtained from Artificial Neural Network using JNN environment without any preprocessing of the dataset