Dynamic effective anisotropy: Asymptotics, simulations, and microwave experiments with dielectric fibers

International audienceWe investigate dynamic effective anisotropy in photonic crystals (PCs) through a combination of an effective medium theory, which is a high-frequency homogenization (HFH) method explicitly developed to operate for short waves, as well as through numerical simulations and microwave experiments. The HFH yields accurate predictions of the effective anisotropic properties of periodic structures when the wavelength is of comparable order to the pitch of the array; specifically, we investigate a square array of pitch 2 cm consisting of dielectric rods of radius 0.5 cm and refractive index n=6√ within an air matrix. This behaves as an effective medium, with strong artificial anisotropy, at a frequency corresponding to a flat band emerging from a Dirac-like point in transverse magnetic (TM) polarization. At this frequency, highly directive emission is predicted for an electric source placed inside this PC, and this artificial anisotropy can be shown to coincide with a change of character of the underlying effective equation from isotropic to unidirective, with coefficients of markedly different magnitudes appearing in the effective equation tensor. In transverse electric (TE) polarization, we note a second radical change of character of the underlying effective equation, this time from elliptic to hyperbolic, near a frequency at which a saddle point occurs in the corresponding dispersion curves. Delicate microwave experiments are performed in both polarizations for such a PC consisting of 80 rods, and we demonstrate that a directive emission in the form of a + (respectively, an X) is indeed seen experimentally at the predicted frequency 9.5 GHz in TM polarization (respectively, 5.9 GHz in TE polarization). These are clearly dynamic effects since in the quasistatic regime the PC just behaves as an isotropic medium

An artificial dielectric slab for ultra high-field MRI: proof of concept

High-permittivity dielectric pads, i.e., thin, flexible slabs, usually consisting of mixed ceramic powders and liquids, have been previously shown to increase the magnetic field at high and ultra high-fields in regions of low efficiency of transmit coils, thus improving the homogeneity of images. However, their material parameters can change with time, and some materials they contain are bio incompatible. This article presents an alternative approach replacing ceramic mixtures with a low-cost and stable artificial dielectric slab. The latter comprises a stack of capacitive grids realized using multiple printed-circuit boards. Results in this article show that the proposed artificial dielectric structure can obtain the same increase in the local transmit radiofrequency magnetic field distribution in a head phantom at 7 T as the conventional dielectric pad. (C) 2020 The Authors. Published by Elsevier Inc.Radiolog

No Efficacy of the Combination of Lopinavir/Ritonavir Plus Hydroxychloroquine Versus Standard of Care in Patients Hospitalized With COVID-19: A Non-Randomized Comparison

Objectives: No specific treatment has been approved for COVID-19. Lopinavir/ritonavir (LPV/r) and hydroxychloroquine (HCQ) have been used with poor results, and a trial showed advantages of combined antiviral therapy vs. single antivirals. The aim of the study was to assess the effectiveness of the combination of antivirals (LPV/r and HCQ) or their single use in COVID-19 hospitalized patients vs. standard of care (SoC). Methods: Patients ≥18 years with SARS-CoV-2 infection, defined as positive RT-PCR from nasal/oropharyngeal (NP/OP) swab or positive serology, admitted at L. Spallanzani Institute (Italy) were included. Primary endpoint: time to invasive ventilation/death. Secondary endpoint: time to two consecutive negative SARS-CoV-2 PCRs in NP/OP swabs. In order to control for measured confounders, a marginal Cox regression model with inverse probability weights was used. Results: A total of 590 patients were included in the analysis: 36.3% female, 64 years (IQR 51-76), and 91% with pneumonia. Cumulative probability of invasive ventilation/death at 14 days was 21.2% (95% CI 17.6, 24.7), without difference between SOC, LPV/r, hydroxychloroquine, HCQ + LPV/r, and SoC. The risk of invasive ventilation/death in the groups appeared to vary by baseline ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO2/FiO2). Overall cumulative probability of confirmed negative nasopharyngeal swabs at 14 days was 44.4% (95% CI 38.9, 49.9), without difference between groups. Conclusion: In this retrospective analysis, we found no difference in the rate of invasive ventilation/death or viral shedding by different strategies, as in randomized trials performed to date. Moreover, even the combination HCQ + LPV/r did not show advantages vs. SoC

Wireless coils based on resonant and nonresonant coupled-wire structure for small animal multinuclear imaging

Earlier work on RF metasurfaces for preclinical MRI has targeted applications such as whole‐body imaging and dual‐frequency coils. In these studies, a nonresonant loop was used to induce currents into a metasurface that was operated as a passive inductively powered resonator. However, as we show in this study, the strategy of using a resonant metasurface reduces the impact of the loop on the global performance of the assembled coil. To mitigate this deficiency, we developed a new approach that relies on the combination of a commercial surface coil and a coupled‐wire structure operated away from its resonance. This strategy enables the extension of the sensitive volume of the surface coil while maintaining its local high sensitivity without any hardware modification. A wireless coil based on a two parallel coupled‐wire structure was designed and electromagnetic field simulations were carried out with different levels of matching and coupling between both components of the coil. For experimental characterization, a prototype was built and tested at two frequencies, 300 MHz for 1H and 282.6 MHz for 19F at 7 T. Phantom and in vivo MRI experiments were conducted in different configurations to study signal and noise figures of the structure. The results showed that the proposed strategy improves the overall sensitive volume while simultaneously maintaining a high signal‐to‐noise ratio (SNR). Metasurfaces based on coupled wires are therefore shown here as promising and versatile elements in the MRI RF chain, as they allow customized adjustment of the sensitive volume as a function of SNR yield. In addition, they can be easily adapted to different Larmor frequencies without loss of performance

Free-space electromagnetics characterization of materials for microwave and radar applications

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Extending a Birdcage Coil for Magnetic Resonance Imaging of a Human Head with an Artificial Magnetic Shield

In magnetic resonance imaging, a birdcage coil is the most commonly used volumetric resonator creating a highly homogeneous radiofrequency magnetic field in a conductive sample. An artificial magnetic radiofrequency shield was recently shown to improve the magnetic field amplitude per unit power (transmit efficiency) of a preclinical birdcage coil by reducing the intrinsic losses in the coil and increasing power absorbed by the sample. In this paper, we propose a new application of an artificial shield in clinical MRI. Thanks to the proposed artificial shield a birdcage coil for human brain imaging operating at 300 MHz (Larmor frequency of protons at static fields of 7 T) can be expanded to increase free space. As a result, the coil becomes more comfortable for the patient and keeping comparable transmit efficiency. The same extended coil with a conventional copper shield would have at least 10% lower efficiency. The proposed artificial shield is implemented as an annular-ring cavity-backed slot in a copper cylinder that tightly surrounds the birdcage. To demonstrate the effect, radiofrequency magnetic field and specific absorption rate distributions were compared numerically and experimentally for the initial and extended coils with different shields.Peer reviewe

A practical realization of an artificial magnetic shield for preclinical birdcage RF coils

In the most of magnetic resonance imaging (MRI) systems, a conventional radiofrequency (RF) electric shield is typically placed around an RF volume coil to avoid the interaction with the other components of the system. Disadvantageously metal shields reduce the transmit efficiency of the RF coil as well as its receive sensitivity due to out-ofphase reflection of electromagnetic waves. In contrast, an ideal magnetic shield having high surface impedance provides in-phase reflection, which can be promising for improvement of RF coil's performance. In this work, we propose an artificial magnetic shield based on a cylindrical miniaturized corrugated structure to improve characteristics of a small-animal birdcage coil at 7T. The coil was simulated in the presence of the metal and ideal magnetic shield as well as the proposed structure. The results demonstrate enhancement of the coil's performance in the presence of the proposed shield, which is comparable with an ideal one.Peer reviewe

Volume coil based on hybridized resonators for magnetic resonance imaging

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Bianisotropy in Metamaterials Near Optical Frequencies

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