2,954 research outputs found
A case for revising the strength of the relationship between childhood asthma and atopy in the developing world
Introduction. Asthma is the commonest chronic condition of children. Diagnosis remains difficult and many surrogate markers are used, such as documenting evidence of atopy.Method. Two studies investigated the role of atopy in childhood asthma. The first documented the prevalence and nature of allergy sensitivities in a group of asthmatic children compared with non-asthmatic children in Pretoria, South Africa. The second enrolled a random sample of asthmatic children and their mothers attending the Childrenâs Chest and Allergy Clinic at Steve Biko Academic Hospital, Pretoria. Children were classified as having atopic or non-atopic asthma. Mothers completed a questionnaire to reveal atopic features.Results. In the first study, only 45.0% of asthmatic children had a positive skin-prick test (SPT), as opposed to 16.2% of control children. This is a lower proportion than in many reported international studies. In the second study, 64 children with atopic asthma and 36 with non-atopic asthma were studied, along with their mothers. The proportion of children with atopic asthma did not differ for mothers with and without a positive SPT (p=0.836), a history of asthma (p=0.045) or symptoms suggestive of an allergic disease (p=1.000), or who were considered to be allergic (p=0.806). The odds ratio (OR) of a child having atopic asthma when he or she had a mother with a doctordiagnosed history of asthma was 4.76, but the sensitivity was low (21.9%).Conclusion. The data demonstrate that fewer asthmatic children in South Africa are atopic than was previously thought. Also, all maternal allergic or asthmatic associations are poor predictors of childhood atopic asthma. Despite the increased risk of atopic asthma in a child of a mother who has a doctor diagnosis of asthma (OR 4.76; p=0.045), this is a poor predictor of atopic asthma (sensitivity 21.9%)
Edging your bets: advantage play, gambling, crime and victimisation
Consumerism, industrial development and regulatory liberalisation have underpinned the ascendance of gambling to a mainstream consumption practice. In particular, the online gambling environment has been marketed as a site of âsafe risksâ where citizens can engage in a multitude of different forms of aleatory consumption. This paper offers a virtual ethnography of an online âadvantage playâ subculture. It demonstrates how advantage players have reinterpreted the online gambling landscape as an environment saturated with crime and victimisation. In this virtual world, advantage play is no longer simply an instrumental act concerned with profit accumulation to finance consumer desires. Rather, it acts as an opportunity for individuals to engage in a unique form of edgework, whereby the threat to oneâs well-being is tested through an ability to avoid crime and victimisation. This paper demonstrates how mediated environments may act as sites for edgeworking and how the potential for victimisation can be something that is actively engaged with
Gravitational Wave Detection by Interferometry (Ground and Space)
Significant progress has been made in recent years on the development of
gravitational wave detectors. Sources such as coalescing compact binary
systems, neutron stars in low-mass X-ray binaries, stellar collapses and
pulsars are all possible candidates for detection. The most promising design of
gravitational wave detector uses test masses a long distance apart and freely
suspended as pendulums on Earth or in drag-free craft in space. The main theme
of this review is a discussion of the mechanical and optical principles used in
the various long baseline systems in operation around the world - LIGO (USA),
Virgo (Italy/France), TAMA300 and LCGT (Japan), and GEO600 (Germany/U.K.) - and
in LISA, a proposed space-borne interferometer. A review of recent science runs
from the current generation of ground-based detectors will be discussed, in
addition to highlighting the astrophysical results gained thus far. Looking to
the future, the major upgrades to LIGO (Advanced LIGO), Virgo (Advanced Virgo),
LCGT and GEO600 (GEO-HF) will be completed over the coming years, which will
create a network of detectors with significantly improved sensitivity required
to detect gravitational waves. Beyond this, the concept and design of possible
future "third generation" gravitational wave detectors, such as the Einstein
Telescope (ET), will be discussed.Comment: Published in Living Reviews in Relativit
Cooling a nanomechanical resonator with quantum back-action
Quantum mechanics demands that the act of measurement must affect the
measured object. When a linear amplifier is used to continuously monitor the
position of an object, the Heisenberg uncertainty relationship requires that
the object be driven by force impulses, called back-action. Here we measure the
back-action of a superconducting single-electron transistor (SSET) on a
radiofrequency nanomechanical resonator. The conductance of the SSET, which is
capacitively coupled to the resonator, provides a sensitive probe of the
latter's position;back-action effects manifest themselves as an effective
thermal bath, the properties of which depend sensitively on SSET bias
conditions. Surprisingly, when the SSET is biased near a transport resonance,
we observe cooling of the nanomechanical mode from 550mK to 300mK-- an effect
that is analogous to laser cooling in atomic physics. Our measurements have
implications for nanomechanical readout of quantum information devices and the
limits of ultrasensitive force microscopy (such as single-nuclear-spin magnetic
resonance force microscopy). Furthermore, we anticipate the use of these
backaction effects to prepare ultracold and quantum states of mechanical
structures, which would not be accessible with existing technology.Comment: 28 pages, 7 figures; accepted for publication in Natur
Single stage repair of a complex pathology: end stage ischaemic cardiomyopathy, ascending aortic aneurysm and thoracic coarctation
The not uncommon combination of ascending aortic pathology with late presenting coarctation is a difficult surgical challenge. The two stage approach is usually adopted. The necessity for cardiac transplantation adds to the complexity: a trans-sternal approach and single stage repair become mandatory
Considerations in the determination of orientational order parameters from X-ray scattering experiments
An assessment of the data processing and analysis methods used to obtain the second- and fourth-rank orientational order parameters of liquid crystals from X-ray scattering experiments has been carried out, using experimental data from four extensively studied alkyl-cyanobiphenyls and calculated data generated from two general types of theoretical orientational distribution function. The application of a background subtraction and two different baseline correction methods to the scattering profiles is assessed, along with three different methods to analyse the processed data. The choice of baseline correction method is shown to have a significant effect: an offset to zero overestimates the order parameters from the experimental and calculated data sets, particularly for lower order parameters arising from broad distributions, whereas an offset to a value estimated from regions of low scattering intensity provides experimental values close to those reported from other experimental techniques. By contrast, the three different analysis methods are shown generally to result in relatively small absolute differences between the order parameters. We outline a straightforward general approach to experimental X-ray scattering data processing and analysis for uniaxial phases that results in order parameters that match well with those reported using other experimental techniques
Physics, Astrophysics and Cosmology with Gravitational Waves
Gravitational wave detectors are already operating at interesting sensitivity
levels, and they have an upgrade path that should result in secure detections
by 2014. We review the physics of gravitational waves, how they interact with
detectors (bars and interferometers), and how these detectors operate. We study
the most likely sources of gravitational waves and review the data analysis
methods that are used to extract their signals from detector noise. Then we
consider the consequences of gravitational wave detections and observations for
physics, astrophysics, and cosmology.Comment: 137 pages, 16 figures, Published version
<http://www.livingreviews.org/lrr-2009-2
Dimension-Six Terms in the Standard Model Lagrangian
When the Standard Model is considered as an effective low-energy theory,
higher dimensional interaction terms appear in the Lagrangian. Dimension-six
terms have been enumerated in the classical article by Buchmueller and Wyler
[3]. Although redundance of some of those operators has been already noted in
the literature, no updated complete list has been published to date. Here we
perform their classification once again from the outset. Assuming baryon number
conservation, we find 15 + 19 + 25 = 59 independent operators (barring flavour
structure and Hermitian conjugations), as compared to 16 + 35 + 29 = 80 in
Ref.[3]. The three summed numbers refer to operators containing 0, 2 and 4
fermion fields. If the assumption of baryon number conservation is relaxed, 4
new operators arise in the four-fermion sector.Comment: 16 pages, no figures, v3: Redundant B-violating operator remove
Electroweak Gauge-Boson Production at Small q_T: Infrared Safety from the Collinear Anomaly
Using methods from effective field theory, we develop a novel, systematic
framework for the calculation of the cross sections for electroweak gauge-boson
production at small and very small transverse momentum q_T, in which large
logarithms of the scale ratio M_V/q_T are resummed to all orders. These cross
sections receive logarithmically enhanced corrections from two sources: the
running of the hard matching coefficient and the collinear factorization
anomaly. The anomaly leads to the dynamical generation of a non-perturbative
scale q_* ~ M_V e^{-const/\alpha_s(M_V)}, which protects the processes from
receiving large long-distance hadronic contributions. Expanding the cross
sections in either \alpha_s or q_T generates strongly divergent series, which
must be resummed. As a by-product, we obtain an explicit non-perturbative
expression for the intercept of the cross sections at q_T=0, including the
normalization and first-order \alpha_s(q_*) correction. We perform a detailed
numerical comparison of our predictions with the available data on the
transverse-momentum distribution in Z-boson production at the Tevatron and LHC.Comment: 34 pages, 9 figure
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