Revision and Translation Tasks in English and European Portuguese: Unfinished by Anabela de Sousa, Madeira: Illustrated by Andrew Picken, A History of Madeira by William Combe, Estudo Sobre o Século XIX na Madeira by Paulo Rodrigues, and História da Madeira Séc. XIX — Volume V by Rui Carita

This internship established with Académica da Madeira focused on carrying out a revision of the unpublished novel by Anabela de Sousa titled Unfinished, a translation revision of the travelog by Andrew Picken titled Madeira: Illustrated (1840), a translation of the travelog by William Combe titled A History of Madeira (1821), and a revision of the publications written by Paulo Rodrigues and Rui Carita titled Estudo Sobre o Século XIX na Madeira (2015) and História da Madeira Séc. XIX — Volume V (2019), respectively. These activities primarily followed the guidelines set forth by Mossop (2020), Fidalgo (2014), Marques (2014), and Künzli (2007). The documents provided in digital PDF format were converted to DOCX, allowing comments and changes to be displayed by using the corresponding functionalities within the Microsoft Word program. For all tasks, online websites have been used, and particularly for the two travelogs, the aforementioned publications regarding Madeira Island in the 19th century written by Rui Carita and Paulo Rodrigues were read—along with the use of publications from other individuals and entities—in order to pinpoint the correct translation of a given term. This internship has not only helped the intern acquire and improve revision and translation techniques in English and European Portuguese but also provided new analysis content for Portuguese historians and linguists regarding Madeira Island as seen by two English visitors during that period.Este estágio estabelecido com a Académica da Madeira focou-se na realização de uma revisão do romance inédito de Anabela de Sousa intitulado Unfinished, uma revisão da tradução do diário de viagem de Andrew Picken intitulado Madeira: Illustrated (1840), uma tradução do diário de viagem de William Combe intitulado A History of Madeira (1821) e uma revisão das obras escritas por Paulo Rodrigues e Rui Carita intituladas Estudo Sobre o Século XIX na Madeira (2015) e História da Madeira Séc. XIX — Volume V (2019), respetivamente. Estas atividades seguiram, principalmente, as orientações propostas por Mossop (2020), Fidalgo (2014), Marques (2014) e Künzli (2007). Os documentos fornecidos em formato digital PDF foram convertidos para DOCX, permitindo a exibição de comentários e alterações através das correspondentes funcionalidades no programa Microsoft Word. Para todas as tarefas, foram utilizados sites online, e, em relação aos dois diários de viagem, foram lidas as supracitadas obras acerca da Ilha da Madeira no século XIX escritas por Rui Carita e Paulo Rodrigues — além de obras de outros indivíduos e entidades — de forma a identificar a tradução correta de um determinado termo. Este estágio não só ajudou o estagiário a adquirir e melhorar técnicas de revisão e tradução em inglês e português europeu, como também forneceu novos conteúdos de análise para historiadores e linguistas portugueses relativamente à forma como a Ilha da Madeira foi encarada por dois visitantes ingleses durante esse período

Reducing periprosthetic joint infection: What really counts?

Periprosthetic joint infection (PJi) remains one of the most challenging complications after joint arthroplasty. Despite improvements in surgical techniques and in the use of antibiotic prophylaxis, it remains a major cause of implant failure and need for revision. PJi is associated with both human host-related and bacterial agentrelated factors that can interact in all the phases of the procedure (preoperative, intraoperative and postoperative). Prevention is the first strategy to implement in order to minimize this catastrophic complication. The present review focuses on the preoperative period, and on what to do once risk factors are fully understood and have been identified

Mason type II and III radial head fracture in patients older than 65: is there still a place for radial head resection?

Purpose: To evaluate the clinical outcomes of radial head excision for multifragmentary radial head fracture in patients over 65 years old. Methods: We retrospectively examined 30 patients over 65 years of age treated with radial head excision for comminuted radial head fractures. Patients were evaluated through clinical examinations, administrative questionnaires (DASH—Disabilities of the Arm, Shoulder and Hand; MEPS—Mayo Elbow Performance Score, VAS—Visual Analog Scale) and plain films. Results: The mean follow-up was 40 months (range 24–72 months); 27 out of 30 patients claimed to be satisfied. The mean DASH score was 13 (range 3–45.8) and mean MEPS was 79 (range 65–97). The radiographic evaluation showed 21 cases of elbow arthritis; only two of them complained about pain. Heterotopic ossification was evident in six cases with functional impairment in only one patient. Six patients with increased ulnar variance had clinical distal radio-ulnar joint instability. Discussion: Radial head excision has been considered a safe surgical procedure with satisfactory clinical outcomes. Development in biomechanical studies and prosthetic replacement of the radial head question the validity of radial head excision. In current literature, there are neither long-term follow-up studies on radial head prosthesis outcomes nor studies which consider elderly patient samples. Conclusion: Radial head resection remains a good option when a radial head fracture occurs in elderly patients, taking into account the influence of poor bone quality and comorbidities on the outcome. Radial head excision is not indicated in the presence of associated lesions, because of the risk of residual elbow instability; complications associated with advanced age must be considered and a strict follow-up granted

Implementation and Review of the Axisymmetric Equilibrium System of RFX-Mod2 within the MARTe2 Framework

A major refurbishment of the toroidal complex of the RFX-mod device is in progress and it will include the removal of the Inconel vacuum vessel and a modification of the stainless steel supporting structure to be made vacuum-tight. The axisymmetric equilibrium control in RFX-mod was responsible for the control of the plasma current, horizontal and vertical position along with its stability and the plasma shape. The new implementation framework, both hardware and software, is described. The system has been fully reviewed and modified, if needed, for its prospective use in RFX-mod2. In order to run tests in an operation-like context, the updated system has also been implemented in the MARTe2 framework, to be deployed for the real-time applications of RFX-mod2. The results of the previous versions were reproduced and the cycle-time requirements were met

skin flap squamous cell carcinoma developed after urethroplasty

Objectives: To describe our experience in diagnosis and treatment of urethral carcinoma following urethroplasty with a Orandi penile skin flap. Material and methods: Our patient underwent to Orandi penile skin flap urethroplasty then developed a urethral epidermoid carcinoma on the flap approximately 15 years later. We treated this case with a partial penectomy surgery and perineostomy. Surgery was followed by chemotherapy with cisplatin and 5-fluorouracil. The progression of the disease led to a salvage surgery of total penectomy and asportation of testicles and scrotum.Results: Despite the success of the surgery, the disease progressed and three months after the last surgical operation the patient died. Conclusions: Urethral carcinoma on skin flap is a rare complication of the urethroplasty surgery but with severe consequences, so we recommend to undertake a long-term urological follow up in patients undergone such kind of surgery

In vivo triglyceride synthesis in subcutaneous adipose tissue of humans correlates with plasma HDL parameters

Backgrounds and aims: Low concentrations of plasma HDL-C are associated with the development of atherosclerotic cardiovascular diseases and type 2 diabetes. Here we aimed to explore the relationship between the in vivo fractional synthesis of triglycerides (fTG) in subcutaneous (s.q.) abdominal adipose tissue (AT), HDL-C concentrations and HDL particle size composition in non-diabetic humans. Methods: The fTG in s.q. abdominal AT was measured in 16 non-diabetic volunteers (7 women, 9 men; Age: 49 ± 20 years; BMI: 31 ± 5 kg/m; Fasting Plasma Glucose: 90 ± 10 mg/dl) after 2H2O labeling. HDL-C concentration and subclasses, large (L-HDL), intermediate (I-HDL) and small (S-HDL) were measured. Results: Linear regression analyses demonstrated significant associations of fTG with plasma concentration of HDL-C (r = 0.625,p = 0.009) and percent contribution of L-HDL (r = 0.798,p < 0.001), I-HDL (r = -0.765,p < 0.001) and S-HDL (r = -0.629, p = 0.009). When analyses were performed by gender, the associations remained significant in women (HDL-C: r = 0.822,p = 0.023; L-HDL: r = 0.892,p = 0.007; I-HDL: r = -0.927,p = 0.003) but not men. Conclusions: Our study demonstrated an in vivo association between subcutaneous abdominal adipose tissue lipid dynamics and HDL parameters in humans, but this was true for women not men. Positive association with L-HDL and negative with I-HDL suggest that subcutaneous abdominal adipose tissue lipid dynamics may play an important role in production of mature functional HDL particles. Further studies evaluating the mechanism responsible for these associations and the observed gender differences are important and warranted to identify potential novel targets of intervention to increase the production of atheroprotective subclasses of HDL-Cs and thus decreasing the risks of development of atherosclerotic conditions

Aggressiveness pattern and second primary tumor risk associated with basaloid squamous cell carcinoma of the larynx

Basaloid squamous cell carcinoma (BSCC) is a rare, aggressive and distinct variant of squamous cell carcinoma (SCC) of the upper respiratory and digestive tract. We have evaluated disease specific survival (DSS) and overall survival (OS) through Kaplan-Meier method and mortality risk through univariate statistical analysis of Cox in 42 cases of BSCC and other 42 of laryngeal SCC (LSCC) matched for both age and sex. We demonstrated that laryngeal BSCC is a more aggressive tumor than LSCC as is associated to higher nodal recurrence of pathology (5 vs 2 patients, median survival, OR 2.7), a reduced survival (median survival 34 vs 40 months, OR 3.2 for mortality); in addition, basaloid patients have a higher risk to be affected by second primary tumors (13 vs 3 patients, OR 5.8) and a higher probability to die for this second tumor (Hazard Risk, HR 4.4). The analysis of survival shows an increased mortality risk concurrent with the parameters assessed by univariate analyses that assume a predictive and statistical significance in second tumor and grading in basaloid LSSC.Basaloid squamous cell carcinoma (BSCC) is a rare, aggressive and distinct variant of squamous cell carcinoma (SCC) of the upper respiratory and digestive tract. We have evaluated disease specific survival (DSS) and overall survival (OS) through Kaplan-Meier method and mortality risk through univariate statistical analysis of Cox in 42 cases of BSCC and other 42 of laryngeal SCC (LSCC) matched for both age and sex. We demonstrated that laryngeal BSCC is a more aggressive tumor than LSCC as is associated to higher nodal recurrence of pathology (5 vs 2 patients, median survival, OR 2.7), a reduced survival (median survival 34 vs 40 months, OR 3.2 for mortality); in addition, basaloid patients have a higher risk to be affected by second primary tumors (13 vs 3 patients, OR 5.8) and a higher probability to die for this second tumor (Hazard Risk, HR 4.4). The analysis of survival shows an increased mortality risk concurrent with the parameters assessed by univariate analyses that assume a predictive and statistical significance in second tumor and grading in basaloid LSSC

Tumor induced osteomalacia: a systematic review and individual patient's data analysis

Context: Tumor induced osteomalacia (TIO) is a rare paraneoplastic syndrome, usually caused by small, benign and slow-growing phosphaturic mesenchymal tumors. Clinically, TIO is characterized by renal phosphate leak, causing hypophosphatemia and osteomalacia. This review was performed to assess the clinical characteristics of TIO patients described worldwide so far. Evidence acquisition: On 06/26/2021, a systematic search was performed in Medline, Google Scholar, Google book, and Cochrane Library using the terms: "tumor induced osteomalacia", "oncogenic osteomalacia", "hypophosphatemia". There were no language restrictions. This review was performed according to PRISMA criteria. Evidence results: Overall, 1725 TIO cases were collected. TIO was more frequent in adult men, who showed a higher incidence of fractures compared to TIO women. The TIO causing neoplasms were identified in 1493 patients. The somatostatin receptor-based imaging modalities have the highest sensitivity for the identification of TIO-causing neoplasms. TIO causing neoplasms were equally located in bone and soft tissues; these latter showed a higher prevalence of fractures and deformities. The surgery is the preferred TIO definitive treatment (successful in &gt;90% of patients). Promising non-surgical therapies are treatments with burosumab in TIO patients with elevated Fibroblast Growth Factor-23 levels, and with radiolabeled somatostatin analogs in patients with TIO-causing neoplasm identified by somatostatin receptor-based imaging techniques. Conclusion: TIO occurs preferentially in adult men. The TIO clinical expressiveness is more severe in men as well as in patients with TIO-causing neoplasms located to soft tissues. Treatments with burosumab and with radiolabeled somatostatin analogs are the most promising non-surgical therapies

Origin of Sn(II) oxidation in tin halide perovskites

Tin-halide perovskites have great potential as photovoltaic materials, but their performance is hampered by undesirable oxidation of Sn(ii) to Sn(iv). NMR proves DMSO to be a main cause of oxidation

Surgical approach to adrenal ganglioneuroma: Case report and literature review

Objective: Ganglioneuroma (GN) is a benign tumor with a slow growth that can originate from any paravertebral sympathetic plexus. It is usually asymptomatic or with nonspecific symptoms. TC and RM scan are helpful to study GN. It is usually represented by an ovalshaped retroperitoneal mass or, in case of adrenal impairment, by low radiologic contrast media attenuation. Surgical treatment is mandatory. Literature shows how the laparoscopic approach is the most used, especially in lesions that are 6 cm or smaller. Our purpose is to describe our experience on an incidental adrenal GN of about 5 cm treated by the laparoscopic transperitoneal approach. Materials and methods: A 33-year-old male had ultrasound occasional finding of an about 4 cm adrenal mass. TC and RM scan identified a retroperitoneal mass (max diameter 48 mm). The lesion was removed with a transperitoneal laparoscopic approach. Results: No intraoperative or postoperative complications occurred. The patient was discharged 3 days after surgery. Conclusions: Up to the present laparoscopic surgery is the best approach for GN treatment