Abstract syntax as interlingua: Scaling up the grammatical framework from controlled languages to robust pipelines

Syntax is an interlingual representation used in compilers. Grammatical Framework (GF) applies the abstract syntax idea to natural languages. The development of GF started in 1998, first as a tool for controlled language implementations, where it has gained an established position in both academic and commercial projects. GF provides grammar resources for over 40 languages, enabling accurate generation and translation, as well as grammar engineering tools and components for mobile and Web applications. On the research side, the focus in the last ten years has been on scaling up GF to wide-coverage language processing. The concept of abstract syntax offers a unified view on many other approaches: Universal Dependencies, WordNets, FrameNets, Construction Grammars, and Abstract Meaning Representations. This makes it possible for GF to utilize data from the other approaches and to build robust pipelines. In return, GF can contribute to data-driven approaches by methods to transfer resources from one language to others, to augment data by rule-based generation, to check the consistency of hand-annotated corpora, and to pipe analyses into high-precision semantic back ends. This article gives an overview of the use of abstract syntax as interlingua through both established and emerging NLP applications involving GF

Developing Novel Therapies for Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 7]: Opportunities From Restorative Neurobiology.

Study design: Narrative review. Objectives: To provide an overview of contemporary therapies for the James Lind Alliance priority setting partnership for degenerative cervical myelopathy (DCM) question: \u27Can novel therapies, including stem-cell, gene, pharmacological and neuroprotective therapies, be identified to improve the health and wellbeing of people living with DCM and slow down disease progression?\u27 Methods: A review of the literature was conducted to outline the pathophysiology of DCM and present contemporary therapies that may hold therapeutic value in 3 broad categories of neuroprotection, neuroregeneration, and neuromodulation. Results: Chronic spinal cord compression leads to ischaemia, neuroinflammation, demyelination, and neuronal loss. Surgical intervention may halt progression and improve symptoms, though the majority do not make a full recovery leading to lifelong disability. Neuroprotective agents disrupt deleterious secondary injury pathways, and one agent, Riluzole, has undergone Phase-III investigation in DCM. Although it did not show efficacy on the primary outcome modified Japanese Orthopaedic Association scale, it showed promising results in pain reduction. Regenerative approaches are in the early stage, with one agent, Ibudilast, currently in a phase-III investigation. Neuromodulation approaches aim to therapeutically alter the state of spinal cord excitation by electrical stimulation with a variety of approaches. Case studies using electrical neuromuscular and spinal cord stimulation have shown positive therapeutic utility. Conclusion: There is limited research into interventions in the 3 broad areas of neuroprotection, neuroregeneration, and neuromodulation for DCM. Contemporary and novel therapies for DCM are now a top 10 priority, and whilst research in these areas is limited in DCM, it is hoped that this review will encourage research into this priority

A New Framework for Investigating the Biological Basis of Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 5]: Mechanical Stress, Vulnerability and Time

Study design: Literature Review (Narrative). Objective: To propose a new framework, to support the investigation and understanding of the pathobiology of DCM, AO Spine RECODE-DCM research priority number 5. Methods: Degenerative cervical myelopathy is a common and disabling spinal cord disorder. In this perspective, we review key knowledge gaps between the clinical phenotype and our biological models. We then propose a reappraisal of the key driving forces behind DCM and an individual\u27s susceptibility, including the proposal of a new framework. Results: Present pathobiological and mechanistic knowledge does not adequately explain the disease phenotype; why only a subset of patients with visualized cord compression show clinical myelopathy, and the amount of cord compression only weakly correlates with disability. We propose that DCM is better represented as a function of several interacting mechanical forces, such as shear, tension and compression, alongside an individual\u27s vulnerability to spinal cord injury, influenced by factors such as age, genetics, their cardiovascular, gastrointestinal and nervous system status, and time. Conclusion: Understanding the disease pathobiology is a fundamental research priority. We believe a framework of mechanical stress, vulnerability, and time may better represent the disease as a whole. Whilst this remains theoretical, we hope that at the very least it will inspire new avenues of research that better encapsulate the full spectrum of disease

Nemateriālo aktīvu grāmatvedības metodoloģiskās problēmas Latvijas Republikā

Nonfluorinated hydrophobic surfaces are of interest for reduced cost, toxicity, and environmental problems. Searching for such surfaces together with versatile processing, A200 silica nanoparticles are modified with an oligodimethylsiloxane and used by themselves or with a polymer matrix. The goal of the surface modification is controlled aggregate size and stable suspensions. Characterization is done by NMR, microanalysis, nitrogen adsorption, and dynamic light scattering. The feasibility of the concept is then demonstrated. The silica aggregates are sprayed in a scalable process to form ultrahydrophobic and imperceptible coatings with surface topographies of controlled nanoscale roughness onto different supports, including nanofibrillated cellulose. To improve adhesion and wear properties, the organosilica was mixed with polymers. The resulting composite coatings are characterized by FE-SEM, AFM, and contact angle measurements. Depending on the nature of the polymer, different functionalities can be developed. Poly­(methyl methacrylate) leads to almost superhydrophobic and highly transparent coatings. Composites based on commercial acrylic car paint show “pearl-bouncing” droplet behavior. A light-emitting polyfluorene is synthesized to prepare luminescent and water repellent coatings on different supports. The interactions between polymers and the organosilica influence coating roughness and are critical for wetting behavior. In summary, the feasibility of a facile, rapid, and fluorine-free hydrophobization concept was successfully demonstrated in multipurpose antiwetting applications

On-board credentials with open provisioning

Securely storing and using credentials is critical for ensuring the security of many modern distributed applications. Dedicated hardware tokens provide high levels of security, but they are expensive, which makes them unattractive for most service providers. A new approach to address the problem has become possible due to the fact that several types of general-purpose secure hardware are becoming widely deployed. These platforms enable, to different degrees, a strongly isolated secure environment. In this paper, we describe how we use general-purpose secure hardware to develop an architecture for credentials which we call On-board Credentials (ObCs). ObCs combine the flexibility of virtual credentials with the higher levels of protection due to the use of secure hardware. A distinguishing feature of the ObC architecture is that it is open: it allows anyone to design and deploy new credential algorithms to ObC-capable devices without approval from the device manufacturer or any other third party. The primary contribution of this paper is showing and solving the technical challenges in achieving openness while avoiding additional costs and without compromising security. Our proposed architecture is designed with the constraints existing secure hardware in mind and has been prototyped on several different platforms including mobile devices based on M-Shield secure hardware