Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry

OBJECTIVES: The Digital Ulcers Outcome (DUO) Registry was designed to describe the clinical and antibody characteristics, disease course and outcomes of patients with digital ulcers associated with systemic sclerosis (SSc). METHODS: The DUO Registry is a European, prospective, multicentre, observational, registry of SSc patients with ongoing digital ulcer disease, irrespective of treatment regimen. Data collected included demographics, SSc duration, SSc subset, internal organ manifestations, autoantibodies, previous and ongoing interventions and complications related to digital ulcers. RESULTS: Up to 19 November 2010 a total of 2439 patients had enrolled into the registry. Most were classified as either limited cutaneous SSc (lcSSc; 52.2%) or diffuse cutaneous SSc (dcSSc; 36.9%). Digital ulcers developed earlier in patients with dcSSc compared with lcSSc. Almost all patients (95.7%) tested positive for antinuclear antibodies, 45.2% for anti-scleroderma-70 and 43.6% for anticentromere antibodies (ACA). The first digital ulcer in the anti-scleroderma-70-positive patient cohort occurred approximately 5 years earlier than the ACA-positive patient group. CONCLUSIONS: This study provides data from a large cohort of SSc patients with a history of digital ulcers. The early occurrence and high frequency of digital ulcer complications are especially seen in patients with dcSSc and/or anti-scleroderma-70 antibodies

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Genetic analysis of growth and egg production traits in synthetic colored broiler female line using animal model

Not AvailableVariance and genetic parameters were estimated for growth and production traits of synthetic broiler female line (PB-2) using REML animal model to delineate the population status, direct additive, maternal genetic, permanent environmental effects, besides genetic trends and performance of economic traits. The overall least squares mean (LSM) for body weights at 0 day (BW0), at 2 weeks (BW2), at 4 weeks (BW4), at 5 weeks (BW5), shank length at 5 weeks (SL5), and breast angle at 5 weeks (BA5) of age were 40.03 g, 207.40 g, 589.58 g, 828.51 g, 76.89 cm, and 80.78, respectively. The overall LSM for egg production up to 40 weeks of age (EP40) and egg weight at 40 weeks (EW40) were 66.02 eggs and 58.23 g, respectively. The heritability estimates using the best model for BW0, BW2, BW4, BW5, SL5, and BA5 were 0.060.03, 0.190.03, 0.150.03, 0.140.02, 0.080.02, and 0.020.01, respectively. The heritability estimates were low to moderate in the magnitude for all early growth traits. The heritability estimate for egg production up to 40 weeks (EP40) was 0.300.05. The heritability estimates for adult body weights at 20 and 40 weeks of age (BW 20 and BW 40), age at sexual maturity (ASM), and egg weight at 40 weeks (EW40) were 0.210.04, 0.190.04, 0.160.03, and 0.330.05, respectively, and the estimates were moderate to high in magnitude. Model 4 with additive, maternal permanent environmental, residual, and phenotypic effects was the best model for growth traits except for BW0 and BA5. The average genetic gain observed in primary trait (BW5) over the five generations was 13.62 g per each generation indicating effective selection. The animal model minimized the overestimation of genetic parameters and improved the accuracy of the BV, thus enabling the breeder to select the suitable breeding strategy for genetic improvement

Genetic analysis of growth and egg production traits in synthetic coloured broiler female line using animal model

Variance and genetic parameters were estimated for growth and production traits of synthetic broiler female line (PB-2) using REML animal model to delineate the population status, direct additive, maternal genetic, permanent environmental effects, besides genetic trends and performance of economic traits. The overall least squares mean (LSM) for body weights at 0 day (BW0), at 2 weeks (BW2), at 4 weeks (BW4), at five weeks (BW5), shank length at 5 weeks (SL5) and breast angle at 5 weeks (BA5) of age were 40.03 g, 207.40 g, 589.58 g, 828.51 g, 76.89 cm and 80.78º, respectively. The overall LSM for egg production up to 40 weeks of age (EP40) and egg weight at 40 weeks (EW40) were 66.02 eggs and 58.23 g, respectively. The heritability estimates using the best model for BW0, BW2, BW4, BW5, SL5 and BA5 were 0.06±0.03, 0.19±0.03, 0.15±0.03, 0.14±0.02, 0.08±0.02 and 0.02±0.01, respectively. The heritability estimates were low to moderate in the magnitude for all early growth traits. The heritability estimate for egg production up to 40 weeks (EP40) was 0.30±0.05. The heritability estimates for adult body weights at 20 and 40 weeks of age (BW 20 and BW 40), age at sexual maturity (ASM) and egg weight at 40 weeks (EW40) were 0.21±0.04, 0.19±0.04, 0.16±0.03 and 0.33±0.05, respectively and the estimates were moderate to high in magnitude. Model 4 with additive, maternal permanent environmental, residual and phenotypic effects was the best model for growth traits except for BW0 and BA5. The average genetic gain observed in primary trait (BW5) over the five generations was 13.62 g per each generation indicating effective selection. The animal model minimized the over-estimation of genetic parameters and improved the accuracy of the BV, thus enabling the breeder to select the suitable breeding strategy for genetic improvement.ICAR-DP