90 research outputs found
Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing and mature hippocampal circuits
- Author
- Publication venue
- 'eLife Sciences Publications, Ltd'
- Publication date
- 06/06/2022
- Field of study
LRRTMs are postsynaptic cell adhesion proteins that have region-restricted expression in the brain. To determine their role in the molecular organization of synapses in vivo, we studied synapse development and plasticity in hippocampal neuronal circuits in mice lacking both Lrrtm1 and Lrrtm2. We found that LRRTM1 and LRRTM2 regulate the density and morphological integrity of excitatory synapses on CA1 pyramidal neurons in the developing brain but are not essential for these roles in the mature circuit. Further, they are required for long-term-potentiation in the CA3-CA1 pathway and the dentate gyrus, and for enduring fear memory in both the developing and mature brain. Our data show that LRRTM1 and LRRTM2 regulate synapse development and function in a cell-type and developmental-stage-specific manner, and thereby contribute to the fine-tuning of hippocampal circuit connectivity and plasticity
Magnetic resonance imaging features of large endolymphatic sac compartments: audiological and clinical correlates
- Author
- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- Field of study
RNA-Seq Mapping and Detection of Gene Fusions with a Suffix Array Algorithm
- Author
- A Ameur
- A McPherson
- A Mortazavi
- A Sboner
- Asim S. Siddiqui
- B Li
- Benjamin S. Kong
- BJ Druker
- BP Lewis
- BP Rubin
- C Adem
- C Kumar-Sinha
- C Lin
- C Tognon
- C Trapnell
- C Trapnell
- CA Maher
- CA Maher
- CA Westbrook
- Catalin Barbacioru
- Chieh-Yuan Li
- D Zerbino
- EL Kwak
- ET Wang
- F De Bona
- F Denoeud
- F Ozsolak
- F Tang
- Fiona C. Hyland
- G Robertson
- H Edgren
- Heinz Breu
- I Birol
- J Wang
- JD Rowley
- Jeffrey K. Ichikawa
- Jian Gu
- Joel P. Brockman
- John P. Bodeau
- JP Koivunen
- K Inaki
- K Kannan
- Kelli S. Bramlett
- KF Au
- KJ McKernan
- KS Kosik
- L Shi
- Liviu Popescu
- M Guttman
- M Kinsella
- M Krzywinski
- M Nicolae
- M Persson
- M Yassour
- Matthew W. Muller
- MC Haffner
- MF Berger
- Milan Radovich
- N Cloonan
- N Cloonan
- N Palanisamy
- Nriti Garg
- O Monni
- OA Hampton
- Onur Sakarya
- P Shepherd
- Paolo Vatta
- Penn P. Whitley
- RD Canales
- Robert C. Nutter
- S Perner
- SA Tomlins
- SG O'Brien
- Sowmi Utiramerur
- SR Knezevich
- U Manber
- U Nagalakshmi
- Vidya Kudlingar
- Weixiong Zhang
- Y Hu
- Y Surget-Groba
- Yongzhi Chen
- Yulei N. Wang
- YW Asmann
- Z Wang
- Zheng Zhang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
High-throughput RNA sequencing enables quantification of transcripts (both known and novel), exon/exon junctions and fusions of exons from different genes. Discovery of gene fusionsâparticularly those expressed with low abundanceâ is a challenge with short- and medium-length sequencing reads. To address this challenge, we implemented an RNA-Seq mapping pipeline within the LifeScope software. We introduced new features including filter and junction mapping, annotation-aided pairing rescue and accurate mapping quality values. We combined this pipeline with a Suffix Array Spliced Read (SASR) aligner to detect chimeric transcripts. Performing paired-end RNA-Seq of the breast cancer cell line MCF-7 using the SOLiD system, we called 40 gene fusions among over 120,000 splicing junctions. We validated 36 of these 40 fusions with TaqMan assays, of which 25 were expressed in MCF-7 but not the Human Brain Reference. An intra-chromosomal gene fusion involving the estrogen receptor alpha gene ESR1, and another involving the RPS6KB1 (Ribosomal protein S6 kinase beta-1) were recurrently expressed in a number of breast tumor cell lines and a clinical tumor sample
Why Functional Pre-Erythrocytic and Bloodstage Malaria Vaccines Fail: A Meta-Analysis of Fully Protective Immunizations and Novel Immunological Model
- Author
- A Barbosa
- A Birkett
- A Falae
- A Heit
- A Hudson
- A Iellem
- A Iellem
- A Kaur
- A Kissenpfennig
- A Kitani
- A Lalvani
- A Laveran
- A Liberati
- A Malik
- A Miller
- A Moreno
- A Reyes-Sandoval
- A Scholzen
- A Siau
- A Sturm
- A Suhrbier
- A Toure-Balde
- A Trimnell
- A Wollenberg
- AA McColm
- AA McColm
- AC Gruner
- AE Anderson
- AE Morelli
- AJ Luty
- AK Mueller
- AK Mueller
- AK Mueller
- AL Mellor
- AM Bradley-Moore
- AN Akbar
- AP Campanelli
- AP Singh
- AS Aly
- AS Aly
- AS Tarun
- AU Orjih
- AU Orjih
- AU Orjih
- AU Orjih
- AV Hill
- AV Hill
- AW Lau
- AW Stowers
- AW Taylor-Robinson
- AW Taylor-Robinson
- B Douradinha
- B Hogh
- B Wizel
- B Wizel
- BC Urban
- BJ Sina
- BJ Sina
- BJ Sina
- BL Perlaza
- BL Perlaza
- BM Greenwood
- BM Greenwood
- BR Ogutu
- C Albanesi
- C Guinovart
- C Hirunpetcharat
- C Hirunpetcharat
- C Hirunpetcharat
- C Möbs
- C Ocaña-Morgner
- C Pasare
- C Roussilhon
- CA Guerra
- CE Demeure
- CE Tadokoro
- CF Anderson
- CI Sigler
- CL Maynard
- D Accapezzato
- D Dieckmann
- D Haribhai
- D Hawiger
- D Herrington
- D Pye
- D. Lys Guilbride
- DA Herrington
- DA Herrington
- DA Horwitz
- DA Horwitz
- DC Gondek
- DE Lanar
- DF Clyde
- DF Clyde
- DF Clyde
- DF Clyde
- DF Verhage
- DG Bowen
- DH Chen
- DH Kaplan
- DI Stanisic
- DJ Pombo
- DJ Wyler
- DL Doolan
- DL Doolan
- DL Doolan
- DL Doolan
- DL Doolan
- DL Doolan
- DL Doolan
- DL Doolan
- DM Jawdat
- DM Zhao
- DR Littman
- DR Palmer
- DW Roberts
- E Belnoue
- E Belnoue
- E Bettelli
- E Klechevsky
- EA Okiro
- EAM Lee
- ED Putrianti
- EG Rodrigues
- EH Nardin
- EH Nardin
- EH Nardin
- EJ Cabrera
- EM Riley
- EV Macete
- F Cottrez
- F Dzierszinski
- F Fowkes
- F Frischknecht
- F Geissmann
- F Geissmann
- F Ginhoux
- F Migot-Nabias
- F Saute
- FH Amante
- FH Osier
- FJ McCallum
- FM Omer
- FM Omer
- FM Thompson
- G Cowan
- G Filaci
- G Krishnegowda
- G Oldenhove
- G Sano
- G Senti
- GA Butcher
- GA Oliveira
- GJ Randolph
- GJ Randolph
- GL Spitalny
- GL Spitalny
- GL Spitalny
- H Groux
- H Hisaeda
- H Jonuleit
- H Jonuleit
- H Reyburn
- H Ueno
- H von Boehmer
- HC Whittle
- HE Shortt
- HK Ziegler
- HW Lim
- I Apostolou
- I Bellinghausen
- I Law
- I Ludwig-Portugall
- I Sagara
- IA Clark
- IA Clark
- IA Clark
- IA Cockburn
- IA Hope
- IF Cook
- IJ Suffia
- IR Williams
- IT Ling
- J Andersson
- J Bayry
- J Huehn
- J Langhorne
- J Lawler
- J Nowell
- J Sacarlal
- J Schneider
- J Schneider
- J Wei
- J Whalen
- J Wipasa
- JA Kapp
- JA Stoute
- JA Vaughan
- JB Sacci Jr
- JC Beier
- JC Hafalla
- JC Hafalla
- JC Hafalla
- JC Sadoff
- JE Egan
- JE Egan
- JF Romero
- JF Romero
- JF Romero
- JH Playfair
- JH Playfair
- JJ Aponte
- JM Burns Jr
- JM Calvo-Calle
- JM Vinetz
- JP Vanderberg
- JP Vanderberg
- JP Vanderberg
- K Brahimi
- K Hirahara
- K Kretschmer
- K Loser
- K Mahnke
- K Mahnke
- K Matuschewski
- K Steinbrink
- KA Bojang
- KA Kumar
- KA Kumar
- KA Lindstedt
- KA Wong
- KE Birch
- KE Kester
- KE Kester
- KE Kester
- KE Kester
- KH Mills
- KH Rieckmann
- KH Rieckmann
- KH Rieckmann
- KJ Robson
- KL Flanagan
- KL White
- KL White
- KN Couper
- L BenMohamed
- L Fahlen
- L Favila-Castillo
- L Florens
- L Kabilan
- L Klein
- L Renia
- L Renia
- L Schofield
- LA Purcell
- LD Kramer
- LF Scheller
- LH Schmidt
- LM Ting
- LM Yamauchi
- M Aidoo
- M Carvalho-Gaspar
- M Gilliet
- M Guebre-Xabier
- M Hommel
- M Labaied
- M Le Borgne
- M Marussig
- M Mauduit
- M Plebanski
- M Rodrigues
- M Roestenberg
- M Sarris
- M Sedagah
- M Sedegah
- M Sedegah
- M Tsuji
- M Tsuji
- M Urosevic
- M Veldhoen
- M Veldhoen
- M Vukmanovic-Stejic
- M Vukmanovic-Stejic
- M Walther
- MA Curotto de Lafaille
- MA Penny
- MA Thera
- Mauricio Martins Rodrigues
- MD Spring
- ME Polhemus
- MF Boyd
- MF Good
- MG Overstreet
- MG Roncarolo
- MG Roncarolo
- MG Torcia
- MJ Donovan
- MJ Stewart
- MJ Stewart
- MK Levings
- ML Chen
- MM Mota
- MM Rodrigues
- MN Wykes
- MO Li
- MO Li
- MP Longhi
- MR van Dijk
- MV Dhodapkar
- N Cools
- N Depinay
- N Khullar
- N Romani
- N Zhang
- ND Pacheco
- NS Butler
- NS Wilson
- NW Schmidt
- NW Schmidt
- O Bruna-Romero
- O Jobe
- O Jobe
- O Silvie
- P Bejon
- P Bejon
- P Bejon
- P Daubersies
- P Daubersies
- P Degano
- P Graves
- P Graves
- P Graves
- P Mettens
- P Michon
- P Potocnjak
- P Romero
- P Stoitzner
- P Sun
- PA Martinez
- PA Reid
- Patrick D. L. Guilbride
- Pawel Gawlinski
- PH Tan
- PL Alonso
- PS Patterson
- Q Tang
- Q Tang
- R Amino
- R Amino
- R Chattopadhyay
- R Edelman
- R Houot
- R Nussenzweig
- R Wang
- R Wang
- R Wang
- RA Clark
- RA Clark
- RA Gramzinski
- RB Griffiths
- RC Reed
- RC Reed
- RI Jaffe
- RK Selvaraj
- RL Beaudoin
- RL Hunter
- RM Steinman
- RS Allan
- RS Nussenzweig
- RW Sauerwein
- S Abdulla
- S Burgdorf
- S Chakravarty
- S Chatterjee
- S Chatterjee
- S Chatterjee
- S Kalia
- S Khusmith
- S Khusmith
- S Kumar
- S Li
- S Mellouk
- S Pichyangkul
- S Pichyangkul
- S Piconese
- S Rothenfusser
- S Sakaguchi
- S Sidjanski
- S Tartz
- S Waki
- S Yoshida
- SA Kaba
- SA Mikolajczak
- SC Gilbert
- SE Bongfen
- SE Bongfen
- SE Bongfen
- SE Farouk
- SE Macatonia
- SG Zheng
- SI Hay
- SI Hay
- SJ Draper
- SJ Lee
- SJ McConkey
- SK Puri
- SK Puri
- SL Hoffman
- SL Hoffman
- SL Hoffman
- SL Hoffman
- SL Hoffman
- SL Okitsu
- SM Todryk
- T Di Pucchio
- T Fandeur
- T Imai
- T Ito
- T Lammermann
- TC George
- TC Luke
- TJ Murphy
- TM Daly
- TR Jones
- U Krzych
- V Flacher
- V Meraldi
- VC McCarthy
- VS Moorthy
- VS Moorthy
- VS Moorthy
- VS Moorthy
- W Chen
- W Janssens
- W Vermi
- WA Siddiqui
- WA Williamson
- WE Collins
- WH Reece
- WP O'Meara
- WR Weiss
- WR Weiss
- WR Weiss
- WR Weiss
- X Chen
- Y Belkaid
- Y Belkaid
- Y Belkaid
- Y Bergqvist
- Y Cao
- Y Charoenvit
- Y Charoenvit
- Y Charoenvit
- Y Charoenvit
- Y Cong
- Y Futagami
- Y Jin
- Z Peng
- Z Peng
- Z Zhou
- ZM Chen
- ZM Khan
- ZX Zhang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Background: Clinically protective malaria vaccines consistently fail to protect adults and children in endemic settings, and at best only partially protect infants. Methodology/Principal Findings: We identify and evaluate 1916 immunization studies between 1965-February 2010, and exclude partially or nonprotective results to find 177 completely protective immunization experiments. Detailed reexamination reveals an unexpectedly mundane basis for selective vaccine failure: live malaria parasites in the skin inhibit vaccine function. We next show published molecular and cellular data support a testable, novel model where parasite-host interactions in the skin induce malaria-specific regulatory T cells, and subvert early antigen-specific immunity to parasite-specific immunotolerance. This ensures infection and tolerance to reinfection. Exposure to Plasmodium-infected mosquito bites therefore systematically triggers immunosuppression of endemic vaccine-elicited responses. The extensive vaccine trial data solidly substantiate this model experimentally. Conclusions/Significance: We conclude skinstage-initiated immunosuppression, unassociated with bloodstage parasites, systematically blocks vaccine function in the field. Our model exposes novel molecular and procedural strategies to significantly and quickly increase protective efficacy in both pipeline and currently ineffective malaria vaccines, and forces fundamental reassessment of central precepts determining vaccine development. This has major implications fo
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
- Author
- Abadia M
- Abassy J
- Abate E
- Abbott Tom EF
- Abdelaal Samir A
- Abdeldayem H
- Abdelkabir M
- Abdelsamed A
- Abdulwahed E
- Abiyere H
- Abou Chaar MK
- Abukhalaf SA
- Abukhalaf Sadi
- Adamina Michel
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adeyeye A
- Adisa Adewale
- Afzal MF
- Agarwal Arnav
- Aggarwal M
- Agnes A
- Agostini C
- Agrawal A
- Agrawal N
- Agresta F
- Aguiar Junior S
- Ahmed A
- Ahmed K
- Ahmed Nafees R
- Ahmed Z
- Ahn JH
- Aime A
- Akhtar N
- Akkulak Murat
- Akrivou D
- Al Abdallah M
- Al Riyami S
- Al Sayed M
- Al-Masri M
- Al-Najjar H
- Al-Slaibi I
- Alaa S
- Alakaloko Felix
- Alameer Ehab
- Alamri Alex
- Alawneh F
- Albertsmeier M
- Albertsmeier Markus
- Alderson Derek
- Aldokali N
- Alemanno G
- Alfieri S
- Algallai M
- Ali AA
- Alkadiki Ghadah Z
- Almaadany Faraj S
- Almeida AC
- Almeida-Reis R
- Almezghwi H
- Almond Max
- Alrahawy M
- Alser Osaid
- Alshaar Muhammad
- Alshareea E
- Alshareef K
- Alshryda Sattar
- Alsoufi A
- Altamirano Riquoir C
- Altomare DF
- Altomi I
- Alurralde C
- Alvarez MR
- Alvi A
- Alwarfly S
- AlZAEDE S
- Alzeerelhouseini IAH
- Amaral MJ
- Amira G
- Amorim E
- Amrani L
- Anania G
- Anastasi A
- Andrade Kam da Silva A
- Andrade R
- Annessi V
- Annicchiarico A
- Antonakis P
- Antonopoulou M
- Aprile A
- Aremu M
- Arias-Amezquita F
- Aribi N
- Aribi S
- Arkadopoulos N
- Armao T
- Armatura G
- Arminio A
- Arnaud Alexis P
- Arora A
- Arslan K
- Ashoush F
- Athanasakis E
- Attia D
- Augestad Knut Magne
- Aversano A
- Avlund T
- Awada Barakat J
- Ayasra F
- Ayasra Faris
- Ayasra Y
- Ayub B
- Ayubi A
- Ayyaz M
- Azevedo C
- Azevedo J
- Azevedo Jose
- Azevedo P
- Azman Mohd ZA
- Azzam AY
- Babalola O
- Badra R
- Bagraith K
- Baili E
- Balabel M
- Balconi A
- Baldari L
- Baldi C
- Baldini E
- Bali K
- Ballabio M
- Ballouhey Q
- Baloyiannis I
- Bandovas JP
- Bankhead-Kendall Brittany K
- Banky B
- Banuelos Romero E
- Baptista VH
- Barker D
- Barlow Emma
- Barod Ravi
- Barone R
- Baronio G
- Barrat B
- Barros Vieira A
- Bartalucci B
- Bartolini I
- Bashir Y
- Bass G
- Batistotti P
- Batstone Martin
- Baxevanidou K
- Beard David
- Becker R
- Bekele K
- Belia F
- Belkhadir ZH
- Bellacci A
- Belli A
- Bellolio F
- Bellora P
- Belluco C
- Belvedere A
- Bendjemar L
- Benkabbou A
- Benson Ruth A
- Bergamini C
- Bergeat D
- Bernante P
- Berselli M
- Bertelli G
- Bertolani E
- Besser N
- Beyer K
- Beyrne C
- Bezerra Santos T
- Bhangu Aneel A
- Bhat GA
- Bhat MA
- Biala M
- Bianchini M
- Bianco F
- Biel Juan Rey
- Bigam D
- Biondi A
- Birolo SL
- Bisagni P
- Blanco-Colino Ruth
- Bodanese B
- Boeker C
- Bondurri A
- Bong C
- Boni L
- Bonilla A
- Bonnet S
- Bordoni P
- Borges Castro F
- Borges N
- Borghi F
- Bork U
- Borroni G
- Bouchagier K
- Bouche PA
- Bouliaris K
- Boutros M
- Bowman S
- Boyce R
- Brachini G
- Bradulskis S
- Braham H
- Brar Amanpreet
- Bravo Ana Minaya
- Breen Kerry A
- Bretherton Chris
- Bristow Rob
- Bromage Steve
- Brown C
- Brunelli Alessandro
- Bruscino A
- Buarque Igor Lima
- Buarque Lima
- Bucci Fares A
- Buerba GA
- Burgan D
- Burke Joshua
- Butt U
- Bywater Edward
- Caccetta M
- Calabro M
- Camacho C
- Camara P
- Camarneiro R
- Caminsky N
- Campagnaro T
- Canas-Martinez A
- Canonico G
- Capelli P
- Capezzuoli L
- Capolupo GT
- Capunge I
- Caram EL
- Carannante F
- Carbone F
- Carcoforo P
- Cardoso N
- Cardoso P
- Carissimi F
- Caruana Edward J
- Carvello MM
- Casati M
- Cassinotti E
- Catena F
- Cecire J
- Ceelen W
- Ceretti Pisani A
- Cervellera M
- Cetares C
- Chaar Mohammad
- Chakrabortee Sohini
- Chan E
- Charalabopoulos A
- Charre L
- Chaturvedi A
- Chaturvedi H
- Chatzikomnitsa P
- Chaudhry Daoud
- Chebaro A
- Chen S
- Chessa A
- Chiappini A
- Chiarugi M
- Chinda J
- Chiozza M
- Chisthi M
- Chiva Luis
- Choong E
- Chowdri N
- Christensen P
- Christensen Peter
- Christidis P
- Christou C
- Chrysos E
- Chumbinho B
- Cianflocca D
- Cicerchia PM
- Cirillo B
- Clarizia G
- Claro M
- Coccolini F
- Cocozza E
- Coelho Nunes M
- Coffey JC
- Cohen Paul
- Colletti G
- Colombo F
- Colquhoun Alexandra
- Confalonieri M
- Connelly T
- Conti L
- Contis I
- Coonar Aman S
- Corbellini C
- Cordera F
- Corless K
- Corrigan M
- Cosentino Marino L
- Cosimelli M
- Costa M
- Costa Matos P
- Costa MJMA
- Costanzi A
- Costeira B
- Cotoia A
- Cotte E
- Cox Daniel
- Cozza V
- Creavin B
- Cremonini C
- Crespo A
- Cuasquen Velasquez BG
- Cukier M
- Cukier Moises
- Cullivan O
- Cunha C
- Cunha MF
- Cunha Miguel F
- Cunha R
- Cunningham RM
- D'Aloisio G
- D'Ugo D
- D'Ugo S
- D'Urso A
- da Cruz Lima L
- da Silva Abreu A
- da Silva Lima C
- Dainius E
- Dajani K
- Daly A
- Danias N
- Davidson Giana H
- Dawson AC
- Dawson Brett E
- de Almeida Ramalho F
- de Barros Figueiredo
- De Lima RK
- De Lucia F
- De Nardi P
- De Palma G
- de Sa Correia T
- de Sampaio Regina L
- De Simone V
- De Sousa X
- De Toma G
- De Troia A
- De Vincenti R
- Deirino A
- Delinasios G
- Dell A
- Della Giustina E
- Dellaportas D
- Delrio P
- Demetriades Andreas K
- Demyttenaere S
- Denet C
- Depalma N
- Derksen T
- Desai Anant
- Desio M
- Desoouza A
- Deus AC
- Devarakonda S
- Devezas V
- Devine M
- Dhamija P
- Dharanipragada K
- Di Bella A
- Di Franco G
- Di Lauro K
- Di Martino C
- Di Marzo F
- Di Saverio Salomone
- Diamantis A
- Diaz P
- Dijan E
- Domingues J
- Donati D
- dos Santos Martins G
- Doudakmanis C
- Dowdy Sean
- Doyle A
- Drake Thomas M
- Drane A
- Droghetti M
- Duchalais E
- Dudi-Venkata NN
- Dumitra Sinziana
- Duran Sosa EE
- Earley H
- Eastmond A
- Ebbehoj AL
- Ebben L
- Economopoulou P
- Edwards John
- Edwards John G
- Efthimiou M
- Egoroff N
- El Ahmadi B
- El Amrani M
- El Arbi N
- El Bouazizi Y
- El Kassas M
- Elazzazy E
- Eldaly A
- Elghazaly MS
- Elhadi Muhammed
- Elliott JA
- Ellojli I
- Elmorsi R
- Emile Sameh
- Emmanuel K
- Enoch E
- Esene Ignatius
- Eskinazi DG
- Esposito G
- Esquide Ruiz M
- Essam E
- Evans Jonathan P
- Evans Richard PT
- Eveno C
- Ewedah M
- Ezanno AC
- Fabbri N
- Facundo H
- Fagotti Anna
- Fahey BA
- Fahmawee T
- Farik Shebani
- Farnesi F
- Farooka MW
- Fathi NQ
- Faustino A
- Fayed Y
- Federico P
- Federico Pipitone NS
- Feo C
- Feo CF
- Fernandes Sousa M
- Fernandes U
- Fernandes V
- Ferrari M
- Ferrario L
- Ferraz I
- Ferreira C
- Ferreira Peralta M
- Ferro Carvalho C
- Ferro Rey M
- Finnegan L
- Fiore M
- Fiore Marco
- Fiori E
- Fiorini A
- Fitzgerald J Edward
- Flamey N
- Fleming CA
- Fleres F
- Fonsi GB
- Foo CC
- Foppa C
- Ford Samuel
- Fortuna L
- Fotopoulou Christina
- Fountain Daniel M
- Fowler A
- Frade S
- Fragoso M
- Francone E
- Franken J
- Frantzeskou K
- Franzini M
- Frattaruolo C
- Frazao J
- Fredon F
- Freitas A
- Frena A
- Freyschlag Christian
- Fritzmann J
- Frongia F
- Frountzas M
- Fujiwar Keiichi
- Fuks D
- Furbetta N
- Futaba K
- Gahwagi M
- Gallo G
- Gallo Gaetano
- Galvao D
- Gani J
- Ganly Ian
- Garba S
- Garberini De Manzoni A
- Garcia JS
- Garfinkle R
- Garg PK
- Garino M
- Garmanova Tatiana
- Garrido R
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- Publication venue
- 'Royal College of Obstetricians & Gynaecologists (RCOG)'
- Publication date
- 01/06/2022
- Field of study
AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4âweeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4âweeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, PÂ =Â 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, Pâ<â0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, PÂ =Â 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, PÂ =Â 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease
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- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
- Ahmad ST
- Ahmed ZM
- Ahumada-Castro U
- Aits S
- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-GĂłmez E
- Alessandri C
- Ali M
- Alim Al-Bari MA
- Aliwaini S
- Alizadeh J
- Almacellas E
- Almasan A
- Alonso A
- Alonso GD
- Altan-Bonnet N
- Altieri DC
- Alves da Costa C
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- Alzaharna MM
- Amadio M
- Amantini C
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- Ambrosio S
- Amer AO
- Ammanathan V
- An Z
- Andersen SU
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- Ălvarez ĂMC
- Ăvalos Y
- Ănal G
- ĂstĂŒn S
- ÄoliÄ M
- ÄokiÄ J
- Ćœerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- A. -G. Wu
- A. C. Ma
- A. K. Au
- Abdel-Aziz A. K.
- Abdelfatah S.
- Abdellatif M.
- Abdoli A.
- Abel S.
- Abeliovich H.
- Abildgaard M. H.
- Abudu Y. P.
- Acevedo-Arozena A.
- Adamopoulos I. E.
- Adeli K.
- Adolph T. E.
- Adornetto A.
- Aflaki E.
- Agam G.
- Agarwal A.
- Aggarwal B. B.
- Agnello M.
- Agostinis P.
- Agrewala J. N.
- Agrotis A.
- Aguilar P. V.
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- Ahmed Z. M.
- Ahumada-Castro U.
- Aits S.
- Aizawa S.
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- Akoumianaki T.
- Akpinar H. A.
- Al-Abd A. M.
- Al-Akra L.
- Al-Gharaibeh A.
- Alaoui-Jamali M. A.
- Alberti S.
- Alcocer-Gomez E.
- Alessandri C.
- Ali M.
- Alim Al-Bari M. A.
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- Alizadeh J.
- Almacellas E.
- Almasan A.
- Alonso A.
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- Zaffagnini G.
- Zambelli V. O.
- Zanella I.
- Zang Q. S.
- Zanivan S.
- Zappavigna S.
- Zaragoza P.
- Zarbalis K. S.
- Zarebkohan A.
- Zarrouk A.
- Zeitlin S. O.
- Zeng J.
- Zeng J. -D.
- Zerovnik E.
- Zhan L.
- Zhang B.
- Zhang D. D.
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- Zhang Z.
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- Zhao H.
- Zhao L.
- Zhao S.
- Zhao T.
- Zhao X. -F.
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- Zhao Y.
- Zheng G.
- Zheng K.
- Zheng L.
- Zheng S.
- Zheng X. -L.
- Zheng Y.
- Zheng Z. -G.
- Zhivotovsky B.
- Zhong Q.
- Zhou A.
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- Zhuang H.
- Zhuang X.
- Zientara-Rytter K.
- Zimmermann C. M.
- Ziviani E.
- Zoladek T.
- Zong W. -X.
- Zorov D. B.
- Zorzano A.
- Zou W.
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- Zuryn S.
- Zwerschke W.
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
Mitochondrial quality, dynamics and functional capacity in Parkinsonâs disease cybrid cell lines selected for Lewy body expression
- Author
- A Siddiqui
- AB Knott
- AJ Harding
- AJ Harding
- AJ Lees
- AR Esteves
- AR Esteves
- B Alberts
- B Zheng
- BP Dranka
- BP Dranka
- CJ Lin
- CS Palmer
- CW Olanow
- CW Shults
- D Safiulina
- DA Ferrick
- DF Bogenhagen
- DW Dickson
- Emily N Cronin-Furman
- F Diaz
- G Mudo
- G Twig
- H Braak
- I Alafuzoff
- I Ferrer
- I Sanchez
- J Bastin
- J Doehner
- J He
- J Zhou
- James P Bennett
- JB Leverenz
- JE Galvin
- JV Hindle
- K Wakabayashi
- KA Conway
- KA Jellinger
- Kristen E Bergquist
- L Lu
- LC Fuentealba
- LC Gomes
- LF Burbulla
- M Bereiter-Hahn JaB
- M Gaspari
- M Kathleen Borland
- M Moran
- M Zick
- MA Rujano
- MB Hock
- MD Brand
- MJ Devine
- MK Borland
- MK Borland
- ML Kramer
- N Ashley
- N Exner
- P Wareski
- PA Trimmer
- PA Trimmer
- PA Trimmer
- PA Trimmer
- Patricia A Trimmer
- PM Keeney
- PM Keeney
- Q Cai
- Q Xia
- R de la Fuente-Fernandez
- RC Scarpulla
- RH Swerdlow
- S Campello
- S Greffard
- S Sekine
- S Srivastava
- SJ Bertrand
- SW Miller
- T Harrower
- T Kanazawa
- T Wenz
- T Wenz
- TP Harrower
- WL Au
- WM Saxton
- Y Chu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
2013 WSES guidelines for management of intra-abdominal infections
- Author
- A Ayite
- A Basoli
- A Chabok
- A Dwivedi
- A Esteban
- A LeppÀniemi
- A McKay
- A Tanaka
- A Winbladh
- A Wysocki
- AC Rogers
- Adamu Ahmed
- AE Sanabria
- AJ Hansen
- AL Adkins
- Alain Chichom Mefire
- Alex Escalona
- Alfredo Verni
- AM Kaiser
- AM Malik
- Andrew Peitzman
- Ari Leppaniemi
- AS Doria
- Ashraf Abbas
- AU van Lent
- AW Kirkpatrick
- AW Meshikhes
- B Lamme
- B Millat
- B Ou-Yang
- B Rumstadt
- B Rumstadt
- B Siewert
- B Sogne
- BC Morse
- BE Murray
- BE Stabile
- BJ Tsuei
- Boonying Siribumrungwong
- Boris Sakakushev
- C Coimbra
- C Holmer
- C Martin
- C Papi
- C Simillis
- C Svanes
- C Tanphiphat
- C Wagner
- CA Ordoñez
- Carlos Ordonez
- CB Moore
- CC Burlew
- CE Edmiston
- Cino Bendinelli
- CJ Taylor
- CK Hui
- CK Kum
- CL Holmes
- CL Ong
- Clay Cothren Burlew
- CM Bartus
- CN Mock
- Cristian TranĂ
- CV Brown
- CW Iqbal
- D Annane
- D De Backer
- D Demetriades
- D Meadows
- D Oliak
- D Stefanidis
- DF Gaieski
- DJ Malinoski
- DL Paterson
- DO Jacobs
- DWH Lee
- DY Won
- E Gotuzzo
- E Myers
- E Myers
- E Rivers
- EA McGillicuddy
- EB Chahine
- EC Lai
- EC Lee
- EJ Goldstein
- Ernest Moore
- ES Lennard
- EW Mueller
- F Agresta
- F Menichetti
- F Meyer
- F Pea
- F Roviello
- FA Robledo
- Fausto Catena
- FC Eggleston
- FC Riché
- Federico Coccolini
- Ferdinando Agresta
- FG Bader
- FJ Fleming
- FM Pieracci
- FR Uggeri
- Frederick A Moore
- FS Taccone
- G Guyatt
- G Weiss
- GE Stein
- George Velmahos
- Gerson Alves Pereira
- Gianluca Guercioni
- GP Patel
- GR Faria
- Gustavo P Fraga
- H Derici
- H Giamarellou
- H Jarvinen
- H Lau
- H Lau
- H Masoomi
- H Masoomi
- HC Lo
- Helmut A Segovia Lohse
- HM Lode
- HO Davies
- HW Boucher
- Ihor Gerych
- IK Lee
- Imtiaz Wani
- J Blenkharn
- J Boey
- J Christiansen
- J Fatima
- J Favuzza
- J Garbino
- J Ho
- J Kellum
- J Kouame
- J Levi
- J Papaparaskevas
- J Rafferty
- J Solomkin
- J Theisen
- JA Lujan
- JA Roberts
- JA Weinberg
- JaeGil Lee
- JBY So
- JC RodrĂguez-SanjuĂĄn
- JF Hesselvik
- JF Westphal
- JG Lee
- JH Duff
- JJ Roslyn
- JJ Tuech
- JK Kim
- JL Brozek
- JL Vincent
- JM Hay
- JO Jansen
- JP Sharpe
- JS Nam
- JS Solomkin
- JT Makela
- JV Roig
- JW Johnson
- JWC Leung
- K Gurusamy
- K Kortram
- K Kuwabara
- K Liu
- K Tsugawa
- Kaoru Koike
- Ken Boffard
- Kenneth Yuh Yen Kok
- Kiyoshi Murata
- KK Varadhan
- KM Jacob
- Kuo-Ching Yuan
- L Ansaloni
- L Corfield
- L Flancbaum
- L Hanau
- L Lorente
- L Salem
- L Salem
- L Trenti
- L Zorcolo
- LC DomĂnguez
- LH Hanau
- LJ Moore
- LJ Moore
- LL Powell
- LS Sasaki
- Luca Ansaloni
- M Cheng
- M Christensen
- M Foinant
- M Hoffmann
- M Johansson
- M Karoui
- M Khurrum Baig
- M Mutignani
- M Sartelli
- M Sartelli
- M Sartelli
- M Schein
- M Sinanan
- M Souli
- M Stapfer
- M Tabbara
- MA Gladman
- MA Malangoni
- Mario Paulo Faro
- Mark Malangoni
- Massimo Sartelli
- ME Falagas
- ME Kreis
- Miklosh Bala
- MJ Bertleff
- MJ Bertleff
- ML Hammond
- ML Townsend
- MM Levy
- MM Ozmen
- MN Al-Hasan
- MS Pearce
- MW Reimer
- N de Korte
- N Patel
- N Torer
- NA Kissane
- Nereo Vettoretto
- NO Machado
- Noel Naidoo
- Norio Sato
- NW Lee
- O Schwandner
- O van Ruler
- O Van Ruler
- O van Ruler
- P Ambrosetti
- P Ambrosetti
- P Augustin
- P Boele van Hensbroek
- P Bucher
- P Gertsch
- P Montravers
- P Montravers
- P Montravers
- P Nordmann
- P Pessaux
- P Seguin
- PA Bradford
- PA Lipsett
- PG Pappas
- Pierluigi Viale
- PR Miller
- R Ben-Ami
- R Enns
- R Kumar
- R Sinha
- Rafael DĂaz-Nieto
- Rao Ivatury
- Raul Coimbra
- RC Bone
- RE Andersson
- RJ Mason
- RM Urbaniak
- RP Dellinger
- RR Hutchins
- RR Kumar
- S Benoist
- S Biondo
- S Janes
- S Jwo
- S Khan
- S Kriwanek
- S Mulier
- S Nasim
- S Pungpapong
- S Sauerland
- S van den Hazel
- SA Cohen
- Salomone Di Saverio
- Sanjay Gupta
- Sanjay Marwah
- SE Araujo
- SK Rasilainen
- SM Hadad
- SM Hollenberg
- SP Hawser
- SR Menakuru
- SS Sarath Chandra
- ST Edino
- Suk-Kyung Hong
- T Eglinton
- T Herzog
- T Kiviluoto
- T Koperna
- T Lehnert
- T Siddiqui
- T Wild
- Takayuki Irahara
- TH Baron
- TH LĂŒning
- TJ Crofts
- TL Hedrick
- Tomohisa Shoko
- U Guller
- V Banz
- V Donckier
- V Emmi
- V Lohsiriwat
- Victor Kong
- VP Bauer
- Wagih Ghnnam
- Walter Biffl
- WJ Lin
- WS Cobb
- WT Siu
- WW Turner Jr
- WY Lau
- Y Abi-Haidar
- Y Adachi
- Yoram Kluger
- Yunfeng Cui
- Zsolt J Balogh
- Publication venue
- Publication date
- 01/01/2013
- Field of study
Peer reviewe
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro CarĂ Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
- Baron Rebecca M.
- Barreau Amelie
- Barreau Amélie
- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bayne Madeleine
- Bean Sarah
- Beane Abi
- Beane Abigail
- Beard Gregory
- Beasley Richard
- Beaudoin Rosalie
- Beavis Sarah
- Beddows Seonaid
- Bedford Caroline
- Beer Deborah
- Beer Sally
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Belletti Allesandro
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Bentley Andrew
- Benyon Sarah
- Benzekri Dalila
- Beqai Besa
- Berdaguer Fernando
- Beresford Stephanie
- Bergin Colin
- Berry Lindsay R.
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
- Bewley Jeremy
- Beyerl Ashley
- Bhagani Sanjay
- Bhandal Khushpreet
- Bharaj Kiranjit
- Bhattarai Bina
- Bhattarai Binita
- Bhonagiri Deepak
- Biddie Simon
- Bigas Judit
- Bihari Shailesh
- Bin Hasan Mohd Shahnaz
- Bindels Manon
- Binnie Alexandra
- Biradar Vishwanath
- Birch Catherine
- Birch Janine
- Birch Sophie
- Birchall Kathrine
- Birkinshaw Isobel
- Black Ethel
- Blackledge Bethany
- Blakemore Hayley
- Blanck Wendy
- Bland Yvonne
- Blank Elisabeth
- Bleasdale John
- Bloomfield Jack
- Bloos Frank
- Board Jasmin
- Boardman Melanie
- Boari Gianluca
- Bocher Simon
- Bociek Aneta
- Boivin Anne-Helene
- Boivin Anne-HĂ©lĂšne
- Bojunga Jörg
- Bomken Charlotte
- Bonaccorso Allesandra
- Bongaerts Katherine
- Bonner Stephen
- Bonten Marc J. M.
- Borgatta Barbara
- Borislavova Borislava
- Borrill Zoe
- Boschert Catherine
- Bossard Isabelle
- Bothma Pieter
- Boudineau Michel
- Boulanger Marie-Claude
- Boumahni Dounia
- Bouman Angela
- Bounab Rania
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Boutin Mireille
- Bouvier Elodie
- Bouw-Ruiter Marianne
- Boué Yvonnick
- Bowen James
- Bowler Helen
- Boyd Craig
- Boyles Rebecca
- Bracke Stephanie
- Bradbury Charlotte A.
- Bradley Paul
- Brady Kara
- Brailsford Jane
- Brain Matthew
- Brakké Karen
- Brant Emily
- Brasselet Aurélie
- Breen Patrick
- Bremmer Pamela
- Brend Morwenna
- Brennan Aoife
- Bretagnol Anne
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Bridges Sarah
- Brieger Klaus-Gerd
- Brightling Chris
- Brimfield Lutece
- Brittain Michael
- Britton Kate
- Brochard Laurent
- Brodbeck Andreas
- Brohi Farooq
- Brooks Nicole
- Brown Cynthia
- Brown Julia
- Brown Louise
- Brown Nerissa
- Brown Zarah
- Brugman Curt
- Brunetta Enrico
- Brunkhorst Frank M.
- Brunskill Nigel
- Bryan-Morris Kayla
- Bryden Emma
- Budd Joanna
- Buehner Ulrike
- Buhay Megan
- Buhr Heidi
- Burbee Dylan
- Burda Dorota
- Burgess Richard
- Burke David
- Burke Tara
- Burkey Jason
- Burnish Rachel
- Burns Dean
- Burns Karen
- Burrell Aidan
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler Magdalena
- Butler Susan
- Buxton Meredith
- Buzgau Adrian
- Byrne Kathleen
- Byrne Rahim
- Cabrelli Louise
- Cabreros Leilani
- Cairns Tom
- Calfee Carolyn
- Callahan Jean-Christophe
- Cambalova Lenka
- Campbell Andrew
- Campbell Bridget
- Campbell Debbie
- Campbell Hilary
- Campbell Lewis
- Campbell Marion
- Campbell Ryan
- Campion Alexandra
- Campisi Josie
- Camsooksai Julie
- Caplin Cecile
- Carbonneau Elaine
- Carmichael Samantha
- Carmona Rosario
- Carn Vanessa
- Carpio Lillian
- Carr Zoe
- Carr-Wilkinson Joanne
- Carrier François
- Carrier Marc
- Carter Angus
- Carter Brittney
- Carter David
- Carter Jay
- Carter Michael
- Casali Sherry
- Casey Ruth
- Casey Siobhan
- Castelain Vincent
- Castle James
- Cathcart Susanne
- Catorze Nuno José Teodoro Amaro dos Santos
- Cattelan Jessy
- Cavayas Alexandros
- Cawley Kathryn
- Cecconi Maurizio
- Centofanti John
- Chambers Emma
- Champanerkar Shreekant
- Chan Carmen
- Chan Charles
- Chan Peter
- Chapman Rachel
- Chapman Susan
- Charles Bethan
- Charles Walton
- Charlewood Richard
- Charlton Sam
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Jonathan
- Chen Lixian
- Chen Yan
- Cheng Allen C.
- Cherian Shiney
- Chhablani Manish
- Chin Teri
- Chudeau Nicolas
- Chukkambotla Sri
- Ciccarelli Michele
- Cirstea Emanuel
- Clair Bernard
- Clark Amy
- Clark Michele
- Clark Richard
- Clark Sarah
- Clarke Frances
- Clarke Jennifer
- Claxton Andrew
- Cleary Joanne
- Clement Ian
- Clere-Jehl Raphael
- Clermont Giles
- Clermont Gilles
- Clinton Alison
- Cloutier Ăve
- Cockrell Maeve
- Codreanu Daniel
- Coetzee Samantha
- Coghlan Phoebe
- Cole Jade
- Coles Jennifer
- Colin Gwenhael
- Collier Dawn
- Collins Amy
- Collins Daniel
- Collins Emma
- Collins Joanne
- Collins Ărin
- Collis Matthew
- Combaux Daniele
- Commons Robert
- Comp Susan
- Concha Pablo
- Connolly Karen
- Constantini Elena
- Constantino-Occhipinti Claudia
- Contou Damien
- Convery Karen
- Conway Robert
- Conzelmann Nadine
- Cook Deborah
- Cook Tim
- Cooke Jill
- Cooke Justin
- Cooper Jamie
- Cooper Josh
- Cooper Lauren
- Cooper Melanie
- Cooper Nichola
- Corbett Sarah
- Corcoran Ele
- Corcoran Kathleen
- Cornell Sarah
- Cornell Thomas
- Cort Jon
- Costerousse Olivier
- Couillard-ChĂ©nard Ămilie
- Courtin Laura
- Coutts Amanda
- Couture Lourie
- Cove Matthew
- Cowdrey Keri-Anne
- Cowley Nicholas
- Cowton Amanda
- Coyne Mark
- Craddock Richard
- Craner Michelle
- Craven Thomas
- Crawshaw Sarah
- Creagh-Brown Ben
- Creange Vanessa
- Cremer Olaf
- Crisp Nikki
- Croft Maria
- Csabi Peter
- Cudlipp Joanna
- Cuesta Jeronimo
- Cuffaro Raffaele
- Curley Gerard
- Currie Andrew
- Cusack Rebecca
- Cuthbertson Brian
- Cutler Sean
- CĂĄrcel Sheila
- CĂŽtĂ© Ămilie
- D?Amato Fabiola
- D?Aragon Frédérick
- Daebis Admad
- Daher Rana
- Dale Katie
- Daley Jessica
- Dalton James
- Daly James
- Daly Zoe
- Daneman Nick
- Dark Paul
- Darnell Robert
- Darreau Cedric
- Daugherty Jason
- Davey Miriam
- Davidson Neil
- Davies Ellie
- Davies Gwyneth
- Davies Jennifer
- Davies Louisa
- Davies Michelle
- Davies Rhys
- Dawson Laura Ann
- Dawvda Ashlish
- Day Christopher
- Da Rocha Joana
- De Bus Liesbet
- de Courcy-Golder Kim
- de Groot Klaas
- de Jong Menno
- de Jonge Evert
- De Keulenaer Bart
- de la Torre Cisneros Julian
- de Man Angelique
- De Neef Mark
- De Smeytere Anouska
- Deacon Bethan
- Dean Steven
- Dean Tessa
- Dearden Joy
- Dechert William
- Declercq Pierre-Louis
- Degracia Anna
- del Sorbo Lorenzo
- Dela Rosa Arnold
- Delaney Kirsha
- Dell Abbie
- del Prado Michael
- Demetriou Carrie
- Dempster Debra
- Denham Lynn
- Denmade Craig
- Dent Martin
- Depante Maria
- Depuydt Pieter
- Dequin Pierre-François
- Derde Lennie P. G.
- Deshpande Kush
- Detry Michelle A.
- Deye Nicolas
- de la Fuente Carmen
- De Waele Jan
- Dheke Krishan
- Di Lucca Giuseppe
- Dias Priya
- Dice Julie
- Digby Stephen
- Diridis Kristina
- Distler Michael
- Dobell-Brown Kelsey
- Doble Patricia
- Dobson Jade
- Doherty Kaleigh
- Doherty Ronan
- Doi Yohei
- Dolman Rozzie
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- Donadee Chenell
- Donaldson Kate
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- Donegan Clare
- Donlon Sinead
- Donnelly Adrian
- Donnelly Kieran
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- Doran Peter
- Dore Rachael
- Dormand Natalie
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- Douillard Thomas
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- Duan Erick
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- Duffy Eamon
- Duffy Oscar
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- Dunsavage Janice
- Duplaix Mathilde
- Duric Natalie
- Duroux Maree
- Dushianthan Ahilanandan
- Dyas Sarah
- Eapen Beena
- Eastgate Christine
- Ebenezer R
- Edmunds Natasha
- Edwards Alexandra
- Efford Georgia
- Egreteau Pierre
- Ehrmann Stephan
- Eichenauer Dennis
- Eisenbeis Simone
- Ekhérian Jean-Michel
- El-Khawas Khaled
- Elender Corinna
- Elgendy Ahmad
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- Ellervee Anneli
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- Elvira Evangeline
- England Jenna
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- Epelmanž Slava
- Eroglu Ege
- Estcourt Lise J.
- Estensen Kristen
- Evans Amy
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- Ewalds Esther
- Ezekowitz Justin
- Fagan Laura
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- Faulkner Beverley
- Faulkner Maria
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- Featherstone Peter
- Felton Tim
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- Ferguson Niall
- Ferguson Susan
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- Fernåndez de Pinedo Artaraz Ziortza
- Ferreira Ricardo Manuel Castro
- Ferrier Janet
- Ferringer Cindy
- Fesz Jessica
- Fierens Jan
- Finch Cheryl
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- Ford Megan
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- Foulds Angela
- Fowler Rob
- Fowler Robert
- Fox Claire
- Fox Eleonore
- Fragner Gertrud
- Frakking Thuy
- Franch-LLasat Diego
- Francis Olesya
- Francoeur François
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- Frankfurter Claudia
- Franz Christopher
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- Fraser Catherine
- Frater Alasdair
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- Frey Christian
- Frise Matthew
- Frost Victoria
- Fuchs Ralph
- Fujitani Shigeki
- Fysh Ed
- Gachet Alexandre
- Galbiati Carola
- Galea James
- Ganesan Arunkumar
- Ganesan Manisha
- Ganguly Saibal
- Garcia Sara
- Gardiner-Hill Caroline
- Garot Denis
- Garrard Hywel
- Garrard William
- Garrett Peter
- Garrier Ludivine
- Garrod Esther
- Garton Mark
- Garvey James
- Gascoyne Rachel
- Gattas David
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- Gemmell Lisa
- Gendall Emma
- Geng Wenli
- Geoghegan Pierce
- Geri Guillaume
- Geurts Heidi
- Ghaffari Mehrdad
- Ghamraoui Ali
- Ghattaoraya Amardeep
- Ghosh Alison
- Giardina Giuseppe
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- Gill Mandy
- Gilliam Matthew
- Gilmour Kate
- Girard Timothy
- Girijadevi Dinuraj
- Gladas Kirsty
- Glasby Kathleen
- Gledhill Lisa
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- Glynou Loukia
- Goddard Wendy
- Godement Mathieu
- Godoy Lucas C.
- Goebeler M.E.
- Golden David
- Goldman John
- Goligher Ewan
- Gomez Keith
- Gommans Frank
- Goodwin Jayne
- Goossens Herman
- Gopal Shameer
- Gopinath Amitha
- Goralski Patricia
- Gordon Anthony C.
- Gosbell Iain
- Gould Richard
- Grady Bart
- Graham Cheryl
- Graham Libby
- Graniewski Jaroslaw
- Grant Caroline
- GrauNovellas Neus
- Greco Massimiliano
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- Greener Danni
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- Gresham Rebecca
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- Grieve Richard
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- Grimmer Lisa
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- Gross Jamie
- GrĂŒnewaldt Achim
- Guanco Mark
- Guerineau Elodie
- Guitton Christophe
- Gummadi Mahitha
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- Guérin Emmanuelle
- GĂłmez Francisco
- Göpel Siri
- Habeichi Wadih
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- Hagel Stefan
- Haghi Theerata
- Haiba Khalid
- Haidar Ghady
- Haider Nafeesah
- Haider Syeda
- Hajdu Bence
- Hakak Sheeba
- Halden Sandra
- Haldeos Anne
- Hall Alistair S
- Hall Amelia
- Hall Andrew
- Hall Kathryn
- Hall Rebecca
- Hamilton David
- Hamilton-Davies Colin
- Hamlyn Vincent
- Hammond Naomi
- Hammonds Fiona
- Hand James
- Haniffa Rashan
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- Hanson Helen
- Hanson Jane
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- Harding Daniel
- Hardy Chloe
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- Harland Cain
- Harper Heather
- Harrington Claire
- Harrington Kate
- Harris Celia
- Harris Jade
- Harris John
- Harrison David A.
- Harrison Susan
- Harrow Kath
- Hartley Melissa
- Harvala-Simmonds Heli
- Harvey Alice
- Harvey Daniel
- Harvey James
- Harward Meg
- Hashmi Madhia
- Hashmi Madiha
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- Hawcutt Daniel
- Hawes Joanne
- Hawkins Nancy
- Hay Sophie
- Haydon Tim
- Hayes Amber
- Hayes Anne
- Hayes Kati
- Hayes Leanne
- HC Ooi
- Headdon William
- Headlam Evie
- Healey Gail
- Hegazy Ahmed
- Hegazy Mohamed
- Heinonen Jonna
- Helms Julie
- Heming Nicholas
- Henderson Kelly
- Henderson Steven
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- Henri-Lagarrigue Matthieu
- Henry Joanne
- Henry Lavinia
- Hensley Joseph
- Heritier Stephane
- Hernandez Erik
- Hewitt Claire
- Hey Samuel
- Hickey John
- Hierons Sarah
- Higgins Alisa M.
- Hill Claire
- Hill Dianne
- Hill Helen
- Hilldrith Anette
- Hills Thomas
- Hin Lui Lok
- Hindle Grace
- Hinrichs Carl
- Hird Clare
- Hodge Christopher
- Hodgson Carol
- Hodgson Helen
- Hoff Uwe
- Hoiting Oscar
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- Holland Andrew
- Holland Nicky
- Holland Susan
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- Homes Jennifer
- Honda Hitoshi
- Hope David
- Hopkins Phil
- Hormis Anil
- Horner Dan
- Hornsby James
- Horton Michelle
- Horvat Christopher M.
- Howcroft Clare
- Howell Alice
- Hower Martin
- Howie Lucy
- Howle Ryan
- Hoxha Elvira
- Huang David T.
- Hughes Debbie
- Hugill Keith
- Huijbens Danique
- Hullegie Sebastiaan
- Hulley Amanda
- Hulme Jonathan
- Hulse Sarah
- Humphrey Charlotte
- Hunt Beverley
- Hunter Stephanie
- Hurford Sally-Anne
- Hussain Mahwish
- Hussain Sajid
- Hutchinson Christina
- Hutton Paula
- HĂŒning Vanessa
- Ichihara Nao
- Ijaz Nazia
- Ikhena Ikhuemose
- Inskip Deborah
- Irving Ben
- Isgro Graziella
- Isguzar Agah
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- Ivatt Helen
- Jackson Carolyn
- Jackson Shane
- Jackson Susan
- Jacob Reni
- Jacquier Sophie
- Jafarzadeh Mina
- Jagannathan Vijay
- Jain Susan
- James Augustian
- James Christie
- Jan Hassing Robert
- Janin Pierre
- Jarczak Dominik
- Jarman Claire
- Jayakumar Deva
- Jayakumar Devachandran
- Jean-Pierre Eraldi
- Jeblaoui Asma
- Jenkins Samuel
- Jenkins Sarah
- Jenkins Steve
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- Jepson Eleanor
- Jerenec Katja
- Jesty Robert
- Jha Avinash
- Jha Rajeev
- Jhanji Shaman
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- Jongebloed Katherine
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- Juffermans Nicole
- Juhaz Vera
- Kadam Umesh
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- Kalchko-Veyssal Selver
- Kalchthaler Kyle
- Kaliappan Agilan
- Kalla Ismail
- Kalogirou Michael
- Kamata Kazuhiro
- Kamel Toufik
- Kampschreur Linda
- Kamra Maneesha
- Kandeepan Revathi
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- Kanwal Darakhshan
- Karachi Tim
- Karim Hina
- Karki Rakshya
- Karlikowski Michal
- Karlsson Sari
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- Katary Amro
- Kato Hideaki
- Kavanagh Lisa
- Kayani Abdul
- Kayastha Srijana
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- Kazi Aayesha
- KC Shirish
- KC Shirsh
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- Keatley Claire
- Keeler Sheryl
- Keen Alexandra
- Keen Sherbrina
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- Kell Kay
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- Kelly Niamh
- Kelsall Olivia
- Kendrick Sara
- Kernan Maeve
- Kerslake Ian
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- Khade Reena
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- Khanal Sushil
- Khare Divya
- Khoso Nasir
- Khoud Ahmed
- Khwaja Kosar
- Kidwai Aneela
- Kiiski Heikki
- Kilner Mari
- Kim Edy Y.
- Kimpton Sarah
- King Andrew
- Kinney Fiona
- Kirk Jill
- Kirk Rosemary
- Kirkby Amy
- Kirkham Simon
- Kit Barbara
- Kitsios Georgios
- Kittridge Lauren
- Klein Daniela
- Klop-Riehl Margreet
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- Kochanek Matthias
- Kochert Erik
- Koelink Maaike
- Koirala Kanchan
- Koirala Sabin
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- Kolovou Angeliki
- Konecny Pam
- Kong Jing
- Koopmans Matty
- Kosa Alma
- Kremling Julius
- KreĂ Gabriele
- Krishnamoorthy S
- Krishnamurthy Vinodh
- Kruger Peter
- Kruisdijk-Gerritsen Arriette
- Kruisselbrink Rebecca
- Kuitunen Anne
- Kumar Anand
- Kumar Nikhil
- Kumar Rohit
- Kummerlen Christine
- Kunishima Hiroyuki
- Kunwar Puja
- Kunz Kevin
- Kurenda Catherine
- Kutsogiannis Demetrios
- Kuybida Yuriy
- Kwan Yvonne
- Kyeremeh Lynsey
- Kyle Laura
- L?Hotellier Sylvie
- Labbe Vincent
- Laffan Mike
- Laffey John
- Laha Shondipon
- Lai Vivian
- Lambert Bridget
- Lamontagne Francois
- Lampro Lamprini
- Landais Michaël
- Landoni Giovanni
- Landsiedel-Mechenbier Elke
- Lang Eva
- Langridge Emma
- Latham Victoria
- Latino Reece
- Laudi Svenja
- Laugs Fabian
- Lavana Jayshree
- Laver Russell D.
- Law Daniel
- Lawler Patrick R.
- Le Basnier Elliot
- Le Guen LenaĂŻg
- Le Loup Guillaume
- Leaf David E.
- Lean Richard
- Leaver Susannah
- Leavis Helen
- Leblond Julie
- Leditschke Anne
- Lee Kelvin
- Lee Stephanie
- Lee Stephen
- Lefevre Montaine
- Leffelaar Evelien
- Lehalleur Adrien
- Lellouche Francois
- Lemaire-Brunel Delphine
- Lembo Rosalba
- Leparco CĂ©cile
- Leroyer Marie-Helene
- Lesona Eden
- Levett Chris
- Lewis Joanne
- Lewis Roger J.
- Lewis Sarah
- LewisProsser Lorraine
- Liao Angela
- Lim Rosario
- Limb James
- Lindergard Gabriella
- Linnett Vanessa
- Linstrum Kelsey M.
- Litton Ed
- Litton Edward
- Liu Theresa
- Lizotte Patricia
- Lock Stephen
- Lockett Teresa
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- Lomme Kaatje
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- Lorenzi Elizabeth
- Lother Sylvain
- Lowe Benjamin
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- Lucas Rachael
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- Luo Ji
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- Lynch Ceri
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- LĂłpez Maria
- LĂłpez Rafael
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- MacLennan Sheila
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- Madani Yasser
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- Maharjan Mili
- Maharjan Radhika
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- Major Emmet
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- Makky Ahmed
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- Manoharan Venika
- Maquigneau Natacha
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- Mariappa Vasanth
- Marin-Corral Judith
- Marin?ek Martin
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- Marion Beuzelin
- Markota Andrej
- Marmol Joy
- Marnai Remy
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- Marroquin Oscar
- Marsden Tracy
- Marsh Emma
- Marshall John C.
- Marshall Lucy
- Marten Nicole
- Martin Elise
- Martin Emma
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- Mason Brittany
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- Masse Marie-Helene
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- Maynard Victoria
- Mayr Florian
- Mc-Kenzie Josette
- McAdams David
- McArthur Colin J.
- McAuley Daniel F.
- McAuley Julie
- McCallion Edmund
- McCarthy Aine
- McClintock Declan
- McConnochie Rachael
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- McCullagh Liz
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- McGhee Christopher
- McGlothlin Anna
- McGloughlin Steve
- McGlynn Deborah
- McGoldrick Clare
- McGuigan Peter
- McGuinness Shay P.
- McIntyre Joanne
- McIntyre Lauralyn
- McKee Madeleine
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- Mclaughlan Danielle
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- McQuilten Zoe
- McVerry Bryan J.
- McWilliam Stephen
- Medhurst Laura
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- Mehrtens Jan
- Mehta Reena
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- Mouncey Paul R.
- Mowery Brent
- Mrad Aymen
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- Nicholier Tiphaine
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- Nicholson Anne
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- Osborne Jason
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- Oza Deepali
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- Panwar Rakshit
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- Paramasivam Elankumaran
- Parekh Dhruv
- Parikh Harshel G.
- Parke Rachael L.
- Parker Jane C.
- Parker Lorraine
- Parker Natasha
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- Polgarova Petra
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- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 nonâcritically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (nâ=â257), ARB (nâ=â248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; nâ=â10), or no RAS inhibitor (control; nâ=â264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ supportâfree days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ supportâfree days among critically ill patients was 10 (â1 to 16) in the ACE inhibitor group (nâ=â231), 8 (â1 to 17) in the ARB group (nâ=â217), and 12 (0 to 17) in the control group (nâ=â231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ supportâfree days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
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