Pengaruh Angin Dan Kelembapan Atmosfer Lapisan Atas Terhadap Lapisan Permukaan Di Manado

Penelitian ini mengkaji lebih dalam kondisi angin dan kelembapan udara pada saat musim hujan dan musim kemarau di Manado dengan menggunakan data di lapisan permukaan dan data udara atas dari Stasiun Meteorologi Sam Ratulangi Manado. Tujuan utama dari penelitian ini adalah mendapatkan hubungan antara kondisi angin dan kelembapan lapisan atas terhadap lapisan permukaan, sehingga dapat memprakirakan kondisi angin dan kelembapan lapisan permukaan dengan berdasarkan keadaan lapisan atas. Metode yang digunakan adalah mengkomponenkan angin dalam arah utara-selatan dan timur-barat, selanjutnya mencari keterkaitan dengan menggunakan teknik korelasi. Hasil penelitian ini menunjukkan pada saat musim hujan angin pada lapisan 1500 m dan angin di lapisan permukaan memiliki arah yang sama dan saling menguatkan untuk komponen timur-barat (zonal) dengan koefisien korelasi r=0,56, sedangkan pada saat musim kemarau angin pada lapisan 1500 m dan angin di lapisan permukaan memiliki arah yang sama dan saling menguatkan untuk komponen utara-selatan (meridional) dengan koefisien korelasi r=0,45. Keterkaitan yang cukup kuat antara angin dengan kelembapan terjadi pada komponen V (meridional) yaitu, pada saat musim hujan, semakin besar kecepatan angin komponen negatif (utara) semakin besar pula kelembapan udara di lapisan permukaan, dengan koefisien korelasi benilai positif r=0.40. Pada saat musim kemarau, semakin besar kecepatan angin komponen positif (selatan) semakin kecil kelembapan udara di lapisan permukaan, dengan koefisien korelasi bernilai negatif r=— 0,48.This study examined the wind and humidity condition in the rainy season and dry season in Manado by using the data in surface layer and upper air data from the Sam Ratulangi Meteorological Station. The primary objective of this study was to find the relationship between wind condition and upper layer humidity to surface layer, using correlation technique, in order to predict wind condition and humidity of the surface layer based on the condition of the upper layer. The results showed that, during the rainy season, the wind at layer 1500 m and surface layer had the same direction and mutually reinforced for the east-west component (zonal) with correlation coefficient r=0.56, whereas during the dry season, wind at layer 1500 m and at surface layer had the same direction and mutually reinforced for the north-south component (meridional) with correlation coefficient r=0.45. A relationship between wind and humidity was found at V component (meridional), which was, at rainy season, the higher the wind speed of negative component (north) the higher the humidity at surface layer with positive correlation coefficient r=0.40. At dry season, the higher the wind speed of positive component (south), the lower the humidity at the surface layer, with negative correlation coefficient r=—0.48

Early Detection Program for Breast and Cervical Cancer in Indonesia: How is Implementation?

Breast and cervical cancer have ranked first and second in terms of the highest cancer cases in Indonesia. The high incidence of breast and cervical cancer is due to the low coverage of early detection. This study aimed to examine the implementation of breast cancer early detection programs using the SADANIS method and cervical cancer using the IVA method. This current study used a qualitative and descriptive approach through input, process, output, and impact variables. Data was collected through in-depth interviews, observation, and documentation review. The results revealed that the number of trained human resources, facilities, and infrastructure was sufficient. The program had also implemented online and offline information systems and was actively conducting inspections integrated with the “Family Planning” program. The high achievement of the program had also been supported by the existence of an innovative screening system and direct examination in the community. The program achievements for 2021-2022 (January-June) and cases of cervical cancer had decreased. Implementing the early detection program for breast and cervical cancer is considered better. It can thus become a model for other regencies

The Influence of Early Marriage History on Stunting Risk: A Systematic Literature Review

Stunting, a chronic growth condition characterized by a height-for-age Z-score below -2 SD of the WHO median, poses significant health, developmental and cognitive challenges. This systematic literature review investigates the relationship between early marriage and the prevalence of stunting, emphasizing its impact on intergenerational malnutrition. Using databases such as ProQuest, Scopus, PubMed and Google Scholar, the study screened 6,679 articles and narrowed them down to 11 high-quality studies based on PRISMA guidelines. Findings showed that children born to teenage mothers face a higher risk of stunting due to lack of nutrition knowledge, limited access to health services and socioeconomic constraints. Early marriage is significantly correlated with high-risk fertility behaviors, including short birth spacing and high parity, which exacerbate stunting rates. In addition, cultural norms that encourage early marriage further exacerbate these challenges. The study highlights the need for multidimensional interventions that focus on delaying marriage and childbirth, improving maternal education, increasing access to healthcare, and empowering women through community- based programs. These strategies aim to break the intergenerational cycle of malnutrition, thereby advancing sustainable development goals and improving children's well-being in the long term

Promosi Kesehatan dalam Meningkatkan Pengetahuan Kesehatan Gigi dan Mulut pada Siswa di SD Muhammadiyah 24 Jakarta

Anak-anak merupakan kelompok yang rentan terhadap masalah kesehatan gigi seperti gigi berlubang dan bau mulut, yang dapat mengganggu fungsi gigi dan aktivitas sehari-hari. Penelitian ini bertujuan untuk mengevaluasi dampak promosi kesehatan menggunakan poster terhadap pengetahuan kesehatan gigi dan mulut pada anak-anak di SD Muhammadiyah 24 Jakarta pada tahun 2024. Metode: Penelitian ini menggunakan desain kuasi-eksperimental satu kelompok pre-post-test dengan 42 anak berusia 10-11 tahun dari kelas 5A dan 5B. Metode ceramah dengan poster digunakan sebagai intervensi. Data dikumpulkan melalui pre-test dan post-test dan dianalisis menggunakan uji-t dependen. Hasil: Rata-rata skor pengetahuan meningkat dari 60 sebelum intervensi menjadi 79,05 setelah intervensi. Peningkatan yang signifikan secara statistik diamati (p-value = 0,005), yang menunjukkan efektivitas intervensi. Kesimpulan: Penggunaan ceramah dan poster secara signifikan meningkatkan pengetahuan anak-anak tentang kesehatan gigi dan mulut. Strategi ini dianggap efektif untuk mempromosikan pengetahuan kesehatan gigi yang lebih baik di kalangan anak-anak Kata Kunci: Anak-anak, ceramah, kesehatan gigi dan mulut, pengetahuan

Association Between Body Mass Index and Mortality in Patients With Tuberculosis-HIV Co-Infection in Asia and Africa: A Systematic Review and Meta-Analysis Protocol

Globally, the prevalence of tuberculosis (TB) and human immunodeficiency virus (HIV) co-infection in 2019 was 8.2%. In 2020, TB-related deaths among individuals with HIV totaled 214,000, representing an increase from the previous year. Previous studies suggest that body mass index (BMI) is a significant predictor of mortality risk in individuals with TB and HIV co-infection, as malnutrition and low BMI are frequently linked to poorer clinical outcomes. This protocol has been developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) guidelines. A systematic review and meta-analysis will be conducted by searching three databases: MEDLINE/PubMed, Scopus, and ProQuest. This protocol aims to outline the stages and procedures of the forthcoming systematic review and meta-analysis, including the justification of the research question; the definition of Population, Exposure, Outcome, and Study design (PEOS); the inclusion and exclusion criteria; the search strategy; study screening and data extraction; and the planned data analysis. Identifying BMI as a prognostic factor through this study may inform nutrition-based interventions and treatment protocols aimed at reducing mortality among individuals co-infected with TB and HIV in Asia and Africa

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Seasonality in pulmonary tuberculosis among migrant workers entering Kuwait

<p>Abstract</p> <p>Background</p> <p>There is paucity of data on seasonal variation in pulmonary tuberculosis (TB) in developing countries contrary to recognized seasonality in the TB notification in western societies. This study examined the seasonal pattern in TB diagnosis among migrant workers from developing countries entering Kuwait.</p> <p>Methods</p> <p>Monthly aggregates of TB diagnosis results for consecutive migrants tested between January I, 1997 and December 31, 2006 were analyzed. We assessed the amplitude (<it>α</it>) of the sinusoidal oscillation and the time at which maximum (<it>θ</it>°) TB cases were detected using Edwards' test. The adequacy of the hypothesized sinusoidal curve was assessed by <it>χ</it>²goodness-of-fit test.</p> <p>Results</p> <p>During the 10 year study period, the proportion (per 100,000) of pulmonary TB cases among the migrants was 198 (4608/2328582), (95% confidence interval: 192 – 204). The adjusted mean monthly number of pulmonary TB cases was 384. Based on the observed seasonal pattern in the data, the maximum number of TB cases was expected during the last week of April (<it>θ</it>° = 112°; <it>P </it>< 0.001). The amplitude (± se) (<it>α </it>= 0.204 ± 0.04) of simple harmonic curve showed 20.4% difference from the mean to maximum TB cases. The peak to low ratio of adjusted number of TB cases was 1.51 (95% CI: 1.39 – 1.65). The <it>χ</it>²goodness-of-test revealed that there was no significant (<it>P </it>> 0.1) departure of observed frequencies from the fitted simple harmonic curve. Seasonal component explained 55% of the total variation in the proportions of TB cases (100,000) among the migrants.</p> <p>Conclusion</p> <p>This regularity of peak seasonality in TB case detection may prove useful to institute measures that warrant a better attendance of migrants. Public health authorities may consider re-allocation of resources in the period of peak seasonality to minimize the risk of <it>Mycobacterium tuberculosis </it>infection to close contacts in this and comparable settings in the region having similar influx of immigrants from high TB burden countries. Epidemiological surveillance for the TB risk in the migrants in subsequent years and required chemotherapy of detected cases may contribute in global efforts to control this public health menace.</p

Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra®, TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome

<p>Abstract</p> <p>Background</p> <p>Ezatiostat hydrochloride liposomes for injection, a glutathione S-transferase P1-1 inhibitor, was evaluated in myelodysplastic syndrome (MDS). The objectives were to determine the safety, pharmacokinetics, and hematologic improvement (HI) rate. Phase 1-2a testing of ezatiostat for the treatment of MDS was conducted in a multidose-escalation, multicenter study. Phase 1 patients received ezatiostat at 5 dose levels (50, 100, 200, 400 and 600 mg/m²) intravenously (IV) on days 1 to 5 of a 14-day cycle until MDS progression or unacceptable toxicity. In phase 2, ezatiostat was administered on 2 dose schedules: 600 mg/m²IV on days 1 to 5 or days 1 to 3 of a 21-day treatment cycle.</p> <p>Results</p> <p>54 patients with histologically confirmed MDS were enrolled. The most common adverse events were grade 1 or 2, respectively, chills (11%, 9%), back pain (15%, 2%), flushing (19%, 0%), nausea (15%, 0%), bone pain (6%, 6%), fatigue (0%, 13%), extremity pain (7%, 4%), dyspnea (9%, 4%), and diarrhea (7%, 4%) related to acute infusional hypersensitivity reactions. The concentration of the primary active metabolites increased proportionate to ezatiostat dosage. Trilineage responses were observed in 4 of 16 patients (25%) with trilineage cytopenia. Hematologic Improvement-Erythroid (HI-E) was observed in 9 of 38 patients (24%), HI-Neutrophil in 11 of 26 patients (42%) and HI-Platelet in 12 of 24 patients (50%). These responses were accompanied by improvement in clinical symptoms and reductions in transfusion requirements. Improvement in bone marrow maturation and cellularity was also observed.</p> <p>Conclusion</p> <p>Phase 2 studies of ezatiostat hydrochloride liposomes for injection in MDS are supported by the tolerability and HI responses observed. An oral formulation of ezatiostat hydrochloride tablets is also in phase 2 clinical development.</p> <p>Trial Registration</p> <p>Clinicaltrials.gov: NCT00035867</p

Investigating the Willingness to Pay for a Contributory National Health Insurance Scheme in Saudi Arabia:A Cross-sectional Stated Preference Approach

Background: The Saudi Healthcare System is universal, financed entirely from government revenue principally derived from oil, and is ‘free at the point of delivery’ (non-contributory). However, this system is unlikely to be sustainable in the medium to long term. This study investigates the feasibility and acceptability of healthcare financing reform by examining households’ willingness to pay (WTP) for a contributory national health insurance scheme. Methods: Using the contingent valuation method, a pre-tested interviewer-administered questionnaire was used to collect data from 1187 heads of household in Jeddah province over a 5-month period. Multi-stage sampling was employed to select the study sample. Using a double-bounded dichotomous choice with the follow-up elicitation method, respondents were asked to state their WTP for a hypothetical contributory national health insurance scheme. Tobit regression analysis was used to examine the factors associated with WTP and assess the construct validity of elicited WTP. Results: Over two-thirds (69.6%) indicated that they were willing to participate in and pay for a contributory national health insurance scheme. The mean WTP was 50 Saudi Riyal (US$13.33) per household member per month. Tobit regression analysis showed that household size, satisfaction with the quality of public healthcare services, perceptions about financing healthcare, education and income were the main determinants of WTP. Conclusions: This study demonstrates a theoretically valid WTP for a contributory national health insurance scheme by Saudi people. The research shows that willingness to participate in and pay for a contributory national health insurance scheme depends on participant characteristics. Identifying and understanding the main influencing factors associated with WTP are important to help facilitate establishing and implementing the national health insurance scheme. The results could assist policy-makers to develop and set insurance premiums, thus providing an additional source of healthcare financing

Canine models of copper toxicosis for understanding mammalian copper metabolism

Hereditary forms of copper toxicosis exist in man and dogs. In man, Wilson’s disease is the best studied disorder of copper overload, resulting from mutations in the gene coding for the copper transporter ATP7B. Forms of copper toxicosis for which no causal gene is known yet are recognized as well, often in young children. Although advances have been made in unraveling the genetic background of disorders of copper metabolism in man, many questions regarding disease mechanisms and copper homeostasis remain unanswered. Genetic studies in the Bedlington terrier, a dog breed affected with copper toxicosis, identified COMMD1, a gene that was previously unknown to be involved in copper metabolism. Besides the Bedlington terrier, a number of other dog breeds suffer from hereditary copper toxicosis and show similar phenotypes to humans with copper storage disorders. Unlike the heterogeneity of most human populations, the genetic structure within a purebred dog population is homogeneous, which is advantageous for unraveling the molecular genetics of complex diseases. This article reviews the work that has been done on the Bedlington terrier, summarizes what was learned from studies into COMMD1 function, describes hereditary copper toxicosis phenotypes in other dog breeds, and discusses the opportunities for genome-wide association studies on copper toxicosis in the dog to contribute to the understanding of mammalian copper metabolism and copper metabolism disorders in man