Implementasi Kurikulum Syari’ah Mohammad Sholeh Y.A.I di Sekolah Dasar Muhammadiyah Program Khusus Kottabarat Tahun 2009/2010

This research is conducted on the basis of thinking that separates between science (general) and the science of religion. This resulted in Muslims being in a state of decline. Another reason for this is the distinction between public schools and Islamic schools. Therefore several attempts have been made to overcome this problem. One form of the solution is an idea put forward by Mochamad Sholeh Y.A.I. He tried to integrate between Shari'ah (al-Qur'an and al-Hadith) with national curriculum and international nuance, because based on the development of the times. The curriculum is a Syari'ah curriculum, and he realizes the idea in a book called Shari'ah Science. By conducting content analysis, the idea of Mochamad Sholeh Y.A.I. contained in the book can be clearly described. The purpose of this research is to understand and understand curriculum integration as well as curriculum integration model in Islamic education in the view of Mochamad Sholeh Y.A.I., while the benefit of this research is theoretically Broadening insights on education, especially on curriculum integration model in Islamic education according to Mochamad Sholeh Y.A.I.The result of this research is that curriculum integration in view of Mochamad Sholeh Y.A.I. is to integrate between the Qur'an, al-hadith, Indonesian nature and international development. Mochamad Sholeh Y.A.I. is a reformer or innovator in Islamic education. The purpose of education by Mochamad Sholeh Y.A.I. is to form a personal ulul albab, a person who always returns at the beginning of human created to become a khalifah on this earth (Q.S. Al Baqarah, 2:30). While the curriculum development model that he practices is a model of integrated curriculum development or an integrated curriculum. It combines al-Qur'an, al-Hadith, national or local curriculum, Indonesian nature and international development. These are the elements of the Syari'ah Curriculum. Evident in the emergence of the idea of the Syari'ah Curriculum which he realizes in the book Shari'ah Science and he practiced in the Muhammadiyah Primary School Special Program of Surakarta in an inclusive learning system

Implementasi Kurikulum Syari’ah Mohammad Sholeh Y.A.I di Sekolah Dasar Muhammadiyah Program Khusus Kottabarat Tahun 2009/2010

This research is conducted on the basis of thinking that separates between science (general) and the science of religion. This resulted in Muslims being in a state of decline. Another reason for this is the distinction between public schools and Islamic schools. Therefore several attempts have been made to overcome this problem. One form of the solution is an idea put forward by Mochamad Sholeh Y.A.I. He tried to integrate between Shari'ah (al-Qur'an and al-Hadith) with national curriculum and international nuance, because based on the development of the times. The curriculum is a Syari'ah curriculum, and he realizes the idea in a book called Shari'ah Science. By conducting content analysis, the idea of Mochamad Sholeh Y.A.I. contained in the book can be clearly described. The purpose of this research is to understand and understand curriculum integration as well as curriculum integration model in Islamic education in the view of Mochamad Sholeh Y.A.I., while the benefit of this research is theoretically Broadening insights on education, especially on curriculum integration model in Islamic education according to Mochamad Sholeh Y.A.I.The result of this research is that curriculum integration in view of Mochamad Sholeh Y.A.I. is to integrate between the Qur'an, al-hadith, Indonesian nature and international development. Mochamad Sholeh Y.A.I. is a reformer or innovator in Islamic education. The purpose of education by Mochamad Sholeh Y.A.I. is to form a personal ulul albab, a person who always returns at the beginning of human created to become a khalifah on this earth (Q.S. Al Baqarah, 2:30). While the curriculum development model that he practices is a model of integrated curriculum development or an integrated curriculum. It combines al-Qur'an, al-Hadith, national or local curriculum, Indonesian nature and international development. These are the elements of the Syari'ah Curriculum. Evident in the emergence of the idea of the Syari'ah Curriculum which he realizes in the book Shari'ah Science and he practiced in the Muhammadiyah Primary School Special Program of Surakarta in an inclusive learning system

Global Assemblages, Resilience, and Earth Stewardship in the Anthropocene

In this paper, we argue that the Anthropocene is an epoch characterized not only by the anthropogenic dominance of the Earth\u27s ecosystems but also by new forms of environmental governance and institutions. Echoing the literature in political ecology, we call these new forms of environmental governance “global assemblages”. Socioecological changes associated with global assemblages disproportionately impact poorer nations and communities along the development continuum, or the “Global South”, and others who depend on natural resources for subsistence. Although global assemblages are powerful mechanisms of socioecological change, we show how transnational networks of grassroots organizations are able to resist their negative social and environmental impacts, and thus foster socioecological resilience

Pemanfaatan Sumber Belajar Berbasis Multimedia Dalam Pembelajaran Pendidikan Agama Islam Di Smp Muhammadiyah Al-Kautsar Program Khusus Tahun Ajaran 2016/2017

ABSTRACT Learning is a complex process that occurs in every person throughout his life. The development of science and technology increasingly encourage renewal efforts in the utilization of technological results in the learning process of teachers required to be able to use the tools that can be provided by the school, and it is possible that these tools in accordance with the development and demands of the times. In a teaching and learning process, two very important elements are teaching methods and multimedia learning. These two aspects are interrelated. Therefore the authors do research on the use of multimedia-based learning resources in learning, especially learning Islamic religious education. The purpose of this study is to know and describe the use of multimedia-based learning resources in learning Islamic Religious Education in SMP Muhammadiyah Al-kautsar Special Program academic year 2016/2017. This research is included in field research by using qualitative descriptive method. Then the data collection method used is, observation, interview and documentation and data analysis using inductive method. Based on the results of research and data analysis, the use of multimedia in learning is very important role on the academic value of student learning, in this case can be seen from the results of student daily re-examination. Before using the multimedia values obtained by the students from the daily test, the student score varies with the lowest average value of the value of the value of 50-65 (E) 65%, 70-80 (C) 25%, 90-95 ( A) 10% while after using the learning process using multimedia result of daily value of student average student who get lowest score 70-75 (C) 65%, value 80-85 (B) 15%, value 90-95 (A) 20% so learning without using the lowest multimedia value of 50 and while the learning using multimedia the lowest value of 70. The learning time used for teaching is not wasted. This is what can make learning time to be effective, and the learning atmosphere to be efficient by using multimedia so that learning is more interesting and interactive. Keywords: Learning Resources, Use, Multimedi

EphA2-receptor deficiency exacerbates myocardial infarction and reduces survival in hyperglycemic mice

Background We have previously shown that EphrinA1/EphA expression profile changes in response to myocardial infarction (MI), exogenous EphrinA1-Fc administration following MI positively influences wound healing, and that deletion of the EphA2 Receptor (EphA2-R) exacerbates injury and remodeling. To determine whether or not ephrinA1-Fc would be of therapeutic value in the hyperglycemic infarcted heart, it is critical to evaluate how ephrinA1/EphA signaling changes in the hyperglycemic myocardium in response to MI. Methods Streptozotocin (STZ)-induced hyperglycemia in wild type (WT) and EphA2-receptor mutant (EphA2-R-M) mice was initiated by an intraperitoneal injection of STZ (150 mg/kg) 10 days before surgery. MI was induced by permanent ligation of the left anterior descending coronary artery and analyses were performed at 4 days post-MI. ANOVAs with Student-Newman Keuls multiple comparison post-hoc analysis illustrated which groups were significantly different, with significance of at least p < 0.05. Results Both WT and EphA2-R-M mice responded adversely to STZ, but only hyperglycemic EphA2-R-M mice had lower ejection fraction (EF) and fractional shortening (FS). At 4 days post-MI, we observed greater post-MI mortality in EphA2-R-M mice compared with WT and this was greater still in the EphA2-R-M hyperglycemic mice. Although infarct size was greater in hyperglycemic WT mice vs normoglycemic mice, there was no difference between hyperglycemic EphA2-R-M mice and normoglycemic EphA2-R-M mice. The hypertrophic response that normally occurs in viable myocardium remote to the infarct was noticeably absent in epicardial cardiomyocytes and cardiac dysfunction worsened in hyperglycemic EphA2-R-M hearts post-MI. The characteristic interstitial fibrotic response in the compensating myocardium remote to the infarct also did not occur in hyperglycemic EphA2-R-M mouse hearts to the same extent as that observed in the hyperglycemic WT mouse hearts. Differences in neutrophil and pan-leukocyte infiltration and serum cytokines implicate EphA2-R in modulation of injury and the differences in ephrinA1 and EphA6-R expression in governing this are discussed. Conclusions We conclude that EphA2-mutant mice are more prone to hyperglycemia-induced increased injury, decreased survival, and worsened LV remodeling due to impaired wound healing

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort

BACKGROUND: Epidemiological studies have observed a positive association between an earlier age at sexual development and prostate cancer, but markers of sexual maturation in boys are imprecise and observational estimates are likely to suffer from a degree of uncontrolled confounding. To obtain causal estimates, we examined the role of pubertal development in prostate cancer using genetic polymorphisms associated with Tanner stage in adolescent boys in a Mendelian randomization (MR) approach. METHODS: We derived a weighted genetic risk score for pubertal development, combining 13 SNPs associated with male Tanner stage. A higher score indicated a later puberty onset. We examined the association of this score with prostate cancer risk, stage and grade in the UK-based ProtecT case-control study (n = 2,927), and used the PRACTICAL consortium (n = 43,737) as a replication sample. RESULTS: In ProtecT, the puberty genetic score was inversely associated with prostate cancer grade (odds ratio (OR) of high- vs. low-grade cancer, per tertile of the score: 0.76; 95 % CI, 0.64-0.89). In an instrumental variable estimation of the causal OR, later physical development in adolescence (equivalent to a difference of one Tanner stage between pubertal boys of the same age) was associated with a 77 % (95 % CI, 43-91 %) reduced odds of high Gleason prostate cancer. In PRACTICAL, the puberty genetic score was associated with prostate cancer stage (OR of advanced vs. localized cancer, per tertile: 0.95; 95 % CI, 0.91-1.00) and prostate cancer-specific mortality (hazard ratio amongst cases, per tertile: 0.94; 95 % CI, 0.90-0.98), but not with disease grade. CONCLUSIONS: Older age at sexual maturation is causally linked to a reduced risk of later prostate cancer, especially aggressive disease

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation

Although genome-wide association studies have identified over 100 risk loci that explain ~33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue as well as between tissue and cell lines. The majority of SNP heritability lies in regions marked by H3k27 acetylation in prostate adenoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines. We find a high degree of similarity between European and African American ancestries suggesting a similar genetic architecture from common variation underlying PrCa risk. Our findings showcase the power of integrating functional annotation with genetic data to understand the genetic basis of PrCa