A systematic review of neuroprotective strategies after cardiac arrest: from bench to bedside (Part I - Protection via specific pathways).

Neurocognitive deficits are a major source of morbidity in survivors of cardiac arrest. Treatment options that could be implemented either during cardiopulmonary resuscitation or after return of spontaneous circulation to improve these neurological deficits are limited. We conducted a literature review of treatment protocols designed to evaluate neurologic outcome and survival following cardiac arrest with associated global cerebral ischemia. The search was limited to investigational therapies that were utilized to treat global cerebral ischemia associated with cardiac arrest. In this review we discuss potential mechanisms of neurologic protection following cardiac arrest including actions of several medical gases such as xenon, argon, and nitric oxide. The 3 included mechanisms are: 1. Modulation of neuronal cell death; 2. Alteration of oxygen free radicals; and 3. Improving cerebral hemodynamics. Only a few approaches have been evaluated in limited fashion in cardiac arrest patients and results show inconclusive neuroprotective effects. Future research focusing on combined neuroprotective strategies that target multiple pathways are compelling in the setting of global brain ischemia resulting from cardiac arrest

Preliminary Calendar of the Nevil Shute Norway Manuscripts Microfilm

In 1971 Syracuse University Library made an agreement with the National Library of Australia, whereby the National Library microfilmed the complete manuscript collection of Nevil Shute Norway\u27s papers in its possession and sent the microfilm to the Arents Library of Syracuse University. Syracuse makes this film available to responsible scholars with the understanding that users of the microfilm will cite the National Library of Australia as the repository owning the original manuscripts and will make all references to the numbering identification system prepared by the National Library

Financial Problems of a Revolutionary: The Memoir of John Wilkins

In this article, Howard L. Applegate describes and includes an excerpt of the autobiography of John Wilkins, a shop owner in Pennsylvania during the American Revolution period who became a militia captain. Instead of detailing the colonial militia of the time, Wilkins related how militia members often took on significant financial burdens in order to keep the regiment intact, and lamented the rampant devaluation, inflation and speculation that occurred during this turbulent period in American history

Interim Land Use Control Implementation Plan

This Interim Land Use Control Implementation Plan (LUCIP) has been prepared to inform current and potential future users of the Kennedy Space Center (KSC) Contractors Road Heavy Equipment (CRHE) Area (SWMU 055; "the Site") of institutional controls that have been implemented at the Site1. Although there are no current unacceptable risks to human health or the environment associated with the CRHE Area, an interim institutional land use control (LUC) is necessary to prevent human health exposure to volatile organic compound (VOC)-affected groundwater at the Site. Controls will include periodic inspection, condition certification, and agency notification

Diffusive behavior of a greedy traveling salesman

Using Monte Carlo simulations we examine the diffusive properties of the greedy algorithm in the d-dimensional traveling salesman problem. Our results show that for d=3 and 4 the average squared distance from the origin is proportional to the number of steps t. In the d=2 case such a scaling is modified with some logarithmic corrections, which might suggest that d=2 is the critical dimension of the problem. The distribution of lengths also shows marked differences between d=2 and d>2 versions. A simple strategy adopted by the salesman might resemble strategies chosen by some foraging and hunting animals, for which anomalous diffusive behavior has recently been reported and interpreted in terms of Levy flights. Our results suggest that broad and Levy-like distributions in such systems might appear due to dimension-dependent properties of a search space.Comment: accepted in Phys. Rev.

Archaeological Evidence of Historic Mining at Forestville Saltpeter Cave (15Ht94), Hart County, Kentucky

Forestville Saltpeter Cave is 1.5 km east of Mammoth Cave National Park on the WKU Green River Preserve. Historically, miners removed sediment from the cave to extract saltpeter for the production of gunpowder. Though dozens of peter-mining sites are known in western Kentucky, Forestville Saltpeter Cave is only the third site investigated by archaeologists. Intensive surface survey documented evidence of mining activity in the cave: working bays, rock piles, tally and other marks, tool marks, inscriptions, and lighting material. The mining likely occurred during the early nineteenth century. The operations were extensive throughout all passages and extracted 856 cu m of sediment

The Yellowstone Permutation

Define a sequence of positive integers by the rule that a(n) = n for 1 <= n = 4, a(n) is the smallest number not already in the sequence which has a common factor with a(n-2) and is relatively prime to a(n-1). We show that this is a permutation of the positive integers. The remarkable graph of this sequence consists of runs of alternating even and odd numbers, interrupted by small downward spikes followed by large upward spikes, suggesting the eruption of geysers in Yellowstone National Park. On a larger scale the points appear to lie on infinitely many distinct curves. There are several unanswered questions concerning the locations of these spikes and the equations for these curves.Comment: 10 pages, 6 figures. Mar 7 2015: mostly stylistic change

OSMD: Cultural competence tool for research, education, and practice

Results from a mixed methods study provide insight into redefining multicultural counseling competencies specific to school counselors. Foci include new counseling competencies and implications for counselor educators. Attendees will explore aspects of multiculturalism, counseling competencies of school counselors, research implications, and its importance for the field. Also discussed will be applying information to the development of skills, knowledge, and awareness of counselors-in-training through specific pedagogical examples. Participant discussion is vital to this presentation to further discuss content area, explore redefining multiculturalism, and implications this research has for both practicing counselors and counselor educators. Attendees can expect to gain groundbreaking theory based in detailed research to restructure multicultural counselor education

Forward

Scientific information has become a centralr ationalef or environmental regulation, and scientific uncertainty is viewed as a major obstacle in developing, justifying, and enforcing environmental laws and policies. In the context of environmental regulation, scientific information may be analyzed as subject to both supply and demand. A regulatory system that supplies more scientific information than it demands can operate effectively to impose protective regulation. By contrast, a system that demands more information than it supplies will face a data gap and will fail to accomplish its protective goals. The data gap can be addressed by applying regulatory techniques that increase the supply of data by providing more information (\u27filling the gap) or that reduce the demand by permitting regulation to proceed despite uncertainty and incomplete information ( bridging the gap). Environmental law is also structured by the divide between pollution control and chemical regulation on the one hand, and resource management on the other. In addressing the data gap, therefore, it is necessary to distinguish not only between supply and demand, but also between chemical and conservation issues. The existence of a data gap between the scientific information necessary for effective environmental regulation and the information available to regulators and the public presents an opportunity to study the causes and extent of the differences in the chemical and conservation regulatory systems. Missing Information: The Scientific Data Gap in Conservation and Chemical Regulation, Symposium held on March 24, 2006 at Indiana University School of Law- Bloomington