8,222 research outputs found
A Deep Learning Framework for Optimization of MISO Downlink Beamforming
Beamforming is an effective means to improve the quality of the received signals in multiuser multiple-input-singleoutput (MISO) systems. Traditionally, finding the optimal beamforming solution relies on iterative algorithms, which introduces high computational delay and is thus not suitable for realtime implementation. In this paper, we propose a deep learning framework for the optimization of downlink beamforming. In particular, the solution is obtained based on convolutional neural networks and exploitation of expert knowledge, such as the uplink-downlink duality and the known structure of optimal solutions. Using this framework, we construct three beamforming neural networks (BNNs) for three typical optimization problems, i.e., the signal-to-interference-plus-noise ratio (SINR) balancing problem, the power minimization problem, and the sum rate maximization problem. For the former two problems the BNNs adopt the supervised learning approach, while for the sum rate maximization problem a hybrid method of supervised and unsupervised learning is employed. Simulation results show that the BNNs can achieve near-optimal solutions to the SINR balancing and power minimization problems, and a performance close to that of the weighted minimum mean squared error algorithm for the sum rate maximization problem, while in all cases enjoy significantly reduced computational complexity. In summary, this work paves the way for fast realization of optimal beamforming in multiuser MISO systems
Use of Cell Viability Assay Data Improves the Prediction Accuracy of Conventional Quantitative StructureâActivity Relationship Models of Animal Carcinogenicity
BackgroundTo develop efficient approaches for rapid evaluation of chemical toxicity and human health risk of environmental compounds, the National Toxicology Program (NTP) in collaboration with the National Center for Chemical Genomics has initiated a project on high-throughput screening (HTS) of environmental chemicals. The first HTS results for a set of 1,408 compounds tested for their effects on cell viability in six different cell lines have recently become available via PubChem.ObjectivesWe have explored these data in terms of their utility for predicting adverse health effects of the environmental agents.Methods and resultsInitially, the classification k nearest neighbor (kNN) quantitative structureâactivity relationship (QSAR) modeling method was applied to the HTS data only, for a curated data set of 384 compounds. The resulting models had prediction accuracies for training, test (containing 275 compounds together), and external validation (109 compounds) sets as high as 89%, 71%, and 74%, respectively. We then asked if HTS results could be of value in predicting rodent carcinogenicity. We identified 383 compounds for which data were available from both the Berkeley Carcinogenic Potency Database and NTPâHTS studies. We found that compounds classified by HTS as âactivesâ in at least one cell line were likely to be rodent carcinogens (sensitivity 77%); however, HTS âinactivesâ were far less informative (specificity 46%). Using chemical descriptors only, kNN QSAR modeling resulted in 62.3% prediction accuracy for rodent carcinogenicity applied to this data set. Importantly, the prediction accuracy of the model was significantly improved (72.7%) when chemical descriptors were augmented by HTS data, which were regarded as biological descriptors.ConclusionsOur studies suggest that combining NTPâHTS profiles with conventional chemical descriptors could considerably improve the predictive power of computational approaches in toxicology
Functionally informative tag SNP selection using a pareto-optimal approach: playing the game of life
Determining Principal Component Cardinality through the Principle of Minimum Description Length
PCA (Principal Component Analysis) and its variants areubiquitous techniques
for matrix dimension reduction and reduced-dimensionlatent-factor extraction.
One significant challenge in using PCA, is thechoice of the number of principal
components. The information-theoreticMDL (Minimum Description Length) principle
gives objective compression-based criteria for model selection, but it is
difficult to analytically applyits modern definition - NML (Normalized Maximum
Likelihood) - to theproblem of PCA. This work shows a general reduction of NML
prob-lems to lower-dimension problems. Applying this reduction, it boundsthe
NML of PCA, by terms of the NML of linear regression, which areknown.Comment: LOD 201
Segregation of Mn, Si, Al, and oxygen during the friction stir welding of DH36 steel
This work investigates the role of welding speed
in elemental segregation of Mn, Si, Al, and oxygen during
friction stir welding (FSW) in DH36 steel. The experimental
work undertaken showed that when the speed of the
FSW process exceeds 500 RPM with a traverse speed of
400 mm/min, then elemental segregation of Mn, Si, Al,
and O occurred. The mechanism of this segregation is not
fully understood; additionally, the presence of oxygen
within these segregated elements needs investigation. This
work examines the elemental segregation within DH36
steel by conducting heat treatment experiments on unwelded
samples incrementally in the range of 1200â1500 °C
and at cooling rates similar to that in FSW process. The
results of heat treatments were compared with samples
welded under two extremes of weld tool speeds, namely
W1 low tool speeds (200 RPM with traverse speed of
100 mm/min) and W2 high tool speeds (550 RPM with
traverse speed of 400 mm/min). The results from the heat
treatment trials showed that segregation commences when
the temperature exceeds 1400 °C and Mn, Si, Al, and
oxygen segregation progress occurs at 1450 °C and at a
cooling rate associated with acicular ferrite formation. It
was also found that high rotational speeds exceeding
500 RPM caused localized melting at the advancing-trailing
side of the friction stir-welded samples. The study aims
to estimate peak temperature limits at which elemental
segregation does not occur and hence prevent their occurrence
in practice by applying the findings to the toolâs
rotational and traverse speed that correspond to the defined
temperature
Weather-based forecasting of mosquito-borne disease outbreaks in Canada.
Early warning systems to predict infectious disease outbreaks have been identified as a key adaptive response to climate change. Warming, climate variability and extreme weather events associated with climate change are expected to drive an increase in frequency and intensity of mosquito-borne disease (MBD) outbreaks globally. In Canada, this will mean an increased risk of endemic and emerging MBD outbreaks such as West Nile virus and other MBDs. The availability of timely information on the risk of impending MBD outbreaks has important public health implications, by allowing implementation of mosquito control measures and targeted communications regarding the need for increased personal protective measures-before an outbreak occurs. In Canada, both mechanistic and statistical weather-based models have been developed to predict West Nile virus outbreaks. These include models for different species of mosquitoes that transmit West Nile virus in different geographical areas of Canada. Although initial results have been promising, further validation and assessment of forecasting skill are needed before wide scale implementation. Weather-based forecasting for other emerging MBDs in Canada, such as Eastern equine encephalitis, may also be feasible
Back reaction, covariant anomaly and effective action
In the presence of back reaction, we first produce the one-loop corrections
for the event horizon and Hawking temperature of the Reissner-Nordstr\"om black
hole. Then, based on the covariant anomaly cancelation method and the effective
action technique, the modified expressions for the fluxes of gauge current and
energy momentum tensor, due to the effect of back reaction, are obtained. The
results are consistent with the Hawking fluxes of a (1+1)-dimensional blackbody
at the temperature with quantum corrections, thus confirming the robustness of
the covariant anomaly cancelation method and the effective action technique for
black holes with back reaction.Comment: 17 page
A Method for Serial Tissue Processing and Parallel Analysis of Aberrant Crypt Morphology, Mucin Depletion, and Beta-Catenin Staining in an Experimental Model of Colon Carcinogenesis
The use of architectural and morphological characteristics of cells for establishing prognostic indicators by which individual pathologies are assigned grade and stage is a well-accepted practice. Advances in automated micro- and macroscopic image acquisition and digital image analysis have created new opportunities in the field of prognostic assessment; but, one area in experimental pathology, animal models for colon cancer, has not taken advantage of these opportunities. This situation is primarily due to the methods available to evaluate the colon of the rodent for the presence of premalignant and malignant pathologies. We report a new method for the excision and processing of the entire colon of the rat and illustrate how this procedure permitted the quantitative assessment of aberrant crypt foci (ACF), a premalignant colon pathology, for characteristics consistent with progression to malignancy. ACF were detected by methylene blue staining and subjected to quantitative morphometric analysis. Colons were then restained with high iron diamineâalcian blue for assessment of mucin depletion using an image overlay to associate morphometric data with mucin depletion. The subsequent evaluation of ACF for beta-catenin staining is also demonstrated. The methods described are particularly relevant to the screening of compounds for cancer chemopreventive activity
Conscious monitoring and control (reinvestment) in surgical performance under pressure.
Research on intraoperative stressors has focused on external factors without considering individual differences in the ability to cope with stress. One individual difference that is implicated in adverse effects of stress on performance is "reinvestment," the propensity for conscious monitoring and control of movements. The aim of this study was to examine the impact of reinvestment on laparoscopic performance under time pressure
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