El conocimiento de segundas lenguas en el marco de la enseñanza basada en competencias

Diseñar las titulaciones en torno a perfiles profesionales y orientar la enseñanza hacia la adquisición de competencias son dos de los grandes retos que se plantean en el proceso de convergencia del EEES. Entre las competencias genéricas que se pretende que adquieran los alumnos se sitúa la enseñanza de una segunda lengua. En este trabajo analizamos la importancia de dicha competencia dentro del contexto de los estudios de Empresariales, análisis que apoyamos en algunos de los datos obtenidos en un estudio realizado por la red europea Thenexom, a la que pertenecen los autores. Establecida dicha importancia, mostramos las vías que la EUEE de la Universidad de Sevilla ofrece a sus alumnos para adquirir tales competencias

Combined treatment of graft versus host disease using donor regulatory T cells and ruxolitinib

Donor derived regulatory T lymphocytes and the JAK1/2 kinase inhibitor ruxolitinib are currently being evaluated as therapeutic options in the treatment of chronic graft versus host disease (cGvHD). In this work, we aimed to determine if the combined use of both agents can exert a synergistic efect in the treatment of GvHD. For this purpose, we studied the efect of this combination both in vitro and in a GvHD mouse model. Our results show that ruxolitinib favors the ratio of thymic regulatory T cells to conventional T cells in culture, without afecting the suppressive capacity of these Treg. The combination of ruxolitinib with Treg showed a higher efcacy as compared to each single treatment alone in our GvHD mouse model in terms of GvHD incidence, severity and survival without hampering graft versus leukemia efect. This benefcial efect correlated with the detection in the bone marrow of recipient mice of the infused donor allogeneic Treg after the adoptive transfer

A detailed analysis of the Gl 486 planetary system

Context. The Gl 486 system consists of a very nearby, relatively bright, weakly active M3.5 V star at just 8 pc with a warm transiting rocky planet of about 1.3 R-circle plus and 3.0 M-circle plus. It is ideal for both transmission and emission spectroscopy and for testing interior models of telluric planets. Aims. To prepare for future studies, we aim to thoroughly characterise the planetary system with new accurate and precise data collected with state-of-the-art photometers from space and spectrometers and interferometers from the ground. Methods. We collected light curves of seven new transits observed with the CHEOPS space mission and new radial velocities obtained with MAROON-X at the 8.1 m Gemini North telescope and CARMENES at the 3.5 m Calar Alto telescope, together with previously published spectroscopic and photometric data from the two spectrographs and TESS. We also performed near-infrared interferometric observations with the CHARA Array and new photometric monitoring with a suite of smaller telescopes (AstroLAB, LCOGT, OSN, TJO). This extraordinary and rich data set was the input for our comprehensive analysis. Results. From interferometry, we measure a limb-darkened disc angular size of the star Gl 486 at theta(LDD) = 0.390 +/- 0.018 mas. Together with a corrected Gaia EDR3 parallax, we obtain a stellar radius R-* = 0.339 +/- 0.015 R-circle plus. We also measure a stellar rotation period at P-rot = 49.9 +/- 5.5 days, an upper limit to its XUV (5-920 A) flux informed by new Hubble/STIS data, and, for the first time, a variety of element abundances (Fe, Mg, Si, V, Sr, Zr, Rb) and C/O ratio. Moreover, we imposed restrictive constraints on the presence of additional components, either stellar or sub-stellar, in the system. With the input stellar parameters and the radial-velocity and transit data, we determine the radius and mass of the planet Gl 486 b at R-p = 1.343(-0.062)(+0.063) R-circle plus and M-p = 3.00(-0.12)(+0.13) M-circle plus, with relative uncertainties of the planet radius and mass of 4.7% and 4.2%, respectively. From the planet parameters and the stellar element abundances, we infer the most probable models of planet internal structure and composition, which are consistent with a relatively small metallic core with respect to the Earth, a deep silicate mantle, and a thin volatile upper layer. With all these ingredients, we outline prospects for Gl 486 b atmospheric studies, especially with forthcoming James Webb Space Telescope (Webb) observations.The David & Lucile Packard FoundationHeising-Simons FoundationGemini ObservatoryUniversity of ChicagoMax Planck SocietyConsejo Superior de Investigaciones Cientificas (CSIC)Spanish GovernmentEuropean Commission FICTS-2011-02 ICTS-2017-07-CAHA-4 CAHA16-CE-3978German Research Foundation (DFG) FOR2544National Science Foundation (NSF) AST-1636624 AST-2034336 2108465 DGE 1746045European Research Council (ERC) 639889National Aeronautics & Space Administration (NASA) XRP NNX16AD43GNational Science Foundation (NSF) AST 1909165Wise Observatory, Tel-Aviv University, Israel TAU2021A-015Agencia Estatal de Investigacion of the Ministerio de Ciencia, Innovacion y Universidades and the ERDF PID2019-109522GB-C5[1:4] PID2019-107061GBC64 PID2019-110689RB-100 PGC2018-095317-B-C21 PGC2018-102108-BI00Centre of Excellence "Severo Ochoa" CEX2019-000920-SCentre of Excellence "Maria de Maeztu" CEX2019-000920-SInstituto de Astrofisica de Andalucia SEV-2017-0709Centro de Astrobiologia MDM2017-0737German Research Foundation (DFG)European Commission FOR2544 (KU 3625/2-1)Germany's Excellence Strategy to the Excellence Cluster ORIGINS EXC-2094 -390783311European Research Council (ERC)European Commission 639889Bulgarian National Science Fund through VIHREN-2021 KP-06-DB/5Schweizerischer Nationalfonds zur Forderung der wissenschaftlichen Forschung/Fonds national suisse de la recherche scientifique PZ00P2_174028United Kingdom Science Technology and Facilities Council 630008203Princeton UniversityUniversidad La Laguna through the Margarita Salas Fellowship from the Spanish Ministerio de UniversidadesEU Next Generation funds UNI/551/2021Generalitat de Catalunya (CERCA programme

Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study

Background: Obesity phenotypes with different metabolic status have been described previously. We analyzed metabolic phenotypes in obese coronary patients during a 5-year follow-up, and examined the factors influencing this evolution. Methods: The CORDIOPREV study is a randomized, long-term secondary prevention study with two healthy diets: Mediterranean and low-fat. All obese patients were classified as either metabolically healthy obese (MHO) or metabolically unhealthy obese (MUO). We evaluated the changes in the metabolic phenotypes and related variables after 5 years of dietary intervention. Results: Initially, 562 out of the 1002 CORDIOPREV patients were obese. After 5 years, 476 obese patients maintained their clinical and dietary visits; 71.8% of MHO patients changed to unhealthy phenotypes (MHO-Progressors), whereas the MHO patients who maintained healthy phenotypes (MHO-Non-Progressors) lost more in terms of their body mass index (BMI) and had a lower fatty liver index (FLI-score) (p < 0.05). Most of the MUO (92%) patients maintained unhealthy phenotypes (MUO-Non-Responders), but 8% became metabolically healthy (MUO-Responders) after a significant decrease in their BMI and FLI-score, with improvement in all metabolic criteria. No differences were found among dietary groups. Conclusions: A greater loss of weight and liver fat is associated with a lower progression of the MHO phenotype to unhealthy phenotypes. Likewise, a marked improvement in these parameters is associated with regression from MUO to healthy phenotypes

TalentoEDU: teacher training for educational attention on giftedness

Se presenta TalentoEDU, Proyecto de Innovación que surge ante las necesidades formativas de los futuros docentes respecto al alumnado con Alta Capacidad Intelectual. Este proyecto que se ha insertado en algunas de las asignaturas que conforman el Plan de Estudios de los Títulos de Grado que se imparten en el Centro de Magisterio “Sagrado Corazón”, adscrito a la Universidad de Córdoba. Pretende promover competencias para la atención a la diversidad en este ámbito. Los resultados de la experiencia indican que TalentoEDU ha contribuido a dicha formación, dada la satisfacción mostrada por los universitarios.This paper frames TalentoEDU Innovation Project that emerges from the academic needs of future teachers considering High Ability students. This project has been included in some of the subjects within the study plan of the Bachelor Degrees belonging to “Sagrado Corazón” teacher-training center, attached to the University of Cordoba. It aims at promoting skills related to attention to diversity in this field. The results of this experience suggest that TalentoEDU has contributed to the training on this field, according to the satisfaction that our college students showed

SARS-CoV-2 viral load in nasopharyngeal swabs is not an independent predictor of unfavorable outcome

The aim was to assess the ability of nasopharyngeal SARS-CoV-2 viral load at first patient’s hospital evaluation to predict unfavorable outcomes. We conducted a prospective cohort study including 321 adult patients with confirmed COVID-19 through RT-PCR in nasopharyngeal swabs. Quantitative Synthetic SARS-CoV-2 RNA cycle threshold values were used to calculate the viral load in log10 copies/mL. Disease severity at the end of follow up was categorized into mild, moderate, and severe. Primary endpoint was a composite of intensive care unit (ICU) admission and/or death (n = 85, 26.4%). Univariable and multivariable logistic regression analyses were performed. Nasopharyngeal SARS-CoV-2 viral load over the second quartile (≥ 7.35 log10 copies/mL, p = 0.003) and second tertile (≥ 8.27 log10 copies/mL, p = 0.01) were associated to unfavorable outcome in the unadjusted logistic regression analysis. However, in the final multivariable analysis, viral load was not independently associated with an unfavorable outcome. Five predictors were independently associated with increased odds of ICU admission and/or death: age ≥ 70 years, SpO2, neutrophils > 7.5 × 103/µL, lactate dehydrogenase ≥ 300 U/L, and C-reactive protein ≥ 100 mg/L. In summary, nasopharyngeal SARS-CoV-2 viral load on admission is generally high in patients with COVID-19, regardless of illness severity, but it cannot be used as an independent predictor of unfavorable clinical outcome

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

Saberes, Culturas y Derechos Sexuales en Colombia

Este libro reúne artículos de gran pertinencia académica en el tema, ponencias y discusiones que realizaron distintos grupos de trabajo en el marco del seminario Hacia una Agenda sobre Sexualidad y Derechos Humanos en Colombia, realizado en Bogotá durante los días 18, 19 y 20 de marzo de 2004. Este texto acerca a un público más amplio el debate que vienen desarrollando en Colombia investigadores, militantes, responsables y ejecutores de políticas públicas en materia de sexualidad y de derechos sexuales y reproductivos. La divulgación de los trabajos presentados en este libro permitirá a los lectores identificar las líneas de debate que orientan la investigación, las políticas públicas, los programas de intervención social y el derecho en este ámbito. El texto presenta hallazgos en torno a estos temas, con el objetivo de construir un referente común sobre la sexualidad como una construcción sociocultural e histórica objeto de una regulación pública. Igualmente, pretende inscribir la sexualidad en el ámbito de la construcción de ciudadanía y de la reivindicación de los derechos humanos

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research