Systemic 5-fluorouracil induced lupus erythematosus: a review of the literature

Drug-induced subacute cutaneous lupus erythematosus (SCLE) is the most common subtype of drug-induced systemic lupus erythematosus and has been associated with more than 100 drugs. It presents weeks to months after initiation of the culprit medication. The eruption is typically in a photodistribution and it is marked by positive serology to anti-Ro (SSA) antibody. Systemic 5-fluorouracil (5-FU) is a less-common culprit of drug-induced SCLE and its occurrence is likely dependent on exposure to ultraviolet light. Herein, we present a review of drug-induced lupus induced by the pyrimidine analog, 5-FU, and its prodrugs, capecitabine and uracil-tegafur. The search was carried out using the following terms: (PubMed: keywords included drug-induced lupus, 5-fluorouracil, subacute cutaneous lupus erythematosus, capecitabine, uracil-tegafur, discoid lupus, systemic lupus erythematosus)

Star Integrals, Convolutions and Simplices

We explore single and multi-loop conformal integrals, such as the ones appearing in dual conformal theories in flat space. Using Mellin amplitudes, a large class of higher loop integrals can be written as simple integro-differential operators on star integrals: one-loop $n$-gon integrals in $n$ dimensions. These are known to be given by volumes of hyperbolic simplices. We explicitly compute the five-dimensional pentagon integral in full generality using Schl\"afli's formula. Then, as a first step to understanding higher loops, we use spline technology to construct explicitly the $6d$ hexagon and $8d$ octagon integrals in two-dimensional kinematics. The fully massive hexagon and octagon integrals are then related to the double box and triple box integrals respectively. We comment on the classes of functions needed to express these integrals in general kinematics, involving elliptic functions and beyond.Comment: 23 page

Ultrafast Dynamic Metallization of Dielectric Nanofilms by Strong Single-Cycle Optical Fields

We predict a dynamic metallization effect where an ultrafast (single-cycle) optical pulse with a field less or on the order of 1 V/Angstrom causes plasmonic metal-like behavior of a dielectric film with a few-nm thickness. This manifests itself in plasmonic oscillations of polarization and a significant population of the conduction band evolving on a femtosecond time scale. These phenomena are due a combination of both adiabatic (reversible) and diabatic (for practical purposes irreversible) pathways.Comment: 4 pages, 4 figure

The Multi-Wavelength Tully-Fisher relation with spatially resolved HI kinematics

In this paper we investigate the statistical properties of the Tully-Fisher relation for a sample of 32 galaxies with measured distances from the Cepheid period-luminosity relation and/or TRGB stars. We take advantage of panchromatic photometry in 12 bands (from FUV to 4.5 $\mu$m) and of spatially resolved HI kinematics. We use these data together with three kinematic measures ($W^{i}_{50}$, $V_{max}$ and $V_{flat}$) extracted from the global HI profiles or HI rotation curves, so as to construct 36 correlations allowing us to select the one with the least scatter. We introduce a tightness parameter $\sigma_{\perp}$ of the TFr, in order to obtain a slope-independent measure of the goodness of fit. We find that the tightest correlation occurs when we select the 3.6 $\mu$m photometric band together with the $V_{flat}$ parameter extracted from the HI rotation curve.Comment: 16 pages, 16 figures, accepted for publication in MNRAS, minor changes due to proof correction

Condotte compulsive in paziente con sindrome di Aicardi. agenesia del corpo calloso

The corpus callosum, which is the largest white matter structure in the brain of all placental mammals, connects the left and right cerebral hemispheres. An alteration in its morphology, hypoconnectivity or hyperconnectivity is a common marker of various neuropsychiatric pathologies. One of these is Aicardi syndrome, which is characterized by a triad of callosal agenesis, infantile spasms and chorioretinal lacunae. Patients affected by Aicardi syndrome frequently display other malformations together with congenital defects of the eyes, ribs and vertebrae. Based on the current clinical knowledge, this syndrome is now recognized as a complex neurodevelopmental disorder that includes neurological and constitutional symptoms. However, literature data have not yet defined the presence of a particular set of symptoms in psychiatric patients with this condition. The present case is the first report in which an on-going compulsive behaviour focused on the insistence to order objects has been observed in Aicardi syndrom

Kompetisi Stasiun Televisi Swasta Nasional Berdasarkan Superiority Direction Dan Superiority Magnitude

: Uses and gratification theory is employed particularly as the teoritical frame of the research to examine the extent to which ten national television stations compete to satisfy Indonesian audiences. In particular, two main concepts of that theory namely audiences “gratification sought and gratifications obtained, are broken down and counted based on superiority direction and superiority magnitude. In general, the findings show that those televisions have satisfied their audiences, although in terms of gratifications to dispersal motives, they haven’t satisfied as much as it was expected. Significant competition occurs between TRANSTV and TRANS7, RCTI and SCTV, and TVONE and METROTV. TVONE become the most satisfiyng television station

Rilevazione statistica della diffusione dei fenomeni di binge drinking, drunkoressia e gambling tra gli adolescenti palermitani

L\u2019obiettivo dello studio \ue8 l\u2019analisi della diffusione dei comportamenti riconducibili ai fenomeni di Binge Drinking, Drunkoressia e Gambling in individui che possiedono un\u2019et\ue0 compresa tra i 13 e 20 anni: si \ue8 deciso di analizzare nello specifico tale fascia d\u2019et\ue0 poich\ue9 la propensione di alcuni soggetti ad assumere condotte pericolose per la propria salute risulta essere particolarmente alta proprio durante la fase adolescenziale. Quest\u2019ultimo \ue8 infatti un periodo di intenso sviluppo neuro- cognitivo che conduce a cambiamenti importanti ai fini del comportamento, dell\u2019affettivit\ue0, della ricerca e della selezione di stimoli pi\uf9 gratificanti: il risultato \ue8 un aumento della predisposizione ad assumere atteggiamenti rischiosi, quali ad esempio abusare d\u2019alcool o giocare d\u2019azzardo.Al fine di ottenere informazioni inerenti all\u2019epidemiologia dei fenomeni sopracitati e ai rischi sulle problematicit\ue0 correlate, \ue8 stato creato un questionario che si articola in otto quesiti totali distribuiti all\u2019interno di due sezioni: in una prima parte si \ue8 deciso di formulare quattro domande relative alle abitudini sul consumo di alcoolici per ricercare atteggiamenti connessi al binge drinking e alla drunkoressia; invece la seconda sezione \ue8 riservata al gambling ed \ue8 anch\u2019essa costituita da quattro quesiti mirati, volti ad evidenziarne la diffusione. Il test \ue8 stato somministrato singolarmente ed in forma anonima, nel periodo compreso fra gennaio e maggio 2017, a studenti dai 13 e ai 20 anni, durante l\u2019orario scolastico. Hanno partecipato a questo studio 2831 studenti palermitani, di cui 1882 femmine e 949 maschi, provenienti dai seguenti istituti secondari di secondo grado: Istituto Magistrale Statale C. Finocchiaro Aprile, Istituto di istruzione superiore Francesco Ferrara, IPSSAR Francesco Paolo Cascino, Istituto profes- sionale e commerciale Luigi Einaudi, Liceo Artistico Statale Catalano, Liceo Classico Vittorio Emanuele II, Istituto magistrale statale De Cosmi. Lo studio ha fatto emergere un preoccupante incremento, tra la popolazione giovanile, di comportamenti correlabili al binge drinking, alla drunkoressia ed al gambling, suggerendo una sempre pi\uf9 mirata azione di prevenzione primaria e promozione della salute, soprattutto in una fascia molto vulnerabile quale quella adolescenzial