Three-Dimensional Lattice Boltzmann Model Results for Complex Fluids Ordering

The kinetics of domain growth of fluid mixtures quenched from a disordered to a lamellar phase has been studied in three dimensions. We use a numerical approach based on the lattice Boltzmann method (LBM). A novel implementation for LBM which "fuses" the collision and streaming steps is used in order to reduce memory and bandwidth requirements. We find that extended defects between stacks of lamellae with different orientation dominate the late time dynamics

Improving Computational Efficiency for Energy Management Systems in Plug-in Hybrid Electric Vehicles Using Dynamic Programming Based Controllers

Reducing computational time has become a critical issue in recent years, particularly in the transportation field, where the complexity of scenarios demands lightweight controllers to run large simulations and gather results to study different behaviors. This study proposes two novel formulations of the Optimal Control Problem (OCP) for the Energy Management System of a Plug-in Hybrid Electric Vehicle (PHEV) and compares their performance with a benchmark found in the literature. Dynamic Programming was chosen as the optimization algorithm to solve the OCP in a Matlab environment, using the DynaProg toolbox. The objective is to address the optimality of the fuel economy solution and computational time. In order to improve the computational efficiency of the algorithm, an existing formulation from the literature was modified, which originally utilized three control inputs. The approach involves leveraging the unique equations that describe the Input-Split Hybrid powertrain, resulting in a reduction of control inputs firstly to two and finally to one in the proposed solutions. The aforementioned formulations are referred to as 2-Controls and a 1-Control. Virtual tests were conducted to evaluate the performance of the two formulations. The simulations were carried out in various scenarios, including urban and highway driving, to ensure the versatility of the controllers. The results demonstrate that both proposed formulations achieve a reduction in computational time compared to the benchmark. The 2-Controls formulation achieved a reduction in computational time of approximately 40 times, while the 1-Control formulation achieved a remarkable reduction of approximately 850 times. These reductions in computational time were achieved while obtaining a maximum difference in fuel economy of approximately 1.5% for the 1-Control formulation with respect to the benchmark solution. Overall, this study provides valuable insights into the development of efficient and optimal controllers for PHEVs, which can be applied to various transportation scenarios. The proposed formulations reduce computational time without sacrificing the optimality of the fuel economy solution, making them a promising approach for future research in this area

Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7γ

Mutations leading to aberrant cytoplasmic localization of nucleophosmin (NPM) are the most frequent genetic alteration in acute myelogenous leukemia (AML). NPM binds the Arf tumor suppressor and protects it from degradation. The AML-associated NPM mutant (NPMmut) also binds p19Arf but is unable to protect it from degradation, which suggests that inactivation of p19Arf contributes to leukemogenesis in AMLs. We report here that NPM regulates turnover of the c-Myc oncoprotein by acting on the F-box protein Fbw7γ, a component of the E3 ligase complex involved in the ubiquitination and proteasome degradation of c-Myc. NPM was required for nucleolar localization and stabilization of Fbw7γ. As a consequence, c-Myc was stabilized in cells lacking NPM. Expression of NPMmut also led to c-Myc stabilization because of its ability to interact with Fbw7γ and delocalize it to the cytoplasm, where it is degraded. Because Fbw7 induces degradation of other growth-promoting proteins, the NPM–Fbw7 interaction emerges as a central tumor suppressor mechanism in human cancer

Microscopic unitary description of tidal excitations in high-energy string-brane collisions

The eikonal operator was originally introduced to describe the effect of tidal excitations on higher-genus elastic string amplitudes at high energy. In this paper we provide a precise interpretation for this operator through the explicit tree-level calculation of generic inelastic transitions between closed strings as they scatter off a stack of parallel Dp-branes. We perform this analysis both in the light-cone gauge, using the Green-Schwarz vertex, and in the covariant formalism, using the Reggeon vertex operator. We also present a detailed discussion of the high energy behaviour of the covariant string amplitudes, showing how to take into account the energy factors that enhance the contribution of the longitudinally polarized massive states in a simple way.Comment: 58 page

Economic Payback Time of Battery Pack Replacement for Hybrid and Plug-in Hybrid Electric Vehicles

This paper investigates the economic viability of replacing the high-voltage battery pack of a power-split hybrid electric vehicle (HEV) and a plug-in hybrid electric vehicle (PHEV) by estimating the impact of battery ageing on the fuel economy, drivability capability and electric range. The HEV is modelled first, an optimal energy management strategy based on dynamic programming is then implemented, and experimental characterization data for the battery cell is presented. The batteries are tested to a heavily aged state, with up to an 84% loss of capacity. The battery pack payback period is estimated by assessing the vehicle operative costs in terms of fuel and electricity as obtained through numerical simulations as a function of battery ageing. Replacing the battery pack at the conventional end-of-life limit of 80% residual capacity is suggested not to be convenient from an economic standpoint for both the HEV and the PHEV. On the other hand, acceptable payback periods (i.e. 2 to 5 years) can be achieved for the battery pack when being replaced at 20% to 40% residual capacity. The proposed methodology can be implemented to advise an HEV or PHEV user regarding the benefit of replacing the battery pack due to excessive ageing

Regge behavior saves string theory from causality violations

Higher-derivative corrections to the Einstein-Hilbert action are present in bosonic string theory leading to the potential causality violations recently pointed out by Camanho et al. [1]. We analyze in detail this question by considering high-energy string-brane collisions at impact parameters b ≤ l s (the string-length parameter) with l s ≫ R p (the characteristic scale of the D p -brane geometry). If we keep only the contribution of the massless states causality is violated for a set of initial states whose polarization is suitably chosen with respect to the impact parameter vector. Such violations are instead neatly avoided when the full structure of string theory — and in particular its Regge behavior — is taken into account

Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population

Background and Purpose: The lectin-like oxidised LDL receptor-1 (OLR1) gene encodes a scavenger receptor implicated in the pathogenesis of atherosclerosis. Although functional roles have been suggested for two variants, epidemiological studies on OLR1 have been inconsistent. Methods - We tested the association between the non-synonymous substitution K167N (rs11053646) and intima media thickness of the common carotid artery (CCA-IMT) in 2,141 samples from the Progression of Lesions in the Intima of the Carotid (PLIC) study (a prospective population-based study). Results: Significantly increased IMT was observed in male carriers of the minor C (N) allele compared to GC and GG (KN and KK) genotype. Functional analysis on macrophages suggested a decreased association to Ox-LDL in NN carriers compared to KN and KK carriers which is also associated with a reduced OLR1 mRNA expression. Macrophages from NN carriers present also a specific inflammatory gene expression pattern compared to cells from KN and KK carriers. Conclusions: These data suggest that the 167N variant of LOX-1 receptor affects the atherogenic process in the carotid artery prior to evidence of disease through an inflammatory process. © 2012 Predazzi et al