I See! Scotland: Tackling sectarianism and promoting community psychosocial health

We developed and tested through two studies a new intervention run as a course, I SEE! Scotland, to reduce and prevent Protestant-Catholic sectarianism in Scotland, a historic inter-group conflict expressed in forms ranging from polite to violent, within a wider population that includes those who feel untouched. Designed to reflect the social ecology of Scotland and engage individuals regardless of sectarian involvement, the intervention aimed to increase cognitive complexity, measured as integrative complexity, through participatory theatre and experiential methods. We hypothesised that the confluence of experiential learning to support multiple forms of self, other, and systems awareness with narrative framing would increase integrative complexity management capacities. Tested with a diverse sample of 104 participants (secondary school staff; achieving, disruptive or vulnerable students; young adults returning to education; other professionals; prisoners; recovering drug addicts; unemployed), study one pre-post comparisons showed significant integrative complexity gains that cohered with second end of intervention integrative complexity measures, replicating results from other integrative complexity interventions despite differences in samples, conflicts, and context. Study two with twenty-eight of the one hundred and four participants showed significant pre post increases in resilience. These results predict peaceful outcomes to intergroup conflict, tackling sectarianism and promoting community psychosocial health. We note future research plans

Attachment in the Early Life Course: Meta-Analytic Evidence for Its Role in Socioemotional Development

After decades of research on early attachment relationships, questions remain concerning whether the evidence supports claims made by attachment theory, in particular, that variation in early attachment predicts children’s developmental adaptation or maladaptation, and that characteristics of children’s temperament does not determine attachment. To evaluate these claims, we conducted meta-analyses on early attachment and children’s social competence with peers, externalizing problems, internalizing symptoms, and temperament. In this article, we summarize our findings, which support attachment theory—though we note caveats. We also call for new measurement models, a focus on mediating and moderating mechanisms, and multisite replications

Attachment and Developmental Psychopathology

This chapter examines the conceptual and empirical contributions of attachment theory to the field of developmental psychopathology. It reviews the major elements and methods of attachment theory and research, and considers current evidence regarding a) the environmental and genetic determinants of attachment, b) short-and long-term continuity in attachment processes, c) the association between attachment and emerging psychopathology, d) candidate mediating mechanisms conveying risk, and d) the efficacy of attachment-focused interventions. We end with a consideration of the broader relevance of attachment theory for understanding the process and mechanisms of change in psychological therapies. We conclude that attachment represents a coherent and generally well-supported developmental construct, which is of great potential value as a framework for prevention and intervention. We also highlight several key outstanding issues and qualifications regarding the measurement of attachment, the scope and limits of its effects on children’s outcomes, and unresolved scientific issues regarding causal mechanisms

Child-father attachment in early childhood and behavior problems: A meta-analysis

This meta-analytic study examined the associations between child-father attachment in early childhood and children's externalizing and internalizing behavior problems. Based on 15 samples (N = 1,304 dyads), the association between child-father attachment insecurity and externalizing behaviors was significant and moderate in magnitude (r = 0.18, 95% CI: 0.10, 0.27 or d = 0.37, 95% CI: 0.20, 0.55). No moderators of this association were identified. Based on 12 samples (N = 1,073), the association between child-father attachment insecurity and internalizing behaviors was also significant, albeit smaller in magnitude (r = 0.09, 95% CI: 0.02, 0.15; or d = 0.17, 95% CI: 0.03, 0.31). Between-study heterogeneity was insufficient to consider moderators. When compared to the effect sizes of prior meta-analyses on child-mother attachment and behavior problems, the quality of the attachment relationship with fathers yields a similar magnitude of associations to children's externalizing and internalizing behaviors. Results support the need to consider the role of the attachment network, which notably includes attachment relationships to both fathers and mothers, to understand how attachment relationships contribute to child development

The response of leptin, interleukin-6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer

At baseline, weight-losing pancreatic cancer patients (n=7) had lower leptin (P<0.05) but higher cortisol, interleukin-6, resting energy expenditure and fat oxidation than healthy subjects (n=6, P<0.05). Over a 4 h feeding period, the areas under the curve for glucose, cortisol and interleukin-6 were greater (P<0.05), but less for leptin in the cancer group (P<0.05). Therefore, it would appear that low leptin concentrations, increased fat oxidation and insulin resistance are associated with increased concentrations of cortisol and interleukin-6 in weight-losing patients with pancreatic cancer

A False Start in the Race Against Doping in Sport: Concerns With Cycling’s Biological Passport

Professional cycling has suffered from a number of doping scandals. The sport’s governing bodies have responded by implementing an aggressive new antidoping program known as the biological passport. Cycling’s biological passport marks a departure from traditional antidoping efforts, which have focused on directly detecting prohibited substances in a cyclist’s system. Instead, the biological passport tracks biological variables in a cyclist’s blood and urine over time, monitoring for fluctuations that are thought to indirectly reveal the effects of doping. Although this method of indirect detection is promising, it also raises serious legal and scientific concerns. Since its introduction, the cycling community has debated the reliability of indirect biological-passport evidence and the clarity, consistency, and transparency of its use in proving doping violations. Such uncertainty undermines the legitimacy of finding cyclists guilty of doping based on this indirect evidence alone. Antidoping authorities should address these important concerns before continuing to pursue doping sanctions against cyclists solely on the basis of their biological passports

A prospective cohort study to investigate cost-minimisation, of Traditional open, open fAst track recovery and laParoscopic fASt track multimodal management, for surgical patients with colon carcinomas (TAPAS study)

Contains fulltext : 87553.pdf (publisher's version ) (Open Access)BACKGROUND: The present developments in colon surgery are characterized by two innovations: the introduction of the laparoscopic operation technique and fast recovery programs such as the Enhanced Recovery After Surgery (ERAS) recovery program. The Tapas-study was conceived to determine which of the three treatment programs: open conventional surgery, open 'ERAS' surgery or laparoscopic 'ERAS' surgery for patients with colon carcinomas is most cost minimizing? METHOD/DESIGN: The Tapas-study is a three-arm multicenter prospective cohort study. All patients with colon carcinoma, eligible for surgical treatment within the study period in four general teaching hospitals and one university hospital will be included. This design produces three cohorts: Conventional open surgery is the control exposure (cohort 1). Open surgery with ERAS recovery (cohort 2) and laparoscopic surgery with ERAS recovery (cohort 3) are the alternative exposures. Three separate time periods are used in order to prevent attrition bias. Primary outcome parameters are the two main cost factors: direct medical costs (real cost price calculation) and the indirect non medical costs (friction method). Secondary outcome parameters are mortality, complications, surgical-oncological resection margins, hospital stay, readmission rates, time back to work/recovery, health status and quality of life. Based on an estimated difference in direct medical costs (highest cost factor) of 38% between open and laparoscopic surgery (alfa = 0.01, beta = 0.05), a group size of 3 x 40 = 120 patients is calculated. DISCUSSION: The Tapas-study is three-arm multicenter cohort study that will provide a cost evaluation of three treatment programs for patients with colon carcinoma, which may serve as a guideline for choice of treatment and investment strategies in hospitals. TRIAL REGISTRATION: ISRCTN44649165

Computational Cancer Biology: An Evolutionary Perspective

ISSN:1553-734XISSN:1553-735

A Computational and Experimental Study of the Regulatory Mechanisms of the Complement System

The complement system is key to innate immunity and its activation is necessary for the clearance of bacteria and apoptotic cells. However, insufficient or excessive complement activation will lead to immune-related diseases. It is so far unknown how the complement activity is up- or down- regulated and what the associated pathophysiological mechanisms are. To quantitatively understand the modulatory mechanisms of the complement system, we built a computational model involving the enhancement and suppression mechanisms that regulate complement activity. Our model consists of a large system of Ordinary Differential Equations (ODEs) accompanied by a dynamic Bayesian network as a probabilistic approximation of the ODE dynamics. Applying Bayesian inference techniques, this approximation was used to perform parameter estimation and sensitivity analysis. Our combined computational and experimental study showed that the antimicrobial response is sensitive to changes in pH and calcium levels, which determines the strength of the crosstalk between CRP and L-ficolin. Our study also revealed differential regulatory effects of C4BP. While C4BP delays but does not decrease the classical complement activation, it attenuates but does not significantly delay the lectin pathway activation. We also found that the major inhibitory role of C4BP is to facilitate the decay of C3 convertase. In summary, the present work elucidates the regulatory mechanisms of the complement system and demonstrates how the bio-pathway machinery maintains the balance between activation and inhibition. The insights we have gained could contribute to the development of therapies targeting the complement system.Singapore. Ministry of Education (Grant T208B3109)Singapore. Agency for Science, Technology and Research (BMRC 08/1/21/19/574)Singapore-MIT Alliance (Computational and Systems Biology Flagship Project)Swedish Research Counci