Traumatic Neuroma Following Sagittal Split Osteotomy of the Mandible

A 16-year-old male underwent bilateral sagittal split osteotomy of the mandible to correct a mandibular deficiency. Twenty-one years later, a routine panoramic radiograph revealed a radiolucent lesion on the left side of the mandible. The lesion was biopsied. As the patient did not have symptoms and the lesion was connected to the inferior alveolar nerve, the lesion was not totally excised in order to preserve nerve function. The histological features were consistent with traumatic neuroma, and no further surgical procedure was planned

Kinetic Monte Carlo simulation of molecular processes on supported metal particles

A general model is proposed to describe the kinetics of molecular reactions taking place on supported metal particles, which are deformed by the effect of temperature, through kinetic Monte Carlo simulations. The model is applied to the study of the CO oxidation reaction. The effects of adsorbate-adsorbate and adsorbate-metal interactions and of CO and metal atoms diffusion on the reaction window and the overall reaction rate are determined.Fil: Sales, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; ArgentinaFil: Gargiulo Almeida, María Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; ArgentinaFil: Zgrablich, G.. Universidad Nacional de San Luis; Argentin

Metallicity inhomogeneities in local star-forming galaxies as sign of recent metal-poor gas accretion

We measure the oxygen metallicity of the ionized gas along the major axis of seven dwarf star-forming galaxies. Two of them, SDSSJ1647+21 and SDSSJ2238+14, show 0.5 dex metallicity decrements in inner regions with enhanced star-formation activity. This behavior is similar to the metallicity drop observed in a number of local tadpole galaxies by Sanchez Almeida et al. (2013) and interpreted as showing early stages of assembling in disk galaxies, with the star formation sustained by external metal-poor gas accretion. The agreement with tadpoles has several implications: (1) it proves that galaxies other than the local tadpoles present the same unusual metallicity pattern. (2) Our metallicity inhomogeneities were inferred using the direct method, thus discarding systematic errors usually attributed to other methods. (3) Taken together with the tadpole data, our findings suggest a threshold around one tenth the solar value for the metallicity drops to show up. Although galaxies with clear metallicity drops are rare, the physical mechanism responsible for them may sustain a significant part of the star-formation activity in the local Universe. We argue that the star-formation dependence of the mass-metallicity relationship, as well as other general properties followed by most local disk galaxies, are naturally interpreted as side effects of pristine gas infall. Alternatives to the metal poor gas accretion are examined too.Comment: Accepted for publication in ApJ. 10 pages. 5 Fig

Extremely Metal-Poor Galaxies: The HI Content

Extremely metal-poor (XMP) galaxies are chemically, and possibly dynamically, primordial objects in the local Universe. Our objective is to characterize the HI content of the XMP galaxies as a class, using as a reference the list of 140 known local XMPs compiled by Morales-Luis et al. (2011). We have observed 29 XMPs, which had not been observed before at 21 cm, using the Effelsberg radio telescope. This information was complemented with HI data published in literature for a further 53 XMPs. In addition, optical data from the literature provided morphologies, stellar masses, star-formation rates and metallicities. Effelsberg HI integrated flux densities are between 1 and 15 Jy km/s, while line widths are between 20 and 120 km/s. HI integrated flux densities and line widths from literature are in the range 0.1 - 200 Jy km/s and 15 - 150 km/s, respectively. Of the 10 new Effelsberg detections, two sources show an asymmetric double-horn profile, while the remaining sources show either asymmetric (7 sources) or symmetric (1 source) single-peak 21 cm line profiles. An asymmetry in the HI line profile is systematically accompanied by an asymmetry in the optical morphology. Typically, the g-band stellar mass-to-light ratios are ~0.1, whereas the HI gas mass-to-light ratios may be up to 2 orders of magnitude larger. Moreover, HI gas-to-stellar mass ratios fall typically between 10 and 20, denoting that XMPs are extremely gas-rich. We find an anti-correlation between the HI gas mass-to-light ratio and the luminosity, whereby fainter XMPs are more gas-rich than brighter XMPs, suggesting that brighter sources have converted a larger fraction of their HI gas into stars. The dynamical masses inferred from the HI line widths imply that the stellar mass does not exceed 5% of the dynamical mass, while the \ion{H}{i} mass constitutes between 20 and 60% of the dynamical mass. (abridged)Comment: 30 pages, accepted for A&

Asfixia perinatal asociada a la mortalidad neonatal temprana: estudio de población de los óbitos evitables

OBJECTIVE: To compare the epidemiological profile of avoidable early neonatal deaths associated with perinatal asphyxia according to region of death in the State of São Paulo, Brazil. METHODS: Population-based cohort study including 2,873 avoidable deaths up to six days of life associated with perinatal asphyxia from January 2001 to December 2003. Perinatal asphyxia was considered if intrauterine hypoxia, birth asphyxia, or meconium aspiration syndrome were written in any line of the original Death Certificate. Epidemiological data were also extracted from the Birth Certificate. RESULTS: During the three years, 1.71 deaths per 1,000 live births were associated with perinatal asphyxia, which corresponded to 22% of the early neonatal deaths. From the 2,873 avoidable deaths, 761 (27%) occurred in São Paulo city; 640 (22%), in the metropolitan region of São Paulo city; and 1,472 (51%), in the countryside of the state. In the first two regions, deaths were more frequent in public hospitals, among newborns with gestational age of 36 weeks or less, and among babies weighing less than 2500g. In the countryside, mortality was more frequent in philanthropic hospitals, in term newborns and in neonates weighing over 2500g. Most of these neonates were born during daytime in their hometown and died at the same institution in which they were born within the first 24 hours after delivery. Meconium aspiration syndrome was related to 18% of the deaths. CONCLUSIONS: Perinatal asphyxia is a frequent contributor to the avoidable early neonatal death in the state with the highest gross domestic product per capita in Brazil, and it shows the need for specific interventions with regionalized focus during labor and birth care.OBJETIVO: Comparar el perfil epidemiológico de los óbitos neonatales tempranos evitables asociados a la asfixia perinatal conforme a la región de ocurrencia del óbito en la provincia de São Paulo (Brasil). MÉTODOS: Cohorte de población constituida por 2.873 óbitos evitables hasta seis días de vida asociados a la asfixia perinatal ocurridos entre enero de 2001 y diciembre de 2003. Se consideró como asfixia perinatal la presencia de hipoxia intraútero, asfixia al nacer o síndrome de aspiración de meconio en cualquier línea de la Declaración de Óbito original. Variables epidemiológicas también fueron extraídas de las Declaraciones de Nacido Vivo. RESULTADOS: En el trienio, 1,71 muertes por 1.000 nacidos vivos estaban asociadas a la asfixia perinatal, correspondiendo al 22% de los óbitos neonatales tempranos. De los 2.873 óbitos evitables, 761 (27%) tuvieron lugar en São Paulo, capital; 640 (22%), en la región metropolitana de la capital; y 1.472 (51%) en el interior de la provincia. En las dos primeras regiones predominaron las muertes en hospitales públicos, recién nacidos con edad gestacional inferior a 37 semanas y peso inferior a 2.500g. En el interior, los óbitos fueron más frecuentes en entidades benéficas, recién nacidos a término y con peso superior a 2.500g. La mayoría de los bebés nació durante el día en el municipio de residencia materna y evolucionó a óbito en el hospital de nacimiento hasta 24 horas después del parto. El síndrome de aspiración de meconio estuvo presente en el 18% de los óbitos. CONCLUSIONES: La asfixia perinatal es un contribuyente frecuente a la muerte neonatal temprana evitable en la provincia con el más grande producto interno bruto per capita de Brasil, lo que evidencia la necesidad de intervenciones específicas con enfoque regionalizado en la asistencia al parto y al nacimiento.OBJETIVO: Comparar o perfil epidemiológico dos óbitos neonatais precoces evitáveis associados à asfixia perinatal conforme a região de ocorrência do óbito no Estado de São Paulo. MÉTODOS: Coorte populacional constituída por 2.873 óbitos evitáveis até seis dias de vida associados à asfixia perinatal ocorridos entre janeiro de 2001 e dezembro de 2003. Considerou-se como asfixia perinatal a presença de hipóxia intraútero, asfixia ao nascer ou síndrome de aspiração de mecônio em qualquer linha da Declaração de Óbito original. Variáveis epidemiológicas também foram extraídas das Declarações de Nascido Vivo. RESULTADOS: No triênio, 1,71 mortes por 1.000 nascidos vivos estavam associadas à asfixia perinatal, correspondendo a 22% dos óbitos neonatais precoces. Dos 2.873 óbitos evitáveis, 761 (27%) ocorreram em São Paulo, capital; 640 (22%), na região metropolitana da capital; e 1.472 (51%), no interior do estado. Nas duas primeiras regiões predominaram as mortes em hospitais públicos, recém-nascidos com idade gestacional inferior a 37 semanas e peso abaixo de 2500g. No interior, os óbitos foram mais frequentes em entidades beneficentes, recém-nascidos a termo e com peso superior a 2500g. A maioria dos bebês nasceu durante o dia no município de residência materna e evoluiu para óbito no hospital de nascimento até 24 horas após o parto. A síndrome de aspiração de mecônio esteve presente em 18% dos óbitos. CONCLUSÕES: A asfixia perinatal é um contribuinte frequente para a morte neonatal precoce evitável no estado com o maior produto interno bruto per capita do Brasil, evidenciando a necessidade de intervenções específicas com enfoque regionalizado na assistência ao parto e ao nascimento.UNIFESP-EPMFundação SEADE Divisão de Produção de Indicadores DemográficosFundação SEADEUNIFESP, EPMSciEL

Left ventricular systolic dysfunction in Marfan syndrome is related to aortic distensibility

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2019.Background: The cardiovascular involvement in Marfan syndrome (MS) is characterized mainly by dilatation and reduced distensibility of the ascending aorta. Left ventricular (LV) dysfunction has been detected in MS and a primary cardiomyopathy has been suggested but the pathophysiology is unclear. The purpose of this study was to evaluate the LV function in patients with MS and to assess the relationship with the aortic distensibility, as possible underlying mechanism. Methods: We studied 53 patients with MS (27.0 ± 11 years, 29 men) without valvular or hypertensive heart disease and a control group of 26 healthy subjects (29 ± 9 years, 17 men). All underwent echocardiography and cardiac magnetic resonance (CMR) and the following indexes were analyzed: a) Echo: mitral flow velocities E/A ratio and deceleration of mitral E; E’ velocity obtained from the medial and lateral mitral ring; E/E’ ratio b) CMR: LV volumes indexed to BSA and ejection fraction (EF); global longitudinal strain (GLS, Circle cvI42); maximal size and distensibility of proximal ascending aorta. Distensibility was calculated from maximal (systolic) and minimum (diastolic) area of maximal proximal ascending aorta (cross-sectional images from SSFP sequence) using the formula=(maximum area-minimum area)/[ minimum area x (systolic BP-diastolic BP)]. Results: 17 from 53 patients with MS had increased LV end-diastolic volume, 14 decreased EF (<50%) and 22 decreased GLS. Compared with the control group, patients with MS showed increased LV end-diastolic volume (85.0 ± 5.2vs 80.1 ± 5.3ml/m2, p = 0.04), lower GLS (17.1 ± 1.9 vs 18.9 ± 2.2, p = 0.01) lower LVEF (53.0 ± 7.1% vs 56.0 ± 5.4%, p = 0.03) and higher E/E’ value (9.2 ± 1.3 vs. 6.2 ± 0.8, p = 0.01) as well as larger dimensions of proximal aorta (39 ± 2.2cm vs 32 ± 0.8,p = 0.010) and lower aortic distensibility (3.4 ± 1.9 vs. 4.4 ± 1.7 dynes cm-1, p = 0.03). In the group of patients, a correlation was found between the aortic distensibility and the LVEF (r = 0.47, p = 0.045) and GLS (r = 0.65, p = 0.02), but not with the other variables. Aortic distensibility was an independent predictor of LV dysfunction using a cutoff of 50% for LVEF and 19% for GLS. Conclusion: In our population of patients with MS, we found changes in the LV function, which were related with aortic distensibility, possibly sharing a common pathway. The prognostic significance of these findings is under evaluation.info:eu-repo/semantics/publishedVersio

Isolamento de vírus de copos de bares e cafés da cidade de São Paulo

Seven strains of viruses were isolated from 8.75% of the 80 lots of drinking glasses, ready for use, in 40 coffee shops and bars in the business district of São Paulo. Three strains were identified as adenovirus type 3, two as echo type 11, one as adenovirus type 4 and one as herpesvirus. Each lot consisted of 5 drinking glasses. The positive lots belonged to 7 different coffee shops and bars. These findings confirm the poor sanitary conditions already observed of the common use utensils in the eating and drinking places of the city of São Paulo. These conditions are the result of the total lack of adoption of sanitation measures regarding such material. The existing conditions are the consequence of the inefficient and even infeasible regulations of the present sanitary laws of the State, concerning the matter.De 8,75% dos 80 lotes de copos, prontos para uso, de 40 «bares e cafés» do centro da cidade de São Paulo, foram isoladas 7 cêpas de vírus, sendo três de adenovírus do tipo 3, duas de vírus ECHO 11, urna de adenovírus do tipo 4 e uma de vírus do herpes simples. Cada lote era constituído de 5 copos. Os 7 lotes positivos provinham de 7 &laquo;bares e cafés&raquo; diferentes. Estes achados comprovam a má situação sanitária dos utensílios de uso comum nos estabelecimentos públicos de distribuição de alimentos e bebidas da cidade de São Paulo, já evidenciada através de investigações bacteriológicas anteriores, e resultam da falta total de aplicação das medidas de saneamento de tal material, nesses locais. As condições existentes são conseqüência das disposições inoperantes e até impraticáveis da atual legislação sanitária estadual concernente à matéria