COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Organic acids and/or compound with defined microorganisms to control Salmonella enterica serovar Enteritidis experimental infection in chickens

The association of human foodborne salmonellosis with poultry products enhanced the efforts to control Salmonella Enteritidis in poultry farms. Dietary organic acid supplementation is one of the measures currently used to reduce the presence of undesirable microorganisms. Another method to control enteric Salmonella in poultry is competitive exclusion using defined or undefined microorganisms products. Organic acids and microbiological methods to accelerate the development of the intestinal microbiota can be used individually or in combination. The present study evaluated the effect of dietary supplementation of an acidifier and of a defined multi-strain microbial mixture (Biomin® PoultryStar) via drinking water in the control of the intestinal colonization of broilers by Salmonella Enteritidis. Four experiments were performed. The first experiment showed that the organic acids mixture was able to prevent Salmonella Enteritidis colonization of ceca in both inclusion rates applied (p<0.05). In the second and third experiments the probiotic either individually or in combination the acidifier, both in high and low doses reduced the incidence of Salmonella Enteritidis in the cecal contents (p<0.05). In these three experiments, birds were orally challenged. Similar results were obtained in a fourth trial, in which challenge was made by contact.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq