1,360 research outputs found
2019 HRS/EHRA/APHRS/LAHRS Expert Consensus Statement on Catheter Ablation of Ventricular Arrhythmias
Ventricular arrhythmias are an important cause of morbidity and mortality and come in a variety of forms, from single premature ventricular complexes to sustained ventricular tachycardia and fibrillation. Rapid developments have taken place over the past decade in our understanding of these arrhythmias and in our ability to diagnose and treat them. The field of catheter ablation has progressed with the development of new methods and tools, and with the publication of large clinical trials. Therefore, global cardiac electrophysiology professional societies undertook to outline recommendations and best practices for these procedures in a document that will update and replace the 2009 EHRA/HRS Expert Consensus on Catheter Ablation of Ventricular Arrhythmias. An expert writing group, after reviewing and discussing the literature, including a systematic review and meta-analysis published in conjunction with this document, and drawing on their own experience, drafted and voted on recommendations and summarized current knowledge and practice in the field. Each recommendation is presented in knowledge byte format and is accompanied by supportive text and references. Further sections provide a practical synopsis of the various techniques and of the specific ventricular arrhythmia sites and substrates encountered in the electrophysiology lab. The purpose of this document is to help electrophysiologists around the world to appropriately select patients for catheter ablation, to perform procedures in a safe and efficacious manner, and to provide follow-up and adjunctive care in order to obtain the best possible outcomes for patients with ventricular arrhythmias
2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias: Executive summary
Ventricular arrhythmias are an important cause of morbidity and mortality and come in a variety of forms, from single premature ventricular complexes to sustained ventricular tachycardia and fibrillation. Rapid developments have taken place over the past decade in our understanding of these arrhythmias and in our ability to diagnose and treat them. The field of catheter ablation has progressed with the development of new methods and tools, and with the publication of large clinical trials. Therefore, global cardiac electrophysiology professional societies undertook to outline recommendations and best practices for these procedures in a document that will update and replace the 2009 EHRA/HRS Expert Consensus on Catheter Ablation of Ventricular Arrhythmias. An expert writing group, after reviewing and discussing the literature, including a systematic review and meta-analysis published in conjunction with this document, and drawing on their own experience, drafted and voted on recommendations and summarized current knowledge and practice in the field. Each recommendation is presented in knowledge byte format and is accompanied by supportive text and references. Further sections provide a practical synopsis of the various techniques and of the specific ventricular arrhythmia sites and substrates encountered in the electrophysiology lab. The purpose of this document is to help electrophysiologists around the world to appropriately select patients for catheter ablation, to perform procedures in a safe and efficacious manner, and to provide follow-up and adjunctive care in order to obtain the best possible outcomes for patients with ventricular arrhythmias
2019 HRS/EHRA/APHRS/LAHRS Expert Consensus Statement on Catheter Ablation of Ventricular Arrhythmias: Executive summary
Ventricular arrhythmias are an important cause of morbidity and mortality and come in a variety of forms, from single premature ventricular complexes to sustained ventricular tachycardia and fibrillation. Rapid developments have taken place over the past decade in our understanding of these arrhythmias and in our ability to diagnose and treat them. The field of catheter ablation has progressed with the development of new methods and tools, and with the publication of large clinical trials. Therefore, global cardiac electrophysiology professional societies undertook to outline recommendations and best practices for these procedures in a document that will update and replace the 2009 EHRA/HRS Expert Consensus on Catheter Ablation of Ventricular Arrhythmias. An expert writing group, after reviewing and discussing the literature, including a systematic review and meta-analysis published in conjunction with this document, and drawing on their own experience, drafted and voted on recommendations and summarized current knowledge and practice in the field. Each recommendation is presented in knowledge byte format and is accompanied by supportive text and references. Further sections provide a practical synopsis of the various techniques and of the specific ventricular arrhythmia sites and substrates encountered in the electrophysiology lab. The purpose of this document is to help electrophysiologists around the world to appropriately select patients for catheter ablation, to perform procedures in a safe and efficacious manner, and to provide follow-up and adjunctive care in order to obtain the best possible outcomes for patients with ventricular arrhythmias
2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias
Ventricular arrhythmias are an important cause of morbidity and mortality and come in a variety of forms, from single premature ventricular complexes to sustained ventricular tachycardia and fibrillation. Rapid developments have taken place over the past decade in our understanding of these arrhythmias and in our ability to diagnose and treat them. The field of catheter ablation has progressed with the development of new methods and tools, and with the publication of large clinical trials. Therefore, global cardiac electrophysiology professional societies undertook to outline recommendations and best practices for these procedures in a document that will update and replace the 2009 EHRA/HRS Expert Consensus on Catheter Ablation of Ventricular Arrhythmias. An expert writing group, after reviewing and discussing the literature, including a systematic review and meta-analysis published in conjunction with this document, and drawing on their own experience, drafted and voted on recommendations and summarized current knowledge and practice in the field. Each recommendation is presented in knowledge byte format and is accompanied by supportive text and references. Further sections provide a practical synopsis of the various techniques and of the specific ventricular arrhythmia sites and substrates encountered in the electrophysiology lab. The purpose of this document is to help electrophysiologists around the world to appropriately select patients for catheter ablation, to perform procedures in a safe and efficacious manner, and to provide follow-up and adjunctive care in order to obtain the best possible outcomes for patients with ventricular arrhythmias
Hybrid Amperometric and Potentiometric Sensing Based on a CMOS ISFET Array
Potentiometry and amperometry are some of the most important techniques for electroanalytical applications. Integrating these two techniques on a single chip using CMOS technology paves the way for more analysis and measurement of chemical solutions. In this paper, we describe the integration of electrode transducers (amperometry) on an ion imager based on an ISFET array (potentiometry). In particular, this integration enables the spatial representation of the potential distribution of active electrodes in a chemical solution under investigation
Ultra-High Energy Cosmic Ray Propagation in the Local Supercluster
We present detailed numerical simulations and analytical approximations of
the propagation of nucleons above 10**(19) eV in the Local Supercluster,
assuming that the ambient magnetic field is turbulent, and its strength 0.01 <
B_rms < 1 micro-Gauss. In such strong magnetic fields, protons in the low
energy part of the spectrum, 10**(19) eV < E < E_C diffuse, while the higher
energy particles, with E > E_C propagate along nearly straight lines. The
magnitude of the transition energy E_C depends mainly on the strength of the
magnetic field, the coherence length, and the distance to the source; for
B_rms=0.1 micro-Gauss, a largest eddy of length 10 Mpc, and a distance to the
source of 10 Mpc, E_C=100 EeV. Our numerical treatment substantially improves
on previous analytical approximations, as it allows to treat carefully the
transition between the two propagation regimes, as well as the effects due to
inhomogeneities expected on scales of a few Mpc. We show that a turbulent
magnetic field B_rms=0.1 micro-Gauss, close to equipartition, would allow to
reproduce exactly the observed spectrum of ultra high energy cosmic rays, up to
the highest energy observed, for a distance to the source below 10 Mpc, for the
geometry of the Local Supercluster, i.e. a sheet of thickness 10 Mpc.
Diffusion, in this case, allows to reproduce the high flux beyond the Greisen
Zatsepin Kuzmin cut-off, with a soft injection spectrum proportional to
E**(-2.4). Moreover, the large deflection angles at the highest energies
observed, typically 10 degrees for the above values, would explain why no
close-by astrophysical counterpart could be associated with these events.Comment: 17 latex pages (tightened format), 9 updated postscript figures, uses
revtex.sty and epsf.sty, extended discussion of numerical results, to appear
in Astroparticle Physic
Reconstruction of Source and Cosmic Magnetic Field Characteristics from Clusters of Ultra-High Energy Cosmic Rays
We present a detailed Monte Carlo study coupled to a likelihood analysis of
the potential of next generation ultra-high energy cosmic ray experiments to
reconstruct properties of the sources and the extra-galactic magnetic field.
Such characteristics are encoded in the distributions of arrival time,
direction, and energy of clusters of charged cosmic rays above a few 10**(19)
eV. The parameters we consider for reconstruction are the emission timescale,
total fluence (or power), injection spectrum, and distance of the source, as
well as the r.m.s. field strength, power spectrum, and coherence length of the
magnetic field. We discuss five generic situations which can be identified
relatively easily and allow a reasonable reconstruction of at least part of
these parameters. Our numerical code is set up such that it can easily be
applied to the data from future experiments.Comment: 23 latex pages, 11 postscript figures included, uses (and includes)
elsart.sty and epsf.sty. Submitted to Astroparticle Physic
N,N′-[4,4′-MethylÂenebis(4,1-phenylÂene)]bisÂ(2,6-difluoroÂbenzamide)
The complete molÂecule of the title compound, C27H18F4N2O2, is generated by crystallographic twofold symmetry, with one C atom lying on the rotation axis. The dihedral angle between fluoro-substituted phenyl ring and the adjacent benzene ring is 10.37 (5)°. In the crystal, molÂecules are connected by N—H⋯O and C—H⋯F hydrogen bonds, resulting in supraÂmolecular chains propagating along the c direction
Barefoot vs common footwear:A systematic review of the kinematic, kinetic and muscle activity differences during walking
Habitual footwear use has been reported to influence foot structure with an acute exposure being shown to alter foot position and mechanics. The foot is highly specialised thus these changes in structure/position could influence functionality. This review aims to investigate the effect of footwear on gait, specifically focussing on studies that have assessed kinematics, kinetics and muscle activity between walking barefoot and in common footwear. In line with PRISMA and published guidelines, a literature search was completed across six databases comprising Medline, EMBASE, Scopus, AMED, Cochrane Library and Web of Science. Fifteen of 466 articles met the predetermined inclusion criteria and were included in the review. All articles were assessed for methodological quality using a modified assessment tool based on the STROBE statement for reporting observational studies and the CASP appraisal tool. Walking barefoot enables increased forefoot spreading under load and habitual barefoot walkers have anatomically wider feet. Spatial-temporal differences including, reduced step/stride length and increased cadence, are observed when barefoot. Flatter foot placement, increased knee flexion and a reduced peak vertical ground reaction force at initial contact are also reported. Habitual barefoot walkers exhibit lower peak plantar pressures and pressure impulses, whereas peak plantar pressures are increased in the habitually shod wearer walking barefoot. Footwear particularly affects the kinematics and kinetics of gait acutely and chronically. Little research has been completed in older age populations (50+ years) and thus further research is required to better understand the effect of footwear on walking across the lifespan
Quantitative Structure - Skin permeability Relationships
This paper reviews in silico models currently available for the prediction of skin permeability with the main focus on the quantitative structure-permeability relationship (QSPR) models. A comprehensive analysis of the main achievements in the field in the last decade is provided. In addition, the mechanistic models are discussed and comparative studies that analyse different models are discussed
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