The Royal Free Hospital score: a calibrated prognostic model for patients with cirrhosis admitted to intensive care unit. Comparison with current models and CLIF-SOFA score

Prognosis for patients with cirrhosis admitted to intensive care unit (ICU) is poor. ICU prognostic models are more accurate than liver-specific models. We identified predictors of mortality, developed a novel prognostic score (Royal Free Hospital (RFH) score), and tested it against established prognostic models and the yet unvalidated Chronic Liver Failure-Sequential Organ Failure Assessment (CLIF-SOFA) model

PENGARUH KOMPETENSI SUMBER DAYA MANUSIA DAN SISTEM INFORMASI AKUNTANSI TERHADAP PENERAPAN STANDAR AKUNTANSI PEMERINTAH BERBASIS AKRUAL (Survey pada Dinas Pemerintahan di Kota Bandung)

ABSTRAK Tujuan dari penelitian ini adalah untuk mengetahui pengaruh kompetensi sumber daya manusia dan sistem informasi akuntansi terhadap penerapan standar akuntansi pemerintah berbasis akrual. Pengumpulan data dilakukan dengan menyebarkan kuesioner kepada kepala dinas, kasubag keuangan, kasubag program dan anggaran pada 17 SKPD Dinas Pemerintahan Kota Bandung sejumlah 34 orang. Analisis dalam penelitian ini menggunakan analisis regresi linier berganda. Setelah data dikumpulkan, data dianalisis menggunakan program SPSS 20. Hasil penelitian menunjukkan bahwa secara parsial Kompetensi Sumber Daya Manusia berpengaruh positif terhadap Penerapan Standar Akuntansi Pemerintah Berbasis Akrual dan Sistem Informasi Akuntansi berpengaruh positif terhadap Penerapan Standar Akuntansi Pemerintah Berbasi Akrual. Selain itu terdapat pengaruh yang signifikan dari Kompetensi Sumber Daya Manusia dan SIA secara simultan terhadap Penerapan Standar Akuntansi Pemerintahan Berbasis Akrual. Kata Kunci: Kompetensi Sumber Daya Manusia, Sistem Informasi Akuntansi, Penerapan Standar Akuntansi Berbasis Akrual

Christmas Disease (Hemophilia B) A Case Report

We report a 25 years old man developed Haemarthrosis of left hip joint with a history of recurrent swelling and pain in multiple joints and prolonged bleeding following minor trauma since childhood. Subsequent investigations revealed Christmas disease (Haemophilia B). Hemophilia B is an X-linked bleeding disorder. This case emphasises the importance of considering a diagnosis of haemophilia in a man with unexplained bleeding, even in the absence of a positive family history. DOI: 10.3329/bsmmuj.v2i2.4766 BSMMU J 2009; 2(2): 90-9

Outcomes of intravitreal methotrexate to salvage eyes with relapsed primary intraocular lymphoma

PURPOSE: To report the outcomes of intravitreal methotrexate (MTX) injections to rescue eyes with relapsed primary intraocular lymphoma (PIOL). METHODS: Retrospective case series of patients with ocular relapse of PIOL who had initially received systemic chemotherapy (all five cases) and external beam radiotherapy (EBRT) to brain and orbits (two cases). Injections of MTX (400 µg/0.1 mL) were given one time per week for 1 month, every other week for 4 months, followed by a maintenance phase of one injection one time per month for 8 months (total of 20 injections in a year). RESULTS: From April 2008 to February 2016, there were nine eyes of five patients (three men; average age at first presentation 62 years) treated with our rescue protocol of intravitreal MTX injections. Ocular relapse occurred at a mean interval of 15 months (range 5-34 months) after the completion of initial systemic treatment. At mean follow-up of 31 months (range 5-104 months), tumour control was achieved in eight out of nine eyes (89%); one eye failed, with persistent retinal infiltrates despite increasing the frequency of injections, resulting in severe keratopathy. The only other complication occurred in one eye, developing cystoid macular oedema from MTX injections that resolved with topical anti-inflammatory medications and reduced frequency of MTX. There were no cases of reduced vision or ocular relapse, but two patients died (one of central nervous system lymphoma). CONCLUSIONS: Intravitreal MTX was a safe and effective treatment modality for relapsed PIOL after systemic chemotherapy and radiotherapy, achieving local tumour control in 89%, and hence represents an optimal choice. However, given the rare nature of PIOL, larger collaborative studies with longer follow-up are needed to corroborate this

Do Building Integrated Photovoltaic (BIPV) windows propose a promising solution for the transition toward zero energy buildings? A review

This is the final version. Available on open access from Elsevier via the DOI in this recordData availability: No data was used for the research described in the article.BIPV windows are the most suitable alternative to conventional windows currently available today. They offer thermal insulation and can generate electricity from the embedded solar cells within their structure while also maintaining the practicality of conventional windows. Different types of BIPV windows will be reviewed in this paper, followed by an assessment of the energy-saving potential, optimal orientation, solar cell technology, Koppen climate impact, and application for each type of BIPV window. From the findings, it was evident that ventilated double BIPV windows had the highest energy-saving potential as well as being the BIPV system that can adapt the most to different Koppen climates. The optimal orientation was the south-facing façade which consumed the least amount of energy while also generating the highest amount of electricity from PV. Amorphous silicon is the most popular solar cell technology in BIPV studies due to its performance however they do have disadvantages. Application of BIPV windows includes BIPV-PCM systems and switchable glazing for smart window technology. Large-scale development integrated with BIPV windows can have a huge influence on meeting ZEB targets. Limitations in the study were observed by limited studies on vacuum BIPV glazing, and limited studies on a variety of Koppen climate classes

SASARAN DAN EVALUASI ANGGARAN: KETIDAKPASTIAN LINGKUNGAN DAN PENGALAMAN MANAJER SEBAGAI VARIABEL KONTINJENSI

Most of budgets studies have focused on budget participation. It was argument that level of participation in budgeting process is most important part of budgeting procedure. The activity could predict and reduce future uncertainty. The others components of budgeting like budget goal and budget evaluation lacked attention. This study aims to investigate the impact of budget goal difficulty and budget evaluation style on managerial performance and job satisfaction with contingency approach.  Level of difficulty would arise when environment uncertainty exist. It should need different style of budget evaluation. But, experience managers seem could anticipate it. Results support hypothesis that budget goal difficulty and budget evaluation style were contingent with manager experience and environment uncertaint

SASARAN DAN EVALUASI ANGGARAN: KETIDAKPASTIAN LINGKUNGAN DAN PENGALAMAN MANAJER SEBAGAI VARIABEL KONTINJENSI

Most of budgets studies have focused on budget participation. It was argument that level of participation in budgeting process is most important part of budgeting procedure. The activity could predict and reduce future uncertainty. The others components of budgeting like budget goal and budget evaluation lacked attention. This study aims to investigate the impact of budget goal difficulty and budget evaluation style on managerial performance and job satisfaction with contingency approach.  Level of difficulty would arise when environment uncertainty exist. It should need different style of budget evaluation. But, experience managers seem could anticipate it. Results support hypothesis that budget goal difficulty and budget evaluation style were contingent with manager experience and environment uncertaint

Phylogenetic diversity analysis of Trichoderma species based on internal transcribed spacer (ITS) marker

The phylogeny of Trichoderma and the phylogenetic relationships of its species was investigated by maximum parsimony analysis and distance analysis of DNA sequences from multiple genetic loci 18S rDNA sequence analysis suggests that the genus Trichoderma evolved at the same time as Hypomyces and Fusarium and thus about 110 Myr ago 28S rDNA sequence analysis shows that the genus Trichoderma is part of a monophyletic branch within the Hypocreaceae. Most isolates of the genus Trichoderma were found to act as mycoparasites of many economically important aerial and soil-borne plant pathogens. Trichoderma has attained importance as a substitute for chemical pesticides and hence an attempt was intended to corroborate the positive relatedness of molecular and morphological characters. Two fungal strains, Trichoderma koningii Tk-5201/CSAU and Trichoderma virens Tvi-4177/CSAU were isolated from a soil sample collected from CSA Farm, Kanpur district of Uttar Pradesh, India. The universal primers (internal transcribed spacer, ITS) were used for the amplification of 18S rRNA gene fragment and strains were thus characterized with the help of ITS marker. It is proposed that the identified strains T. koningii Tk-5201/CSAU and T. virens Tvi-4177/CSAU be assigned as the type strains of a species of genus Trichoderma based on phylogenetic tree analysis together with the 18S rRNA gene sequence search in Ribosomal Database Project, small subunit rRNA and large subunit rRNA databases. The sequence was deposited in GenBank with the accession numbers KC800923 and KC800924, respectively. Thus an integrated approach of morphological and molecular markers can be employed to identify a superior strain of Trichoderma for its commercial exploitation.Keywords: 18S ribosomal RNA gene, Trichoderma, phylogenetic analysis, internal transcribed spacer (ITS), DNA sequencing, GenBankAfrican Journal of Biotechnology, Vol. 13(3), pp. 449-455, 15 January, 201