Sensitivities of Lagrangian modeling of mid-latitude cirrus clouds to trajectory data quality

Simulations of cirrus are subject to uncertainties in model physics and meteorological input data. Here we model cirrus clouds along air mass trajectories, whose extinction has been measured with an elastic backscatter lidar at Jungfraujoch research station in the Swiss Alps, with a microphysical stacked box model. The sensitivities of these simulations to input data uncertainties (trajectory resolution, unresolved vertical velocities, ice nuclei number density and upstream specific humidity) are investigated. Variations in the temporal resolution of the wind field data (COSMO-Model at 2.2 km resolution) between 20 s and 1 h have only a marginal impact on the trajectory path, while the representation of the vertical velocity variability and therefore the cooling rate distribution are significantly affected. A temporal resolution better than 5 min must be chosen in order to resolve cooling rates required to explain the measured extinction. A further increase in the temporal resolution improves the simulation results slightly. The close match between the modelled and observed extinction profile for high-resolution trajectories suggests that the cooling rate spectra calculated by the COSMO-2 model suffice on the selected day. The modelled cooling rate spectra are, however, characterized by significantly lower vertical velocity amplitudes than those found previously in some aircraft campaigns (SUCCESS, MACPEX). A climatological analysis of the vertical velocity amplitude in the Alpine region based on COSMO-2 analyses and balloon sounding data suggests large day-to-day variability in small-scale temperature fluctuations. This demonstrates the necessity to apply numerical weather prediction models with high spatial and temporal resolutions in cirrus modelling, whereas using climatological means for the amplitude of the unresolved air motions does generally not suffice. The box model simulations further suggest that uncertainties in the upstream specific humidity (± 10 % of the model prediction) and in the ice nuclei number density (0–100 L−1) are more important for the modelled cirrus cloud than the unresolved temperature fluctuations if temporally highly resolved trajectories are used. For the presented case the simulations are incompatible with ice nuclei number densities larger than 20 L−1 and insensitive to variations below this value

Single image defocus estimation by modified gaussian function

© 2019 John Wiley & Sons, Ltd. This article presents an algorithm to estimate the defocus blur from a single image. Most of the existing methods estimate the defocus blur at edge locations, which further involves the reblurring process. For this purpose, existing methods use the traditional Gaussian function in the phase of reblurring but it is found that the traditional Gaussian kernel is sensitive to the edges and can cause loss of edges information. Hence, there are more chances of missing spatially varying blur at edge locations. We offer the repeated averaging filters as an alternative to the traditional Gaussian function, which is more effective, and estimate the spatially varying defocus blur at edge locations. By using repeated averaging filters, a blur sparse map is computed. The obtained sparse map is propagated by integration of superpixels segmentation and transductive inference to estimate full defocus blur map. Our adopted method of repeated averaging filters has less computational time of defocus blur map estimation and has better visual estimates of the final defocus recovered map. Moreover, it has surpassed many previous state-of-the-art proposed systems in terms of quantative analysis

Ischaemic post-conditioning protects lung from ischaemia-reperfusion injury by up-regulation of haeme oxygenase-1

Objective: The emergence of ischaemic post-conditioning (IPO) provides a potential method for experimentally and clinically attenuating various types of organ injuries. There has been little work, however, examining its effects in the setting of lung ischaemia reperfusion (IR). The stress protein, haeme oxygenase-1 (HO-1), has been found to exert a potent, protective role in a variety of lung injury models. In this study, we hypothesised that the induction of HO-1 by IPO plays a protective role against the deleterious effects of IR in the lung. Methods: Anaesthetised and mechanically ventilated adult Sprague-Dawley rats were randomly assigned to one of the following groups (n = 8 each): the sham-operated control group, the IR group (40 min of left-lung ischaemia and 105 min of reperfusion), the IPO group (three successive cycles of 30-s reperfusion per 30-s occlusion before restoring full perfusion) and the ZnPPIX + IPO group (ZnPPIX, an inhibitor of HO-1, was injected intra-peritoneally at 20 mg kg -1 24 h prior to the experiment and the rest of the procedures were similar to that of the IPO group). Lung injury was assessed by arterial blood gas analysis, wet-to-dry lung weight ratio and tissue histological changes. The extent of lipid peroxidation was determined by measuring plasma levels of malondialdehyde (MDA) production. Expression of HO-1 was determined by immunohistochemistry. Results: Lung IR resulted in a significant reduction of PaO 2 (data in IR, P < 0.05 vs. data in sham) and increase of lung wet-to-dry weight ratio, accompanied with increased MDA production and severe lung pathological morphological changes as well as a compensatory increase in HO-1 protein expression, as compared with sham (All P < 0.05). IPO markedly attenuated all the above pathological changes seen in the IR group and further increased HO-1 expression. Treatment with ZnPPIX abolished all the protective effects of post-conditioning. Conclusion: It may be concluded that IPO protects IR-induced lung injury via induction of HO-1. © 2009 Elsevier Ltd. All rights reserved.postprin

X-ray Insights into the Nature of Quasars with Redshifted Broad Absorption Lines

We present $Chandra$ observations of seven broad absorption line (BAL) quasars at $z=0.863$-2.516 with redshifted BAL troughs (RSBALs). Five of our seven targets were detected by $Chandra$ in 4-13 ks exposures with ACIS-S. The $\alpha_{\rm ox}$ values, $\Delta\alpha_{\rm ox}$ values, and spectral energy distributions of our targets demonstrate they are all X-ray weak relative to expectations for non-BAL quasars, and the degree of X-ray weakness is consistent with that of appropriately-matched BAL quasars generally. Furthermore, our five detected targets show evidence for hard X-ray spectral shapes with a stacked effective power-law photon index of $\Gamma_{\rm eff}=0.5^{+0.5}_{-0.4}$. These findings support the presence of heavy X-ray absorption ($N_{\rm H}\approx 2 \times 10^{23}$ cm$^{-2}$) in RSBAL quasars, likely by the shielding gas found to be common in BAL quasars more generally. We use these X-ray measurements to assess models for the nature of RSBAL quasars, finding that a rotationally-dominated outflow model is favored while an infall model also remains plausible with some stipulations. The X-ray data disfavor a binary quasar model for RSBAL quasars in general.Comment: 11 pages, 5 figures, and 3 table

The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis.

ObjectiveTofacitinib is an oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). The pathways affected by tofacitinib and the effects on gene expression in situ are unknown. Therefore, tofacitinib effects on synovial pathobiology were investigated.MethodsA randomised, double-blind, phase II serial synovial biopsy study (A3921073; NCT00976599) in patients with RA with an inadequate methotrexate response. Patients on background methotrexate received tofacitinib 10 mg twice daily or placebo for 28 days. Synovial biopsies were performed on Days -7 and 28 and analysed by immunoassay or quantitative PCR. Clinical response was determined by disease activity score and European League Against Rheumatism (EULAR) response on Day 28 in A3921073, and at Month 3 in a long-term extension study (A3921024; NCT00413699).ResultsTofacitinib exposure led to EULAR moderate to good responses (11/14 patients), while placebo was ineffective (1/14 patients) on Day 28. Tofacitinib treatment significantly reduced synovial mRNA expression of matrix metalloproteinase (MMP)-1 and MMP-3 (p&lt;0.05) and chemokines CCL2, CXCL10 and CXCL13 (p&lt;0.05). No overall changes were observed in synovial inflammation score or the presence of T cells, B cells or macrophages. Changes in synovial phosphorylation of signal transducer and activator of transcription 1 (STAT1) and STAT3 strongly correlated with 4-month clinical responses (p&lt;0.002). Tofacitinib significantly decreased plasma CXCL10 (p&lt;0.005) at Day 28 compared with placebo.ConclusionsTofacitinib reduces metalloproteinase and interferon-regulated gene expression in rheumatoid synovium, and clinical improvement correlates with reductions in STAT1 and STAT3 phosphorylation. JAK1-mediated interferon and interleukin-6 signalling likely play a key role in the synovial response.Trial registration numberNCT00976599

X-ray and multi-epoch optical/UV investigations of BAL to non-BAL quasar transformations

We report on an X-ray and optical/UV study of eight Broad Absorption Line (BAL) to non-BAL transforming quasars at $z\,\approx\,$1.7-2.2 over 0.29-4.95 rest-frame years with at least three spectroscopic epochs for each quasar from the SDSS, BOSS, $Gemini$, and ARC 3.5-m telescopes. New $Chandra$ observations obtained for these objects show their values of $\alpha_{\rm ox}$ and $\Delta{\alpha}_{\rm ox}$, as well as their spectral energy distributions, are consistent with those of non-BAL quasars. Moreover, our targets have X-ray spectral shapes that are, on average, consistent with weakened absorption with an effective power-law photon index of $\Gamma_{\rm eff}\,=\,1.69^{+0.25}_{-0.25}$. The newer $Gemini$ and ARC 3.5-m spectra reveal that the BAL troughs have remained absent since the BOSS observations where the BAL disappearance was discovered. The X-ray and optical/UV results in tandem are consistent with at least the X-ray absorbing material moving out of the line-of-sight, leaving an X-ray unabsorbed non-BAL quasar. The UV absorber might have become more highly ionized (in a shielding-gas scenario) or also moved out of the line-of-sight (in a wind-clumping scenario).Comment: 14 pages, 5 figures, Accepted for publication in MNRA

Outcomes Associated With Oral Anticoagulants Plus Antiplatelets in Patients With Newly Diagnosed Atrial Fibrillation.

Importance: Patients with nonvalvular atrial fibrillation at risk of stroke should receive oral anticoagulants (OAC). However, approximately 1 in 8 patients in the Global Anticoagulant Registry in the Field (GARFIELD-AF) registry are treated with antiplatelet (AP) drugs in addition to OAC, with or without documented vascular disease or other indications for AP therapy. Objective: To investigate baseline characteristics and outcomes of patients who were prescribed OAC plus AP therapy vs OAC alone. Design, Setting, and Participants: Prospective cohort study of the GARFIELD-AF registry, an international, multicenter, observational study of adults aged 18 years and older with recently diagnosed nonvalvular atrial fibrillation and at least 1 risk factor for stroke enrolled between March 2010 and August 2016. Data were extracted for analysis in October 2017 and analyzed from April 2018 to June 2019. Exposure: Participants received either OAC plus AP or OAC alone. Main Outcomes and Measures: Clinical outcomes were measured over 3 and 12 months. Outcomes were adjusted for 40 covariates, including baseline conditions and medications. Results: A total of 24 436 patients (13 438 [55.0%] male; median [interquartile range] age, 71 [64-78] years) were analyzed. Among eligible patients, those receiving OAC plus AP therapy had a greater prevalence of cardiovascular indications for AP, including acute coronary syndromes (22.0% vs 4.3%), coronary artery disease (39.1% vs 9.8%), and carotid occlusive disease (4.8% vs 2.0%). Over 1 year, patients treated with OAC plus AP had significantly higher incidence rates of stroke (adjusted hazard ratio [aHR], 1.49; 95% CI, 1.01-2.20) and any bleeding event (aHR, 1.41; 95% CI, 1.17-1.70) than those treated with OAC alone. These patients did not show evidence of reduced all-cause mortality (aHR, 1.22; 95% CI, 0.98-1.51). Risk of acute coronary syndrome was not reduced in patients taking OAC plus AP compared with OAC alone (aHR, 1.16; 95% CI, 0.70-1.94). Patients treated with OAC plus AP also had higher rates of all clinical outcomes than those treated with OAC alone over the short term (3 months). Conclusions and Relevance: This study challenges the practice of coprescribing OAC plus AP unless there is a clear indication for adding AP to OAC therapy in newly diagnosed atrial fibrillation

Characterizing Workload of Web Applications on Virtualized Servers

With the ever increasing demands of cloud computing services, planning and management of cloud resources has become a more and more important issue which directed affects the resource utilization and SLA and customer satisfaction. But before any management strategy is made, a good understanding of applications' workload in virtualized environment is the basic fact and principle to the resource management methods. Unfortunately, little work has been focused on this area. Lack of raw data could be one reason; another reason is that people still use the traditional models or methods shared under non-virtualized environment. The study of applications' workload in virtualized environment should take on some of its peculiar features comparing to the non-virtualized environment. In this paper, we are open to analyze the workload demands that reflect applications' behavior and the impact of virtualization. The results are obtained from an experimental cloud testbed running web applications, specifically the RUBiS benchmark application. We profile the workload dynamics on both virtualized and non-virtualized environments and compare the findings. The experimental results are valuable for us to estimate the performance of applications on computer architectures, to predict SLA compliance or violation based on the projected application workload and to guide the decision making to support applications with the right hardware.Comment: 8 pages, 8 figures, The Fourth Workshop on Big Data Benchmarks, Performance Optimization, and Emerging Hardware in conjunction with the 19th ACM International Conference on Architectural Support for Programming Languages and Operating Systems (ASPLOS-2014), Salt Lake City, Utah, USA, March 1-5, 201

Random Numbers Certified by Bell's Theorem

Randomness is a fundamental feature in nature and a valuable resource for applications ranging from cryptography and gambling to numerical simulation of physical and biological systems. Random numbers, however, are difficult to characterize mathematically, and their generation must rely on an unpredictable physical process. Inaccuracies in the theoretical modelling of such processes or failures of the devices, possibly due to adversarial attacks, limit the reliability of random number generators in ways that are difficult to control and detect. Here, inspired by earlier work on nonlocality based and device independent quantum information processing, we show that the nonlocal correlations of entangled quantum particles can be used to certify the presence of genuine randomness. It is thereby possible to design of a new type of cryptographically secure random number generator which does not require any assumption on the internal working of the devices. This strong form of randomness generation is impossible classically and possible in quantum systems only if certified by a Bell inequality violation. We carry out a proof-of-concept demonstration of this proposal in a system of two entangled atoms separated by approximately 1 meter. The observed Bell inequality violation, featuring near-perfect detection efficiency, guarantees that 42 new random numbers are generated with 99% confidence. Our results lay the groundwork for future device-independent quantum information experiments and for addressing fundamental issues raised by the intrinsic randomness of quantum theory.Comment: 10 pages, 3 figures, 16 page appendix. Version as close as possible to the published version following the terms of the journa

Gamma-rays from millisecond pulsars in Globular Clusters

Globular clusters (GCs) with their ages of the order of several billion years contain many final products of evolution of stars such as: neutron stars, white dwarfs and probably also black holes. These compact objects can be at present responsible for the acceleration of particles to relativistic energies. Therefore, gamma-ray emission is expected from GCs as a result of radiation processes occurring either in the inner magnetosperes of millisecond pulsars or in the vicinity of accreting neutron stars and white dwarfs or as a result of interaction of particles leaving the compact objects with the strong radiation field within the GC. Recently, GeV gamma-ray emission has been detected from several GCs by the new satellite observatory Fermi. Also Cherenkov telescopes reported interesting upper limits at the TeV energies which start to constrain the content of GCs. We review the results of these gamma-ray observations in the context of recent scenarios for their origin.Comment: 20 pages, 9 figures, will be published in Astrophysics and Space Science Series (Springer), eds. N. Rea and D.F. Torre