Chern-Simons terms in Noncommutative Geometry and its application to Bilayer Quantum Hall Systems

Considering bilayer systems as extensions of the planar ones by an internal space of two discrete points, we use the ideas of Noncommutative Geometry to construct the gauge theories for these systems. After integrating over the discrete space we find an effective $2+1$ action involving an extra complex scalar field, which can be interpreted as arising from the tunneling between the layers. The gauge fields are found in different phases corresponding to the different correlations due to the Coulomb interaction between the layers. In a particular phase, when the radial part of the complex scalar field is a constant, we recover the Wen-Zee model of Bilayer Quantum Hall systems. There are some circumstances, where this radial part may become dynamical and cause dissipation in the oscillating supercurrent between the layers.Comment: 17 pages, more explanations have been added to make our points clearer compared with the previous densed versio

Localized States and Resultant Band Bending in Graphene Antidot Superlattices

We fabricated dye sensitized graphene antidot superlattices with the purpose of elucidating the role of the localized edge state density. The fluorescence from deposited dye molecules was found to strongly quench as a function of increasing antidot filling fraction, whereas it was enhanced in unpatterned but electrically back-gated samples. This contrasting behavior is strongly indicative of a built-in lateral electric field that accounts for fluorescence quenching as well as p-type doping. These findings are of great interest for light-harvesting applications that require field separation of electron-hole pairs.Comment: NanoLetters, 201

Distribution of abo blood group, rhesus factor and haemoglobin genotype in Maiduguri Metropolis, North-eastern Nigeria

To establish the frequency distribution of ABO, Rhesus (Rh) blood groups and haemoglobin genotype in Maiduguri metropolis. Methods: A total of four hundred and seventy subjects consisting of males and females were enrolled into the study. The subjects enrolled were university students and patients coming to the haematology department of the university of Maiduguri teaching hospital they were randomly selected and their ABO blood groups, Rhesus D antigen and genotype were determined. Results: The distribution of the blood groups antigen evaluated by our study are as follows; Blood group O were found to be231 (49.1%), blood group B categorized as 104 (22.1%),blood group A91 (19.3%), and blood group AB had the least 46 (9.3%).The Rhesus (Rh D) factor positivity was 399 (85%), and that (Rh D) negativity were71 (15%). The haemoglobin genotype were expressed as HbAA, AS, SS, AC and SC and the study revealed frequencies of AA, 297 (63.2%), AS, 122 (26%), SS,32 (6.8%),AC 12 (2.5%) and SC 07 (1.4%). Conclusion: This study showed that blood group O is predominant than the other blood groups and that blood group AB had the least. Rhesus (D) positivity was 85% as compared to Rhesus (D) negativity of 15%. The haemoglobin genotype showed HbAA had the highest occurrence, while SC had the least

Phytochemical and antimicrobial screening of the crude petroleum spirit and methanol extracts of the stem bark, leaves and roots of Ficus thoningii (blume)

Ficus thoningii which has some traditional medicinal uses was investigated. Phytochemical screening of the stem bark, leaves and roots gave positive results for carbohydrates, glycosides, saponins and alkaloids. Antimicrobial screening of the crude petroleum spirit and methanol extracts showed activity against Klebsiella pneumoniae, Staphylococcus aureus, Escherichia coli, Providencia stauti and Bacillus subtilis but no activity was observed against Salmonella typhi. The crude petroleum spiritextracts of the leaves and stem bark of the plant had minimum inhibitory concentrations at 50 mg/ml while the roots had no minimum inhibitory concentration at the test concentration. The crude methanolextracts of the various plant parts showed minimum inhibitory concentration at 50 mg/ml on all the pathogens tested for

FPGA based time-to-digital converters

Time-to-digital converters are a key component in many photonics systems, ranging from LiDAR, quantum key distribution, quantum optics experiments and time correlated single photon counting applications. A novel efficient timeto- digital converter non-linearity calibration technique has been developed and demonstrated on a Spartan 6 LX150 field programmable gate array (FPGA). Most FPGA based time-to-digital converters either use post processing or have calibration techniques which do not focus on minimizing resource utilization. With the move towards imaging with arrays of single photon detectors, scalable timing instrumentation is required. The calibration system demonstrated minimizes block memory utilization, using the same memory for probability density function measurement and cumulative distribution function generation, creating a look up table which can be used to calibrate the sub-clock timing module of the time-to-digital converter. The system developed contains 16 time-to-digital converters and demonstrates an average accuracy of 21ps RMS (14.85ps single channel) with a resolution of 1.86ps

Mutation of SLC35D3 causes metabolic syndrome by impairing dopamine signaling in striatal D1 neurons

We thank Dr. Ya-Qin Feng from Shanxi Medical University, Dr. Tian-Yun Gao from Nanjing University and Dr. Yan-Hong Xue from Institute of Biophysics (CAS) for technical assistance in this study. We are very thankful to Drs. Richard T. Swank and Xiao-Jiang Li for their critical reading of this manuscript and invaluable advice. Funding: This work was partially supported by grants from National Basic Research Program of China (2013CB530605; 2014CB942803), from National Natural Science Foundation of China 1230046; 31071252; 81101182) and from Chinese Academy of Sciences (KSCX2-EW-R-05, KJZD-EW-L08). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

Rab3-GEF controls active zone development at the Drosophila neuromuscular junction

Synaptic signaling involves the release of neurotransmitter from presynaptic active zones (AZs). Proteins that regulate vesicle exocytosis cluster at AZs, composing the cytomatrix at the active zone (CAZ). At the Drosophila neuromuscular junction (NMJ), the small GTPase Rab3 controls the distribution of CAZ proteins across release sites, thereby regulating the efficacy of individual AZs. Here we identify Rab3-GEF as a second protein that acts in conjunction with Rab3 to control AZ protein composition. At rab3-GEF mutant NMJs, Bruchpilot (Brp) and Ca(2+) channels are enriched at a subset of AZs, leaving the remaining sites devoid of key CAZ components in a manner that is indistinguishable from rab3 mutant NMJs. As the Drosophila homologue of mammalian DENN/MADD and Caenorhabditis elegans AEX-3, Rab3-GEF is a guanine nucleotide exchange factor (GEF) for Rab3 that stimulates GDP to GTP exchange. Mechanistic studies reveal that although Rab3 and Rab3-GEF act within the same mechanism to control AZ development, Rab3-GEF is involved in multiple roles. We show that Rab3-GEF is required for transport of Rab3. However, the synaptic phenotype in the rab3-GEF mutant cannot be fully explained by defective transport and loss of GEF activity. A transgenically expressed GTP-locked variant of Rab3 accumulates at the NMJ at wild-type levels and fully rescues the rab3 mutant but is unable to rescue the rab3-GEF mutant. Our results suggest that although Rab3-GEF acts upstream of Rab3 to control Rab3 localization and likely GTP-binding, it also acts downstream to regulate CAZ development, potentially as a Rab3 effector at the synapse

Convergence of TOR-nitrogen and Snf1-glucose signaling pathways onto Gln3

Carbon and nitrogen are two basic nutrient sources for cellular organisms. They supply precursors for energy metabolism and metabolic biosynthesis. In the yeast Saccharomyces cerevisiae, distinct sensing and signaling pathways have been described that regulate gene expression in response to the quality of carbon and nitrogen sources, respectively. Gln3 is a GATA-type transcription factor of nitrogen catabolite-repressible (NCR) genes. Previous observations indicate that the quality of nitrogen sources controls the phosphorylation and cytoplasmic retention of Gln3 via the target of rapamycin (TOR) protein. In this study, we show that glucose also regulates Gln3 phosphorylation and subcellular localization, which is mediated by Snf1, the yeast homolog of AMP-dependent protein kinase and a cytoplasmic glucose sensor. Our data show that glucose and nitrogen signaling pathways converge onto Gln3, which may be critical for both nutrient sensing and starvation responses