UCP4C mediates uncoupled respiration in larvae of Drosophila melanogaster

Larvae of Drosophila melanogaster reared at 23\ub0C and switched to 14\ub0C for 1 h are 0.5\ub0C warmer than the surrounding medium. In keeping with dissipation of energy, respiration of Drosophila melanogaster larvae cannot be decreased by the F-ATPase inhibitor oligomycin or stimulated by protonophore. Silencing of Ucp4C conferred sensitivity of respiration to oligomycin and uncoupler, and prevented larva-to-adult progression at 15\ub0C but not 23\ub0C. Uncoupled respiration of larval mitochondria required palmitate, was dependent on Ucp4C and was inhibited by guanosine diphosphate. UCP4C is required for development through the prepupal stages at low temperatures and may be an uncoupling protein

How a Diverse Research Ecosystem Has Generated New Rehabilitation Technologies: Review of NIDILRR’s Rehabilitation Engineering Research Centers

Over 50 million United States citizens (1 in 6 people in the US) have a developmental, acquired, or degenerative disability. The average US citizen can expect to live 20% of his or her life with a disability. Rehabilitation technologies play a major role in improving the quality of life for people with a disability, yet widespread and highly challenging needs remain. Within the US, a major effort aimed at the creation and evaluation of rehabilitation technology has been the Rehabilitation Engineering Research Centers (RERCs) sponsored by the National Institute on Disability, Independent Living, and Rehabilitation Research. As envisioned at their conception by a panel of the National Academy of Science in 1970, these centers were intended to take a “total approach to rehabilitation”, combining medicine, engineering, and related science, to improve the quality of life of individuals with a disability. Here, we review the scope, achievements, and ongoing projects of an unbiased sample of 19 currently active or recently terminated RERCs. Specifically, for each center, we briefly explain the needs it targets, summarize key historical advances, identify emerging innovations, and consider future directions. Our assessment from this review is that the RERC program indeed involves a multidisciplinary approach, with 36 professional fields involved, although 70% of research and development staff are in engineering fields, 23% in clinical fields, and only 7% in basic science fields; significantly, 11% of the professional staff have a disability related to their research. We observe that the RERC program has substantially diversified the scope of its work since the 1970’s, addressing more types of disabilities using more technologies, and, in particular, often now focusing on information technologies. RERC work also now often views users as integrated into an interdependent society through technologies that both people with and without disabilities co-use (such as the internet, wireless communication, and architecture). In addition, RERC research has evolved to view users as able at improving outcomes through learning, exercise, and plasticity (rather than being static), which can be optimally timed. We provide examples of rehabilitation technology innovation produced by the RERCs that illustrate this increasingly diversifying scope and evolving perspective. We conclude by discussing growth opportunities and possible future directions of the RERC program

Creating, moving and merging Dirac points with a Fermi gas in a tunable honeycomb lattice

Dirac points lie at the heart of many fascinating phenomena in condensed matter physics, from massless electrons in graphene to the emergence of conducting edge states in topological insulators [1, 2]. At a Dirac point, two energy bands intersect linearly and the particles behave as relativistic Dirac fermions. In solids, the rigid structure of the material sets the mass and velocity of the particles, as well as their interactions. A different, highly flexible approach is to create model systems using fermionic atoms trapped in the periodic potential of interfering laser beams, a method which so far has only been applied to explore simple lattice structures [3, 4]. Here we report on the creation of Dirac points with adjustable properties in a tunable honeycomb optical lattice. Using momentum-resolved interband transitions, we observe a minimum band gap inside the Brillouin zone at the position of the Dirac points. We exploit the unique tunability of our lattice potential to adjust the effective mass of the Dirac fermions by breaking inversion symmetry. Moreover, changing the lattice anisotropy allows us to move the position of the Dirac points inside the Brillouin zone. When increasing the anisotropy beyond a critical limit, the two Dirac points merge and annihilate each other - a situation which has recently attracted considerable theoretical interest [5-9], but seems extremely challenging to observe in solids [10]. We map out this topological transition in lattice parameter space and find excellent agreement with ab initio calculations. Our results not only pave the way to model materials where the topology of the band structure plays a crucial role, but also provide an avenue to explore many-body phases resulting from the interplay of complex lattice geometries with interactions [11, 12]

A gravitational lensing detection of filamentary structures connecting luminous red galaxies

We present a weak lensing detection of filamentary structures in the cosmic web, combining data from the Kilo-Degree Survey, the Red Cluster Sequence Lensing Survey, and the Canada-France-Hawaii Telescope Lensing Survey. The line connecting luminous red galaxies with a separation of 3 − 5 h−1 Mpc was chosen as a proxy for the location of filaments. We measured the average weak lensing shear around ∼11 000 candidate filaments selected in this way from the Sloan Digital Sky Survey. After nulling the shear induced by the dark matter haloes around each galaxy, we reported a 3.4σ detection of an anisotropic shear signal from the matter that connects them. Adopting a filament density profile, motivated from N-body simulations, the average density at the centre of these filamentary structures was found to be 15 ± 4 times the critical density

Decentralised Evaluation of Temporal Patterns over Component-based Systems at Runtime

Long version of the paper accepted for FACS 2014 - The 11th International Symposium on Formal Aspects of Component SoftwareInternational audienceSelf-adaptation allows systems to modify their structure and/or their behaviour depending on the environment and the system itself. Since reconfigurations must not happen at any but in suitable circumstances, guiding and controlling dynamic reconfigurations at runtime is an important issue. This paper contributes to two essential topics of the self-adaptation---a runtime temporal properties evaluation, and a decentralization of control loopsSelf-adaptation allows systems to modify their structure and/or their behaviour depending on the environment and the system itself. Since reconfigurations must not happen at any but in suitable circumstances, guiding and controlling dynamic reconfigurations at runtime is an important issue. This paper contributes to two essential topics of the self-adaptation - a runtime temporal properties evaluation, and a decentralization of control loops. It extends the work on the adaptation of component-based systems at runtime via policies with temporal patterns by providing a) a specific progressive semantics of temporal patterns and b) a decentralised method which is suitable to deal with temporal patterns of component-based systems at runtime

Joint constraints on cosmology and the impact of baryon feedback: Combining KiDS-1000 lensing with the thermal Sunyaeva- Zeldovich effect from Planck and ACT

We conduct a pseudo-analysis of the tomographic cross-correlation between 1000 deg2 of weak-lensing data from the Kilo-Degree Survey (KiDS-1000) and the thermal Sunyaeva- Zeldovich (tSZ) effect measured by Planck and the Atacama Cosmology Telescope (ACT). Using HMX, a halo-model-based approach that consistently models the gas, star, and dark matter components, we are able to derive constraints on both cosmology and baryon feedback for the first time from these data, marginalising over redshift uncertainties, intrinsic alignment of galaxies, and contamination by the cosmic infrared background (CIB). We find our results to be insensitive to the CIB, while intrinsic alignment provides a small but significant contribution to the lensinga- tSZ cross-correlation. The cosmological constraints are consistent with those of other low-redshift probes and prefer strong baryon feedback. The inferred amplitude of the lensinga- tSZ cross-correlation signal, which scales as I8(Om/0.3)0.2, is low by compared to the primary cosmic microwave background constraints by Planck. The lensinga- tSZ measurements are then combined with pseudo-CAmeasurements of KiDS-1000 cosmic shear into a novel joint analysis, accounting for the full cross-covariance between the probes, providing tight cosmological constraints by breaking parameter degeneracies inherent to both probes. The joint analysis gives an improvement of 40% on the constraint of S8 = I8Om/0.3 over cosmic shear alone, while providing constraints on baryon feedback consistent with hydrodynamical simulations, demonstrating the potential of such joint analyses with baryonic tracers such as the tSZ effect. We discuss remaining modelling challenges that need to be addressed if these baryonic probes are to be included in future precision-cosmology analyses

Hallux valgus angle as main predictor for correction of hallux valgus

Contains fulltext : 70112.pdf ( ) (Open Access)BACKGROUND: It is recognized that different types of hallux valgus exist. Classification occurs with radiographic and clinical parameters. Severity of different parameters is used in algorithms to choose between different surgical procedures. Because there is no consensus about each parameter nor their cut-off point we conducted this study to analyze the influence of these variables on the postoperative hallux valgus angle. METHODS: After informed consent 115 patients (136 feet) were included. Bunionectomy, osteotomy, lateralization of the distal fragment, lateral release and medial capsulorrhaphy were performed in all patients. Data were collected on preoperative and postoperative HVA, IMA and DMAA measurements. Forty cases were included since our findings in a previous article 1, therefore, current data concern an expanded study group with longer follow-up and were not published before. At least two-year follow-up data were evaluated with logistic regression and independent t-tests. RESULTS: Preoperative HVA was significant for prediction of postoperative HVA in logistic regression. IMA and DMAA were not significant for prediction of postoperative HVA in logistic regression, although they were significantly increased in larger deformities. In patients with preoperative HVA of 37 degrees or more, satisfactory correction could be obtained in 65 percent. The other nine of these 26 patients developed subluxation. CONCLUSION: The preoperative HVA was the main radiological predictor for correction of hallux valgus, correction rate declined from preoperative HVA of 37. IMA and DMAA did have a minor role in patients with preoperative HVA lower than 37 degrees, however, likely contributed to preoperative HVA of 37 degrees or more

Environmental Health Disparities: A Framework Integrating Psychosocial and Environmental Concepts

Although it is often acknowledged that social and environmental factors interact to produce racial and ethnic environmental health disparities, it is still unclear how this occurs. Despite continued controversy, the environmental justice movement has provided some insight by suggesting that disadvantaged communities face greater likelihood of exposure to ambient hazards. The exposure–disease paradigm has long suggested that differential “vulnerability” may modify the effects of toxicants on biological systems. However, relatively little work has been done to specify whether racial and ethnic minorities may have greater vulnerability than do majority populations and, further, what these vulnerabilities may be. We suggest that psychosocial stress may be the vulnerability factor that links social conditions with environmental hazards. Psychosocial stress can lead to acute and chronic changes in the functioning of body systems (e.g., immune) and also lead directly to illness. In this article we present a multidisciplinary framework integrating these ideas. We also argue that residential segregation leads to differential experiences of community stress, exposure to pollutants, and access to community resources. When not counterbalanced by resources, stressors may lead to heightened vulnerability to environmental hazards