3,108 research outputs found
Super-shell structure in harmonically trapped fermionic gases and its semi-classical interpretation
It was recently shown in self-consistent Hartree-Fock calculations that a
harmonically trapped dilute gas of fermionic atoms with a repulsive two-body
interaction exhibits a pronounced {\it super-shell} structure: the shell
fillings due to the spherical harmonic trapping potential are modulated by a
beat mode. This changes the ``magic numbers'' occurring between the beat nodes
by half a period. The length and amplitude of the beating mode depends on the
strength of the interaction. We give a qualitative interpretation of the beat
structure in terms of a semiclassical trace formula that uniformly describes
the symmetry breaking U(3) SO(3) in a 3D harmonic oscillator potential
perturbed by an anharmonic term with arbitrary strength. We show
that at low Fermi energies (or particle numbers), the beating gross-shell
structure of this system is dominated solely by the two-fold degenerate
circular and (diametrically) pendulating orbits.Comment: Final version of procedings for the 'Nilsson conference
Uniform semiclassical trace formula for U(3) --> SO(3) symmetry breaking
We develop a uniform semiclassical trace formula for the density of states of
a three-dimensional isotropic harmonic oscillator (HO), perturbed by a term
. This term breaks the U(3) symmetry of the HO, resulting in a
spherical system with SO(3) symmetry. We first treat the anharmonic term in
semiclassical perturbation theory by integration of the action of the perturbed
periodic HO orbits over the manifold P which characterizes
their 4-fold degeneracy. Then we obtain an analytical uniform trace formula
which in the limit of strong perturbations (or high energy) asymptotically goes
over into the correct trace formula of the full anharmonic system with SO(3)
symmetry, and in the limit (or energy) restores the HO trace
formula with U(3) symmetry. We demonstrate that the gross-shell structure of
this anharmonically perturbed system is dominated by the two-fold degenerate
diameter and circular orbits, and {\it not} by the orbits with the largest
classical degeneracy, which are the three-fold degenerate tori with rational
ratios of radial and angular frequencies. The same
holds also for the limit of a purely quartic spherical potential .Comment: LaTeX (revtex4), 26pp., 5 figures, 1 table; final version to be
published in J. Phys. A (without appendices C and D
Chiral tunneling and the Klein paradox in graphene
The so-called Klein paradox - unimpeded penetration of relativistic particles
through high and wide potential barriers - is one of the most exotic and
counterintuitive consequences of quantum electrodynamics (QED). The phenomenon
is discussed in many contexts in particle, nuclear and astro- physics but
direct tests of the Klein paradox using elementary particles have so far proved
impossible. Here we show that the effect can be tested in a conceptually simple
condensed-matter experiment by using electrostatic barriers in single- and
bi-layer graphene. Due to the chiral nature of their quasiparticles, quantum
tunneling in these materials becomes highly anisotropic, qualitatively
different from the case of normal, nonrelativistic electrons. Massless Dirac
fermions in graphene allow a close realization of Klein's gedanken experiment
whereas massive chiral fermions in bilayer graphene offer an interesting
complementary system that elucidates the basic physics involved.Comment: 15 pages, 4 figure
Categorical Dimensions of Human Odor Descriptor Space Revealed by Non-Negative Matrix Factorization
In contrast to most other sensory modalities, the basic perceptual dimensions of olfaction remain unclear. Here, we use non-negative matrix factorization (NMF) – a dimensionality reduction technique – to uncover structure in a panel of odor profiles, with each odor defined as a point in multi-dimensional descriptor space. The properties of NMF are favorable for the analysis of such lexical and perceptual data, and lead to a high-dimensional account of odor space. We further provide evidence that odor dimensions apply categorically. That is, odor space is not occupied homogenously, but rather in a discrete and intrinsically clustered manner. We discuss the potential implications of these results for the neural coding of odors, as well as for developing classifiers on larger datasets that may be useful for predicting perceptual qualities from chemical structures
Structural Insight into Host Recognition by Aggregative Adherence Fimbriae of Enteroaggregative Escherichia coli
AVZ is supported by the Finnish Academy (grant 273075; http://sciencenordic.com/partner/academy-finland). The EACEA (http://eacea.ec.europa.eu) supports NP for an Erasmus Mundus scholarship. SM is supported by the Wellcome Trust (Senior Investigator Award 100280, Programme grant 079819; equipment grant 085464; http://www.wellcome.ac.uk)) and the Leverhulme Trust (RPG-2012-559; http://www.leverhulme.ac.uk). JPN and AAB are supported by a US Public Health Service grant (AI-033096; www.usphs.gov). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
Thermal stress induces glycolytic beige fat formation via a myogenic state.
Environmental cues profoundly affect cellular plasticity in multicellular organisms. For instance, exercise promotes a glycolytic-to-oxidative fibre-type switch in skeletal muscle, and cold acclimation induces beige adipocyte biogenesis in adipose tissue. However, the molecular mechanisms by which physiological or pathological cues evoke developmental plasticity remain incompletely understood. Here we report a type of beige adipocyte that has a critical role in chronic cold adaptation in the absence of β-adrenergic receptor signalling. This beige fat is distinct from conventional beige fat with respect to developmental origin and regulation, and displays enhanced glucose oxidation. We therefore refer to it as glycolytic beige fat. Mechanistically, we identify GA-binding protein α as a regulator of glycolytic beige adipocyte differentiation through a myogenic intermediate. Our study reveals a non-canonical adaptive mechanism by which thermal stress induces progenitor cell plasticity and recruits a distinct form of thermogenic cell that is required for energy homeostasis and survival
Quantum Simulation of Tunneling in Small Systems
A number of quantum algorithms have been performed on small quantum
computers; these include Shor's prime factorization algorithm, error
correction, Grover's search algorithm and a number of analog and digital
quantum simulations. Because of the number of gates and qubits necessary,
however, digital quantum particle simulations remain untested. A contributing
factor to the system size required is the number of ancillary qubits needed to
implement matrix exponentials of the potential operator. Here, we show that a
set of tunneling problems may be investigated with no ancillary qubits and a
cost of one single-qubit operator per time step for the potential evolution. We
show that physically interesting simulations of tunneling using 2 qubits (i.e.
on 4 lattice point grids) may be performed with 40 single and two-qubit gates.
Approximately 70 to 140 gates are needed to see interesting tunneling dynamics
in three-qubit (8 lattice point) simulations.Comment: 4 pages, 2 figure
Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders
How the genome activates or silences transcriptional programmes governs organ formation. Little is known in human embryos undermining our ability to benchmark the fidelity of stem cell differentiation or cell programming, or interpret the pathogenicity of noncoding variation. Here, we study histone modifications across thirteen tissues during human organogenesis. We integrate the data with transcription to build an overview of how the human genome differentially regulates alternative organ fates including by repression. Promoters from nearly 20,000 genes partition into discrete states. Key developmental gene sets are actively repressed outside of the appropriate organ without obvious bivalency. Candidate enhancers, functional in zebrafish, allow imputation of tissue-specific and shared patterns of transcription factor binding. Overlaying more than 700 noncoding mutations from patients with developmental disorders allows correlation to unanticipated target genes. Taken together, the data provide a comprehensive genomic framework for investigating normal and abnormal human development
Topological Photonics
Topology is revolutionizing photonics, bringing with it new theoretical
discoveries and a wealth of potential applications. This field was inspired by
the discovery of topological insulators, in which interfacial electrons
transport without dissipation even in the presence of impurities. Similarly,
new optical mirrors of different wave-vector space topologies have been
constructed to support new states of light propagating at their interfaces.
These novel waveguides allow light to flow around large imperfections without
back-reflection. The present review explains the underlying principles and
highlights the major findings in photonic crystals, coupled resonators,
metamaterials and quasicrystals.Comment: progress and review of an emerging field, 12 pages, 6 figures and 1
tabl
Disease progression in Plasmodium knowlesi malaria is linked to variation in invasion gene family members.
Emerging pathogens undermine initiatives to control the global health impact of infectious diseases. Zoonotic malaria is no exception. Plasmodium knowlesi, a malaria parasite of Southeast Asian macaques, has entered the human population. P. knowlesi, like Plasmodium falciparum, can reach high parasitaemia in human infections, and the World Health Organization guidelines for severe malaria list hyperparasitaemia among the measures of severe malaria in both infections. Not all patients with P. knowlesi infections develop hyperparasitaemia, and it is important to determine why. Between isolate variability in erythrocyte invasion, efficiency seems key. Here we investigate the idea that particular alleles of two P. knowlesi erythrocyte invasion genes, P. knowlesi normocyte binding protein Pknbpxa and Pknbpxb, influence parasitaemia and human disease progression. Pknbpxa and Pknbpxb reference DNA sequences were generated from five geographically and temporally distinct P. knowlesi patient isolates. Polymorphic regions of each gene (approximately 800 bp) were identified by haplotyping 147 patient isolates at each locus. Parasitaemia in the study cohort was associated with markers of disease severity including liver and renal dysfunction, haemoglobin, platelets and lactate, (r = ≥ 0.34, p = <0.0001 for all). Seventy-five and 51 Pknbpxa and Pknbpxb haplotypes were resolved in 138 (94%) and 134 (92%) patient isolates respectively. The haplotypes formed twelve Pknbpxa and two Pknbpxb allelic groups. Patients infected with parasites with particular Pknbpxa and Pknbpxb alleles within the groups had significantly higher parasitaemia and other markers of disease severity. Our study strongly suggests that P. knowlesi invasion gene variants contribute to parasite virulence. We focused on two invasion genes, and we anticipate that additional virulent loci will be identified in pathogen genome-wide studies. The multiple sustained entries of this diverse pathogen into the human population must give cause for concern to malaria elimination strategists in the Southeast Asian region
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