62 research outputs found
Mirror Symmetry and Other Miracles in Superstring Theory
The dominance of string theory in the research landscape of quantum gravity
physics (despite any direct experimental evidence) can, I think, be justified
in a variety of ways. Here I focus on an argument from mathematical fertility,
broadly similar to Hilary Putnam's 'no miracles argument' that, I argue, many
string theorists in fact espouse. String theory leads to many surprising,
useful, and well-confirmed mathematical 'predictions' - here I focus on mirror
symmetry. These predictions are made on the basis of general physical
principles entering into string theory. The success of the mathematical
predictions are then seen as evidence for framework that generated them. I
attempt to defend this argument, but there are nonetheless some serious
objections to be faced. These objections can only be evaded at a high
(philosophical) price.Comment: For submission to a Foundations of Physics special issue on "Forty
Years Of String Theory: Reflecting On the Foundations" (edited by G. `t
Hooft, E. Verlinde, D. Dieks and S. de Haro)
Precision Measurement of the p(e,e ' p)pi(0) Reaction at Threshold
New results are reported from a measurement of electroproduction near
threshold using the reaction. The experiment was
designed to determine precisely the energy dependence of and wave
electromagnetic multipoles as a stringent test of the predictions of Chiral
Perturbation Theory (ChPT). The data were taken with an electron beam energy of
1192 MeV using a two-spectrometer setup in Hall A at Jefferson Lab. For the
first time, complete coverage of the and angles
in the center-of-mass was obtained for invariant energies above
threshold from 0.5 MeV up to 15 MeV. The 4-momentum transfer coverage
ranges from 0.05 to 0.155 (GeV/c) in fine steps. A simple phenomenological
analysis of our data shows strong disagreement with wave predictions from
ChPT for (GeV/c), while the wave predictions are in
reasonable agreement.Comment: 5 pages, 6 figure
Gluons and the quark sea at high energies: distributions, polarization, tomography
This report is based on a ten-week program on "Gluons and the quark sea at
high-energies", which took place at the Institute for Nuclear Theory in Seattle
in Fall 2010. The principal aim of the program was to develop and sharpen the
science case for an Electron-Ion Collider (EIC), a facility that will be able
to collide electrons and positrons with polarized protons and with light to
heavy nuclei at high energies, offering unprecedented possibilities for
in-depth studies of quantum chromodynamics. This report is organized around
four major themes: i) the spin and flavor structure of the proton, ii)
three-dimensional structure of nucleons and nuclei in momentum and
configuration space, iii) QCD matter in nuclei, and iv) Electroweak physics and
the search for physics beyond the Standard Model. Beginning with an executive
summary, the report contains tables of key measurements, chapter overviews for
each of the major scientific themes, and detailed individual contributions on
various aspects of the scientific opportunities presented by an EIC.Comment: 547 pages, A report on the joint BNL/INT/Jlab program on the science
case for an Electron-Ion Collider, September 13 to November 19, 2010,
Institute for Nuclear Theory, Seattle; v2 with minor changes, matches printed
versio
Use of SMS texts for facilitating access to online alcohol interventions: a feasibility study
A41 Use of SMS texts for facilitating access to online alcohol interventions: a feasibility study
In: Addiction Science & Clinical Practice 2017, 12(Suppl 1): A4
Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease
Tissue fibrosis is a core pathologic process that contributes to mortality in ~45% of the population and is likely to be influenced by the host genetic architecture. Here we demonstrate, using liver disease as a model, that a single-nucleotide polymorphism (rs12979860) in the intronic region of interferon-λ4 (IFNL4) is a strong predictor of fibrosis in an aetiology-independent manner. In a cohort of 4,172 patients, including 3,129 with chronic hepatitis C (CHC), 555 with chronic hepatitis B (CHB) and 488 with non-alcoholic fatty liver disease (NAFLD), those with rs12979860CC have greater hepatic inflammation and fibrosis. In CHC, those with rs12979860CC also have greater stage-constant and stage-specific fibrosis progression rates (P<0.0001 for all). The impact of rs12979860 genotypes on fibrosis is maximal in young females, especially those with HCV genotype 3. These findings establish rs12979860 genotype as a strong aetiology-independent predictor of tissue inflammation and fibrosis
TIPS bilateral noise reduction in 4D CT perfusion scans produces high-quality cerebral blood flow maps
Contains fulltext :
98391.pdf ( ) (Closed access)Cerebral computed tomography perfusion (CTP) scans are acquired to detect areas of abnormal perfusion in patients with cerebrovascular diseases. These 4D CTP scans consist of multiple sequential 3D CT scans over time. Therefore, to reduce radiation exposure to the patient, the amount of x-ray radiation that can be used per sequential scan is limited, which results in a high level of noise. To detect areas of abnormal perfusion, perfusion parameters are derived from the CTP data, such as the cerebral blood flow (CBF). Algorithms to determine perfusion parameters, especially singular value decomposition, are very sensitive to noise. Therefore, noise reduction is an important preprocessing step for CTP analysis. In this paper, we propose a time-intensity profile similarity (TIPS) bilateral filter to reduce noise in 4D CTP scans, while preserving the time-intensity profiles (fourth dimension) that are essential for determining the perfusion parameters. The proposed TIPS bilateral filter is compared to standard Gaussian filtering, and 4D and 3D (applied separately to each sequential scan) bilateral filtering on both phantom and patient data. Results on the phantom data show that the TIPS bilateral filter is best able to approach the ground truth (noise-free phantom), compared to the other filtering methods (lowest root mean square error). An observer study is performed using CBF maps derived from fifteen CTP scans of acute stroke patients filtered with standard Gaussian, 3D, 4D and TIPS bilateral filtering. These CBF maps were blindly presented to two observers that indicated which map they preferred for (1) gray/white matter differentiation, (2) detectability of infarcted area and (3) overall image quality. Based on these results, the TIPS bilateral filter ranked best and its CBF maps were scored to have the best overall image quality in 100% of the cases by both observers. Furthermore, quantitative CBF and cerebral blood volume values in both the phantom and the patient data showed that the TIPS bilateral filter resulted in realistic mean values with a smaller standard deviation than the other evaluated filters and higher contrast-to-noise ratios. Therefore, applying the proposed TIPS bilateral filtering method to 4D CTP data produces higher quality CBF maps than applying the standard Gaussian, 3D bilateral or 4D bilateral filter. Furthermore, the TIPS bilateral filter is computationally faster than both the 3D and 4D bilateral filters
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