Outside the Voucher: Evaluating the Creative Voucher Scheme

This chapter seeks to elaborate on what one might have expected to be the straightforward task of delivering and evaluating Creativeworks London’s (CWL) Creative Voucher scheme.1 What made the project difficult was that the notion of the “creative” voucher has not been used before; it was not a policy developed from a direct evidence base. Moreover, the Creativeworks London project was premised on the delivery of three funding streams of which the vouchers were one; indeed something approaching half of these funds were targeted to resource creative vouchers. This chapter offers a discussion of how we implemented the creative vouchers, the product of which makes up most of this volume. It also raises the question of what and how one might evaluate vouchers; something, we argue, that does not gain from a reduction to a limited set of quantitative indicators. Indeed, our reflections on the process projected us into a far more exploratory and nuanced narrative account of the vouchers; hence the chapters of this book which represent a range of different facets and experiences of the creative voucher scheme. Traditional evaluations of innovation and knowledge transfer are based upon simplistic mono-causal models whereby the dominant notion is that knowledge will naturally diffuse from high concentrations to low concentrations: like a gas; this of course is a social physics model. The failure to diffuse evenly, it is normally hypothesized, must be due to some “blockage” or “barrier.” In keeping with mechanical analogies, much policy action is focused on “fixing the plumbing” that is the leaky knowledge pipelines. The challenge is that the logic behind knowledge transfer, let alone policies such as vouchers, are seldom explicitly stated, but rather assumed as common sense. As we experience the transformation from mass production economies to those based on what are variously termed service economies, knowledge economies, or even cultural economies the physical movement of goods, innovation and ideas materialized as “solutions” (as “technology” has commonly been) has been replaced by weightless or virtual goods: ideas. Physicalist analogies might have been helpful in an old manufacturing economy; it is clear that they are less helpful in either dematerialized production, or the realm of ideas exclusively. Moreover, the Creativeworks London project was explicitly funded by the Arts and Humanities Research Council (AHRC) with a view to demonstrating the role of what the arts and humanities can contribute to the processes of knowledge transfer between universities and the creative economy (see Chapter One). It is obvious that the arts and humanities favor different approaches to knowledge than that of the sciences; in particular the humanities focus on the nature of human experience and ideas—one might argue that it is the ideal type of knowledge transfer. The humanities has a rather more nuanced and relational perspective on knowledge and human experience than the sciences, focused as they often are on physical processes and outcomes. We saw it as our task to explore and reflect on creative vouchers and meanings. Whereas the individual voucher stories provide a rich narrative of what the knowledge exchange process “looks like” and at times what it might “feel like,” and what meanings it produces for those involved, this chapter attempts to examine a linked story across the voucher process. It is not seeking to generalize or summarize, rather it explores the voucher process. In this sense we resist the traditional notion of evaluation, arguing that it is necessary to understand the process before we can possibly evaluate it against objectives, personal, institutional or political

Protocol for the cultural adaptation of pulmonary rehabilitation and subsequent testing in a randomised controlled feasibility trial for adults with chronic obstructive pulmonary disease in Sri Lanka

Introduction: International guidelines recommend pulmonary rehabilitation (PR) should be offered to adults living with chronic obstructive pulmonary disease (COPD), but PR availability is limited in Sri Lanka. Culturally appropriate PR needs to be designed and implemented in Sri Lanka. The study aims to adapt PR to the Sri Lankan context and determine the feasibility of conducting a future trial of the adapted PR in Sri Lanka. Methods and analysis: Eligible participants will be identified and will be invited to take part in the randomised controlled feasibility trial, which will be conducted in Central Chest Clinic, Colombo, Sri Lanka. A total of 50 participants will be recruited (anticipated from April 2021) to the trial and randomised (1:1) into one of two groups; control group receiving usual care or the intervention group receiving adapted PR. The trial intervention is a Sri Lankan-specific PR programme, which will consist of 12 sessions of exercise and health education, delivered over 6 weeks. Focus groups with adults living with COPD, caregivers and nurses and in-depth interviews with doctors and physiotherapist will be conducted to inform the Sri Lankan specific PR adaptations. After completion of PR, routine measures in both groups will be assessed by a blinded assessor. The primary outcome measure is feasibility, including assessing eligibility, uptake and completion. Qualitative evaluation of the trial using focus groups with participants and in-depth interviews with PR deliverers will be conducted to further determine feasibility and acceptability of PR, as well as the ability to run a larger future trial. Ethics and dissemination: Ethical approval was obtained from the ethics review committee of Faculty of Medical Sciences, University of Sri Jayewardenepura, Sri Lanka and University of Leicester, UK. The results of the trial will be disseminated through patient and public involvement events, local and international conference proceedings, and peer-reviewed journals. Trial registration number ISRCTN1336773

Classification of Supernovae

The current classification scheme for supernovae is presented. The main observational features of the supernova types are described and the physical implications briefly addressed. Differences between the homogeneous thermonuclear type Ia and similarities among the heterogeneous core collapse type Ib, Ic and II are highlighted. Transforming type IIb, narrow line type IIn, supernovae associated with GRBs and few peculiar objects are also discussed.Comment: 16 Pages, 4 figures, to be published in "Supernovae and Gamma-Ray Bursters," ed. Kurt W. Weile

Dust in Supernovae and Supernova Remnants I : Formation Scenarios

Supernovae are considered as prime sources of dust in space. Observations of local supernovae over the past couple of decades have detected the presence of dust in supernova ejecta. The reddening of the high redshift quasars also indicate the presence of large masses of dust in early galaxies. Considering the top heavy IMF in the early galaxies, supernovae are assumed to be the major contributor to these large amounts of dust. However, the composition and morphology of dust grains formed in a supernova ejecta is yet to be understood with clarity. Moreover, the dust masses inferred from observations in mid-infrared and submillimeter wavelength regimes differ by two orders of magnitude or more. Therefore, the mechanism responsible for the synthesis of molecules and dust in such environments plays a crucial role in studying the evolution of cosmic dust in galaxies. This review summarises our current knowledge of dust formation in supernova ejecta and tries to quantify the role of supernovae as dust producers in a galaxy.Peer reviewe

Track D Social Science, Human Rights and Political Science

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138414/1/jia218442.pd

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

The SARS-CoV-2 Omicron BA.1 variant emerged in 20211 and has multiple mutations in its spike protein2. Here we show that the spike protein of Omicron has a higher affinity for ACE2 compared with Delta, and a marked change in its antigenicity increases Omicron’s evasion of therapeutic monoclonal and vaccine-elicited polyclonal neutralizing antibodies after two doses. mRNA vaccination as a third vaccine dose rescues and broadens neutralization. Importantly, the antiviral drugs remdesivir and molnupiravir retain efficacy against Omicron BA.1. Replication was similar for Omicron and Delta virus isolates in human nasal epithelial cultures. However, in lung cells and gut cells, Omicron demonstrated lower replication. Omicron spike protein was less efficiently cleaved compared with Delta. The differences in replication were mapped to the entry efficiency of the virus on the basis of spike-pseudotyped virus assays. The defect in entry of Omicron pseudotyped virus to specific cell types effectively correlated with higher cellular RNA expression of TMPRSS2, and deletion of TMPRSS2 affected Delta entry to a greater extent than Omicron. Furthermore, drug inhibitors targeting specific entry pathways3 demonstrated that the Omicron spike inefficiently uses the cellular protease TMPRSS2, which promotes cell entry through plasma membrane fusion, with greater dependency on cell entry through the endocytic pathway. Consistent with suboptimal S1/S2 cleavage and inability to use TMPRSS2, syncytium formation by the Omicron spike was substantially impaired compared with the Delta spike. The less efficient spike cleavage of Omicron at S1/S2 is associated with a shift in cellular tropism away from TMPRSS2-expressing cells, with implications for altered pathogenesis

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

An estimate of the potential economic impact of pine pitch canker in Australia

This paper estimates the economic benefits Australian pine plantations can expect to enjoy if the pine pitch canker fungus can be prevented from entering the country at any time over the next 30 years. It presents a stochastic bioeconomic model that estimates the additional costs imposed by producer behavioural changes as the pathogen enters the country and begins to spread. The avoidance of these large cost and revenue effects can be interpreted as the benefits of exclusion. Our results indicate that delaying the process of entry and spread by as little as two to three years will produce economic benefits of almost $13 million over time

Chiral symmetry restoration and deconfinement in the CPN model with fermions

SIGLEAvailable from British Library Lending Division - LD:9106.16(DAMTP--85-1) / BLDSC - British Library Document Supply CentreGBUnited Kingdo