Stellar population analysis of two ellipticals

The spatial distributions of the mean luminosity-weighted stellar age, metallicity, and alpha/Fe ratio along both photometric axes of two nearby elliptical galaxies have been obtained using Lick index measurements on long slit spectra in order to reconstruct the star formation history in their kinematically distinct subsystems. Lick indexes were compared with those of single-aged stellar population (SSP) models. A population synthesis method was also applied in order to help disentangling the age-metallicity degeneracy. The stars characteristics are associated with their kinematics: they are older and alpha-enhanced in the not rotating bulge of NGC 1052 and counter rotating core of NGC 7796, while they show a strong spread of alpha/Fe and age along the rotating disk of NGC 1052 and an outwards radial decreasing of them outside the core of NGC 7796.Comment: 2 pages, to appear in the Proceedings of IAU Symposium 241 "Stellar populations as building blocks of galaxies", A. Vazdekis & R. Peletier, ed

C and N abundances of MS and SGB stars in NGC 1851

We present the first chemical analysis of stars on the double subgiant branch (SGB) of the globular cluster NGC 1851. We obtained 48 Magellan IMACS spectra of subgiants and fainter stars covering the spectral region between 3650-6750\AA, to derive C and N abundances from the spectral features at 4300\AA (G-band) and at ~ 3883\AA (CN). We added to our sample ~ 45 unvevolved stars previously observed with FORS2 at the VLT. These two datasets were homogeneously reduced and analyzed. We derived abundances of C and N for a total of 64 stars and found considerable star-to-star variations in both [C/H] and [N/H] at all luminosities extending to the red giant branch (RGB) base (V~18.9). These abundances appear to be strongly anticorrelated, as would be expected from the CN-cycle enrichment, but we did not detect any bimodality in the C or N content. We used HST and ground-based photometry to select two groups of faint- and bright-SGB stars from the visual and Str\"omgren color-magnitude diagrams. Significant variations in the carbon and nitrogen abundances are present among stars of each group, which indicates that each SGB hosts multiple subgenerations of stars. Bright- and faint-SGB stars differ in the total C+N content, where the fainter SGB have about 2.5 times the C+N content of the brighter ones. Coupling our results with literature photometric data and abundance determinations from high-resolution studies, we identify the fainter SGB with the red-RGB population, which also should be richer on average in Ba and other s-process elements, as well as in Na and N, when compared to brighter SGB and the blue-RGB population.Comment: 17 pages, 3 tables, 16 figures; typos corrected, added checks on temperature scale; A&A accepted (in press

The double sub-giant branch of NGC 6656 (M22): a chemical characterization

We present an abundance analysis of 101 subgiant branch (SGB) stars in the globular cluster M22. Using low resolution FLAMES/GIRAFFE spectra we have determined abundances of the neutron-capture strontium and barium and the light element carbon. With these data we explore relationships between the observed SGB photometric split in this cluster and two stellar groups characterized by different contents of iron, slow neutron-capture process (s-process) elements, and the alpha element calcium, that we previously discovered in M22's red-giant stars. We show that the SGB stars correlate in chemical composition and color-magnitude diagram position: the stars with higher metallicity and relative s-process abundances define a fainter SGB, while stars with lower metallicity and s-process content reside on a relatively brighter SGB. This result has implications for the relative ages of the two stellar groups of M22. In particular, it is inconsistent with a large spread in ages of the two SGBs. By accounting for the chemical content of the two stellar groups, isochrone fitting of the double SGB suggests that their ages are not different by more than 300 Myr.Comment: 21 pages, 12 figures, accepted for publication in A&

MCAO near-IR photometry of the Globular Cluster NGC 6388: MAD observations in crowded fields

Deep photometry of crowded fields, such as Galactic Globular Clusters, is severely limited by the actual resolution of ground-based telescopes. On the other hand, the Hubble Space Telescope does not provide the near-infrared (NIR) filters needed to allow large color baselines. In this work we aim at demonstrating how ground based observations can reach the required resolution when using Multi-Conjugated Adaptive Optic (MCAO) devices in the NIR, such as the experimental infrared camera (MAD) available on the VLT. This is particularly important since these corrections are planned to be available on all ground--based telescopes in the near future. We do this by combining the infrared photometry obtained by MAD/VLT with ACS/HST optical photometry of our scientific target, the bulge globular cluster NGC 6388, in which we imaged two fields. In particular, we constructed color-magnitude diagrams with an extremely wide color baseline in order to investigate the presence of multiple stellar populations in this cluster. From the analysis of the external field, observed with better seeing conditions, we derived the deepest optical-NIR CMD of NGC 6388 to date. The high-precision photometry reveals that two distinct sub-giant branches are clearly present in this cluster. We also use the CMD from the central region to estimate the distance ((m-M)=15.33) and the reddening (E(B-V)=0.38) for this cluster. We estimate the age to be ~11.5+/- 1.5 Gyr. The large relative-age error reflects the bimodal distribution of the SGB stars. This study clearly demonstrates how MCAO correction in the NIR bands implemented on ground based telescopes can complement the high-resolution optical data from HST.Comment: 9 pages, 10 figures. Accepted for publication on A. &

Robotic colorectal cancer surgery. How to reach expertise? a single surgeon-experience

The complexity associated with laparoscopic colorectal surgery requires several skills to overcome the technical difficulties related to this procedure. To overcome the technical challenges of laparoscopic surgery, a robotic approach has been introduced. Our study reports the surgical outcomes obtained by the transition from laparoscopic to robotic approach in colorectal cancer surgery to establish in which type of approach the proficiency is easier to reach. Data about the first consecutive 15 laparoscopic and the first 15 consecutive robotic cases are extracted, adopting as a comparator of proficiency the last 15 laparoscopic colorectal resections for cancer. The variables studied are operative time, number of harvested nodes, conversion rate, postoperative complications, recovery outcomes. Our analysis includes 15 patients per group. Our results show that operative time is significantly longer in the first 15 laparoscopic cases (p = 0.001). A significantly lower number of harvested nodes was retrieved in the first 15 laparoscopic cases (p = 0.003). Clavien Dindo I complication rate was higher in the first laparoscopic group, but without a significant difference among the three groups (p = 0.09). Our results show that the surgeon needed no apparent learning curve to reach their laparoscopic standards. However, further multicentric prospective studies are needed to confirm this conclusion

Redox regulation of cellular stress response in multiple sclerosis

Multiple sclerosis (MS) is an autoimmune-mediated neurodegenerative disease with characteristic foci of inflammatory demyelination in the brain, spinal cord, and optic nerves. Recent studies have demonstrated not only that axonal damage and neuronal loss are significant pathologic components of MS, but that this neuronal damage is thought to cause the permanent neurologic disability often seen in MS patients. Emerging finding suggests that altered redox homeostasis and increased oxidative stress, primarily implicated in the pathogenesis of MS, are a trigger for activation of a brain stress response. Relevant to maintenance of redox homeostasis, integrated mechanisms controlled by vitagenes operate in brain in preserving neuronal survival during stressful conditions. Vitagenes encode for heat shock proteins (Hsp) Hsp32, Hsp70, the thioredoxin and the sirtuin protein systems. In the present study we assess stress response mechanisms in the CSF, plasma and lymphocytes of control patients compared to MS patients. We found that the levels of vitagenes Hsp72, Hsc70, HO-1, as well as oxidative stress markers carbonyls and hydroxynonenals were significantly higher in the blood and CSF of MS patients than in control patients. In addition, an increased expression of Trx and sirtuin 1, together with a decrease in the expression of TrxR were observed. Our data strongly support a pivotal role for redox homeostasis disruption in the pathogenesis of MS and, consistently with the notion that new therapies that prevent neurodegeneration through nonimmunomodulatory mechanisms can have a tremendous potential to work synergistically with current MS therapies, unravel important targets for new cytoprotective strategies

The two metallicity groups of the globular cluster M22: a chemical perspective

We present a detailed chemical composition analysis of 35 red giant stars in the globular cluster M22. High resolution spectra for this study were obtained at five observatories, and analyzed in a uniform manner. We have determined abundances of representative light proton-capture, alpha, Fe-peak and neutron-capture element groups. Our aim is to better understand the peculiar chemical enrichment history of this cluster, in which two stellar groups are characterized by a different content in iron, neutron capture elements Y, Zr and Ba, and alpha element Ca. The principal results of this study are: (i) substantial star-to-star metallicity scatter (-2.0<[Fe/H]<-1.6); (ii) enhancement of s-process/r-process neutron-capture abundance ratios in a fraction of giants, positively correlated with metallicity; (iii) sharp separation between the s-process rich and s-process poor groups by [La/Eu] ratio; (iv) possible increase of [Cu/Fe] ratios with increasing [Fe/H], suggesting that this element also has a significant s-process component; and (v) presence of Na-O and C-N anticorrelations in both the stellar groups.Comment: 26 pages, 19 figures. Accepted for publication in A&

Efficacy and safety of dasatinib vs. Imatinib in Latin american subpopulation from the dasision trial in patients with newly diagnosed chronic myeloid leukemia (CML) in chronic phase (CP)

sem informação100120th Congress of European-Hematology-Associationsem informaçã

Surgical stress and metabolic response after totally laparoscopic right colectomy

No clear consensus on the need to perform an intracorporeal anastomosis (IA) after laparoscopic right colectomy is currently available. One of the potential benefits of intracorporeal anastomosis may be a reduction in surgical stress. Herein, we evaluated the surgical stress response and the metabolic response in patients who underwent right colonic resection for colon cancer. Fifty-nine patients who underwent laparoscopic resection for right colon cancer were randomized to receive an intracorporeal or an extracorporeal anastomosis (EA). Data including demographics (age, sex, BMI and ASA score), pathological (AJCC tumour stage and tumour localization) and surgical results were recorded. Moreover, to determine the levels of the inflammatory response, mediators, such as C-reactive protein (CRP), tumour necrosis factor (TNF), interleukin 1β (IL-1β), IL-6, IL-10, and IL-13, were evaluated. Similarly, cortisol and insulin levels were evaluated as hormonal responses to surgical stress. We found that the proinflammatory mediator IL-6, CRP, TNF and IL-1β levels, were significantly reduced in IA compared to EA. Concurrently, an improved profile of the anti-inflammatory cytokines IL-10 and IL-13 was observed in the IA group. Relative to the hormone response to surgical stress, cortisol was increased in patients who underwent EA, while insulin was reduced in the EA group. Based on these results, surgical stress and metabolic response to IA justify advocating the adoption of a totally laparoscopic approach when performing a right colectomy for cancer. This trial is registered on ClinicalTrials.gov (ID: NCT03422588)