Strategy for diagnosis and correction of vaginal dysbiosis in terms of preparation of pregnant for planned cesarean section and prevention of postpartum endometritis.

Clinical features of vaginal dysbiosis as a factor in the high risk of septic complications, especially in pregnant women diagnosed with anaerobic vaginal dysbiosis were examined. Low efficiency of the traditional methods of treating bacterial dysbiosis, a high rate of recurrences and the risk of preterm delivery dictate the need to find alternative methods of treatment and prevention of antenatal and post-natal complications. The widespread introduction of caesarean section into obstetric practice contributed to the reduction of perinatal loss. However, together with the expansion of indications for cesarean section, increase in the frequency and severity of post-natal chronic inflammatory diseases is associated. The number of purulent-inflammatory diseases in the early postoperative period and in the long-term period after C-section is large, reaching 3,3-54,3%. Postpartum period, even in physiological course and particularly in the presence of risk factors is favorable for the development of infectious complications. Almost all the authors identify caesarean section as a significant risk factor for postpartum endometritis, since, making only 10 - 20% of the total number of deliveries, cesarean section causes 80% of all postpartum endometritis. We propose a diagnostic algorithm, drug correction and prevention for this common group of patients

Into the deep: New data on the lipid and fatty acid profile of redfish Sebastes mentella inhabiting different depths in the Irminger Sea

New data on lipid and fatty acid profiles are presented, and the dynamics of the studied components in muscles in the males and females of the beaked redfish, Sebastes mentella, in the depth gradient of the Irminger Sea (North Atlantic) is discussed. The contents of the total lipids (TLs), total phospholipids (PLs), monoacylglycerols (MAGs), diacylglycerols (DAGs), triacylglycerols (TAGs), cholesterol (Chol), Chol esters, non-esterified fatty acids (NEFAs), and wax esters were determined by HPTLC; the phosphatidylserine (PS), phosphatidylethanolamine (PE), phosphatidylinositol (PI), phosphatidylcholine (PC), and lysophosphatidylcholine (LPC) were determined by HPLC; and fatty acids of total lipids were determined using GC. The Chol esters prevailed in muscles over the storage TAGs, and the wax ester content was high, which is a characteristic trait of vertically migrating species. Specific dynamics in certain PL in redfish were found to be depended on depth, suggesting that PLs are involved in the re-arrangement of the membrane physicochemical state and the maintenance of motor activity under high hydrostatic pressure. The high contents of DHA and EPA were observed in beaked redfish muscles is the species’ characteristic trait. The MUFAs in muscles include dietary markers of zooplankton (copepods)—20:1(n-9) and 22:1(n-11), whose content was found to be lower in fish sampled from greater depth

Variational calculations for the hydrogen-antihydrogen system with a mass-scaled Born-Oppenheimer potential

The problem of proton-antiproton motion in the ${\rm H}$--${\rm \bar{H}}$ system is investigated by means of the variational method. We introduce a modified nuclear interaction through mass-scaling of the Born-Oppenheimer potential. This improved treatment of the interaction includes the nondivergent part of the otherwise divergent adiabatic correction and shows the correct threshold behavior. Using this potential we calculate the vibrational energy levels with angular momentum 0 and 1 and the corresponding nuclear wave functions, as well as the S-wave scattering length. We obtain a full set of all bound states together with a large number of discretized continuum states that might be utilized in variational four-body calculations. The results of our calculations gives an indication of resonance states in the hydrogen-antihydrogen system

Enabling propagation of anisotropic polaritons along forbidden directions via a topological transition

Polaritons with directional in-plane propagation and ultralow losses in van der Waals (vdW) crystals promise unprecedented manipulation of light at the nanoscale. However, these polaritons present a crucial limitation: their directional propagation is intrinsically determined by the crystal structure of the host material, imposing forbidden directions of propagation. Here, we demonstrate that directional polaritons (in-plane hyperbolic phonon polaritons) in a vdW crystal (α-phase molybdenum trioxide) can be directed along forbidden directions by inducing an optical topological transition, which emerges when the slab is placed on a substrate with a given negative permittivity (4H–silicon carbide). By visualizing the transition in real space, we observe exotic polaritonic states between mutually orthogonal hyperbolic regimes, which unveil the topological origin of the transition: a gap opening in the dispersion. This work provides insights into optical topological transitions in vdW crystals, which introduce a route to direct light at the nanoscale

Development of a PbWO4 Detector for Single-Shot Positron Annihilation Lifetime Spectroscopy at the GBAR Experiment

We have developed a PbWO4 (PWO) detector with a large dynamic range to measure the intensity of a positron beam and the absolute density of the ortho-positronium (o-Ps) cloud it creates. A simulation study shows that a setup based on such detectors may be used to determine the angular distribution of the emission and reflection of o-Ps to reduce part of the uncertainties of the measurement. These will allow to improve the precision in the measurement of the cross-section for the (anti)hydrogen formation by (anti)proton-positronium charge exchange and to optimize the yield of antihydrogen ion which is an essential parameter in the GBAR experiment

Novel membrane mimetic systems based on amphiphilic oxyethylated calix[4]arene: Aggregative and liquid crystalline behavior

Self-organization of amphiphilic calixarenes oxyethylated at a lower rim has been investigated in water and water-organic solutions. In the range of isotropic solutions three types of structural transitions were indicated by a complex of methods. The first critical point indicated by surface tension, dynamic light scattering and atomic force microscopy methods is probably connected with the formation of " infinite" organized structures (of hundreds nanometers in size) through the open association model. This aggregative phenomenon covers the concentration range below 10-3M. In the case of aqueous calixarene solutions these large aggregates co-exist with small micelle-like particles and undergo a rearrangement with an increase in the concentration. The second structural transition occurs beyond 10-3M. It is revealed in aqueous calixarene solutions by surface tension, spine probe, viscosimetry and dynamic light scattering methods. Small aggregates (~10nm in diameter) are formed in this range through a closed model typical for conventional surfactants. The third transition indicated by viscosimetry and in single case by tensiometry can be connected with an elongation of aggregates. The polarization microscopy and X-ray diffraction studies reveal the anisotropic behavior with the concentration of solutions. Parameters of the existence of liquid crystalline mesophases are found to be influenced by the structure of substituents at both the upper and lower rims, as well as by the nature of solvent. © 2010 Elsevier B.V

Tunka Advanced Instrument for cosmic rays and Gamma Astronomy

The paper is a script of a lecture given at the ISAPP-Baikal summer school in 2018. The lecture gives an overview of the Tunka Advanced Instrument for cosmic rays and Gamma Astronomy (TAIGA) facility including historical introduction, description of existing and future setups, and outreach and open data activities.Comment: Lectures given at the ISAPP-Baikal Summer School 2018: Exploring the Universe through multiple messengers, 12-21 July 2018, Bol'shie Koty, Russi

Giant optical anisotropy in transition metal dichalcogenides for next-generation photonics

Large optical anisotropy observed in a broad spectral range is of paramount importance for efficient light manipulation in countless devices. Although a giant anisotropy was recently observed in the mid-infrared wavelength range, for visible and near-infrared spectral intervals, the problem remains acute with the highest reported birefringence values of 0.8 in BaTiS3 and h-BN crystals. This inspired an intensive search for giant optical anisotropy among natural and artificial materials. Here, we demonstrate that layered transition metal dichalcogenides (TMDCs) provide an answer to this quest owing to their fundamental differences between intralayer strong covalent bonding and weak interlayer van der Walls interaction. To do this, we carried out a correlative far- and near-field characterization validated by first-principle calculations that reveals an unprecedented birefringence of 1.5 in the infrared and 3 in the visible light for MoS2. Our findings demonstrate that this outstanding anisotropy allows for tackling the diffraction limit enabling an avenue for on-chip next-generation photonics.Comment: 20 pages, 5 figure

Endoprosthesis replacement at the treatment of elbow joint defects

Results of 25 total endoprosthesis operations in patients with defects of the elbow joint of various ethiology are analysed. The endoprostheses produced by Endoservis (Russia] and Coоnrad/Mоrrey Zimmer (USA] were used. The technique of operation and postoperative rehabilitation is described in the article. The estimation of results of treatment was performed by «the Estimation of surgery of an elbow» (American Shoulder and Elbow Surgeons (ASES] Assessments; Richards R.R. et al. 1994]. Radiographically the results of treatment were estimated by the method of X-ray stability of the implants by O.A. Kudinov, V.l. Nujdin. The majority of patients undergoing arthroplasty of the elbow joint for its defects were of young age (40-45 years], and that has left its mark on the technology of operation and maintenance of the patients in different periods after surgery. The analysis of results of treatmentfor 1 year until 1-15 years after the operation was carried out. Good and excellent results, were received in 68 %, satisfactory - in 30 %. The unsatisfactory result of endoprosthesis surgery took place in 8 % of operated (2 patients]. It has been established that the endoprosthesis replacement for elbow joint defects in high-tech surgery is definitely an alternative to traditional methods of treatment, and in most cases should be seen as a method of choice for treatment of this disease