Electrophilic behavior of 3-methyl-2-methylthio-1,3,4-thiadiazolium salts: A multimodal theoretical approach

The chemical reactivity of 3-methyl-2-methylthio-1,3,4-thiadiazolium salts towards a variety of nucleophiles has been examined from several theoretical points of view including thermochemical analysis of the global reactions, the evaluation of aromaticity-related parameters - ASE (Aromatic Stabilization Energy), NICS (Nucleus Independent Chemical Shift), HOMA (Harmonic Oscillator Model of Aromaticity) - for the resulting products, the qualitative application of the HSAB- (Hard- and Soft- Acid and Bases) principle, quantitative calculation of DFT- (Density Functional Theory)- derived local and group properties such as softness and philicity, as well as the estimation of interaction energies. Two well-distinguished reaction paths are characterized depending on the nucleophilicity of the reagent. ©ARKAT

Data Set on the Use of Continuous Improvement Programs in Companies From Open-Ended Questions

Juarez-Tarraga, A.; Santandreu Mascarell, C.; Marin-Garcia, JA. (2021). Data Set on the Use of Continuous Improvement Programs in Companies From Open-Ended Questions. Frontiers in Psychology. 12:1-10. https://doi.org/10.3389/fpsyg.2021.693727S1101

What are the main concerns of human resource managers in organizations?

[EN] Purpose: This study examines whether high involvement work programs (HIWP) are included in, and respond to, the priorities of HR managers in organizations. We analyze reports to identify the main concerns for managers, and compare the solutions implemented to address them, to evaluate the extent to which HIWP are adopted to meet these challenges. Design/methodology: To conduct this study we carried out a systematic literature review, selecting reports by consulting firms and human resource management associations. Findings: Our key findings from this research suggest that HIWP are used as a lever for change to meet the challenges faced by HR managers in organizations, the most urgent of which are talent management and improving leadership. Research limitations/implications: The paper identifies possible lines of research that respond specifically to the interests of the professional ambit and would be better appreciated by HR managers in companies. Practical implications: The issues raised are relevant to HR professionals, allowing them to compare their priorities against those of managers occupying similar positions, and to view a selection of the most commonly used programs to solve priority problems. This enables HRMs to plan ahead and prepare by providing them with an overview of the most important challenges they have to face. Originality/value: On the one hand in the professional arena, as they provide professionals with an overview of the challenges they face, so they can plan optimal HR management programs, work methods geared and identify improvement opportunities. And on the other hand, in the academic sphere, our study opens possible future research lines that may contribute to the development of the profession, identify research lines that genuinely address the concerns of professionals and could help reduce the gap that some researchers have identified between the academic and professional spheres.Juarez-Tarraga, A.; Santandreu Mascarell, C.; Marin-Garcia, JA. (2019). What are the main concerns of human resource managers in organizations?. Intangible Capital. 15(1):72-95. https://doi.org/10.3926/ic.1342S729515

Tratamiento ácido de cetohexosas

Acid treatment of cetohexoses (D-fructose and L-sorbose) was made. By spectroscopic and chromatographic methods, 3-deoxy-D-erythrohexosulose, disaccharide with l-2'-glycosidic bond, di-cetopyranose 1,2' : 2,r-dianhydride and cetopyranose-cetofuranose 1,2' : 2,r-dianhydride, have been identified

GlobTherm, a global database on thermal tolerances for aquatic and terrestrial organisms

CITATION: Bennett, J. M., et al. 2018. GlobTherm, a global database on thermal tolerances for aquatic and terrestrial organisms. Scientific Data, 5:180022, doi:10.1038/sdata.2018.22.The original publication is available at https://www.nature.comHow climate affects species distributions is a longstanding question receiving renewed interest owing to the need to predict the impacts of global warming on biodiversity. Is climate change forcing species to live near their critical thermal limits? Are these limits likely to change through natural selection? These and other important questions can be addressed with models relating geographical distributions of species with climate data, but inferences made with these models are highly contingent on non-climatic factors such as biotic interactions. Improved understanding of climate change effects on species will require extensive analysis of thermal physiological traits, but such data are both scarce and scattered. To overcome current limitations, we created the GlobTherm database. The database contains experimentally derived species’ thermal tolerance data currently comprising over 2,000 species of terrestrial, freshwater, intertidal and marine multicellular algae, plants, fungi, and animals. The GlobTherm database will be maintained and curated by iDiv with the aim to keep expanding it, and enable further investigations on the effects of climate on the distribution of life on Earth.https://www.nature.com/articles/sdata201822Publisher's versio

Genes relacionados a procesos inflamatorios en macrófagos humanos THP1

El objetivo fue estudiar la expresión de genes implicados en el proceso inflamatorio y en el metabolismo de glucocorticoides en macrófagos expuestos a LDL oxidadas (LDL-Ox). Fracciones de LDL fueron aisladas a partir de plasma humano y luego peroxidadas in vitro con Cu++.Facultad de Ciencias Médica

Genes relacionados a procesos inflamatorios en macrófagos humanos THP1

El objetivo fue estudiar la expresión de genes implicados en el proceso inflamatorio y en el metabolismo de glucocorticoides en macrófagos expuestos a LDL oxidadas (LDL-Ox). Fracciones de LDL fueron aisladas a partir de plasma humano y luego peroxidadas in vitro con Cu++.Facultad de Ciencias Médica

VISMapper: ultra-fast exhaustive cartography of viral insertion sites for gene therapy

Background -- The possibility of integrating viral vectors to become a persistent part of the host genome makes them a crucial element of clinical gene therapy. However, viral integration has associated risks, such as the unintentional activation of oncogenes that can result in cancer. Therefore, the analysis of integration sites of retroviral vectors is a crucial step in developing safer vectors for therapeutic use. Results -- Here we present VISMapper, a vector integration site analysis web server, to analyze next-generation sequencing data for retroviral vector integration sites. VISMapper can be found at: http://vismapper.babelomics.org. Conclusions -- Because it uses novel mapping algorithms VISMapper is remarkably faster than previous available programs. It also provides a useful graphical interface to analyze the integration sites found in the genomic context